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List of works by Tsai-Kun Li

5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity.

scientific article published on May 2003

A negative feedback of the HIF-1α pathway via interferon-stimulated gene 15 and ISGylation

scientific article published on 20 September 2013

A novel small molecule hybrid of vorinostat and DACA displays anticancer activity against human hormone-refractory metastatic prostate cancer through dual inhibition of histone deacetylase and topoisomerase I.

scientific article

Acidic pH induces topoisomerase II-mediated DNA damage.

scientific article

Aminoglycoside complexation with a DNA.RNA hybrid duplex: the thermodynamics of recognition and inhibition of RNA processing enzymes.

scientific article

Anthracenedione-methionine conjugates are novel topoisomerase II-targeting anticancer agents with favorable drug resistance profiles

scientific article published on 25 January 2012

Calcium-induced cleavage of DNA topoisomerase I involves the cytoplasmic-nuclear shuttling of calpain 2.

scientific article published on 18 November 2010

Cell type-specific effects of Adenosine 5'-triphosphate and pyrophosphate on the antitumor activity of doxorubicin

scientific article

Cellular processing pathways contribute to the activation of etoposide-induced DNA damage responses.

scientific article

DNA Topoisomerase II Is Involved in Regulation of Cyst Wall Protein Genes and Differentiation in Giardia lamblia ⬇️

scientific article published on May 16, 2013

DNA damage-mediated apoptosis induced by selenium compounds.

scientific article published on 24 May 2003

DNA minor groove binding-directed poisoning of human DNA topoisomerase I by terbenzimidazoles

scientific article published on 01 March 1998

DNA topoisomerase III alpha regulates p53-mediated tumor suppression

scientific article published on 13 February 2014

Diaza- and triazachrysenes: potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft, MDA-MB-435

scientific article published on 01 November 2002

Differential Poisoning of Topoisomerases by Menogaril and Nogalamycin Dictated by the Minor Groove-Binding Nogalose Sugar†

scientific article published on 01 October 1997

Docosahexaenoic acid enhances hepatic serum amyloid A expression via protein kinase A-dependent mechanism.

scientific article published on 15 September 2009

Docosahexaenoic acid suppresses the expression of FoxO and its target genes.

scientific article

Evaluation of an Epitypified Ophiocordyceps formosana (Cordyceps s.l.) for Its Pharmacological Potential

scientific article

Genistein induces apoptosis in human hepatocellular carcinomas via interaction of endoplasmic reticulum stress and mitochondrial insult.

scientific article published on 3 December 2006

Hydrogen peroxide induces topoisomerase I-mediated DNA damage and cell death.

scientific article published on 19 December 2003

Inactivation of Cdc13p triggers MEC1-dependent apoptotic signals in yeast.

scientific article

Involvement of p38 MAPK in the Anticancer Activity of Cultivated Cordyceps militaris.

scientific article published on 24 July 2015

Mitoxantrone inhibits HIF-1α expression in a topoisomerase II-independent pathway.

scientific article published on 8 June 2011

Multiple domains of the tobacco mosaic virus p126 protein can independently suppress local and systemic RNA silencing

scientific article published in May 2012

Nitro and amino substitution in the D-ring of 5-(2-dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: effect on topoisomerase-I targeting activity and cytotoxicity.

scientific article published in May 2003

Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: influence on topoisomerase I-targeting activity and cytotoxicity.

scientific article published on July 2004

QS‐ZYX‐1‐61 induces apoptosis through topoisomerase II in human non‐small‐cell lung cancer A549 cells ⬇️

scientific article published on October 17, 2011

Rhapontigenin inhibits TGF-β-mediated epithelial‑mesenchymal transition via the PI3K/AKT/mTOR pathway and is not associated with HIF-1α degradation.

scientific article

Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathway ⬇️

scientific article published on April 2, 2012

Selective cytotoxicity of topoisomerase-directed protoberberines against glioblastoma cells ⬇️

scientific article published on November 1, 1998

Single-stranded DNA induces ataxia telangiectasia mutant (ATM)/p53-dependent DNA damage and apoptotic signals.

scientific article

Sodium salicylate acts through direct inhibition of phosphoinositide 3-kinase-like kinases to modulate topoisomerase-mediated DNA damage responses

scientific article

Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide ⬇️

scientific article published on July 22, 2011

Substituted dibenzo[c,h]cinnolines: topoisomerase I-targeting anticancer agents.

scientific article published on April 2003

Synergistic property of cordycepin in cultivated Cordyceps militaris-mediated apoptosis in human leukemia cells

scientific article published on 28 August 2014

Synthesis, DNA binding, and cytotoxicity of 1,4-bis(2-amino-ethylamino)anthraquinone-amino acid conjugates.

scientific article

Topoisomerase II inhibition suppresses the proliferation of telomerase-negative cancers.

scientific article

Tumor cell death induced by topoisomerase-targeting drugs.

scientific article

WRC-213, an l-methionine-conjugated mitoxantrone derivative, displays anticancer activity with reduced cardiotoxicity and drug resistance: identification of topoisomerase II inhibition and apoptotic machinery in prostate cancers.

scientific article published on 22 October 2007

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