List of works - James E McLaren

A T cell-inducing influenza vaccine for the elderly: safety and immunogenicity of MVA-NP+M1 in adults aged over 50 years

scientific article

A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells

scientific article

Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity

scientific article

CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold

scientific article published on 27 September 2016

CD8+ TCR Bias and Immunodominance in HIV-1 Infection

scientific article published on 24 April 2015

Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance

scientific article published on March 2017

Complex T-cell receptor repertoire dynamics underlie the CD8+ T-cell response to HIV-1

scientific article published on 15 October 2014

Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy.

scientific article

Determinants of gliadin-specific T cell selection in celiac disease

scientific article

Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8+ TCR-Vβ+ expansions

scientific article published on 7 February 2018

ERK Is Integral to the IFN-γ–Mediated Activation of STAT1, the Expression of Key Genes Implicated in Atherosclerosis, and the Uptake of Modified Lipoproteins by Human Macrophages ⬇️

scientific article published on July 30, 2010

Early innate responses to pathogens: pattern recognition by unconventional human T-cells

scientific article

Eicosapentaenoic acid and docosahexaenoic acid regulate modified LDL uptake and macropinocytosis in human macrophages.

scientific article

Exploring the pre-immune landscape of antigen-specific T cells

scientific article published on 25 August 2018

Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8+ T cell response

scientific article published on 25 September 2017

Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1-specific CD8+ T cells

scientific article published on 12 June 2020

IL-33 reduces macrophage foam cell formation.

scientific article published on 11 June 2010

Interferon gamma: a master regulator of atherosclerosis.

scientific article

Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors

scientific article published in February 2018

MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage

scientific article

Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics

scientific article

Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation

scientific article published on 10 January 2022

Primary EBV Infection Induces an Acute Wave of Activated Antigen-Specific Cytotoxic CD4+ T Cells

scientific article published on 15 July 2019

Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load

scientific article

Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8+ T Cells.

scientific article published on 07 March 2016

Proteomic profiling of human respiratory epithelia by iTRAQ reveals biomarkers of exposure and harm by tobacco smoke components

scientific article

Role of naive-derived T memory stem cells in T-cell reconstitution following allogeneic transplantation.

scientific article published on 5 March 2015

SIV-specific CD8+ T cells are clonotypically distinct across lymphoid and mucosal tissues

scientific article published on 01 February 2020

T Cell Immunity to Bacterial Pathogens: Mechanisms of Immune Control and Bacterial Evasion

scientific article published on 26 August 2020

T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids.

scientific article published on 12 March 2018

TRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis.

scientific article published on 5 June 2019

Targeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies.

scientific article published on 17 October 2016

The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro.

scientific article

The link between CD8⁺ T-cell antigen-sensitivity and HIV-suppressive capacity depends on HLA restriction, target epitope and viral isolate

scientific article published on February 2014

VDJdb: a curated database of T-cell receptor sequences with known antigen specificity

scientific article published on September 2017

β-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure

scientific article

List of works by James E McLaren

A T cell-inducing influenza vaccine for the elderly: safety and immunogenicity of MVA-NP+M1 in adults aged over 50 years

A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells

Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity

CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold

CD8+ TCR Bias and Immunodominance in HIV-1 Infection

Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance

Complex T-cell receptor repertoire dynamics underlie the CD8+ T-cell response to HIV-1

Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy.

Determinants of gliadin-specific T cell selection in celiac disease

Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8+ TCR-Vβ+ expansions

ERK Is Integral to the IFN-γ–Mediated Activation of STAT1, the Expression of Key Genes Implicated in Atherosclerosis, and the Uptake of Modified Lipoproteins by Human Macrophages ⬇️

Early innate responses to pathogens: pattern recognition by unconventional human T-cells

Eicosapentaenoic acid and docosahexaenoic acid regulate modified LDL uptake and macropinocytosis in human macrophages.

Exploring the pre-immune landscape of antigen-specific T cells

Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8+ T cell response

Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1-specific CD8+ T cells

IL-33 reduces macrophage foam cell formation.

Interferon gamma: a master regulator of atherosclerosis.

Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors

MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage

Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics

Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation

Primary EBV Infection Induces an Acute Wave of Activated Antigen-Specific Cytotoxic CD4+ T Cells

Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load

Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8+ T Cells.

Proteomic profiling of human respiratory epithelia by iTRAQ reveals biomarkers of exposure and harm by tobacco smoke components

Role of naive-derived T memory stem cells in T-cell reconstitution following allogeneic transplantation.

SIV-specific CD8+ T cells are clonotypically distinct across lymphoid and mucosal tissues

T Cell Immunity to Bacterial Pathogens: Mechanisms of Immune Control and Bacterial Evasion

T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids.

TRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis.

Targeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies.

The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro.

The link between CD8⁺ T-cell antigen-sensitivity and HIV-suppressive capacity depends on HLA restriction, target epitope and viral isolate

VDJdb: a curated database of T-cell receptor sequences with known antigen specificity

β-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure