Search filters

List of works by Hindrik Mulder

13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)

scientific article

A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis

scientific article published on 21 November 2008

A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes

scientific article published on January 2011

Adrenomedullin: localization in the gastrointestinal tract and effects on insulin secretion

scientific article published on 01 April 1996

Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss

scientific article

Anaplerosis via pyruvate carboxylase is required for the fuel-induced rise in the ATP:ADP ratio in rat pancreatic islets.

scientific article

Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology

scientific journal article

Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue

scientific article

Bioenergetic Impairment in Congenital Muscular Dystrophy Type 1A and Leigh Syndrome Muscle Cells

scientific article published on 3 April 2017

CART regulates islet hormone secretion and is expressed in the beta-cells of type 2 diabetic rats

scientific journal article

CaV1.2 rather than CaV1.3 is coupled to glucose-stimulated insulin secretion in INS-1 832/13 cells

scientific article

Calcitonin gene-related peptide and nitric oxide in the trigeminal ganglion: cerebral vasodilatation from trigeminal nerve stimulation involves mainly calcitonin gene-related peptide

scientific article

Calcium modulation of exocytosis-linked plasma membrane potential oscillations in INS-1 832/13 cells

scientific article published on 4 August 2015

Cartilage oligomeric matrix protein contributes to the development and metastasis of breast cancer.

scientific article published on 11 April 2016

Cartilage oligomeric matrix protein promotes prostate cancer progression by enhancing invasion and disrupting intracellular calcium homeostasis

scientific article published on 21 September 2017

Cerebrospinal fluid levels of orexin-A are not a clinically useful biomarker for Huntington disease.

scientific article published in July 2006

Characterization of stimulus-secretion coupling in the human pancreatic EndoC-βH1 beta cell line.

scientific article

Chronic high glucose and pyruvate levels differentially affect mitochondrial bioenergetics and fuel-stimulated insulin secretion from clonal INS-1 832/13 cells

scientific article published on 19 December 2013

Cocaine- and amphetamine-regulated transcript (CART) is expressed in several islet cell types during rat development

scientific article (publication date: February 2004)

Cocaine- and amphetamine-regulated transcript is increased in Huntington disease

scientific article

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

scientific article

Coordinate changes in histone modifications, mRNA levels, and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity

scientific article published on 8 March 2013

Development and optimization of a metabolomic method for analysis of adherent cell cultures

scientific article published on 22 April 2010

Diabetes in Friedreich ataxia

scientific article published on August 2013

Differential effect of insulin treatment on islet amyloid polypeptide (amylin) and insulin gene expression in streptozotocin-induced diabetes in rats

scientific article published on 01 March 1997

Differential expression of islet amyloid polypeptide (amylin) and insulin in experimental diabetes in rodents

scientific article published on 01 October 1995

Discriminative Prediction of A-To-I RNA Editing Events from DNA Sequence

scientific article

Dissociated insulinotropic sensitivity to glucose and carbachol in high-fat diet-induced insulin resistance in C57BL/6J mice

scientific article published on 01 January 1997

Distribution of melatonin receptors in murine pancreatic islets.

scientific article

Effect of murine strain on metabolic pathways of glucose production after brief or prolonged fasting.

scientific article published on 29 March 2005

Effects of growth hormone on the function of beta-adrenoceptor subtypes in rat adipocytes

scientific article published on February 2004

Effects of ingestion routes on hormonal and metabolic profiles in gastric-bypassed humans

scientific article published on 30 April 2013

Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell

scientific article

Enhanced cAMP protein kinase A signaling determines improved insulin secretion in a clonal insulin-producing beta-cell line (INS-1 832/13).

scientific article published on 27 May 2004

Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet

scientific article

Fracture mechanics of collagen fibrils: influence of natural cross-links

scientific article published on June 2013

Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass

scientific article

Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes

scientific article published on September 2017

Gastric bypass improves β-cell function and increases β-cell mass in a porcine model

scientific article published on 31 January 2014

Genotype-based treatment of type 2 diabetes with an α2A-adrenergic receptor antagonist

scientific article published on 01 October 2014

Ghrelin is expressed in a novel endocrine cell type in developing rat islets and inhibits insulin secretion from INS-1 (832/13) cells

scientific article published on March 2004

Glucagon-like peptide 1 stimulates insulin secretion via inhibiting RhoA/ROCK signaling and disassembling glucotoxicity-induced stress fibers

scientific article published on 22 September 2014

Glutamate dehydrogenase, insulin secretion, and type 2 diabetes: a new means to protect the pancreatic β-cell?

scientific article published on 9 January 2012

Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 (GLP-1) is Governed by an Activated Glutamate Dehydrogenase

scientific article published on 11 December 2017

Glycogen metabolism in the glucose-sensing and supply-driven β-cell

scientific article published on 05 November 2016

HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells

scientific article published on 29 October 2016

Hormone-sensitive lipase deficiency in mouse islets abolishes neutral cholesterol ester hydrolase activity but leaves lipolysis, acylglycerides, fat oxidation, and insulin secretion intact

scientific article

Hormone-sensitive lipase null mice exhibit signs of impaired insulin sensitivity whereas insulin secretion is intact

scientific article published on 30 June 2003

Hormone-sensitive lipase, the rate-limiting enzyme in triglyceride hydrolysis, is expressed and active in beta-cells

scientific article published on 01 January 1999

Increased Insulin Secretion and Glucose Tolerance in Mice Lacking Islet Amyloid Polypeptide (Amylin) ⬇️

scientific article published on September 18, 1998

Increased metabolism in the R6/2 mouse model of Huntington's disease.

scientific article

Inhibition of lipase activity and lipolysis in rat islets reduces insulin secretion

scientific article published in January 2004

Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion

scientific article

Is shortening of telomeres the missing link between aging and the Type 2 Diabetes epidemic? ⬇️

scientific article published on October 1, 2010

Islet amyloid polypeptide (amylin) and insulin are differentially expressed in chronic diabetes induced by streptozotocin in rats

scientific article published on 01 June 1996

Islet amyloid polypeptide and calcitonin gene-related peptide expression are down-regulated in dorsal root ganglia upon sciatic nerve transection ⬇️

scientific article published on July 1, 1997

Islet amyloid polypeptide and calcitonin gene-related peptide expression are upregulated in lumbar dorsal root ganglia after unilateral adjuvant-induced inflammation in the rat paw.

scientific article published in October 1997

Islet amyloid polypeptide gene expression in the endocrine pancreas of the rat: a combined in situ hybridization and immunocytochemical study

scientific article published on 01 December 1993

Islet amyloid polypeptide in the gut and pancreas: localization, ontogeny and gut motility effects

scientific article published on 01 January 1997

Islet amyloid polypeptide is expressed in endocrine cells of the gastric mucosa in the rat and mouse

scientific article published on 01 September 1994

Islet beta-cell area and hormone expression are unaltered in Huntington's disease

scientific article published on 8 February 2008

Lipases in the pancreatic beta-cell: implications for insulin secretion

scientific article published on October 2008

Localization of hormone-sensitive lipase to rat Sertoli cells and its expression in developing and degenerating testes

scientific article published on 01 November 1994

Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes

scientific article published on 10 June 2014

Matrix metalloproteinases: keys to healthier blood vessels in diabetes? ⬇️

scientific article published on 09 May 2011

Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene

scientific article published on 18 April 2009

Melatonin signalling and type 2 diabetes risk: too little, too much or just right?

scientific article published on 16 March 2017

Metabolic coupling in pancreatic beta cells: lipolysis revisited

scientific article published on 22 September 2016

Metabolite profile deviations in an oral glucose tolerance test-a comparison between lean and obese individuals

scientific article published on 11 August 2014

Metabolite profiling reveals normal metabolic control in carriers of mutations in the glucokinase gene (MODY2)

scientific article published on 8 November 2012

Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal β-cell lines

scientific article published on April 2011

Metabolomic and proteomic analysis of a clonal insulin-producing beta-cell line (INS-1 832/13).

scientific article published on 7 December 2007

Mitochondrial dysfunction in pancreatic beta-cells in Type 2 diabetes

scientific article published on 07 July 2008

Mitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic β-cells

scientific article

Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase

scientific article

Mutant huntingtin interacts with {beta}-tubulin and disrupts vesicular transport and insulin secretion

scientific article

NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells

scientific article

NOS-containing neurons in the rat gut and coeliac ganglia

scientific article published on 01 November 1994

Non-parallelism of islet amyloid polypeptide (amylin) and insulin gene expression in rats islets following dexamethasone treatment

scientific article published on 01 April 1995

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables

scientific article published in March 2018

Orexin loss in Huntington's disease.

scientific article published on 3 November 2004

Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells

scientific article

Pituitary adenylate cyclase activating polypeptide (PACAP) in the gastrointestinal tract of the rat: distribution and effects of capsaicin or denervation.

scientific article

Pituitary adenylate cyclase activating polypeptide expression in sensory neurons

scientific article published on 01 November 1994

Pituitary adenylate cyclase activating polypeptide is expressed in autonomic neurons

scientific article published on 01 September 1995

Pituitary adenylate cyclase-activating peptide is upregulated in sensory neurons by inflammation

scientific article published on 01 August 1998

Pituitary adenylate cyclase-activating polypeptide and islet amyloid polypeptide in primary sensory neurons: functional implications from plasticity in expression on nerve injury and inflammation.

scientific article

Plasma membrane potential oscillations in insulin secreting Ins-1 832/13 cells do not require glycolysis and are not initiated by fluctuations in mitochondrial bioenergetics

scientific article

Precise expression of Fis1 is important for glucose responsiveness of beta cells

scientific article published on 13 May 2016

Primary clear cell renal carcinoma cells display minimal mitochondrial respiratory capacity resulting in pronounced sensitivity to glycolytic inhibition by 3-Bromopyruvate

scientific article

Progressive alterations in the hypothalamic-pituitary-adrenal axis in the R6/2 transgenic mouse model of Huntington's disease

scientific article published on 13 April 2006

Protein kinase B is expressed in pancreatic beta cells and activated upon stimulation with insulin-like growth factor I

scientific article published on 01 September 1998

Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells

scientific article

Rat insulin promoter 2-Cre recombinase mice bred onto a pure C57BL/6J background exhibit unaltered glucose tolerance

scientific article published in September 2007

Reduced nociceptive behavior in islet amyloid polypeptide (amylin) knockout mice

scientific journal article

Reduction of GnRH and infertility in the R6/2 mouse model of Huntington's disease

scientific article published in September 2005

Regulated exocytosis of GABA-containing synaptic-like microvesicles in pancreatic beta-cells.

scientific article

Regulation of core clock genes in human islets

scientific article published on 2 February 2012

Season-dependent associations of circadian rhythm-regulating loci (CRY1, CRY2 and MTNR1B) and glucose homeostasis: the GLACIER Study

scientific article published on 24 February 2015

Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes

scientific article

Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes.

scientific article

TIGER: The gene expression regulatory variation landscape of human pancreatic islets

scientific article published on 01 October 2021

The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient beta-cell mass and exocytosis

scientific article published on 13 January 2005

The effects of high glucose exposure on global gene expression and DNA methylation in human pancreatic islets

scientific article published on 25 November 2017

The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas.

scientific article

The pathogenetic role of β-cell mitochondria in type 2 diabetes

scientific article published in March 2018

The transcriptional co-repressor myeloid translocation gene 16 inhibits glycolysis and stimulates mitochondrial respiration

scientific article

Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion

scientific article published on 21 September 2009

Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release

scientific article published in March 2013

Transcribing β-cell mitochondria in health and disease

scientific article published on 31 May 2017

Unaltered pancreatic islet blood perfusion in islet amyloid polypeptide-deficient mice

scientific article published in January 2002

Unique and Shared Metabolic Regulation in Clonal β-Cells and Primary Islets Derived From Rat Revealed by Metabolomics Analysis

scientific article published on 16 March 2015

Use of RNA interference to investigate cytokine signal transduction in pancreatic beta cells

scientific article published on 01 January 2012

Paulina is supported by:

About Paulina

Help