List of works - Emmanuel Valjent

A novel mechanism by which reward and drugs of abuse alter chromatin in neurons

scientific article

A phosphatase cascade by which rewarding stimuli control nucleosomal response

scientific article

Absence of delta -9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice.

scientific article published in December 2001

Addictive and non-addictive drugs induce distinct and specific patterns of ERK activation in mouse brain.

scientific article published in April 2004

Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation.

scientific article published on 6 December 2017

Anatomical and molecular characterization of dopamine D1 receptor-expressing neurons of the mouse CA1 dorsal hippocampus

scientific article

Behavioural and biochemical evidence for interactions between Delta 9-tetrahydrocannabinol and nicotine.

scientific article

Behavioural and biochemical evidence for signs of abstinence in mice chronically treated with delta-9-tetrahydrocannabinol

scientific article

Blockade of T-type calcium channels prevents tonic-clonic seizures in a maximal electroshock seizure model

scientific article published on 9 October 2015

Cafeteria diet induces neuroplastic modifications in the nucleus accumbens mediated by microglia activation

scientific article published on 5 September 2017

Calcineurin is essential for depolarization-induced nuclear translocation and tyrosine phosphorylation of PYK2 in neurons

scientific article published on 07 August 2007

Cannabinoid withdrawal is dependent upon PKA activation in the cerebellum

scientific article published on 01 March 2000

Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin knock-out mice

scientific article published on 01 December 2000

Cartography of hevin-expressing cells in the adult brain reveals prominent expression in astrocytes and parvalbumin neurons

scientific article published on 17 January 2019

Cell Type-Specific mRNA Dysregulation in Hippocampal CA1 Pyramidal Neurons of the Fragile X Syndrome Mouse Model

scientific article published on 20 October 2017

Characterization of dopamine D1 and D2 receptor-expressing neurons in the mouse hippocampus.

scientific article published on 6 July 2012

Cocaine conditioned place preference: unexpected suppression of preference due to testing combined with strong conditioning.

scientific article published on 10 January 2018

Cognitive dysfunction, elevated anxiety, and reduced cocaine response in circadian clock-deficient cryptochrome knockout mice

scientific article published on 24 October 2013

Combination of group I mGlu receptors antagonist with dopaminergic agonists strengthens the synaptic transmission at corticostriatal synapses in culture.

scientific article published on 23 March 2012

Combinatorial topography and cell-type specific regulation of the ERK pathway by dopaminergic agonists in the mouse striatum.

scientific article

Contrasting forms of cocaine-evoked plasticity control components of relapse

scientific article published in May 2014

Contrasting patterns of ERK activation in the tail of the striatum in response to aversive and rewarding signals

scientific article published on 15 September 2019

Convulsant doses of a dopamine D1 receptor agonist result in Erk-dependent increases in Zif268 and Arc/Arg3.1 expression in mouse dentate gyrus

scientific article

Critical involvement of cAMP/DARPP-32 and extracellular signal-regulated protein kinase signaling in L-DOPA-induced dyskinesia

scientific article published in June 2007

Delayed, context- and dopamine D1 receptor-dependent activation of ERK in morphine-sensitized mice

scientific article published on 3 June 2008

Delta 9-tetrahydrocannabinol-induced MAPK/ERK and Elk-1 activation in vivo depends on dopaminergic transmission.

scientific article

Depolarization activates ERK and proline-rich tyrosine kinase 2 (PYK2) independently in different cellular compartments in hippocampal slices

scientific journal article

Direct and indirect interactions between cannabinoid CB1 receptor and group II metabotropic glutamate receptor signalling in layer V pyramidal neurons from the rat prefrontal cortex.

scientific article published in March 2003

Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors

scientific article

Distribution and compartmental organization of GABAergic medium-sized spiny neurons in the mouse nucleus accumbens.

scientific article published on 19 February 2013

Dopamine D2 receptors gate generalization of conditioned threat responses through mTORC1 signaling in the extended amygdala

scientific article

Dopamine induces a PI3-kinase-independent activation of Akt in striatal neurons: a new route to cAMP response element-binding protein phosphorylation.

scientific article published in October 2002

Dopamine signaling in the striatum

scientific article published on 22 February 2019

Drugs of abuse, protein phosphatases, and ERK pathway

scientific article published in May 2005

Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4.

scientific article published on 20 December 2016

ERK2: a logical AND gate critical for drug-induced plasticity?

scientific article published on 7 November 2006

Early administration of RS 67333, a specific 5-HT4 receptor agonist, prevents amyloidogenesis and behavioral deficits in the 5XFAD mouse model of Alzheimer's disease

scientific article published on 24 December 2013

Functional and molecular heterogeneity of D2R neurons along dorsal ventral axis in the striatum

scientific article published on 23 April 2020

Glutamate Counteracts Dopamine/PKA Signaling via Dephosphorylation of DARPP-32 Ser-97 and Alteration of Its Cytonuclear Distribution

scientific article

Gα(olf) mutation allows parsing the role of cAMP-dependent and extracellular signal-regulated kinase-dependent signaling in L-3,4-dihydroxyphenylalanine-induced dyskinesia.

scientific article

Haloperidol promotes mTORC1-dependent phosphorylation of ribosomal protein S6 via dopamine- and cAMP-regulated phosphoprotein of 32 kDa and inhibition of protein phosphatase-1.

scientific article published on 3 May 2013

Haloperidol regulates the state of phosphorylation of ribosomal protein S6 via activation of PKA and phosphorylation of DARPP-32

scientific article

Histone H3 phosphorylation is under the opposite tonic control of dopamine D2 and adenosine A2A receptors in striatopallidal neurons.

scientific article published on 21 January 2009

Inhibition of ERK pathway or protein synthesis during reexposure to drugs of abuse erases previously learned place preference

scholarly article

Inhibition of mTOR signaling in Parkinson's disease prevents L-DOPA-induced dyskinesia.

scientific article published on 21 July 2009

Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties.

scientific article published in December 2000

L-DOPA activates ERK signaling and phosphorylates histone H3 in the striatonigral medium spiny neurons of hemiparkinsonian mice

scientific article published in February 2009

Lack of CB1 cannabinoid receptors modifies nicotine behavioural responses, but not nicotine abstinence.

scientific article published in October 2002

Looking BAC at striatal signaling: cell-specific analysis in new transgenic mice.

scientific article published on 16 September 2009

Mechanisms of locomotor sensitization to drugs of abuse in a two-injection protocol.

scientific article published on January 2010

Mitogen-activated protein kinase/extracellular signal-regulated kinase induced gene regulation in brain: a molecular substrate for learning and memory?

scientific article

Monoacylglycerol lipase blockade impairs fine motor coordination and triggers cerebellar neuroinflammation through cyclooxygenase-2

scientific article published on 25 June 2019

Mouse hippocampal phosphorylation footprint induced by generalized seizures: Focus on ERK, mTORC1 and Akt/GSK-3 pathways.

scientific article published on 3 November 2015

Operant behavior to obtain palatable food modifies ERK activity in the brain reward circuit.

scientific article

Operant behavior to obtain palatable food modifies neuronal plasticity in the brain reward circuit.

scientific article

Opposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidol

scientific article published in May 2008

PKA-dependent phosphorylation of ribosomal protein S6 does not correlate with translation efficiency in striatonigral and striatopallidal medium-sized spiny neurons

scientific article published in March 2015

Parkinson's disease: levodopa-induced dyskinesia and signal transduction.

scientific article published on 12 February 2008

Parsing molecular and behavioral effects of cocaine in mitogen- and stress-activated protein kinase-1-deficient mice.

scientific article

Persistent increase in olfactory type G-protein alpha subunit levels may underlie D1 receptor functional hypersensitivity in Parkinson disease.

scientific article

Plasticity-associated gene Krox24/Zif268 is required for long-lasting behavioral effects of cocaine.

scientific article

Plug-and-play metabolic transducers expand the chemical detection space of cell-free biosensors

Presynaptic serotonin 2A receptors modulate thalamocortical plasticity and associative learning

scientific article

Quantitative changes in Galphaolf protein levels, but not D1 receptor, alter specifically acute responses to psychostimulants

scientific article published on 25 October 2006

Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) controls activation of extracellular signal-regulated kinase (ERK) signaling in the striatum and long-term behavioral responses to cocaine.

scientific article published on 15 May 2009

Regulation of GluA1 phosphorylation by d-amphetamine and methylphenidate in the cerebellum

scientific article published on 26 December 2020

Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum

scientific article

Regulation of cocaine-induced activator protein 1 transcription factors by the extracellular signal-regulated kinase pathway.

scientific article published on 2 November 2005

Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus.

scientific article published in March 2003

Regulation of the ERK pathway in the dentate gyrus by in vivo dopamine D1 receptor stimulation requires glutamatergic transmission

scientific article published on 13 July 2012

Repeated Exposure to D-Amphetamine Decreases Global Protein Synthesis and Regulates the Translation of a Subset of mRNAs in the Striatum

scientific article published on January 2016

Repeated stimulation of dopamine D1-like receptor and hyperactivation of mTOR signaling lead to generalized seizures, altered dentate gyrus plasticity, and memory deficits.

scientific article published on 23 July 2014

Ribosomal Protein S6 Phosphorylation Is Involved in Novelty-Induced Locomotion, Synaptic Plasticity and mRNA Translation

scientific article published on 21 December 2017

Ribosomal Protein S6 Phosphorylation in the Nervous System: From Regulation to Function

scientific article

Role of cannabinoid type 1 receptors in locomotor activity and striatal signaling in response to psychostimulants

scientific article published in June 2007

Role of the ERK pathway in psychostimulant-induced locomotor sensitization.

scientific article

Role of the atypical vesicular glutamate transporter VGLUT3 in l-DOPA-induced dyskinesia.

scientific article published on 19 December 2015

Role of the plasticity-associated transcription factor zif268 in the early phase of instrumental learning

scientific article published on 23 January 2014

Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3)

scientific article

Serotonin 2B Receptors in Mesoaccumbens Dopamine Pathway Regulate Cocaine Responses.

scientific article

Serotonin 5-HT2B receptors are required for 3,4-methylenedioxymethamphetamine-induced hyperlocomotion and 5-HT release in vivo and in vitro

scientific article

Spatial distribution of D1R- and D2R-expressing medium-sized spiny neurons differs along the rostro-caudal axis of the mouse dorsal striatum

scientific article published on 29 July 2013

Striatal cholinergic interneurons display activity-related phosphorylation of ribosomal protein S6

scientific article

Striatal medium-sized spiny neurons: identification by nuclear staining and study of neuronal subpopulations in BAC transgenic mice

scientific article

Striatal signaling: two decades of progress.

scientific article published on 16 October 2012

T-type calcium channel Cav3.2 deficient mice show elevated anxiety, impaired memory and reduced sensitivity to psychostimulants

scientific article

The orphan receptor GPR3 modulates the early phases of cocaine reinforcement.

scientific article published on October 2012

What is the degree of segregation between striatonigral and striatopallidal projections? ⬇️

scientific article published on October 7, 2010

cAMP and extracellular signal-regulated kinase signaling in response to d-amphetamine and methylphenidate in the prefrontal cortex in vivo: role of beta 1-adrenoceptors

scientific article published on 12 May 2005

drd2-cre:ribotag mouse line unravels the possible diversity of dopamine d2 receptor-expressing cells of the dorsal mouse hippocampus

scientific article published on 11 February 2015

mTORC1 signaling in Parkinson's disease and L-DOPA-induced dyskinesia: A sensitized matter

scientific article published on 27 July 2010

List of works by Emmanuel Valjent

A novel mechanism by which reward and drugs of abuse alter chromatin in neurons

A phosphatase cascade by which rewarding stimuli control nucleosomal response

Absence of delta -9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice.

Addictive and non-addictive drugs induce distinct and specific patterns of ERK activation in mouse brain.

Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation.

Anatomical and molecular characterization of dopamine D1 receptor-expressing neurons of the mouse CA1 dorsal hippocampus

Behavioural and biochemical evidence for interactions between Delta 9-tetrahydrocannabinol and nicotine.

Behavioural and biochemical evidence for signs of abstinence in mice chronically treated with delta-9-tetrahydrocannabinol

Blockade of T-type calcium channels prevents tonic-clonic seizures in a maximal electroshock seizure model

Cafeteria diet induces neuroplastic modifications in the nucleus accumbens mediated by microglia activation

Calcineurin is essential for depolarization-induced nuclear translocation and tyrosine phosphorylation of PYK2 in neurons

Cannabinoid withdrawal is dependent upon PKA activation in the cerebellum

Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin knock-out mice

Cartography of hevin-expressing cells in the adult brain reveals prominent expression in astrocytes and parvalbumin neurons

Cell Type-Specific mRNA Dysregulation in Hippocampal CA1 Pyramidal Neurons of the Fragile X Syndrome Mouse Model

Characterization of dopamine D1 and D2 receptor-expressing neurons in the mouse hippocampus.

Cocaine conditioned place preference: unexpected suppression of preference due to testing combined with strong conditioning.

Cognitive dysfunction, elevated anxiety, and reduced cocaine response in circadian clock-deficient cryptochrome knockout mice

Combination of group I mGlu receptors antagonist with dopaminergic agonists strengthens the synaptic transmission at corticostriatal synapses in culture.

Combinatorial topography and cell-type specific regulation of the ERK pathway by dopaminergic agonists in the mouse striatum.

Contrasting forms of cocaine-evoked plasticity control components of relapse

Contrasting patterns of ERK activation in the tail of the striatum in response to aversive and rewarding signals

Convulsant doses of a dopamine D1 receptor agonist result in Erk-dependent increases in Zif268 and Arc/Arg3.1 expression in mouse dentate gyrus

Critical involvement of cAMP/DARPP-32 and extracellular signal-regulated protein kinase signaling in L-DOPA-induced dyskinesia

Delayed, context- and dopamine D1 receptor-dependent activation of ERK in morphine-sensitized mice

Delta 9-tetrahydrocannabinol-induced MAPK/ERK and Elk-1 activation in vivo depends on dopaminergic transmission.

Depolarization activates ERK and proline-rich tyrosine kinase 2 (PYK2) independently in different cellular compartments in hippocampal slices

Direct and indirect interactions between cannabinoid CB1 receptor and group II metabotropic glutamate receptor signalling in layer V pyramidal neurons from the rat prefrontal cortex.

Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors

Distribution and compartmental organization of GABAergic medium-sized spiny neurons in the mouse nucleus accumbens.

Dopamine D2 receptors gate generalization of conditioned threat responses through mTORC1 signaling in the extended amygdala

Dopamine induces a PI3-kinase-independent activation of Akt in striatal neurons: a new route to cAMP response element-binding protein phosphorylation.

Dopamine signaling in the striatum

Drugs of abuse, protein phosphatases, and ERK pathway

Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4.

ERK2: a logical AND gate critical for drug-induced plasticity?

Early administration of RS 67333, a specific 5-HT4 receptor agonist, prevents amyloidogenesis and behavioral deficits in the 5XFAD mouse model of Alzheimer's disease

Functional and molecular heterogeneity of D2R neurons along dorsal ventral axis in the striatum

Glutamate Counteracts Dopamine/PKA Signaling via Dephosphorylation of DARPP-32 Ser-97 and Alteration of Its Cytonuclear Distribution

Gα(olf) mutation allows parsing the role of cAMP-dependent and extracellular signal-regulated kinase-dependent signaling in L-3,4-dihydroxyphenylalanine-induced dyskinesia.

Haloperidol promotes mTORC1-dependent phosphorylation of ribosomal protein S6 via dopamine- and cAMP-regulated phosphoprotein of 32 kDa and inhibition of protein phosphatase-1.

Haloperidol regulates the state of phosphorylation of ribosomal protein S6 via activation of PKA and phosphorylation of DARPP-32

Histone H3 phosphorylation is under the opposite tonic control of dopamine D2 and adenosine A2A receptors in striatopallidal neurons.

Inhibition of ERK pathway or protein synthesis during reexposure to drugs of abuse erases previously learned place preference

Inhibition of mTOR signaling in Parkinson's disease prevents L-DOPA-induced dyskinesia.

Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties.

L-DOPA activates ERK signaling and phosphorylates histone H3 in the striatonigral medium spiny neurons of hemiparkinsonian mice

Lack of CB1 cannabinoid receptors modifies nicotine behavioural responses, but not nicotine abstinence.

Looking BAC at striatal signaling: cell-specific analysis in new transgenic mice.

Mechanisms of locomotor sensitization to drugs of abuse in a two-injection protocol.

Mitogen-activated protein kinase/extracellular signal-regulated kinase induced gene regulation in brain: a molecular substrate for learning and memory?

Monoacylglycerol lipase blockade impairs fine motor coordination and triggers cerebellar neuroinflammation through cyclooxygenase-2

Mouse hippocampal phosphorylation footprint induced by generalized seizures: Focus on ERK, mTORC1 and Akt/GSK-3 pathways.

Operant behavior to obtain palatable food modifies ERK activity in the brain reward circuit.

Operant behavior to obtain palatable food modifies neuronal plasticity in the brain reward circuit.

Opposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidol

PKA-dependent phosphorylation of ribosomal protein S6 does not correlate with translation efficiency in striatonigral and striatopallidal medium-sized spiny neurons

Parkinson's disease: levodopa-induced dyskinesia and signal transduction.

Parsing molecular and behavioral effects of cocaine in mitogen- and stress-activated protein kinase-1-deficient mice.

Persistent increase in olfactory type G-protein alpha subunit levels may underlie D1 receptor functional hypersensitivity in Parkinson disease.

Plasticity-associated gene Krox24/Zif268 is required for long-lasting behavioral effects of cocaine.

Plug-and-play metabolic transducers expand the chemical detection space of cell-free biosensors

Presynaptic serotonin 2A receptors modulate thalamocortical plasticity and associative learning

Quantitative changes in Galphaolf protein levels, but not D1 receptor, alter specifically acute responses to psychostimulants

Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) controls activation of extracellular signal-regulated kinase (ERK) signaling in the striatum and long-term behavioral responses to cocaine.

Regulation of GluA1 phosphorylation by d-amphetamine and methylphenidate in the cerebellum

Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum

Regulation of cocaine-induced activator protein 1 transcription factors by the extracellular signal-regulated kinase pathway.

Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus.

Regulation of the ERK pathway in the dentate gyrus by in vivo dopamine D1 receptor stimulation requires glutamatergic transmission

Repeated Exposure to D-Amphetamine Decreases Global Protein Synthesis and Regulates the Translation of a Subset of mRNAs in the Striatum

Repeated stimulation of dopamine D1-like receptor and hyperactivation of mTOR signaling lead to generalized seizures, altered dentate gyrus plasticity, and memory deficits.

Ribosomal Protein S6 Phosphorylation Is Involved in Novelty-Induced Locomotion, Synaptic Plasticity and mRNA Translation

Ribosomal Protein S6 Phosphorylation in the Nervous System: From Regulation to Function

Role of cannabinoid type 1 receptors in locomotor activity and striatal signaling in response to psychostimulants

Role of the ERK pathway in psychostimulant-induced locomotor sensitization.

Role of the atypical vesicular glutamate transporter VGLUT3 in l-DOPA-induced dyskinesia.

Role of the plasticity-associated transcription factor zif268 in the early phase of instrumental learning

Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3)