List of works - Dirk T.S. Rijkers

A micelle-shedding thermosensitive hydrogel as sustained release formulation.

scientific article published on 21 August 2012

A synergistic effect between cholesterol and tryptophan-flanked transmembrane helices modulates membrane curvature.

scientific article

ATRP, subsequent azide substitution and ‘click’ chemistry: three reactions using one catalyst in one pot

scientific article published on 17 May 2011

Aggregation of transmembrane peptides studied by spin-label EPR

scientific article published on 01 September 2009

An electrostatic/hydrogen bond switch as the basis for the specific interaction of phosphatidic acid with proteins

scientific article published in Journal of Biological Chemistry

Backbone-modified amylin derivatives: implications for amyloid inhibitor design and as template for self-assembling bionanomaterials.

scientific article published on November 2007

Cu(I)- and Ru(II)-mediated "click" cyclization of tripeptides toward vancomycin-inspired mimics

scientific article published on 26 May 2011

Delayed fibril formation of amylin(20-29) by incorporation of alkene dipeptidosulfonamide isosteres obtained by solid phase olefin cross metathesis.

scientific article published on 6 November 2007

Development of selective bisubstrate-based inhibitors against protein kinase C (PKC) isozymes by using dynamic peptide microarrays

scientific article published on 01 August 2009

Efficient microwave-assisted synthesis of multivalent dendrimeric peptides using cycloaddition reaction (click) chemistry

scientific article published on 19 August 2005

Enzymatic synthesis of C-terminal arylamides of amino acids and peptides.

scientific article

Highly efficient coupling of beta-substituted aminoethane sulfonyl azides with thio acids, toward a new chemical ligation reaction

scientific article published on 01 March 2005

Improving the biological activity of the antimicrobial peptide anoplin by membrane anchoring through a lipophilic amino acid derivative.

scientific article published on 9 May 2013

Influence of flanking residues on tilt and rotation angles of transmembrane peptides in lipid bilayers. A solid-state 2H NMR study.

scientific article published in January 2005

Influence of hydrophobic mismatch and palmitoylation on the association of transmembrane alpha-helical peptides with detergent-resistant membranes.

scientific article

Influence of trifluoroethanol on membrane interfacial anchoring interactions of transmembrane alpha-helical peptides.

scientific article

Inhibition of Octreotide Acylation Inside PLGA Microspheres by Derivatization of the Amines of the Peptide with a Self-Immolative Protecting Group.

scientific article published on 4 January 2016

Interfacial properties of the M1 segment of the nicotinic acetylcholine receptor.

scientific article published on 13 February 2006

Is there a preferential interaction between cholesterol and tryptophan residues in membrane proteins?

scientific article

Islet amyloid polypeptide inserts into phospholipid monolayers as monomer

scientific article published on 21 December 2005

Lipid dependence of membrane anchoring properties and snorkeling behavior of aromatic and charged residues in transmembrane peptides.

scientific article published in June 2002

Looped Structure of Flowerlike Micelles Revealed by1H NMR Relaxometry and Light Scattering

scientific article published on 20 July 2011

Membrane-spanning peptides induce phospholipid flop: a model for phospholipid translocation across the inner membrane of E. coli.

scientific article

Microwave-assisted click polymerization for the synthesis of Abeta(16-22) cyclic oligomers and their self-assembly into polymorphous aggregates

scientific article published on 27 August 2009

Mode of action of cGMP-dependent protein kinase-specific inhibitors probed by photoaffinity cross-linking mass spectrometry.

scientific article published on 15 April 2009

Pre-organization induced synthesis of a crossed alkene-bridged nisin Z DE-ring mimic by ring-closing metathesis.

scientific article

Preparation of novel alkylated arginine derivatives suitable for click-cycloaddition chemistry and their incorporation into pseudosubstrate- and bisubstrate-based kinase inhibitors.

scientific article published on 4 February 2010

Prevention of the influence of fibrin and alpha2-macroglobulin in the continuous measurement of the thrombin potential: implications for an endpoint determination of the optical density.

scientific article published in February 1998

Probing membrane protein orientation and structure using fast magic-angle-spinning solid-state NMR

scientific article published on 01 November 2004

Proteome-wide profiling of protein assemblies by cross-linking mass spectrometry.

scientific article

Resin-bound sulfonyl azides: efficient loading and activation strategy for the preparation of the N-acyl sulfonamide linker

scientific article published on 12 May 2007

Ring-closing alkyne metathesis approach toward the synthesis of alkyne mimics of thioether A-, B-, C-, and DE-ring systems of the lantibiotic nisin Z

scientific article published on 01 July 2005

Ring-closing metathesis for the synthesis of side chain knotted pentapeptides inspired by vancomycin.

scientific article published on 24 August 2004

Scalable purification of the lantibiotic nisin and isolation of chemical/enzymatic cleavage fragments suitable for semi-synthesis.

scientific article published on 11 September 2013

Selective enrichment of Ser-/Thr-phosphorylated peptides in the presence of Ser-/Thr-glycosylated peptides

scientific article published on 01 December 2006

Self-assembly of amylin(20-29) amide-bond derivatives into helical ribbons and peptide nanotubes rather than fibrils.

scientific article published in May 2006

Self-association of transmembrane alpha-helices in model membranes: importance of helix orientation and role of hydrophobic mismatch.

scientific article published on 15 September 2005

Semi-synthesis of biologically active nisin hybrids composed of the native lanthionine ABC-fragment and a cross-stapled synthetic DE-fragment.

scientific article published on 2 August 2014

Step-wise and pre-organization induced synthesis of a crossed alkene-bridged nisin Z DE-ring mimic by ring-closing metathesis

scientific article published on 07 February 2007

Strength of integration of transmembrane alpha-helical peptides in lipid bilayers as determined by atomic force spectroscopy.

scientific article published in November 2004

Synthesis and applications of biomedical and pharmaceutical polymers via click chemistry methodologies.

scientific article

Synthesis and biological activity of N-terminal lipidated and/or fluorescently labeled conjugates of astressin as corticotropin releasing factor antagonists.

scientific article published on October 2004

Synthesis and structural characterization of the individual diastereoisomers of a cross-stapled alkene-bridged nisin DE-ring mimic.

scientific article published in November 2013

Synthesis and structural investigations of N-alkylated beta-peptidosulfonamide-peptide hybrids of the amyloidogenic amylin(20-29) sequence: Implications of supramolecular folding for the design of peptide-based bionanomaterials.

scientific article

Synthesis of DOTA-conjugated multimeric [Tyr3]octreotide peptides via a combination of Cu(I)-catalyzed "click" cycloaddition and thio acid/sulfonyl azide "sulfo-click" amidation and their in vivo evaluation.

scientific article published on May 2010

Synthesis of DOTA-conjugated multivalent cyclic-RGD peptide dendrimers via 1,3-dipolar cycloaddition and their biological evaluation: implications for tumor targeting and tumor imaging purposes

scientific article published on 29 January 2007

Synthesis of bicyclic alkene-/alkane-bridged nisin mimics by ring-closing metathesis and their biochemical evaluation as lipid II binders: toward the design of potential novel antibiotics.

scientific article published on September 2007

Synthesis of nisin AB dicarba analogs using ring-closing metathesis: influence of sp(3) versus sp(2) hybridization of the α-carbon atom of residues dehydrobutyrine-2 and dehydroalanine-5 on the lipid II binding affinity.

scientific article published on June 2015

Synthesis of peptide-based polymers by microwave-assisted cycloaddition backbone polymerization

scientific article published on 01 February 2007

Synthesis, antimicrobial activity, and membrane permeabilizing properties of C-terminally modified nisin conjugates accessed by CuAAC

scientific article published on 05 December 2013

The Effects of Hydrophobic Mismatch between Phosphatidylcholine Bilayers and Transmembrane α-Helical Peptides Depend on the Nature of Interfacially Exposed Aromatic and Charged Residues†

scientific article published on 01 July 2002

Tilt and rotation angles of a transmembrane model peptide as studied by fluorescence spectroscopy.

scientific article published on October 2009

Tilt angles of transmembrane model peptides in oriented and non-oriented lipid bilayers as determined by 2H solid-state NMR.

scientific article

Transformation of the amyloidogenic peptide amylin(20-29) into its corresponding peptoid and retropeptoid: access to both an amyloid inhibitor and template for self-assembled supramolecular tapes

scientific article published on 24 January 2007

Versatile conjugation of octreotide to dendrimers by cycloaddition ("click") chemistry to yield high-affinity multivalent cyclic Peptide dendrimers.

scientific article

pH-controlled aggregation polymorphism of amyloidogenic Aβ(16-22): insights for obtaining peptide tapes and peptide nanotubes, as function of the N-terminal capping moiety.

scientific article published on 25 July 2014

β-Sheet Structured β-Amyloid(1-40) Perturbs Phosphatidylcholine Model Membranes

article

List of works by Dirk T.S. Rijkers

A micelle-shedding thermosensitive hydrogel as sustained release formulation.

A synergistic effect between cholesterol and tryptophan-flanked transmembrane helices modulates membrane curvature.

ATRP, subsequent azide substitution and ‘click’ chemistry: three reactions using one catalyst in one pot

Aggregation of transmembrane peptides studied by spin-label EPR

An electrostatic/hydrogen bond switch as the basis for the specific interaction of phosphatidic acid with proteins

Backbone-modified amylin derivatives: implications for amyloid inhibitor design and as template for self-assembling bionanomaterials.

Cu(I)- and Ru(II)-mediated "click" cyclization of tripeptides toward vancomycin-inspired mimics

Delayed fibril formation of amylin(20-29) by incorporation of alkene dipeptidosulfonamide isosteres obtained by solid phase olefin cross metathesis.

Development of selective bisubstrate-based inhibitors against protein kinase C (PKC) isozymes by using dynamic peptide microarrays

Efficient microwave-assisted synthesis of multivalent dendrimeric peptides using cycloaddition reaction (click) chemistry

Enzymatic synthesis of C-terminal arylamides of amino acids and peptides.

Highly efficient coupling of beta-substituted aminoethane sulfonyl azides with thio acids, toward a new chemical ligation reaction

Improving the biological activity of the antimicrobial peptide anoplin by membrane anchoring through a lipophilic amino acid derivative.

Influence of flanking residues on tilt and rotation angles of transmembrane peptides in lipid bilayers. A solid-state 2H NMR study.

Influence of hydrophobic mismatch and palmitoylation on the association of transmembrane alpha-helical peptides with detergent-resistant membranes.

Influence of trifluoroethanol on membrane interfacial anchoring interactions of transmembrane alpha-helical peptides.

Inhibition of Octreotide Acylation Inside PLGA Microspheres by Derivatization of the Amines of the Peptide with a Self-Immolative Protecting Group.

Interfacial properties of the M1 segment of the nicotinic acetylcholine receptor.

Is there a preferential interaction between cholesterol and tryptophan residues in membrane proteins?

Islet amyloid polypeptide inserts into phospholipid monolayers as monomer

Lipid dependence of membrane anchoring properties and snorkeling behavior of aromatic and charged residues in transmembrane peptides.

Looped Structure of Flowerlike Micelles Revealed by1H NMR Relaxometry and Light Scattering

Membrane-spanning peptides induce phospholipid flop: a model for phospholipid translocation across the inner membrane of E. coli.

Microwave-assisted click polymerization for the synthesis of Abeta(16-22) cyclic oligomers and their self-assembly into polymorphous aggregates

Mode of action of cGMP-dependent protein kinase-specific inhibitors probed by photoaffinity cross-linking mass spectrometry.

Pre-organization induced synthesis of a crossed alkene-bridged nisin Z DE-ring mimic by ring-closing metathesis.

Preparation of novel alkylated arginine derivatives suitable for click-cycloaddition chemistry and their incorporation into pseudosubstrate- and bisubstrate-based kinase inhibitors.

Prevention of the influence of fibrin and alpha2-macroglobulin in the continuous measurement of the thrombin potential: implications for an endpoint determination of the optical density.

Probing membrane protein orientation and structure using fast magic-angle-spinning solid-state NMR

Proteome-wide profiling of protein assemblies by cross-linking mass spectrometry.

Resin-bound sulfonyl azides: efficient loading and activation strategy for the preparation of the N-acyl sulfonamide linker

Ring-closing alkyne metathesis approach toward the synthesis of alkyne mimics of thioether A-, B-, C-, and DE-ring systems of the lantibiotic nisin Z

Ring-closing metathesis for the synthesis of side chain knotted pentapeptides inspired by vancomycin.

Scalable purification of the lantibiotic nisin and isolation of chemical/enzymatic cleavage fragments suitable for semi-synthesis.

Selective enrichment of Ser-/Thr-phosphorylated peptides in the presence of Ser-/Thr-glycosylated peptides

Self-assembly of amylin(20-29) amide-bond derivatives into helical ribbons and peptide nanotubes rather than fibrils.

Self-association of transmembrane alpha-helices in model membranes: importance of helix orientation and role of hydrophobic mismatch.

Semi-synthesis of biologically active nisin hybrids composed of the native lanthionine ABC-fragment and a cross-stapled synthetic DE-fragment.

Step-wise and pre-organization induced synthesis of a crossed alkene-bridged nisin Z DE-ring mimic by ring-closing metathesis

Strength of integration of transmembrane alpha-helical peptides in lipid bilayers as determined by atomic force spectroscopy.

Synthesis and applications of biomedical and pharmaceutical polymers via click chemistry methodologies.

Synthesis and biological activity of N-terminal lipidated and/or fluorescently labeled conjugates of astressin as corticotropin releasing factor antagonists.

Synthesis and structural characterization of the individual diastereoisomers of a cross-stapled alkene-bridged nisin DE-ring mimic.

Synthesis and structural investigations of N-alkylated beta-peptidosulfonamide-peptide hybrids of the amyloidogenic amylin(20-29) sequence: Implications of supramolecular folding for the design of peptide-based bionanomaterials.

Synthesis of DOTA-conjugated multimeric [Tyr3]octreotide peptides via a combination of Cu(I)-catalyzed "click" cycloaddition and thio acid/sulfonyl azide "sulfo-click" amidation and their in vivo evaluation.

Synthesis of DOTA-conjugated multivalent cyclic-RGD peptide dendrimers via 1,3-dipolar cycloaddition and their biological evaluation: implications for tumor targeting and tumor imaging purposes

Synthesis of bicyclic alkene-/alkane-bridged nisin mimics by ring-closing metathesis and their biochemical evaluation as lipid II binders: toward the design of potential novel antibiotics.

Synthesis of nisin AB dicarba analogs using ring-closing metathesis: influence of sp(3) versus sp(2) hybridization of the α-carbon atom of residues dehydrobutyrine-2 and dehydroalanine-5 on the lipid II binding affinity.

Synthesis of peptide-based polymers by microwave-assisted cycloaddition backbone polymerization

Synthesis, antimicrobial activity, and membrane permeabilizing properties of C-terminally modified nisin conjugates accessed by CuAAC

The Effects of Hydrophobic Mismatch between Phosphatidylcholine Bilayers and Transmembrane α-Helical Peptides Depend on the Nature of Interfacially Exposed Aromatic and Charged Residues†

Tilt and rotation angles of a transmembrane model peptide as studied by fluorescence spectroscopy.

Tilt angles of transmembrane model peptides in oriented and non-oriented lipid bilayers as determined by 2H solid-state NMR.

Transformation of the amyloidogenic peptide amylin(20-29) into its corresponding peptoid and retropeptoid: access to both an amyloid inhibitor and template for self-assembled supramolecular tapes

Versatile conjugation of octreotide to dendrimers by cycloaddition ("click") chemistry to yield high-affinity multivalent cyclic Peptide dendrimers.

pH-controlled aggregation polymorphism of amyloidogenic Aβ(16-22): insights for obtaining peptide tapes and peptide nanotubes, as function of the N-terminal capping moiety.

β-Sheet Structured β-Amyloid(1-40) Perturbs Phosphatidylcholine Model Membranes