List of works - Vesna Jevtovic-Todorovic

5beta-reduced neuroactive steroids are novel voltage-dependent blockers of T-type Ca2+ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivo

scientific article

A case series discussing the anaesthetic management of pregnant patients with brain tumours

scientific article

A holistic approach to anesthesia-induced neurotoxicity and its implications for future mechanistic studies

scientific article published on 28 December 2016

Anesthesia and the developing brain: are we getting closer to understanding the truth?

scientific article

Anesthesia-Induced Developmental Neurodegeneration: The Role of Neuronal Organelles ⬇️

scientific article published on October 11, 2012

Anesthesia-induced developmental neuroapoptosis. Does it happen in humans?

scientific article

Anesthetics and Cognitive Impairments in Developing Children: What Is Our Responsibility?

scientific article

Are neuroactive steroids promising therapeutic agents in the management of acute and chronic pain?

scientific article

CaV3.2 T-type calcium channels in peripheral sensory neurons are important for mibefradil-induced reversal of hyperalgesia and allodynia in rats with painful diabetic neuropathy

scientific article

CaV3.2 is the major molecular substrate for redox regulation of T-type Ca2+ channels in the rat and mouse thalamus

scientific article

Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neurons

scientific article

Chronic exposure to nitrous oxide increases [3H]MK801 binding in the cerebral cortex, but not in the hippocampus of adult mice

scientific article published in August 2005

Clinical anesthesia causes permanent damage to the fetal guinea pig brain

scientific article

Consensus statement: First International Workshop on Anesthetics and Alzheimer's disease

scientific article

Developing brain and general anesthesia -- is there a cause for concern? ⬇️

scientific article published on September 8, 2010

Developmental Synaptogenesis and General Anesthesia: A Kiss of Death? ⬇️

scientific article published on January 1, 2012

Differential effects of endogenous cysteine analogs on peripheral thermal nociception in intact rats

scientific article

Do pediatric drugs cause developing neurons to commit suicide?

scientific article published on March 2004

Dorsal Root Ganglion Application of Muscimol Prevents Hyperalgesia and Stimulates Myelin Protein Expression After Sciatic Nerve Injury in Rats ⬇️

scientific article published on December 20, 2011

Drug-induced apoptotic neurodegeneration in the developing brain.

scientific article

Early Exposure to General Anesthesia with Isoflurane Downregulates Inhibitory Synaptic Neurotransmission in the Rat Thalamus

scientific article

Early Exposure to Ketamine Impairs Axonal Pruning in Developing Mouse Hippocampus

scientific article published on 24 August 2017

Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits

scientific article

Early exposure to general anesthesia disturbs mitochondrial fission and fusion in the developing rat brain

scientific article

Exposure of Developing Brain to General Anesthesia: What Is the Animal Evidence?

scientific article published on 22 December 2017

Faculty of 1000 evaluation for MicroPET/CT imaging of [18F]-FEPPA in the nonhuman primate: a potential biomarker of pathogenic processes associated with anesthetic-induced neurotoxicity

Faculty of 1000 evaluation for Refinement of the retinogeniculate synapse by bouton clustering

Functional Implications of an Early Exposure to General Anesthesia: Are We Changing the Behavior of Our Children? ⬇️

scientific article published on July 3, 2013

General Anesthesia Causes Epigenetic Histone Modulation of c-Fos and Brain-derived Neurotrophic Factor, Target Genes Important for Neuronal Development in the Immature Rat Hippocampus

scientific article

General Anesthesia Causes Long-term Impairment of Mitochondrial Morphogenesis and Synaptic Transmission in Developing Rat Brain ⬇️

scientific article published on November 1, 2011

General Anesthesia and Young Brain: What is New?

scientific article

General Anesthetics and Neurotoxicity: How Much Do We Know?

scientific article published on September 2016

General anesthesia activates BDNF-dependent neuroapoptosis in the developing rat brain

scientific journal article

General anesthetics and the developing brain: friends or foes?

scientific article

Glutamate and GABA receptor dysfunction in the fetal alcohol syndrome

scientific article published in June 2002

Good gas, bad gas: isoflurane, carbon monoxide, and which is which?

scientific article

Hematopoietic pannexin 1 function is critical for neuropathic pain

scientific article

Histone Deacetylase Inhibitor Entinostat (MS-275) Restores Anesthesia-induced Alteration of Inhibitory Synaptic Transmission in the Developing Rat Hippocampus

scientific article published on 24 August 2017

Hyperexcitability of rat thalamocortical networks after exposure to general anesthesia during brain development

scientific article

In vivo silencing of the Ca(V)3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathy

scientific article

Inhibition of CaV3.2 T-type calcium channels in peripheral sensory neurons contributes to analgesic properties of epipregnanolone.

scientific article

Introduction to the special issue "Developmental neurotoxicity associated with pediatric general anesthesia: Preclinical findings".

scientific article published on 4 February 2017

Isoflurane Impairs Immature Astroglia Development In Vitro: The Role of Actin Cytoskeleton ⬇️

scientific article published on April 1, 2011

Journal-related and other special activities at the 2008 American Society of Anesthesiologists Annual Meeting

scientific article published in September 2008

Mechanical and thermal anti-nociception in rats after systemic administration of verapamil

scientific article

Mechanical and thermal antinociception in rats following systemic administration of mibefradil, a T-type calcium channel blocker

scientific article

Melatonin reduces the severity of anesthesia-induced apoptotic neurodegeneration in the developing rat brain

scientific article

Molecular mechanisms of lipoic acid modulation of T-type calcium channels in pain pathway

scientific article

Motoneuronal TASK channels contribute to immobilizing effects of inhalational general anesthetics

scientific article

Nanoparticle fullerol alleviates radiculopathy via NLRP3 inflammasome and neuropeptides

scientific article

Neuropathic pain: role for presynaptic T-type channels in nociceptive signaling ⬇️

scientific article published on January 16, 2013

Neurosteroids in Pain Management: A New Perspective on an Old Player

scholarly article by Sonja L Joksimovic et al published 2018 in Frontiers in Pharmacology

New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids

scientific article

PRO: Anesthesia-induced developmental neuroapoptosis: status of the evidence

scientific article published in June 2008

Pediatric anesthesia neurotoxicity: an overview of the 2011 SmartTots panel

scientific article published in November 2011

Potent analgesic effects of anticonvulsants on peripheral thermal nociception in rats

scientific article

Potential of ketamine and midazolam, individually or in combination, to induce apoptotic neurodegeneration in the infant mouse brain

scientific article

Propofol-induced changes in neurotrophic signaling in the developing nervous system in vivo

scientific article

Recovery profiles of general anesthesia and spinal anesthesia for chemotherapeutic perfusion with circulatory block (stop-flow perfusion).

scientific article published in November 2007

Redox modulation of peripheral T-type Ca2+ channels in vivo: alteration of nerve injury-induced thermal hyperalgesia

scientific article

Redox regulation of neuronal voltage-gated calcium channels

scientific article

Regulation of T-type calcium channels in the peripheral pain pathway

scientific article

Reversal of neuropathic pain in diabetes by targeting glycosylation of Ca(V)3.2 T-type calcium channels

scientific article

Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice

scientific article

Sevoflurane Exposure Results in Sex-Specific Transgenerational Upregulation of Target IEGs in the Subiculum

scientific article published on 12 September 2019

Silencing the α2 subunit of γ-aminobutyric acid type A receptors in rat dorsal root ganglia reveals its major role in antinociception posttraumatic nerve injury

scientific article

TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent

scientific article

Targeting of CaV3.2 T-type calcium channels in peripheral sensory neurons for the treatment of painful diabetic neuropathy

scientific article

The anesthetics nitrous oxide and ketamine are more neurotoxic to old than to young rat brain

scientific article

The enigma of fetal alcohol neurotoxicity

scientific article

The role of T-type calcium channels in peripheral and central pain processing

scientific article

The role of peripheral T-type calcium channels in pain transmission

scientific article

Timing versus duration: determinants of anesthesia-induced developmental apoptosis in the young mammalian brain

scientific article

T‐type voltage‐gated calcium channels as targets for the development of novel pain therapies ⬇️

scientific article published on June 1, 2011

Upregulation of the T-type calcium current in small rat sensory neurons after chronic constrictive injury of the sciatic nerve

scientific article

Using animal models to evaluate the functional consequences of anesthesia during early neurodevelopment

scientific article published on 14 March 2018

List of works by Vesna Jevtovic-Todorovic

5beta-reduced neuroactive steroids are novel voltage-dependent blockers of T-type Ca2+ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivo

A case series discussing the anaesthetic management of pregnant patients with brain tumours

A holistic approach to anesthesia-induced neurotoxicity and its implications for future mechanistic studies

Anesthesia and the developing brain: are we getting closer to understanding the truth?

Anesthesia-Induced Developmental Neurodegeneration: The Role of Neuronal Organelles ⬇️

Anesthesia-induced developmental neuroapoptosis. Does it happen in humans?

Anesthetics and Cognitive Impairments in Developing Children: What Is Our Responsibility?

Are neuroactive steroids promising therapeutic agents in the management of acute and chronic pain?

CaV3.2 T-type calcium channels in peripheral sensory neurons are important for mibefradil-induced reversal of hyperalgesia and allodynia in rats with painful diabetic neuropathy

CaV3.2 is the major molecular substrate for redox regulation of T-type Ca2+ channels in the rat and mouse thalamus

Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neurons

Chronic exposure to nitrous oxide increases [3H]MK801 binding in the cerebral cortex, but not in the hippocampus of adult mice

Clinical anesthesia causes permanent damage to the fetal guinea pig brain

Consensus statement: First International Workshop on Anesthetics and Alzheimer's disease

Developing brain and general anesthesia -- is there a cause for concern? ⬇️

Developmental Synaptogenesis and General Anesthesia: A Kiss of Death? ⬇️

Differential effects of endogenous cysteine analogs on peripheral thermal nociception in intact rats

Do pediatric drugs cause developing neurons to commit suicide?

Dorsal Root Ganglion Application of Muscimol Prevents Hyperalgesia and Stimulates Myelin Protein Expression After Sciatic Nerve Injury in Rats ⬇️

Drug-induced apoptotic neurodegeneration in the developing brain.

Early Exposure to General Anesthesia with Isoflurane Downregulates Inhibitory Synaptic Neurotransmission in the Rat Thalamus

Early Exposure to Ketamine Impairs Axonal Pruning in Developing Mouse Hippocampus

Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits

Early exposure to general anesthesia disturbs mitochondrial fission and fusion in the developing rat brain

Exposure of Developing Brain to General Anesthesia: What Is the Animal Evidence?

Faculty of 1000 evaluation for MicroPET/CT imaging of [18F]-FEPPA in the nonhuman primate: a potential biomarker of pathogenic processes associated with anesthetic-induced neurotoxicity

Faculty of 1000 evaluation for Refinement of the retinogeniculate synapse by bouton clustering

Functional Implications of an Early Exposure to General Anesthesia: Are We Changing the Behavior of Our Children? ⬇️

General Anesthesia Causes Epigenetic Histone Modulation of c-Fos and Brain-derived Neurotrophic Factor, Target Genes Important for Neuronal Development in the Immature Rat Hippocampus

General Anesthesia Causes Long-term Impairment of Mitochondrial Morphogenesis and Synaptic Transmission in Developing Rat Brain ⬇️

General Anesthesia and Young Brain: What is New?

General Anesthetics and Neurotoxicity: How Much Do We Know?

General anesthesia activates BDNF-dependent neuroapoptosis in the developing rat brain

General anesthetics and the developing brain: friends or foes?

Glutamate and GABA receptor dysfunction in the fetal alcohol syndrome

Good gas, bad gas: isoflurane, carbon monoxide, and which is which?

Hematopoietic pannexin 1 function is critical for neuropathic pain

Histone Deacetylase Inhibitor Entinostat (MS-275) Restores Anesthesia-induced Alteration of Inhibitory Synaptic Transmission in the Developing Rat Hippocampus

Hyperexcitability of rat thalamocortical networks after exposure to general anesthesia during brain development

In vivo silencing of the Ca(V)3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathy

Inhibition of CaV3.2 T-type calcium channels in peripheral sensory neurons contributes to analgesic properties of epipregnanolone.

Introduction to the special issue "Developmental neurotoxicity associated with pediatric general anesthesia: Preclinical findings".

Isoflurane Impairs Immature Astroglia Development In Vitro: The Role of Actin Cytoskeleton ⬇️

Journal-related and other special activities at the 2008 American Society of Anesthesiologists Annual Meeting

Mechanical and thermal anti-nociception in rats after systemic administration of verapamil

Mechanical and thermal antinociception in rats following systemic administration of mibefradil, a T-type calcium channel blocker

Melatonin reduces the severity of anesthesia-induced apoptotic neurodegeneration in the developing rat brain

Molecular mechanisms of lipoic acid modulation of T-type calcium channels in pain pathway

Motoneuronal TASK channels contribute to immobilizing effects of inhalational general anesthetics

Nanoparticle fullerol alleviates radiculopathy via NLRP3 inflammasome and neuropeptides

Neuropathic pain: role for presynaptic T-type channels in nociceptive signaling ⬇️

Neurosteroids in Pain Management: A New Perspective on an Old Player

New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids

PRO: Anesthesia-induced developmental neuroapoptosis: status of the evidence

Pediatric anesthesia neurotoxicity: an overview of the 2011 SmartTots panel

Potent analgesic effects of anticonvulsants on peripheral thermal nociception in rats

Potential of ketamine and midazolam, individually or in combination, to induce apoptotic neurodegeneration in the infant mouse brain

Propofol-induced changes in neurotrophic signaling in the developing nervous system in vivo

Recovery profiles of general anesthesia and spinal anesthesia for chemotherapeutic perfusion with circulatory block (stop-flow perfusion).

Redox modulation of peripheral T-type Ca2+ channels in vivo: alteration of nerve injury-induced thermal hyperalgesia

Redox regulation of neuronal voltage-gated calcium channels

Regulation of T-type calcium channels in the peripheral pain pathway

Reversal of neuropathic pain in diabetes by targeting glycosylation of Ca(V)3.2 T-type calcium channels

Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice

Sevoflurane Exposure Results in Sex-Specific Transgenerational Upregulation of Target IEGs in the Subiculum

Silencing the α2 subunit of γ-aminobutyric acid type A receptors in rat dorsal root ganglia reveals its major role in antinociception posttraumatic nerve injury

TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent

Targeting of CaV3.2 T-type calcium channels in peripheral sensory neurons for the treatment of painful diabetic neuropathy

The anesthetics nitrous oxide and ketamine are more neurotoxic to old than to young rat brain

The enigma of fetal alcohol neurotoxicity

The role of T-type calcium channels in peripheral and central pain processing

The role of peripheral T-type calcium channels in pain transmission

Timing versus duration: determinants of anesthesia-induced developmental apoptosis in the young mammalian brain

T‐type voltage‐gated calcium channels as targets for the development of novel pain therapies ⬇️

Upregulation of the T-type calcium current in small rat sensory neurons after chronic constrictive injury of the sciatic nerve

Using animal models to evaluate the functional consequences of anesthesia during early neurodevelopment