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List of works by Alan D. Cherrington

2005 Presidential Address: Diabetes: past, present, and future

scientific article published on 01 September 2006

40 EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004 ⬇️

article

A Cyclic Guanosine Monophosphate–Dependent Pathway Can Regulate Net Hepatic Glucose Uptake in Vivo ⬇️

scientific article published on June 11, 2012

A New Animal Model of Insulin-Glucose Dynamics in the Intraperitoneal Space Enhances Closed-Loop Control Performance

scientific article published on 23 February 2019

A Soluble Guanylate Cyclase–Dependent Mechanism Is Involved in the Regulation of Net Hepatic Glucose Uptake by Nitric Oxide in Vivo ⬇️

scientific article published on September 7, 2010

A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog

scientific article published on 01 November 1996

A fall in portal vein insulin does not cause the alpha-cell response to mild, non-insulin-induced hypoglycemia in conscious dogs ⬇️

scientific article published on November 1, 2003

A high-fat, high-fructose diet accelerates nutrient absorption and impairs net hepatic glucose uptake in response to a mixed meal in partially pancreatectomized dogs

scientific article published on 20 July 2011

A negative arterial-portal venous glucose gradient decreases skeletal muscle glucose uptake ⬇️

scientific article published on July 1, 1998

A negative arterial-portal venous glucose gradient increases net hepatic glucose uptake in euglycemic dogs

scientific article published on 01 July 1999

A novel glucagon receptor antagonist, NNC 25-0926, blunts hepatic glucose production in the conscious dog.

scientific article published on 16 February 2007

A physiological increase in the hepatic glycogen level does not affect the response of net hepatic glucose uptake to insulin

scientific article published on 26 May 2009

Absorption and disposition of a glucose load in the conscious dog

scientific article published on 01 June 1982

Acute Fructose Administration Decreases the Glycemic Response to an Oral Glucose Tolerance Test in Normal Adults1

article

Acute fructose administration improves oral glucose tolerance in adults with type 2 diabetes

scientific article published in November 2001

Acute hormonal regulation of gluconeogenesis in the conscious dog.

scientific article

Alpha- and beta-cell responses to small changes in plasma glucose in the conscious dog.

scientific article

Alterations in basal glucose metabolism during late pregnancy in the conscious dog

scientific article published on 01 November 2000

Altered ability of the liver to produce glucose following a period of glucagon deficiency

scientific article published on 01 June 1981

An important role for glucagon in the regulation of glucose production in vivo

scientific article published on 01 November 1976

Animal models of obesity and diabetes mellitus

scientific article published on 19 January 2018

Arginine infusion in dogs. Model for the roles of insulin and glucagon in regulating glucose turnover and free fatty acid levels

scientific article published on 01 October 1974

Autoregulation of hepatic glucose production ⬇️

scientific article published on March 1, 1998

Basal hepatic glucose production is regulated by the portal vein insulin concentration ⬇️

scientific article published on April 1, 1998

Biologic comparison of inhaled insulin formulations: Exubera™ and novel spray-dried engineered particles of dextran-10.

scientific article

Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs.

scientific article

Brain of the conscious dog is sensitive to physiological changes in circulating insulin

scientific article

Bromocriptine Mesylate Improves Glucose Tolerance and Disposal in a High-Fat-Fed Canine Model

scientific article published on 27 May 2020

Canine body composition quantification using 3 tesla fat-water MRI

scientific article

Central versus peripheral glucose sensing and the response to hypoglycemia

scientific article published in May 2008

Changes in glucose and fat metabolism in response to the administration of a hepato-preferential insulin analog.

scientific article

Chronic consumption of a high-fat/high-fructose diet renders the liver incapable of net hepatic glucose uptake.

scientific article

Chronic hepatic artery ligation does not prevent liver from differentiating portal vs. peripheral glucose delivery

scientific article published on 28 May 2003

Chronic hyperinsulinemia decreases insulin action but not insulin sensitivity

scientific article published on 01 September 1990

Chronic overeating impairs hepatic glucose uptake and disposition.

scientific article

Combined intraportal infusion of acetylcholine and adrenergic blockers augments net hepatic glucose uptake

scientific article published on 01 March 2000

Comparison of the direct and indirect effects of epinephrine on hepatic glucose production

scientific article published on March 1997

Comparison of the time courses of insulin and the portal signal on hepatic glucose and glycogen metabolism in the conscious dog.

scientific article published on January 1996

Compartmental modeling of glucagon kinetics in the conscious dog

scientific article published on 01 April 1995

Contribution of the liver and extrasplanchnic tissues to the hypoglycemic action of dichloroacetate in the conscious dog

scientific article published on 01 April 1982

Control of hepatic glucose output by glucagon and insulin in the intact dog

scientific article published on January 1, 1978

Counterregulation by epinephrine and glucagon during insulin-induced hypoglycemia in the conscious dog

scientific article published on 01 March 1996

Counterregulation during hypoglycemia is directed by widespread brain regions

scientific article published on 01 September 1993

Current strategies for the inhibition of hepatic glucose production in type 2 diabetes

scientific article published on January 2009

Dichloroacetate--its in vivo effects on carbohydrate metabolism in the conscious dog

scientific article published on 01 September 1980

Dichloroacetate: Direct Inhibitor of Lipolysis in the Conscious Dog ⬇️

scientific article published on February 1, 1982

Differential effect of amino acid infusion route on net hepatic glucose uptake in the dog

scientific article published on 01 February 1999

Differential time course of glucagon's effect on glycogenolysis and gluconeogenesis in the conscious dog

scientific article published on 01 March 1981

Direct and indirect effects of insulin on glucose uptake and storage by the liver

scientific article published in June 2002

Direct effects of catecholamines on hepatic glucose production in conscious dog are due to glycogenolysis

scientific article published on 01 July 1996

Direct quantification of norepinephrine spillover and hormone output from the pancreas of the conscious dog

scientific article published on 01 May 1997

Disposition of a mixed meal by conscious dogs after seven days of treatment with cyclosporine A and prednisone

scientific article published on 01 July 2000

Disposition of a mixed meal by the conscious dog

scientific article published on 01 April 1994

Dissecting the actions of widely used diabetes drugs

scientific article published on 01 March 2013

Dose-related effects of epinephrine on glucose production in conscious dogs

scientific article published on 01 March 1991

Dr. Mladen Vranic-A Legend in Diabetes Research: 1930-2019

scientific article published on 23 July 2020

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

scientific journal article

Dynamics of hepatic lactate and glucose balances during prolonged exercise and recovery in the dog

scientific article published on 01 December 1987

Effect of 11 beta-hydroxysteroid dehydrogenase-1 inhibition on hepatic glucose metabolism in the conscious dog.

scientific article

Effect of Arginine on Glucose Turnover and Plasma Free Fatty Acids in Normal Dogs ⬇️

scientific article published on 01 July 1973

Effect of a mixed meal on hepatic lactate and gluconeogenic precursor metabolism in dogs

scientific article published on 01 September 1984

Effect of a selective rise in hepatic artery insulin on hepatic glucose production in the conscious dog.

scientific article published in April 1999

Effect of a selective rise in sinusoidal norepinephrine on HGP is due to an increase in glycogenolysis ⬇️

scientific article published on 01 January 1998

Effect of alanine concentration independent of changes in insulin and glucagon on alanine and glucose homeostasis in the conscious dog.

scientific article published in January 1988

Effect of dichloroacetate on gluconeogenesis in vivo in the presence of a fixed gluconeogenic substrate supply to the liver

scientific article published on 01 September 1981

Effect of epinephrine on glycogenolysis and gluconeogenesis in conscious overnight-fasted dogs

scientific article published on 01 August 1984

Effect of fast duration on disposition of an intraduodenal glucose load in the conscious dog.

scientific article published in March 1999

Effect of glucagon on glucose production during insulin deficiency in the dog ⬇️

scientific article published on September 1, 1978

Effect of glucagon on hepatic lactate metabolism in the conscious dog

scientific article published on 01 April 1985

Effect of glucose, independent of changes in insulin and glucagon secretion, on alanine metabolism in the conscious dog.

scientific article published on February 1980

Effect of hepatic denervation on peripheral insulin sensitivity in conscious dogs

scientific article published in February 2002

Effect of hepatic denervation on the counterregulatory response to insulin-induced hypoglycemia in the dog

scientific article published on 01 December 2000

Effect of hepatic nerves on disposition of an intraduodenal glucose load

scientific article published on 01 September 1993

Effect of hyperglucagonemia on hepatic glycogenolysis and gluconeogenesis after a prolonged fast

scientific article published in May 1990

Effect of hyperglycemia independent of changes in insulin or glucagon on lipolysis in the conscious dog

scientific article published on 01 April 1980

Effect of interaction between insulin and glucagon on glucose turnover and FFA concentration in normal and depancreatized dogs

scientific article published on 01 August 1974

Effect of intraportal glucagon-like peptide-1 on glucose metabolism in conscious dogs

scientific article

Effect of portal glucose sensing on incretin hormone secretion in a canine model

scientific article published on 21 May 2019

Effect of prior exercise on the partitioning of an intestinal glucose load between splanchnic bed and skeletal muscle

scientific article published on July 1996

Effect of somatostatin on glucose homeostasis in conscious long-fasted dogs

scientific article published in October 1987

Effect of somatostatin on nonesterified fatty acid levels modifies glucose homeostasis during fasting

scientific article published in October 1987

Effect of the glucagon-like peptide-1 receptor agonist lixisenatide on postprandial hepatic glucose metabolism in the conscious dog

scientific article published on 22 October 2013

Effect of vagal cooling on the counterregulatory response to hypoglycemia induced by a low dose of insulin in the conscious dog.

scientific article published in March 2001

Effects of 11β-hydroxysteroid dehydrogenase-1 inhibition on hepatic glycogenolysis and gluconeogenesis.

scientific article published on 12 February 2013

Effects of Increased Glucokinase Gene Copy Number on Glucose Homeostasis and Hepatic Glucose Metabolism

scientific article published in Journal of Biological Chemistry

Effects of an acute increase in epinephrine and cortisol on carbohydrate metabolism during insulin deficiency

scientific article published on 01 June 1995

Effects of chronic elevation in plasma cortisol on hepatic carbohydrate metabolism

scientific article published on 01 January 1993

Effects of chronic hypercortisolemia on carbohydrate metabolism during insulin deficiency

scientific article published on 01 April 1994

Effects of cyclosporine A and prednisone treatment on mixed meal disposition in dogs with hepatic denervation

scientific article published in January 2002

Effects of differing insulin levels on response to equivalent hypoglycemia in conscious dogs

scientific article published on 01 October 1992

Effects of fasting and glucocorticoids on hepatic gluconeogenesis assessed using two independent methods in vivo

scientific article published in November 2002

Effects of fasting on gluconeogenesis from alanine in nondiabetic man ⬇️

scientific article published on January 1, 1979

Effects of free fatty acids on hepatic glycogenolysis and gluconeogenesis in conscious dogs

scientific article published in February 2002

Effects of fructose on hepatic glucose metabolism

scientific article

Effects of hyperglycemia on hepatic gluconeogenic flux during glycogen phosphorylase inhibition in the conscious dog.

scientific article

Effects of hyperglycemia, glucagon, and epinephrine on renal glucose release in the conscious dog.

scientific article published in July 2004

Effects of hyperinsulinemia on the subsequent hormonal response to hypoglycemia in conscious dogs

scientific article published on 01 May 1993

Effects of insulin at two dose levels on gluconeogenesis from alanine in fasting man.

scientific article published in September 1980

Effects of insulin deficiency or excess on hepatic gluconeogenic flux during glycogenolytic inhibition in the conscious dog.

scientific article published in November 2002

Effects of insulin on glucagon-stimulated glucose production in the conscious dog

scientific article published on 01 December 1990

Effects of insulin on the counterregulatory response to equivalent hypoglycemia in normal females

scientific article published on 01 November 1993

Effects of insulin on the metabolic control of hepatic gluconeogenesis in vivo.

scientific article published on 15 September 2009

Effects of intraportal exenatide on hepatic glucose metabolism in the conscious dog.

scientific article published on 14 May 2013

Effects of morphine on glucose homeostasis in the conscious dog ⬇️

scientific article published on October 1, 1984

Effects of pharmacologic hyperglucagonemia on plasma amino acid concentrations in normal and diabetic man

scientific article published on 01 December 1981

Effects of physiological hyperinsulinemia on counterregulatory response to prolonged hypoglycemia in normal humans

scientific article published on 01 September 1994

Effects of small changes in glucagon on glucose production during a euglycemic, hyperinsulinemic clamp

scientific article published on 01 January 1991

Effects of the nitric oxide donor SIN-1 on net hepatic glucose uptake in the conscious dog.

scientific article published on 20 November 2007

Effects of vagal blockade on the counterregulatory response to insulin-induced hypoglycemia in the dog ⬇️

scientific article published on December 1, 1997

Efficiency of compensation for absence of fall in insulin during exercise

scientific article published on 01 November 1991

Endogenously released GLP-1 is not sufficient to alter postprandial glucose regulation in the dog

scientific article published on 10 March 2011

Endoscopic Duodenal Mucosal Resurfacing for the Treatment of Type 2 Diabetes: 6-Month Interim Analysis From the First-in-Human Proof-of-Concept Study.

scientific article

Enhanced muscle glucose uptake facilitates nitrogen efflux from exercised muscle ⬇️

scientific article published on 01 June 1998

Enterically delivered insulin tregopil exhibits rapid absorption characteristics and a pharmacodynamic effect similar to human insulin in conscious dogs

scientific article published on 16 September 2018

Evidence against a physiologic role for acute changes in CNS insulin action in the rapid regulation of hepatic glucose production ⬇️

scientific article published on May 2, 2012

Evidence for an important role of glucagon in the regulation of hepatic glucose production in normal man.

scientific article published on February 1977

Evidence for an intrahepatic contribution to the waning effect of glucagon on glucose production in the conscious dog

scientific article published on 01 October 1982

Evidence that the brain of the conscious dog is insulin sensitive

scientific article

Evolution of Exenatide as a Diabetes Therapeutic ⬇️

scientific article published on March 1, 2013

Exaggerated epinephrine response to hypoglycemia in a physically fit, well-controlled IDDM subject

scientific article published on 01 January 1994

Exercise-induced fall in insulin and hepatic carbohydrate metabolism during muscular work

scientific article published on 01 April 1989

Exercise-induced fall in insulin and increase in fat metabolism during prolonged muscular work

scientific article published on 01 April 1989

Exercise-induced rise in glucagon and ketogenesis during prolonged muscular work

scientific article published on 01 June 1989

Factors Which Regulate Net Hepatic Glucose Uptake In Vivo ⬇️

scientific article published on May 1, 1991

Failure of somatostatin to modify effect of glucagon on carbohydrate metabolism in the dog ⬇️

scientific article published on 01 June 1983

Glucagon as a Critical Factor in the Pathology of Diabetes ⬇️

scientific article published on February 1, 2011

Glucagon as a regulator of hepatic glucose production in vivo

scientific article published on 01 December 1987

Glucagon is a primary controller of hepatic glycogenolysis and gluconeogenesis during muscular work

scientific article published on 01 July 1989

Glucagon's actions are modified by the combination of epinephrine and gluconeogenic precursor infusion ⬇️

scientific article published on May 7, 2003

Glucagon's effect on liver protein metabolism in vivo.

scientific article

Glucagon's yin and yang effects on hepatic glucose production

scientific article published on June 2013

Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover ⬇️

scientific article published on January 3, 2012

Glucokinase gene locus transgenic mice are resistant to the development of obesity-induced type 2 diabetes

scientific article published in March 2001

Gluconeogenesis: methodological approaches in vivo

scientific article published on February 1, 1977

Glucose autoregulation is the dominant component of the hormone-independent counterregulatory response to hypoglycemia in the conscious dog.

scientific article published on 16 May 2017

Glucose disposal during insulinopenia in somatostatin-treated dogs. The roles of glucose and glucagon

scientific article published on August 1978

Glyburide sensitizes perfused rat liver to insulin-induced suppression of glucose output

scientific article published on 01 April 1987

Hepatic and Whole-Body Insulin Metabolism during Proestrus and Estrus in Mongrel Dogs

scientific article published on January 2016

Hepatic and gut clearance of catecholamines in the conscious dog

scientific article published on 01 February 1999

Hepatic denervation alters the disposition of an enteral glucose load in conscious dogs

scientific article published on 01 August 1991

Hepatic denervation alters the transition from the fed to the food-deprived state in conscious dogs

scientific article published on 01 October 1993

Hepatic denervation does not significantly change the response of the liver to glucagon in conscious dogs

scientific article published on 01 February 1995

Hepatic fuel metabolism during muscular work: role and regulation

scientific article published on 01 June 1991

Hepatic glucocorticoid receptor antagonism is sufficient to reduce elevated hepatic glucose output and improve glucose control in animal models of type 2 diabetes

scientific article published on 22 March 2005

Hepatic glucose disposition during concomitant portal glucose and amino acid infusions in the dog ⬇️

scientific article published on 01 May 1998

Hepatic glucose uptake and disposition during short-term high-fat vs. high-fructose feeding

scientific article

Hepatic glucose uptake rapidly decreases after removal of the portal signal in conscious dogs

scientific article published on 01 December 1998

Hepatic glycogen can regulate hypoglycemic counterregulation via a liver-brain axis.

scientific article published on 03 May 2016

Hepatic glycogen supercompensation activates AMP-activated protein kinase, impairs insulin signaling, and reduces glycogen deposition in the liver.

scientific article

Hepatic nerves are not essential to the increase in hepatic glucose production during muscular work

scientific article

Hepatic portal venous delivery of a nitric oxide synthase inhibitor enhances net hepatic glucose uptake

scientific article published on 22 January 2008

Hydrothermal Duodenal Mucosal Resurfacing: Role in the Treatment of Metabolic Disease

scientific article

Hyperglycemia per se (insulin and glucagon withdrawn) can inhibit hepatic glucose production in man ⬇️

scientific article published on January 1, 1979

Hypoglycemia, gluconeogenesis and the brain

scientific article published on January 1991

Iatrogenic Hyperinsulinemia, Not Hyperglycemia, Drives Insulin Resistance in Type 1 Diabetes as Revealed by Comparison With GCK-MODY (MODY2)

scientific article published on 15 May 2019

Impact of Insulin Tregopil and Its Permeation Enhancer on Pharmacokinetics of Metformin in Healthy Volunteers: Randomized, Open-Label, Placebo-Controlled, Crossover Study

Impact of a Glycogen Phosphorylase Inhibitor and Metformin on Basal and Glucagon-Stimulated Hepatic Glucose Flux in Conscious Dogs ⬇️

scientific article published on March 1, 2011

Impact of acute epinephrine removal on hepatic glucose metabolism during stress hormone infusion

scientific article published on 01 July 1999

Impact of chronic stress hormone infusion on hepatic carbohydrate metabolism in the conscious dog

scientific article published on 01 August 1993

Impact of continuous and pulsatile insulin delivery on net hepatic glucose uptake

scientific article

Importance of basal glucagon in maintaining hepatic glucose production during a prolonged fast in conscious dogs

scientific article published on September 1, 1992

Importance of hypoglycemia-induced glucose production during isolated glucagon deficiency ⬇️

scientific article published on March 1, 1979

Importance of intrahepatic mechanisms to gluconeogenesis from alanine during exercise and recovery

scientific article published on 01 April 1988

Importance of the hepatic arterial glucose level in generation of the portal signal in conscious dogs

scientific article published on 01 August 2000

Importance of the route of intravenous glucose delivery to hepatic glucose balance in the conscious dog

scientific article

In the absence of counterregulatory hormones, the increase in hepatic glucose production during insulin-induced hypoglycemia in the dog is initiated in the liver rather than the brain

scientific article published in December 1996

Inability of hyperglycemia to counter the ability of glucagon to increase net glucose output and activate glycogen phosphorylase in the perfused rat liver

scientific article published on 01 April 1996

Inclusion of low amounts of fructose with an intraduodenal glucose load markedly reduces postprandial hyperglycemia and hyperinsulinemia in the conscious dog.

scientific article published in February 2002

Inclusion of low amounts of fructose with an intraportal glucose load increases net hepatic glucose uptake in the presence of relative insulin deficiency in dog.

scientific article published on 25 January 2005

Inhalation of human insulin (exubera) augments the efficiency of muscle glucose uptake in vivo

scientific article published in December 2006

Inhalation of human insulin is associated with improved insulin action compared with subcutaneous injection and endogenous secretion in dogs

scientific article published on 08 September 2006

Inhalation of insulin (Exubera) is associated with augmented disposal of portally infused glucose in dogs

scientific article published in April 2005

Inhalation of insulin in dogs: assessment of insulin levels and comparison to subcutaneous injection

scientific article published in April 2004

Inhaled insulin is associated with prolonged enhancement of glucose disposal in muscle and liver in the canine

scientific article

Inhibition of dipeptidyl peptidase-4 by vildagliptin during glucagon-like Peptide 1 infusion increases liver glucose uptake in the conscious dog

scientific article published on 7 October 2008

Inhibition of glycogenolysis enhances gluconeogenic precursor uptake by the liver of conscious dogs ⬇️

scientific article published on November 1, 1997

Insulin Delivery Into the Peripheral Circulation: A Key Contributor to Hypoglycemia in Type 1 Diabetes

scientific article

Insulin Infusion Is Linked to Increased <i>NPPC</i> Expression in Muscle and Plasma C-type Natriuretic Peptide in Male Dogs

publication published on 08 May 2021

Insulin action on the liver in vivo

scientific article published on November 2007

Insulin as a mediator of hepatic glucose uptake in the conscious dog

scientific article published on 01 February 1982

Insulin is required for the liver to respond to intraportal glucose delivery in the conscious dog

scientific article published on October 1, 1992

Insulin secretion-independent effects of GLP-1 on canine liver glucose metabolism do not involve portal vein GLP-1 receptors.

scientific article published on 28 July 2005

Insulin sensitively controls the glucagon response to mild hypoglycemia in the dog.

scientific article

Insulin's direct effects on the liver dominate the control of hepatic glucose production

scientific article published on February 2006

Insulin's direct hepatic effect explains the inhibition of glucose production caused by insulin secretion

scientific article published on 23 March 2017

Insulin, glucagon, and glucose as regulators of hepatic glucose uptake and production in vivo

scientific article

Insulin- and glucagon-independent effects of calcitonin gene-related peptide in the conscious dog

scientific article published on 01 May 1999

Insulin-independent effects of GLP-1 on canine liver glucose metabolism: duration of infusion and involvement of hepatoportal region.

scientific article published on 16 March 2004

Insulin-induced hypoglycemia increases hepatic sensitivity to glucagon in dogs

scientific article

Interaction between insulin and glucose-delivery route in regulation of net hepatic glucose uptake in conscious dogs

scientific article published in January 1990

Interaction between the central and peripheral effects of insulin in controlling hepatic glucose metabolism in the conscious dog.

scientific article

Interaction of a selective serotonin reuptake inhibitor with insulin in the control of hepatic glucose uptake in conscious dogs.

scientific article

Interaction of equal increments in arterial and portal vein insulin on hepatic glucose production in the dog ⬇️

scientific article published on 01 November 1997

Interaction of free fatty acids and epinephrine in regulating hepatic glucose production in conscious dogs

scientific article published in February 2003

Interaction of glucagon and epinephrine in the control of hepatic glucose production in the conscious dog.

scientific article published on 27 December 2002

Intraportal GLP-1 infusion increases nonhepatic glucose utilization without changing pancreatic hormone levels

scientific article published on 07 August 2007

Intraportal administration of neuropeptide Y and hepatic glucose metabolism

scientific article published on 30 January 2008

Intraportal glucose delivery alters the relationship between net hepatic glucose uptake and the insulin concentration

scientific article published in March 1991

Intraportal glucose delivery enhances the effects of hepatic glucose load on net hepatic glucose uptake in vivo

scientific article

Intraportal hyperinsulinemia decreases insulin-stimulated glucose uptake in the dog.

scientific article

Intraportally delivered GLP-1, in the presence of hyperglycemia induced via peripheral glucose infusion, does not change whole body glucose utilization

scientific article published on 4 December 2007

Involvement of the vagus nerves in the regulation of basal hepatic glucose production in conscious dogs

scientific article published in November 2002

Is brain insulin action relevant to the control of plasma glucose in humans?

scientific article published on March 2015

Islet auto-transplantation into an omental or splenic site results in a normal beta cell but abnormal alpha cell response to mild non-insulin-induced hypoglycemia

scientific article

Ketone body turnover and net hepatic ketone production in fasted and diabetic dogs

scientific article published on August 1, 1978

Lack of effect of somatostatin on epinephrine-stimulated glucose production in the dog

scientific article published on 01 May 1987

Lack of effect of somatostatin on the stimulation of hepatic glycogenolysis by epinephrine in isolated canine hepatocytes

scientific article published on 01 August 1984

Lactate as substrate for glycogen resynthesis after exercise

scientific article published on 01 June 1987

Liver Glycogen Loading Dampens Glycogen Synthesis Seen in Response to Either Hyperinsulinemia or Intraportal Glucose Infusion ⬇️

scientific article published on August 24, 2012

Magnitude of negative arterial-portal glucose gradient alters net hepatic glucose balance in conscious dogs

scientific article published in December 1991

Mechanism of epinephrine's glycogenolytic effect in isolated canine hepatocytes

Mechanisms of catecholamine actions on liver carbohydrate metabolism

scientific article published on January 1, 1978

Mechanisms of hormonal regulation of liver metabolism

scientific article published on 01 January 1981

MetAP2 inhibitor treatment of high-fat and -fructose-fed dogs: impact on the response to oral glucose ingestion and a hyperinsulinemic hyperglycemic clamp

scientific article published on 28 January 2020

Metabolic role of the exercise-induced increment in epinephrine in the dog

scientific article published on 01 October 1988

Molecular characterization of insulin-mediated suppression of hepatic glucose production in vivo ⬇️

scientific article

Molecular engineering of safe and efficacious oral basal insulin

scientific article published on 27 July 2020

Morning Hyperinsulinemia Primes the Liver for Glucose Uptake and Glycogen Storage Later in the Day

scientific article published on 17 April 2018

Net hepatic gluconeogenic amino acid uptake in response to peripheral versus portal amino acid infusion in conscious dogs

scientific article published on 01 December 1999

Net hepatic lactate balance following mixed meal feeding in the four-day fasted conscious dog.

scientific article published in September 1987

Neural and pancreatic influences on net hepatic glucose uptake and glycogen synthesis

scientific article published on 01 August 1996

Nonesterified fatty acids and hepatic glucose metabolism in the conscious dog.

scientific article published in January 2004

Nonhepatic response to portal glucose delivery in conscious dogs

scientific article published on 01 December 2000

Noninvasive measurements of glycogen in perfused mouse livers using chemical exchange saturation transfer NMR and comparison to (13)C NMR spectroscopy

scientific article

Novel PEGylated basal insulin LY2605541 has a preferential hepatic effect on glucose metabolism

scientific article published on 2 October 2013

Odd Chain Fatty Acids; New Insights of the Relationship Between the Gut Microbiota, Dietary Intake, Biosynthesis and Glucose Intolerance

scientific article published on 23 March 2017

Pancreatic response to mild non-insulin-induced hypoglycemia does not involve extrinsic neural input

scientific article published in November 2001

Paradoxical insulin-induced increase in gluconeogenesis in response to prolonged hypoglycemia in conscious dogs

scientific article published on 01 March 1995

Peripherally delivered hepatopreferential insulin analog insulin-406 mimics the hypoglycaemia-sparing effect of portal vein human insulin infusion in dogs

scientific article published on 08 July 2019

Persistent stimulatory effect of glucagon on glucose production despite downregulation ⬇️

scientific article published on November 1, 1978

Pharmacokinetics and Pharmacodynamics of Insulin Tregopil in Relation to Premeal Dosing Time, Between Meal Interval, and Meal Composition in Patients With Type 2 Diabetes Mellitus

scientific article published on 07 August 2019

Physiologic action of glucagon on liver glucose metabolism ⬇️

scientific article published on October 1, 2011

Physiological changes in circulating glucagon alter hepatic glucose disposition during portal glucose delivery ⬇️

scientific article published on September 1, 1997

Physiological consequences of phasic insulin release in the normal animal

scientific article

Portal 5-hydroxytryptophan infusion enhances glucose disposal in conscious dogs

scientific article published on 8 March 2005

Portal Vein Glucose Entry Triggers a Coordinated Cellular Response That Potentiates Hepatic Glucose Uptake and Storage in Normal but Not High-Fat/High-Fructose–Fed Dogs ⬇️

scientific article published on October 1, 2012

Portal adrenergic blockade does not inhibit the gluconeogenic effects of circulating catecholamines on the liver

scientific article published on 01 April 1997

Portal glucose delivery stimulates muscle but not liver protein metabolism ⬇️

scientific article published on September 25, 2012

Portal glucose infusion exerts an incretin effect associated with changes in pancreatic neural activity in conscious dogs

scientific article published in October 2002

Portal glucose infusion increases hepatic glycogen deposition in conscious unrestrained rats

scientific article published on 01 October 1999

Portal infusion of a selective serotonin reuptake inhibitor enhances hepatic glucose disposal in conscious dogs.

scientific article

Portal infusion of amino acids is more efficient than peripheral infusion in stimulating liver protein synthesis at the same hepatic amino acid load in dogs

scientific article published on October 2008

Portal infusion of escitalopram enhances hepatic glucose disposal in conscious dogs

scientific article published on April 2009

Portal serotonin infusion and glucose disposal in conscious dogs

scientific article published in January 2004

Possible mechanism by which somatostatin-induced glucagon suppression improves glucose tolerance during insulinopaenia in man ⬇️

scientific article published on 01 September 1979

Priming Effect of a Morning Meal on Hepatic Glucose Disposition Later in the Day.

scientific article published on 7 February 2017

Prior exercise increases net hepatic glucose uptake during a glucose load

scientific article published on 01 June 1999

Pulsatility does not alter the response to a physiological increment in glucagon in the conscious dog

scientific article published on 01 March 1994

Rapid reversal of the effects of the portal signal under hyperinsulinemic conditions in the conscious dog

scientific article published on 01 May 1999

Rapid translocation of hepatic glucokinase in response to intraduodenal glucose infusion and changes in plasma glucose and insulin in conscious rats

scientific article

Rates of glucagon activation and deactivation of hepatic glucose production in conscious dogs

scientific article published on 01 February 1998

Regulation of Hepatic Glucose Uptake and Storage In Vivo ⬇️

scientific article published on May 1, 2012

Regulation of glucose metabolism by norepinephrine in conscious dogs

scientific article published in December 1991

Regulation of hepatic and peripheral glucose disposal

scientific article

Regulation of hepatic metabolism by enteral delivery of nutrients

scientific article

Regulation of ketogenesis by epinephrine and norepinephrine in the overnight-fasted, conscious dog.

scientific article published in May 1985

Regulation of lipolysis and ketogenesis by norepinephrine in conscious dogs

scientific article published on 01 October 1991

Regulation of net hepatic substrate balance by phenacylimidazolium ions in the conscious dog

scientific article published on 01 January 1993

Relationship between decrements in glucose level and metabolic response to hypoglycemia in absence of counterregulatory hormones in the conscious dog

scientific article published on 01 October 1992

Relationship between the plasma glucose level and glucose uptake in the conscious dog

scientific article published on July 1, 1978

Relative importance of first- and second-phase insulin secretion in glucose homeostasis in conscious dog. II. Effects on gluconeogenesis

scientific article published on 01 July 1986

Renal contribution to glucose production after a brief fast: fact or fancy?

scientific article published on June 1994

Retardant Effect of Hyperglycemia on the Rise in Plasma Fatty Acids Following Insulin Withdrawal in Man ⬇️

scientific article published on 01 October 1981

Role of a negative arterial-portal venous glucose gradient in the postexercise state

scientific article published on 01 December 1999

Role of brain in counterregulation of insulin-induced hypoglycemia in dogs

scientific article published on 01 January 1989

Role of cortisol in the metabolic response to stress hormone infusion in the conscious dog

scientific article published on 01 May 1996

Role of epinephrine and norepinephrine in the metabolic response to stress hormone infusion in the conscious dog ⬇️

scientific article published on 01 October 1997

Role of glucagon and insulin in control of glucose turnover ⬇️

scientific article published on 01 June 1971

Role of glucagon in countering hypoglycemia induced by insulin infusion in dogs

scientific article published on 01 December 1991

Role of glucagon in the metabolic response to stress hormone infusion in the conscious dog

scientific article published on 01 March 1994

Role of glucagon suppression on gluconeogenesis during insulin treatment of the conscious diabetic dog

scientific article published on 01 October 1987

Role of gluconeogenesis in sustaining glucose production during hypoglycemia caused by continuous insulin infusion in conscious dogs

scientific article published on 01 June 1988

Role of hepatic nerves in response of liver to intraportal glucose delivery in dogs

scientific article published on 01 May 1992

Role of insulin in the regulation of leucine kinetics in the conscious dog

scientific article published on November 1982

Role of the hepatic sympathetic nerves in the regulation of net hepatic glucose uptake and the mediation of the portal glucose signal

scientific article published on 16 August 2005

Selective antagonism of the hepatic glucocorticoid receptor reduces hepatic glucose production

scientific article published on 01 September 2006

Selective stimulation of G-6-Pase catalytic subunit but not G-6-P transporter gene expression by glucagon in vivo and cAMP in situ

scientific article

Selective tonic inhibition of G-6-Pase catalytic subunit, but not G-6-P transporter, gene expression by insulin in vivo

scientific article

Similar dose responsiveness of hepatic glycogenolysis and gluconeogenesis to glucagon in vivo

scientific article published in March 1987

Simulated first-phase insulin release using Humulin or insulin analog HIM2 is associated with prolonged improvement in postprandial glycemia

scientific article published on 15 February 2005

Small amounts of fructose markedly augment net hepatic glucose uptake in the conscious dog ⬇️

scientific article published on June 1, 1998

Small increases in insulin inhibit hepatic glucose production solely caused by an effect on glycogen metabolism

scientific article published in August 2001

Sources of carbon for hepatic glycogen synthesis in the conscious dog ⬇️

scientific article published on August 1, 1991

Splanchnic cortisol production in dogs occurs primarily in the liver: evidence for substantial hepatic specific 11beta hydroxysteroid dehydrogenase type 1 activity

scientific article published on 01 November 2006

Splanchnic free fatty acid kinetics ⬇️

scientific article published on June 1, 2003

Stimulation of glucose production through hormone secretion and other mechanisms during insulin-induced hypoglycemia

scientific article published on 01 November 1988

Studies of the role of beta-adrenergic receptors in the activation of phosphorylase in rat hepatocytes by catecholamines

scientific article published on August 1, 1977

Studies on the alpha-andrenergic activation of hepatic glucose output. II. Investigation of the roles of adenosine 3':5'-monophosphate and adenosine 3':5'-monophosphate-dependent protein kinase in the actions of phenylephrine in isolated hepatocytes ⬇️

scientific article published on September 10, 1976

Studies on the role of cAMP-dependent protein kinase in the actions of glucagon and catecholamines on liver glycogen metabolism ⬇️

scientific article published on November 1, 1976

Substrate-induced nuclear export and peripheral compartmentalization of hepatic glucokinase correlates with glycogen deposition

scientific article

Superior Glycemic Control With a Glucose-Responsive Insulin Analog: Hepatic and Nonhepatic Impacts

scientific article published on 14 March 2018

Sympathetic Denervation of the Common Hepatic Artery Lessens Glucose Intolerance in the Fat- and Fructose-Fed Dog

scientific article published on 01 April 2019

Targeting insulin to the liver corrects defects in glucose metabolism caused by peripheral insulin delivery

article published in 2019

The Effect of Somatostatin on Glucose Uptake and Production by Rat Tissues in Vitro ⬇️

scientific article published on August 1, 1977

The Peripheral Peril: Injected Insulin Induces Insulin Insensitivity in Type 1 Diabetes

scientific article published on 01 May 2020

The acute effect of metformin on glucose production in the conscious dog is primarily attributable to inhibition of glycogenolysis

scientific article published on 01 December 2000

The direct and indirect effects of insulin on hepatic glucose production in vivo ⬇️

scientific article published on 01 September 1998

The direct effects of catecholamines on hepatic glucose production occur via alpha(1)- and beta(2)-receptors in the dog

scientific article published on 01 August 2000

The effect of acute glucagon removal on the metabolic response to stress hormone infusion in the conscious dog

scientific article published on 01 October 1994

The effect of an acute elevation of NEFA concentrations on glucagon-stimulated hepatic glucose output

scientific article published on 11 April 2006

The effect of the hepatic nerves on the disposition of a mixed meal by conscious dogs

scientific article published in May 1994

The effect of vagal cooling on canine hepatic glucose metabolism in the presence of hyperglycemia of peripheral origin

scientific article published on 01 June 2007

The effects of acute elevations in plasma cortisol levels on alanine metabolism in the conscious dog.

scientific article

The effects of acute hypercortisolemia on beta-hydroxybutyrate and glycerol metabolism during insulin deficiency

scientific article published on 01 January 1994

The effects of differing insulin levels on the hormonal and metabolic response to equivalent hypoglycemia in normal humans

scientific article published on 01 February 1993

The effects of epinephrine on ketogenesis in the dog after a prolonged fast

scientific article published in October 1991

The effects of insulin on the counterregulatory response to equivalent hypoglycemia in patients with insulin-dependent diabetes mellitus

scientific article published on 01 November 1993

The effects of lactate loading on alanine and glucose metabolism in the conscious dog

scientific article published on 01 February 1993

The head arterial glucose level is not the reference site for generation of the portal signal in conscious dogs

scientific article published on 01 October 1999

The hormonal and metabolic responses to prolonged hypoglycemia.

scientific article published on January 1993

The kinetics of glucagon action on the liver during insulin-induced hypoglycemia

scientific article published on 24 March 2020

The relationship between plasma concentration and disappearance rate of immunoreactive insulin in the conscious dog

scientific article published on 01 November 1985

The relative importance of first- and second-phase insulin secretion in countering the action of glucagon on glucose turnover in the conscious dog

scientific article published on 01 November 1982

The role of CCK8 in the inhibition of glucose production

scientific article

The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog

scientific article published on 01 February 1997

The role of hepatic insulin receptors in the regulation of glucose production

scientific article published on May 2005

The role of insulin and glucagon in the regulation of basal glucose production in the postabsorptive dog ⬇️

scientific article published on December 1, 1976

The role of neural signalling and hypoglycaemia per se in the counterregulatory response.

scientific article

The roles of insulin and glucagon in the regulation of gluconeogenesis in the postabsorptive dog

scientific article published on September 1, 1977

The roles of insulin, glucagon, and free fatty acids in the regulation of ketogenesis in dogs

scientific article published on November 1, 1977

The synthetic 32-46 fragment of human growth hormone increases insulin and glucagon levels in the conscious dog

scientific article published on 01 April 1987

The synthetic human growth hormone fragment (32-38) increases glucose uptake in the conscious dog

scientific article published on 01 April 1988

Triglyceride uptake and lipoprotein lipase-generated fatty acid spillover in the splanchnic bed of dogs

scientific article published on 06 April 2007

Unlike mice, dogs exhibit effective glucoregulation during low-dose portal and peripheral glucose infusion ⬇️

scientific article published on September 30, 2003

Vagal cooling and concomitant portal norepinephrine infusion do not reduce net hepatic glucose uptake in conscious dogs

scientific article

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