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List of works by Eithne Costello

5-Fluorouracil or gemcitabine combined with adenoviral-mediated reintroduction of p16INK4A greatly enhanced cytotoxicity in Panc-1 pancreatic adenocarcinoma cells

scientific article published on May 2004

A combination of urinary biomarker panel and PancRISK score for earlier detection of pancreatic cancer: A case-control study

scientific article published on 10 December 2020

A metabolomics-based biomarker signature discriminates pancreatic cancer from chronic pancreatitis

scientific article published on 24 May 2017

A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer

scientific article published on 01 February 2021

A systems approach identifies time-dependent associations of multimorbidities with pancreatic cancer risk.

scientific article published on 5 April 2017

A technically detailed and pragmatic protocol for quantitative serum proteomics using iTRAQ.

scientific article published on 3 August 2009

Activated Schwann cells in pancreatic cancer are linked to analgesia via suppression of spinal astroglia and microglia

scientific article

Analysis of gene expression in cancer cell lines identifies candidate markers for pancreatic tumorigenesis and metastasis

scientific article

Application of laser capture microdissection combined with two-dimensional electrophoresis for the discovery of differentially regulated proteins in pancreatic ductal adenocarcinoma

scientific article

Biology and management of pancreatic cancer

scientific article

Biomarkers for early diagnosis of pancreatic cancer

scientific article

Choline Kinase Alpha (CHKα) as a Therapeutic Target in Pancreatic Ductal Adenocarcinoma: Expression, Predictive Value, and Sensitivity to Inhibitors.

scientific article published on 14 January 2016

Circulating microRNAs as potential markers of human drug-induced liver injury

article

Confounding effect of obstructive jaundice in the interpretation of proteomic plasma profiling data for pancreatic cancer

scientific article

Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer.

scientific article published on September 2010

Cytoplasmic HuR Status Predicts Disease-free Survival in Resected Pancreatic Cancer: A Post-hoc Analysis From the International Phase III ESPAC-3 Clinical Trial.

scientific article published on 23 November 2016

Deciphering the complex interplay between pancreatic cancer, diabetes mellitus subtypes and obesity/BMI through causal inference and mediation analyses

scientific article published on 14 May 2020

Decreased Serum Thrombospondin-1 Levels in Pancreatic Cancer Patients Up to 24 Months Prior to Clinical Diagnosis: Association with Diabetes Mellitus

scientific article published on 16 November 2015

Designing a bio-inspired biomimetic in vitro system for the optimization of ex vivo studies of pancreatic cancer

scientific article published on 30 January 2017

Diagnosis of pancreatic ductal adenocarcinoma and chronic pancreatitis by measurement of microRNA abundance in blood and tissue

scientific article (publication date: 2012)

Dual-color proteomic profiling of complex samples with a microarray of 810 cancer-related antibodies

scientific article

EU Pancreas: an integrated European platform for pancreas cancer research--from basic science to clinical and public health interventions for a rare disease

scientific article published in January 2013

Early Epigenetic Downregulation of microRNA-192 Expression Promotes Pancreatic Cancer Progression

scientific article published on 23 May 2016

Enhancing the translation of cancer biomarkers ⬇️

scientific article published on May 10, 2011

Evaluation in pre-diagnosis samples discounts ICAM-1 and TIMP-1 as biomarkers for earlier diagnosis of pancreatic cancer

scientific article published on 01 January 2015

Expression of DRD2 Is Increased in Human Pancreatic Ductal Adenocarcinoma and Inhibitors Slow Tumor Growth in Mice

scientific article published on 28 August 2016

Expression of dihydropyrimidine dehydrogenase (DPD) and hENT1 predicts survival in pancreatic cancer

scientific article published on 8 March 2018

FF-ATP Synthase Inhibitory Factor 1 in the Normal Pancreas and in Pancreatic Ductal Adenocarcinoma: Effects on Bioenergetics, Invasion and Proliferation

scientific article published on 11 July 2018

Fibroblasts from distinct pancreatic pathologies exhibit disease-specific properties

scientific article published on 11 May 2020

From mice to men: Murine models of colorectal cancer for use in translational research

scientific article

Functional single nucleotide polymorphisms within the cyclin-dependent kinase inhibitor 2A/2B region affect pancreatic cancer risk

scientific article published on 29 July 2016

GATA4 and GATA6 loss-of-expression is associated with extinction of the classical programme and poor outcome in pancreatic ductal adenocarcinoma

scientific article published in 2022

GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer

scientific article published on 20 June 2016

Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial

scientific article published on 19 June 2014

Gene therapy for pancreatic cancer--current and prospective strategies.

scientific article

Gene transfer into stimulated and unstimulated T lymphocytes by HIV-1-derived lentiviral vectors.

scientific article

Genetic susceptibility to pancreatic cancer and its functional characterisation: the PANcreatic Disease ReseArch (PANDoRA) consortium

scientific article published in December 2012

Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

scientific article

High mobility group chromosomal protein 1 binds to the adeno-associated virus replication protein (Rep) and promotes Rep-mediated site-specific cleavage of DNA, ATPase activity and transcriptional repression ⬇️

scientific article published on October 1, 1997

High nuclear S100A6 (Calcyclin) is significantly associated with poor survival in pancreatic cancer patients

scientific article published in April 2005

Identification of Cystic Lesions by Secondary Screening of Familial Pancreatic Cancer (FPC) Kindreds Is Not Associated with the Stratified Risk of Cancer

Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma

scientific article

Immune Cell and Stromal Signature Associated With Progression-Free Survival of Patients With Resected Pancreatic Ductal Adenocarcinoma

scientific article published on 06 August 2018

Immunobiological effects of gemcitabine and capecitabine combination chemotherapy in advanced pancreatic ductal adenocarcinoma

scientific article published on 4 February 2016

Increased plasma levels of galectin-1 in pancreatic cancer: potential use as biomarker

article published in 2018

Inhibition of CD47 Effectively Targets Pancreatic Cancer Stem Cells via Dual Mechanisms

scientific article

Intratumoural expression of deoxycytidylate deaminase or ribonuceotide reductase subunit M1 expression are not related to survival in patients with resected pancreatic cancer given adjuvant chemotherapy

scientific article published on 9 March 2018

Lack of Association for Reported Endocrine Pancreatic Cancer Risk Loci in the PANDoRA Consortium

scientific article published on August 2017

Lack of Replication of Seven Pancreatic Cancer Susceptibility Loci Identified in Two Asian Populations

article

Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer

scientific article published in November 2010

Molecular alterations in pancreatic carcinoma: expression profiling shows that dysregulated expression of S100 genes is highly prevalent

scientific article

Multifunctional Fe3O4 nanoparticles for targeted bi-modal imaging of pancreatic cancer

Nanotechnology advances in upper gastrointestinal, liver and pancreatic cancer

scientific article published on June 2012

New biomarkers and targets in pancreatic cancer and their application to treatment

scientific article published on 26 June 2012

New treatment options for advanced pancreatic cancer

scientific article published on October 2008

Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy

scientific article

Overexpression of Mos, Ras, Src, and Fos inhibits mouse mammary epithelial cell differentiation.

scientific article published on September 1992

Pancreatic cancer and autoimmune diseases: An association sustained by computational and epidemiological case-control approaches

scholarly article by Paulina Gomez-Rubio et al published 1 April 2019 in International Journal of Cancer

Pancreatic cancer cells overexpress gelsolin family-capping proteins, which contribute to their cell motility

scientific article published on 17 July 2006

Pancreatic cancer hENT1 expression and survival from gemcitabine in patients from the ESPAC-3 trial

scientific article

Pancreatic cancer in 2010: new insights for early intervention and detection

scientific article published on February 2011

Pancreatic cancer risk in relation to lifetime smoking patterns, tobacco type, and dose-response relationships

scientific article published on 12 February 2020

Pancreatic cancer susceptibility loci and their role in survival

scientific article

Pancreatic cancer: proteomic approaches to a challenging disease

scientific article published on 04 August 2009

Pancreatic mass in a young CFTR carrier with a heterozygous p.R117H CFTR gene mutation and homozygous 7T.

scientific article

Proteomic analysis of chronic pancreatitis and pancreatic adenocarcinoma.

scientific article

Proteomic analysis of pancreatic cancer stem cells: Functional role of fatty acid synthesis and mevalonate pathways

scientific article

Proteomic technologies and their application to pancreatic cancer

scientific article

Reduced risk of pancreatic cancer associated with asthma and nasal allergies.

scientific article

Risk of pancreatic cancer associated with family history of cancer and other medical conditions by accounting for smoking among relatives.

scientific article published on 10 January 2018

S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility

scientific article

S100A8 and S100A9 proteins form part of a paracrine feedback loop between pancreatic cancer cells and monocytes

scientific article published on 17 December 2018

Secretome protein signature of human pancreatic cancer stem-like cells

scientific article published on 2 February 2016

Serum CA19-9 is significantly upregulated up to 2 years before diagnosis with pancreatic cancer: implications for early disease detection.

scientific article

Serum cytokine biomarker panels for discriminating pancreatic cancer from benign pancreatic disease

scientific article

Smad4 loss is associated with fewer S100A8-positive monocytes in colorectal tumors and attenuated response to S100A8 in colorectal and pancreatic cancer cells.

scientific article

Somatic mutations in exocrine pancreatic tumors: association with patient survival

scientific article

TERT gene harbors multiple variants associated with pancreatic cancer susceptibility

scientific article

Tetracycline-inducible protein expression in pancreatic cancer cells: effects of CapG overexpression

scientific article

The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.

scientific article published on 5 June 2018

The expression of S100A8 in pancreatic cancer-associated monocytes is associated with the Smad4 status of pancreatic cancer cells

scientific article

The impact of diabetes mellitus on survival following resection and adjuvant chemotherapy for pancreatic cancer

scientific article

The minute virus of mice (MVM) nonstructural protein NS1 induces nicking of MVM DNA at a unique site of the right-end telomere in both hairpin and duplex conformations in vitro ⬇️

scientific article published on October 1, 1997

The pancreatic cancer proteome – recent advances and future promise ⬇️

scientific article published on September 1, 2007

The role of inflammatory cells in fostering pancreatic cancer cell growth and invasion

scientific article

The unfolded protein response regulator GRP78 is a novel predictive biomarker in colorectal cancer.

scientific article

Therapeutic developments in pancreatic cancer: current and future perspectives

scientific article published on 01 June 2018

Transcriptional variations in the wider peritumoral tissue environment of pancreatic cancer

scientific article published on 6 October 2017

Trials of gene therapy for pancreatic carcinoma

scientific article

UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis

scientific article published on 24 October 2015

Vandetanib plus gemcitabine versus placebo plus gemcitabine in locally advanced or metastatic pancreatic carcinoma (ViP): a prospective, randomised, double-blind, multicentre phase 2 trial.

scientific article

cAMP inhibits migration, ruffling and paxillin accumulation in focal adhesions of pancreatic ductal adenocarcinoma cells: effects of PKA and EPAC.

scientific article

iTRAQ reveals candidate pancreatic cancer serum biomarkers: influence of obstructive jaundice on their performance

scientific article published on 11 April 2013

miRNA dynamics in tumor-infiltrating myeloid cells modulating tumor progression in pancreatic cancer

scientific article published on 9 May 2016

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