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List of works by Heini W Dirr

(-)-Epigallocatechin-3-Gallate Inhibits the Chaperone Activity of Plasmodium falciparum Hsp70 Chaperones and Abrogates Their Association with Functional Partners

scientific article published on 5 December 2017

A Lys-Trp cation-π interaction mediates the dimerization and function of the chloride intracellular channel protein 1 transmembrane domain.

scientific article published on 20 December 2013

A Phosphomimetic Study Implicates Ser557 in Regulation of FOXP2 DNA Binding

scientific article published on 01 August 2018

A Single Amino Acid in the Hinge Loop Region of the FOXP Forkhead Domain is Significant for Dimerisation.

scientific article

A conserved N-capping motif contributes significantly to the stabilization and dynamics of the C-terminal region of class Alpha glutathione S-transferases.

scientific article

A conserved cation binding site in the DNA binding domain of forkhead box transcription factors regulates DNA binding by FOXP2

scientific article published on 15 September 2018

A conserved cationic motif enhances membrane binding and insertion of the chloride intracellular channel protein 1 transmembrane domain

scientific article published on 13 June 2014

A topologically conserved aliphatic residue in alpha-helix 6 stabilizes the hydrophobic core in domain II of glutathione transferases and is a structural determinant for the unfolding pathway.

scientific article published in December 1998

Active-site mutations in the South african human immunodeficiency virus type 1 subtype C protease have a significant impact on clinical inhibitor binding: kinetic and thermodynamic study

scientific article published on 03 September 2008

Aflatoxin B1 and sulphobromophthalein binding to the dimeric human glutathione S-transferase A1-1: a fluorescence spectroscopic analysis.

scientific article published on October 1998

Aflatoxin B1 transport in rat blood plasma. Binding to albumin in vivo and in vitro and spectrofluorimetric studies into the nature of the interaction

scientific article published on 01 May 1986

Amide hydrogen exchange in HIV-1 subtype B and C proteases--insights into reduced drug susceptibility and dimer stability.

scientific article published on 4 November 2014

An update on the biophysical character of the human eukaryotic elongation factor 1 beta: Perspectives from interaction with elongation factor 1 gamma.

scientific article

Analysis of the levels of conservation of the J domain among the various types of DnaJ-like proteins.

scientific article

Arginine 15 stabilizes an S(N)Ar reaction transition state and the binding of anionic ligands at the active site of human glutathione transferase A1-1

scientific article

Characterization of the aflatoxin B1-binding site of rat albumin

scientific article published on 01 July 1987

Class sigma glutathione transferase unfolds via a dimeric and a monomeric intermediate: impact of subunit interface on conformational stability in the superfamily.

scientific article published in November 1998

Class-pi glutathione S-transferase is unable to regain its native conformation after oxidative inactivation by hydrogen peroxide

scientific article published on 01 December 1996

Conformational stability of Cys45‐alkylated and hydrogen peroxide‐oxidised glutathione S‐transferase ⬇️

scientific article published on September 4, 1995

Domain-domain interface packing at conserved Trp-20 in class alpha glutathione transferase impacts on protein stability.

scientific article

Double mutation at the subunit interface of glutathione transferase rGSTM1-1 results in a stable, folded monomer.

scientific article

Effect of aflatoxin b1 on human platelet protein kinase C ⬇️

scientific article published on January 1, 1991

Effect of glutathione, glutathione sulphonate and S-hexylglutathione on the conformational stability of class pi glutathione S-transferase

scientific article published on 01 August 1996

Electrostatic interactions affecting the active site of class sigma glutathione S-transferase.

scientific article published in April 2000

Energetics of Glutathione Binding to Human Eukaryotic Elongation Factor 1 Gamma: Isothermal Titration Calorimetry and Molecular Dynamics Studies.

scientific article published on 14 November 2016

Energetics of ligand binding to human glutathione transferase A1-1: Tyr-9 associated localisation of the C-terminal helix is ligand-dependent.

scientific article published on 12 April 2011

Equilibrium and kinetic unfolding properties of dimeric human glutathione transferase A1-1

scientific article published on 01 April 1998

Equilibrium unfolding of class pi glutathione S-transferase

scientific article published on 01 October 1991

F99 is critical for dimerization and activation of South African HIV-1 subtype C protease.

scientific article published on October 2013

Folding and assembly of dimeric human glutathione transferase A1-1

scientific article published on 01 December 1999

Formation of an unfolding intermediate state of soluble chloride intracellular channel protein CLIC1 at acidic pH

scientific article published on 14 October 2008

Glutamate 85 and glutamate 228 contribute to the pH-response of the soluble form of chloride intracellular channel 1.

scientific article published on 11 September 2014

JNK1β1 is phosphorylated during expression in E. coli and in vitro by MKK4 at three identical novel sites.

scientific article published on 12 February 2013

Molecular recognition at the dimer interface of a class mu glutathione transferase: role of a hydrophobic interaction motif in dimer stability and protein function.

scientific article

Mutational substitution of residues implicated by crystal structure in binding the substrate glutathione to human glutathione S-transferase pi

scientific article published on 01 July 1992

Native dimer stabilizes the subunit tertiary structure of porcine class pi glutathione S-transferase

scientific article published on 01 June 1995

Overexpression, Purification and Characterisation of the Plasmodium falciparum Hsp70-z (PfHsp70-z) Protein

scientific article (publication date: 2015)

Overexpression, Purification and Functional Characterisation of Wild-Type HIV-1 Subtype C Protease and Two Variants Using a Thioredoxin and His-Tag Protein Fusion System

article

Phosphorylation- and nucleotide-binding-induced changes to the stability and hydrogen exchange patterns of JNK1β1 provide insight into its mechanisms of activation.

scientific article published on 29 August 2014

Plasmodium falciparum Hsp70-z, an Hsp110 homologue, exhibits independent chaperone activity and interacts with Hsp70-1 in a nucleotide-dependent fashion

scientific article (publication date: May 2016)

Polymyxin B inhibits the chaperone activity of Plasmodium falciparum Hsp70.

scientific article published on 28 April 2017

Porcine class π glutathione S-transferase: anionic ligand binding and conformational analysis ⬇️

scientific article published on March 15, 1995

Probing the nature of the Co(III) ion in corrins: a comparison of the thermodynamics and kinetics of the ligand substitution reactions of aquacyanocobyrinic acid heptamethyl ester and stable yellow aquacyanocobyrinic acid heptamethyl ester

scientific article published on 18 August 2011

Purification and characterisation of recombinant human eukaryotic elongation factor 1 gamma

scientific article published on 13 April 2014

Purification and partial characterization of the glutathione S-transferase of rat erythrocytes

scientific article published on 01 November 1988

Refined crystal structure of porcine class Pi glutathione S-transferase (pGST P1-1) at 2.1 A resolution

scientific article

Residue 219 impacts on the dynamics of the C-terminal region in glutathione transferase A1-1: implications for stability and catalytic and ligandin functions.

scientific article published in December 2003

Role of arginine 29 and glutamic acid 81 interactions in the conformational stability of human chloride intracellular channel 1.

scientific article

Role of individual histidines in the pH-dependent global stability of human chloride intracellular channel 1

scientific article

Role of the C-terminal helix 9 in the stability and ligandin function of class alpha glutathione transferase A1-1

scientific article published on 01 November 1999

S-Nitrosation destabilizes glutathione transferase P1-1.

scientific article published on 2 December 2013

S-nitrosation of glutathione transferase p1-1 is controlled by the conformation of a dynamic active site helix.

scientific article published on 9 April 2013

Stability of the domain interface contributes towards the catalytic function at the H-site of class alpha glutathione transferase A1-1

scientific article

Structural and biochemical characterization of Plasmodium falciparum Hsp70-x reveals functional versatility of its C-terminal EEVN motif

scientific article published on 29 September 2018

Structural dynamics of soluble chloride intracellular channel protein CLIC1 examined by amide hydrogen-deuterium exchange mass spectrometry.

scientific article published on September 2009

Structural insights into the South African HIV-1 subtype C protease: impact of hinge region dynamics and flap flexibility in drug resistance

scientific article published on 12 November 2012

Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes

scientific article

Tertiary interactions stabilise the C-terminal region of human glutathione transferase A1-1: a crystallographic and calorimetric study.

scientific article published in June 2005

The FOXP2 forkhead domain binds to a variety of DNA sequences with different rates and affinities.

scientific article published on 18 January 2017

The Lyssavirus glycoprotein: A key to cross-immunity.

scientific article published on 8 September 2016

The cochaperone murine stress-inducible protein 1: overexpression, purification, and characterization.

scientific article

The effects of mutating Tyr9 and Arg15 on the structure, stability, conformational dynamics and mechanism of GSTA3-3.

scientific article published in March 2017

The forkhead domain hinge-loop plays a pivotal role in DNA binding and transcriptional activity of FOXP2

scientific article published on 01 July 2018

The hydrophobic lock-and-key intersubunit motif of glutathione transferase A1-1: implications for catalysis, ligandin function and stability.

scientific article published on January 2000

The intersubunit lock-and-key motif in human glutathione transferase A1-1: role of the key residues Met51 and Phe52 in function and dimer stability

scientific article published on January 2006

The isomerization of Δ5-androstene-3,17-dione by the human glutathione transferase A3-3 proceeds via a conjugated heteroannular diene intermediate

scientific article

The role of a topologically conserved isoleucine in glutathione transferase structure, stability and function

scientific article

Thermodynamics of the ligandin function of human class Alpha glutathione transferase A1-1: energetics of organic anion ligand binding.

scientific article published on April 2002

Three-dimensional structure of class π glutathione S-transferase from human placenta in complex with S-hexylglutathione at 2.8 Å resolution

article

X-ray crystal structures of cytosolic glutathione S-transferases. Implications for protein architecture, substrate recognition and catalytic function

scientific article

X-ray structure methods for glutathione binding

scientific article published on 01 January 1995

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