List of works - Anna Łęgowska

Analogues of Trypsin Inhibitor SFTI-1 with Disulfide Bridge Substituted by Various Length of Carbonyl Bridges

scientific article published on 01 October 2010

Analysis of urinary cathepsin C for diagnosing Papillon-Lefèvre syndrome

scientific article published in 2016

Antifungal action of human cathelicidin fragment (LL13-37) on Candida albicans

scientific article published on 26 August 2011

Antimicrobial Activity of Chimera Peptides Composed of Human Neutrophil Peptide 1 (HNP-1) Truncated Analogues and Bovine Lactoferrampin

scientific article published on 10 August 2018

Application of specific cell permeable cathepsin G inhibitors resulted in reduced antigen processing in primary dendritic cells.

scientific article published on 16 July 2009

Atomic resolution crystal structure of HV-BBI protease inhibitor from amphibian skin in complex with bovine trypsin

scientific article

Conformational solution studies of neuropeptide gamma using CD and NMR spectroscopy.

scientific article published in May 2002

Conformational studies of [Abu(3, 11)]-SFTI-1, an analogue of the trypsin inhibitor isolated from sunflower seeds.

scientific article

Conjugates of Ciprofloxacin and Levofloxacin with Cell-Penetrating Peptide Exhibit Antifungal Activity and Mammalian Cytotoxicity ⬇️

scientific article published on 30 June 2020

Convenient preparation of deuterium-labeled analogs of peptides containing N-substituted glycines for a stable isotope dilution LC-MS quantitative analysis.

scientific article

Copper(II) complexes with Fusobacterium nucleatum adhesin FadA: Coordination pattern, physicochemical properties and reactivity

scientific article published on 18 September 2018

Correction: Stability of Cu(II) complexes with FomA protein fragments containing two His residues in the peptide chain

scientific article published on 15 December 2020

Cu(II) complexes with peptides from FomA protein containing -His-Xaa-Yaa-Zaa-His and -His-His-motifs. ROS generation and DNA degradation

scientific article published on 06 September 2020

Cyclic Peptidic Furin Inhibitors Developed by Combinatorial Chemistry

scientific article published on 13 April 2023

Design and chemical syntheses of potent matriptase-2 inhibitors based on trypsin inhibitor SFTI-1 isolated from sunflower seeds.

scientific article published on 27 May 2017

Design of selective substrates of proteinase 3 using combinatorial chemistry methods

scientific article published on 07 April 2008

Designing of substrates and inhibitors of bovine alpha-chymotrypsin with synthetic phenylalanine analogues in position P(1).

scientific article published in January 2008

Development of sensitive cathepsin G fluorogenic substrate using combinatorial chemistry methods.

scientific article

Effects of cathelicidin and its fragments on three key enzymes of HIV-1.

scientific article published on 22 April 2011

Fluorescent analogs of trypsin inhibitor SFTI-1 isolated from sunflower seeds--synthesis and applications.

scientific article published on January 2014

Highly specific substrates of proteinase 3 containing 3-(2-benzoxazol-5-yl)-l-alanine and their application for detection of this enzyme in human serum.

scientific article

Hybrid analogues of SFTI-1 modified in P1position by β- and γ-amino acids andN-substituted β-alanines

scientific article published on 01 April 2013

Inhibition of human and yeast 20S proteasome by analogues of trypsin inhibitor SFTI-1

scientific article

Inhibitors of Matriptase-2 Based on the Trypsin Inhibitor SFTI-1

scientific article published on 19 June 2015

Inhibitory activity of double-sequence analogues of trypsin inhibitor SFTI-1 from sunflower seeds: an example of peptide splicing

scientific article published on 19 April 2010

Inhibitory and antimicrobial activities of OGTI and HV-BBI peptides, fragments and analogs derived from amphibian skin

scientific article

Introduction of Pro and Its Analogues in the Conserved P1 Position of Trypsin Inhibitor SFTI-1 Retains Its Inhibitory Activity

scientific article published on 01 November 2011

Investigation of Serine-Proteinase-Catalyzed Peptide Splicing in Analogues of Sunflower Trypsin Inhibitor 1 (SFTI-1)

scientific article

Investigation of peptide splicing using two-peptide-chain analogs of trypsin inhibitor SFTI-1.

scientific article

Low-molecular-weight aldehyde inhibitors of cathepsin G.

scientific article

Matriptase-2: monitoring and inhibiting its proteolytic activity

Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases

scientific article published on 16 February 2016

New analogs of somatostatin: inhibiting effectively GH, glucagon and insulin levels

scientific article published on 01 January 1999

New chromogenic substrates of human neutrophil cathepsin G containing non-natural aromatic amino acid residues in position P(1) selected by combinatorial chemistry methods.

scientific article

New potent cathepsin G phosphonate inhibitors

scientific article published on 31 August 2008

New selective peptidyl di(chlorophenyl) phosphonate esters for visualizing and blocking neutrophil proteinase 3 in human diseases

scientific article

Noncovalent inhibitors of human 20S and 26S proteasome based on trypsin inhibitor SFTI-1.

scientific article published on 3 June 2016

Peptide conjugates of lactoferricin analogues and antimicrobials-Design, chemical synthesis, and evaluation of antimicrobial activity and mammalian cytotoxicity

scientific article published on 05 April 2019

Peptide splicing in a double-sequence analogue of trypsin inhibitor SFTI-1 substituted in the P₁ positions by peptoid monomers.

scientific article published in May 2015

Peptomeric analogues of trypsin inhibitor SFTI-1 isolated from sunflower seeds

scientific article published in April 2008

Relationship between copper(ii) complexes with FomA adhesin fragments of F. nucleatum and colorectal cancer. Coordination pattern and ability to promote ROS production

scientific article published on 01 April 2018

Selection of peptomeric inhibitors of bovine alpha-chymotrypsin and cathepsin G based on trypsin inhibitor SFTI-1 using a combinatorial chemistry approach

scientific article

Solution conformational study of nociceptin an(d its 1-13 and 1-11 fragments using circular dichroism and two-dimensional NMR in conjunction with theoretical conformational analysis

scientific article

Spliced analogues of trypsin inhibitor SFTI-1 and their application for tracing proteolysis and delivery of cargos inside the cells

scientific article published on 14 September 2016

Structural and Dynamic Characterization of Copper(II) Binding of the Human Prion Protein Outside the Octarepeat Region

scientific article published on 01 January 2007

Sunflower trypsin inhibitor 1 as a molecular scaffold for drug discovery

scientific article published on December 2011

The dimeric and tetrameric octarepeat fragments of prion protein behave differently to its monomeric unit

scientific article published on 29 March 2004

The influence of substrate peptide length on human beta-tryptase specificity

scientific article

The new fluorogenic substrates of neutrophil proteinase 3 optimized in prime site region.

scientific article published on 13 January 2010

The prion peptide forms ion channels in planar lipid bilayers.

scientific article published in January 2003

Three Wavelength Substrate System of Neutrophil Serine Proteinases

scientific article published on 08 August 2012

Truncation of Huia versabilis Bowman-Birk inhibitor increases its selectivity, matriptase-1 inhibitory activity and proteolytic stability

scientific article published on 10 March 2020

List of works by Anna Łęgowska

Analogues of Trypsin Inhibitor SFTI-1 with Disulfide Bridge Substituted by Various Length of Carbonyl Bridges

Analysis of urinary cathepsin C for diagnosing Papillon-Lefèvre syndrome

Antifungal action of human cathelicidin fragment (LL13-37) on Candida albicans

Antimicrobial Activity of Chimera Peptides Composed of Human Neutrophil Peptide 1 (HNP-1) Truncated Analogues and Bovine Lactoferrampin

Application of specific cell permeable cathepsin G inhibitors resulted in reduced antigen processing in primary dendritic cells.

Atomic resolution crystal structure of HV-BBI protease inhibitor from amphibian skin in complex with bovine trypsin

Conformational solution studies of neuropeptide gamma using CD and NMR spectroscopy.

Conformational studies of [Abu(3, 11)]-SFTI-1, an analogue of the trypsin inhibitor isolated from sunflower seeds.

Conjugates of Ciprofloxacin and Levofloxacin with Cell-Penetrating Peptide Exhibit Antifungal Activity and Mammalian Cytotoxicity ⬇️

Convenient preparation of deuterium-labeled analogs of peptides containing N-substituted glycines for a stable isotope dilution LC-MS quantitative analysis.

Copper(II) complexes with Fusobacterium nucleatum adhesin FadA: Coordination pattern, physicochemical properties and reactivity

Correction: Stability of Cu(II) complexes with FomA protein fragments containing two His residues in the peptide chain

Cu(II) complexes with peptides from FomA protein containing -His-Xaa-Yaa-Zaa-His and -His-His-motifs. ROS generation and DNA degradation

Cyclic Peptidic Furin Inhibitors Developed by Combinatorial Chemistry

Design and chemical syntheses of potent matriptase-2 inhibitors based on trypsin inhibitor SFTI-1 isolated from sunflower seeds.

Design of selective substrates of proteinase 3 using combinatorial chemistry methods

Designing of substrates and inhibitors of bovine alpha-chymotrypsin with synthetic phenylalanine analogues in position P(1).

Development of sensitive cathepsin G fluorogenic substrate using combinatorial chemistry methods.

Effects of cathelicidin and its fragments on three key enzymes of HIV-1.

Fluorescent analogs of trypsin inhibitor SFTI-1 isolated from sunflower seeds--synthesis and applications.

Highly specific substrates of proteinase 3 containing 3-(2-benzoxazol-5-yl)-l-alanine and their application for detection of this enzyme in human serum.

Hybrid analogues of SFTI-1 modified in P1position by β- and γ-amino acids andN-substituted β-alanines

Inhibition of human and yeast 20S proteasome by analogues of trypsin inhibitor SFTI-1

Inhibitors of Matriptase-2 Based on the Trypsin Inhibitor SFTI-1

Inhibitory activity of double-sequence analogues of trypsin inhibitor SFTI-1 from sunflower seeds: an example of peptide splicing

Inhibitory and antimicrobial activities of OGTI and HV-BBI peptides, fragments and analogs derived from amphibian skin

Introduction of Pro and Its Analogues in the Conserved P1 Position of Trypsin Inhibitor SFTI-1 Retains Its Inhibitory Activity

Investigation of Serine-Proteinase-Catalyzed Peptide Splicing in Analogues of Sunflower Trypsin Inhibitor 1 (SFTI-1)

Investigation of peptide splicing using two-peptide-chain analogs of trypsin inhibitor SFTI-1.

Low-molecular-weight aldehyde inhibitors of cathepsin G.

Matriptase-2: monitoring and inhibiting its proteolytic activity

Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases

New analogs of somatostatin: inhibiting effectively GH, glucagon and insulin levels

New chromogenic substrates of human neutrophil cathepsin G containing non-natural aromatic amino acid residues in position P(1) selected by combinatorial chemistry methods.

New potent cathepsin G phosphonate inhibitors

New selective peptidyl di(chlorophenyl) phosphonate esters for visualizing and blocking neutrophil proteinase 3 in human diseases

Noncovalent inhibitors of human 20S and 26S proteasome based on trypsin inhibitor SFTI-1.

Peptide conjugates of lactoferricin analogues and antimicrobials-Design, chemical synthesis, and evaluation of antimicrobial activity and mammalian cytotoxicity

Peptide splicing in a double-sequence analogue of trypsin inhibitor SFTI-1 substituted in the P₁ positions by peptoid monomers.

Peptomeric analogues of trypsin inhibitor SFTI-1 isolated from sunflower seeds

Relationship between copper(ii) complexes with FomA adhesin fragments of F. nucleatum and colorectal cancer. Coordination pattern and ability to promote ROS production

Selection of peptomeric inhibitors of bovine alpha-chymotrypsin and cathepsin G based on trypsin inhibitor SFTI-1 using a combinatorial chemistry approach

Solution conformational study of nociceptin an(d its 1-13 and 1-11 fragments using circular dichroism and two-dimensional NMR in conjunction with theoretical conformational analysis

Spliced analogues of trypsin inhibitor SFTI-1 and their application for tracing proteolysis and delivery of cargos inside the cells

Structural and Dynamic Characterization of Copper(II) Binding of the Human Prion Protein Outside the Octarepeat Region

Sunflower trypsin inhibitor 1 as a molecular scaffold for drug discovery

The dimeric and tetrameric octarepeat fragments of prion protein behave differently to its monomeric unit

The influence of substrate peptide length on human beta-tryptase specificity

The new fluorogenic substrates of neutrophil proteinase 3 optimized in prime site region.

The prion peptide forms ion channels in planar lipid bilayers.

Three Wavelength Substrate System of Neutrophil Serine Proteinases

Truncation of Huia versabilis Bowman-Birk inhibitor increases its selectivity, matriptase-1 inhibitory activity and proteolytic stability