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List of works by Karim Boumediene

3-Deazaneplanocin A (DZNep), an inhibitor of the histone methyltransferase EZH2, induces apoptosis and reduces cell migration in chondrosarcoma cells

scientific article

Anti-inflammatory and chondroprotective effects of the S-adenosylhomocysteine hydrolase inhibitor 3-Deazaneplanocin A, in human articular chondrocytes.

scientific article published on 25 July 2017

Anti-inflammatory effects of an injectable copolymer of fatty acids (Ara 3000 beta®) in joint diseases.

scientific article published on 23 February 2015

Antiproliferative effect of the histone demethylase inhibitor GSK-J4 in chondrosarcomas

scientific article published on 26 June 2019

Asporin expression is highly regulated in human chondrocytes.

scientific article published on 25 April 2011

Avocado/soya unsaponifiables enhance the expression of transforming growth factor beta1 and beta2 in cultured articular chondrocytes

scientific article published on 01 January 1999

BMP-2, hypoxia, and COL1A1/HtrA1 siRNAs favor neo-cartilage hyaline matrix formation in chondrocytes

scientific article

Cell density-dependent proliferative effects of transforming growth factor (TGF)-beta 1, beta 2, and beta 3 in human chondrosarcoma cells HCS-2/8 are associated with changes in the expression of TGF-beta receptor type I.

scientific article

Cell-cycle-dependent expression of transforming growth factor beta type I receptor correlates with differential proliferative effects of TGFbeta1 in articular chondrocytes.

scientific article published on August 1998

Characterization of distinct mesenchymal-like cell populations from human skeletal muscle in situ and in vitro.

scientific article published on 27 April 2010

Chondroitin sulphate decreases collagen synthesis in normal and scleroderma fibroblasts through a Smad-independent TGF-beta pathway--implication of C-Krox and Sp1.

scientific article published on 24 February 2008

Comparative proteomic analysis of human mesenchymal and embryonic stem cells: towards the definition of a mesenchymal stem cell proteomic signature.

scientific article

Deciphering chondrocyte behaviour in matrix-induced autologous chondrocyte implantation to undergo accurate cartilage repair with hyaline matrix ⬇️

scientific article published on April 18, 2012

Decrease of cartilage transforming growth factor-beta receptor II expression in the rabbit experimental osteoarthritis--potential role in cartilage breakdown.

scientific article published in March 1998

Development of a simple osteoarthritis model useful to predict in vitro the anti-hypertrophic action of drugs

scientific article published on 13 August 2019

Different phosphorylated forms of inositolphosphate glycan could be involved in the transforming growth factor-gb 1 (TGF-β1) signalling pathway

scientific article published on 01 February 1994

Differential effects of hyaluronan and its fragments on fibroblasts: relation to wound healing.

scientific article

Differentiation potential of human muscle-derived cells towards chondrogenic phenotype in alginate beads culture.

scientific article published on 13 June 2008

Effect of hypoxia and reoxygenation on gene expression and response to interleukin-1 in cultured articular chondrocytes.

scientific article published in November 2004

Effect of interleukin-1beta on transforming growth factor-beta and bone morphogenetic protein-2 expression in human periodontal ligament and alveolar bone cells in culture: modulation by avocado and soybean unsaponifiables.

scientific article

Enhanced hyaline cartilage matrix synthesis in collagen sponge scaffolds by using siRNA to stabilize chondrocytes phenotype cultured with bone morphogenetic protein-2 under hypoxia.

scientific article published on 19 February 2013

Epigenetic dynamic during endochondral ossification and articular cartilage development

article

Evaluation of the impact of S-adenosylmethionine-dependent methyltransferase inhibitor, 3-deazaneplanocin A, on tissue injury and cognitive function in mice.

scientific article

Evaluation of ursolic acid isolated from Ilex paraguariensis and derivatives on aromatase inhibition

scientific article

Expression of TGF-betas and their receptors is differentially modulated by reactive oxygen species and nitric oxide in human articular chondrocytes.

scientific article published in May 2002

Flow cytometric detection of transforming growth factor-β expression in rabbit articular chondrocytes (RAC) in culture—Association with S-phase traverse

article

Genetic Determinism of Primary Early-Onset Osteoarthritis.

scientific article published on 12 December 2015

Histone methylases as novel drug targets: developing inhibitors of EZH2.

scientific article published on January 2014

Hypoxia inducible factor 1 alpha down-regulates type i collagen through Sp3 transcription factor in human chondrocytes

scientific article published on 13 August 2016

Hypoxia-inducible factor 1alpha inhibits the fibroblast-like markers type I and type III collagen during hypoxia-induced chondrocyte redifferentiation: hypoxia not only induces type II collagen and aggrecan, but it also inhibits type I and type III

scientific article published on 01 October 2009

Identification of an easy to use 3D culture model to investigate invasion and anticancer drug response in chondrosarcomas

scientific article

Immunohistochemical analysis of transforming growth factor beta isoforms and their receptors in human cartilage from normal and osteoarthritic femoral heads

scientific article published on 14 November 2003

Interleukin-1beta impairment of transforming growth factor beta1 signaling by down-regulation of transforming growth factor beta receptor type II and up-regulation of Smad7 in human articular chondrocytes

scientific article published on 01 September 2007

Interleukin-1beta up-regulation of Smad7 via NF-kappaB activation in human chondrocytes.

scientific article published in January 2008

Interleukin-6 (IL-6) and/or soluble IL-6 receptor down-regulation of human type II collagen gene expression in articular chondrocytes requires a decrease of Sp1.Sp3 ratio and of the binding activity of both factors to the COL2A1 promoter

scientific article published on 07 December 2007

Mediation of interleukin-1beta-induced transforming growth factor beta1 expression by activator protein 4 transcription factor in primary cultures of bovine articular chondrocytes: possible cooperation with activator protein 1.

scientific article

Modulation of Skin Inflammatory Response by Active Components of Silymarin

scientific article published on 30 December 2018

Modulation of transforming growth factor beta signalling pathway genes by transforming growth factor beta in human osteoarthritic chondrocytes: involvement of Sp1 in both early and late response cells to transforming growth factor beta ⬇️

scientific article published on February 15, 2011

Molecular mechanism of hypoxia-induced chondrogenesis and its application in in vivo cartilage tissue engineering ⬇️

scientific article published on June 6, 2012

NF-κB accumulation associated with COL1A1 transactivators defects during chronological aging represses type I collagen expression through a -112/-61-bp region of the COL1A1 promoter in human skin fibroblasts

scientific article published on 07 June 2012

NFkappaB mediates IL-1beta-induced down-regulation of TbetaRII through the modulation of Sp3 expression.

scientific article published on 10 December 2007

Regulation and Role of TGFβ Signaling Pathway in Aging and Osteoarthritis Joints

scientific article

Regulatory mechanism of transforming growth factor beta receptor type II degradation by interleukin-1 in primary chondrocytes.

scientific article

Semiquantitative reverse transcription-polymerase chain reaction analysis of syndecan-1 and -4 messages in cartilage and cultured chondrocytes from osteoarthritic joints

scientific article published on 01 January 2000

Sox9/Sox6 and Sp1 are involved in the insulin-like growth factor-I-mediated upregulation of human type II collagen gene expression in articular chondrocytes.

scientific article published on 4 January 2012

Stimulating effect of diacerein on TGF-beta1 and beta2 expression in articular chondrocytes cultured with and without interleukin-1.

scientific article published on May 1999

TOL19-001 reduces inflammation and MMP expression in monolayer cultures of tendon cells

scientific article published on 9 July 2015

The Antitumoral Effect of the S-Adenosylhomocysteine Hydrolase Inhibitor, 3-Deazaneplanocin A, is Independent of EZH2 but is Correlated with EGFR Downregulation in Chondrosarcomas

scientific article published on 01 January 2019

The p65 subunit of NF-κB inhibits COL1A1 gene transcription in human dermal and scleroderma fibroblasts through its recruitment on promoter by protein interaction with transcriptional activators (c-Krox, Sp1, and Sp3).

scientific article

Type II TGFβ receptor modulates chondrocyte phenotype.

scientific article published on June 2012

Up-regulation of type II collagen gene by 17β-estradiol in articular chondrocytes involves Sp1/3, Sox-9, and estrogen receptor α.

scientific article published on 2 August 2014

Use of Adult Stem Cells for Cartilage Tissue Engineering: Current Status and Future Developments

scientific article (publication date: 2015)

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