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List of works by Jerrold M. Olefsky

"Tertiary" hyperparathyroidism and apparent "cure" of vitamin-D-resistant rickets after removal of an ossifying mesenchymal tumor of the pharynx

scientific article published on 01 April 1972

8 Pancreas ⬇️

scientific article published on 01 November 1979

A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice

scientific article published on 6 July 2014

A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis

scientific article

A Tribute to Robert Roy Henry-The Classic "Academic Triple Threat": Accomplished Researcher, Inspiring Teacher, and Compassionate Clinician

scientific article published on 21 January 2020

A comparison of troglitazone and metformin on insulin requirements in euglycemic intensively insulin-treated type 2 diabetic patients

scientific article published on December 1999

A functional assessment of insulin/insulin-like growth factor-I hybrid receptors

scientific article published in April 1995

A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis

scientific article published in October 1987

A new antidiabetic compound attenuates inflammation and insulin resistance in Zucker diabetic fatty rats

scientific article

A noninvasive method to measure splanchnic glucose uptake after oral glucose administration

scientific article

A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.

scientific article

A structurally abnormal insulin causing human diabetes ⬇️

scientific article published on September 13, 1979

A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways

scientific article published on 04 October 2007

A truncated human insulin receptor missing the COOH-terminal 365 amino acid residues does not undergo insulin-mediated receptor migration or aggregation

scientific article published on 01 April 1993

APPLied mechanics: uncovering how adiponectin modulates insulin action

scientific article published on July 2006

Ability of circulating insulin to chronically regulate the cellular glucose transport system

scientific article published on December 1, 1978

Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals

scientific article published on October 2008

Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression

scientific article

Activated phosphatidylinositol 3-kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes

scientific article

Acute and chronic effects of insulin on leptin production in humans: Studies in vivo and in vitro

scientific article

Acute effects of troglitazone on in vivo insulin action in normal rats ⬇️

scientific article published on September 1, 1995

Adenosine modulates insulin activation of insulin receptor kinase in intact rat adipocytes

scientific article published on 01 June 1987

Adenovirus-Mediated Overexpression of IRS-1 Interacting Domains Abolishes Insulin-Stimulated Mitogenesis without Affecting Glucose Transport in 3T3-L1 Adipocytes ⬇️

scientific article published on December 1, 1997

Adenovirus-mediated adiponectin expression augments skeletal muscle insulin sensitivity in male Wistar rats

scientific article published in May 2005

Adenovirus-mediated chronic "hyper-resistinemia" leads to in vivo insulin resistance in normal rats

scientific article

Adenovirus-mediated chronic “hyper-resistinemia” leads to in vivo insulin resistance in normal rats

scholarly article by Hiroaki Satoh et al published 15 July 2004 in Journal of Clinical Investigation

Adipocyte NCoR knockout decreases PPARγ phosphorylation and enhances PPARγ activity and insulin sensitivity

scientific article

Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity

scientific article published on 5 March 2015

Adipocyte glycogen synthase and pyruvate dehydrogenase in obese and type II diabetic subjects

scientific article

Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LbetaT2 gonadotropes

scientific article

Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity

scientific article

Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle

scientific article

Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3)

scientific journal article

Amelioration of glucose intolerance by the synthetic androstene HE3286: link to inflammatory pathways

scientific article published on 12 January 2010

Amylin release during oral glucose tolerance test

scientific article published in June 1997

An Integrated View of Immunometabolism

scientific article published in January 2018

An SH2 domain-containing 5' inositolphosphatase inhibits insulin-induced GLUT4 translocation and growth factor-induced actin filament rearrangement

scientific article published on February 1999

An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

scientific article

Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus

scientific article

Annexin II is a thiazolidinedione-responsive gene involved in insulin-induced glucose transporter isoform 4 translocation in 3T3-L1 adipocytes

scientific article published on 15 January 2004

Antiinsulin receptor antibodies in an insulin-dependent diabetic may arise as autoantiidiotypes

scientific article published on 01 July 1986

Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin

scientific article

Beta -Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of beta 2 adrenergic receptor Galpha s signaling in 3T3-L1 adipocytes

scholarly article

Beta-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic beta cells

scholarly article

Biochemical and functional heterogeneity of rat adipocyte glucose transporters

scientific article

Biochemical characterization and subcellular distribution of the glucose transporter from rat brain microvessels

scientific article

Biosynthetic Human Insulin and Proinsulin Have Additive but Not Synergistic Effects on Total Body Glucose Disposal* ⬇️

scientific article published on 01 June 1984

Blockade of alpha4 integrin signaling ameliorates the metabolic consequences of high-fat diet-induced obesity

scientific article published on 21 April 2008

Blood-brain glucose transfer in diabetes mellitus. Decreased number of glucose transporters at blood-brain barrier

scientific article

Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance

scientific article

Brain PPAR-γ promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones

scientific article

C/EBPα regulates macrophage activation and systemic metabolism

scientific article

Cdc42 is a Rho GTPase family member that can mediate insulin signaling to glucose transport in 3T3-L1 adipocytes

scientific article published on 3 February 2003

Cell signaling. A new way to burn fat.

scientific article published in June 2006

Cellular and molecular mechanisms of non-insulin dependent diabetes mellitus

scientific article

Cellular effects of small molecule PTP1B inhibitors on insulin signaling

scientific article published on November 2003

Cellular insulin resistance in adipocytes from obese polycystic ovary syndrome subjects involves adenosine modulation of insulin sensitivity

scientific article

Cellular mechanisms of insulin resistance in non-insulin-dependent (type II) diabetes

scientific article

Cellular mechanisms of insulin resistance in polycystic ovarian syndrome

scientific article published on August 1, 1992

Characteristics of Binding of a Low Affinity, Noncooperative Insulin ([LeuB25]Insulin) to IM-9 Lymphocytes* ⬇️

scientific article published on 01 December 1983

Characterization of an insulin receptor mutant lacking the subunit processing site

scientific article

Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice

scientific article published on 14 October 2014

Characterization of insulin-induced receptor loss and evidence for internalization of the insulin receptor

scientific article published on September 1981

Characterization of insulin-like growth factor (IGF) binding proteins and their role in modulating IGF-I action in BHK cells ⬇️

scientific article published on December 15, 1992

Characterization of the receptor binding properties of monoiodoinsulin isomers and the identification of different insulin receptor specificities in hepatic and extrahepatic tissues

scientific article published on 01 August 1983

Chronic endothelin-1 treatment leads to heterologous desensitization of insulin signaling in 3T3-L1 adipocytes

scientific article

Chronic endothelin-1 treatment leads to insulin resistance in vivo

scientific article published in August 2003

Chronic fractalkine administration improves glucose tolerance and pancreatic endocrine function

scientific article published on 5 March 2018

Clinical, cellular, and physiologic effects of glyburide in non-insulin-dependent diabetes mellitus.

scientific article published in September 1985

Comparison of 125I-Insulin Binding and Degradation to Isolated Rat Hepatocytes and Liver Membranes ⬇️

scientific article published on September 1, 1975

Comparison of the Effects of Insulin and Insulin-like Agents on Different Aspects of Adipocyte Metabolism ⬇️

scientific article published on March 1, 1979

Comparison of the effects of insulin and H2O2 on adipocyte glucose transport

scientific article published on 01 March 1982

Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signaling pathways

scientific article published on 01 October 1996

Comparison of the intracellular itineraries of insulin-like growth factor-I and insulin and their receptors in Rat-1 fibroblasts

scientific article published in June 1994

Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity

scientific article published on 29 December 2003

Contribution of postprandial insulin and glucose to glucose disposal in normal and insulin-resistant obese subjects

scientific article published on 01 October 1991

Coupling of insulin receptors to glucose transport: A temperature-dependent time lag in activation of glucose transport ⬇️

scientific article published on March 1, 1979

Cutaneous Manifestations of Leprechaunism ⬇️

scientific article published on 01 September 1981

Cycloheximide decreases glucose transporters in rat adipocyte plasma membranes without affecting insulin-stimulated glucose transport

scientific article published on April 1988

Day-long integrated serum insulin and C-peptide profiles in patients with NIDDM. Correlation with urinary C-peptide excretion

scientific article

Decreased Insulin Binding to Lymphocytes from Diabetic Subjects ⬇️

scientific article published on December 1, 1974

Decreased activation rate of insulin-stimulated glucose transport in adipocytes from obese subjects

scientific article

Decreased insulin binding to adipocytes and circulating monocytes from obese subjects ⬇️

scientific article published on May 1, 1976

Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects

scientific article

Decreased susceptibility to fatty acid-induced peripheral tissue insulin resistance in women

scientific article published in June 2001

Defect in glucose removal in nonketotic diabetic patients with fasting hyperglycemia ⬇️

scientific article published on January 1, 1979

Defective insulin receptor function in down-regulated HepG2 cells.

scientific article published in October 1990

Degradation of Insulin Receptors in Rat Adipocytes ⬇️

scientific article published on November 1, 1983

Delayed onset of insulin activation of the insulin receptor kinase in vivo in human skeletal muscle

scientific article

Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action

scientific article

Deletion of exon 21 of the insulin receptor eliminates tyrosine kinase activity but preserves mitogenic signaling

scientific article published on December 1993

Deletion of the insulin receptor beta-subunit acidic domain results in enhanced metabolic signaling

scientific article published on September 1993

Demonstration of insulin receptors and modulation of alkaline phosphatase activity by insulin in rat osteoblastic cells

scientific article published on October 1986

Demonstration of insulin resistance in untreated adult onset diabetic subjects with fasting hyperglycemia ⬇️

scientific article published on March 1, 1975

Diabetes due to secretion of an abnormal insulin

scientific article published in January 1980

Diabetes. Gene therapy for rats and mice

scientific article published in November 2000

Direct and indirect effects of insulin to inhibit hepatic glucose output in obese subjects

scientific article published on 01 May 1987

Direct in vitro effect of a sulfonylurea to increase human fibroblast insulin receptors

scientific article published on September 1980

Disassociation of the plasma insulin response from the blood glucose concentration during glucose infusions in normal dogs ⬇️

scientific article published on October 1, 1973

Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators

scientific article published in March 2009

Disruption of microtubules ablates the specificity of insulin signaling to GLUT4 translocation in 3T3-L1 adipocytes

scientific article published on 20 October 2005

Dissection of the growth versus metabolic effects of insulin and insulin-like growth factor-I in transfected cells expressing kinase-defective human insulin receptors

scientific article published in January 1990

Dissociation of insulin resistance and decreased insulin receptor binding in Duchenne muscular dystrophy

scientific article published in February 1985

Do the Oral and Intravenous Glucose Tolerance Tests Provide Similar Diagnostic Information in Patients with Chemical Diabetes Mellitus? ⬇️

scientific article published on 01 March 1973

Does glucagon play a role in the insulin resistance of patients with adult non-ketotic diabetes?

scientific article published on August 1, 1977

Effect of Obesity on Insulin Resistance in Normal Subjects and Patients With NIDDM ⬇️

scientific article published on September 1, 1995

Effect of a High Carbohydrate Diet on Insulin Binding to Adipocytes and on Insulin Action in vivo in Man ⬇️

scientific article published on August 1, 1979

Effect of a glucosidase inhibitor on the metabolic response of diabetic rats to a high carbohydrate diet, consisting of starch and sucrose, or glucose

scientific article published on 01 January 1982

Effect of a high carbohydrate diet on adipocyte glucose metabolism in spontaneously obese rats and insulin-deficient diabetic rats

scientific article published on 01 December 1980

Effect of a major histocompatibility complex class I peptide on insulin-like growth factor-I receptor internalization and biological signaling

scientific article published in September 1993

Effect of dexamethasone on insulin binding, glucose transport, and glucose oxidation of isolated rat adipocytes ⬇️

scientific article published on December 1, 1975

Effect of experimental hyperinsulinaemia on intracellular glucose metabolism of isolated adipocytes ⬇️

scientific article published on 01 August 1979

Effect of experimental hyperinsulinemia on insulin binding and glucose transport in isolated rat adipocytes

scientific article published in July 1978

Effect of heterozygous PPARgamma deficiency and TZD treatment on insulin resistance associated with age and high-fat feeding

scientific article

Effect of intravenous glucose infusion on plasma insulin removal rate

scientific article published on 01 June 1974

Effect of obesity on susceptibility to fatty acid-induced peripheral tissue insulin resistance

scientific article published in February 2003

Effect of temperature on coupling of insulin receptors to stimulation of glucose transport in isolated rat adipocytes ⬇️

scientific article published on 01 October 1983

Effect of troglitazone on leptin production. Studies in vitro and in human subjects

scientific article

Effects of Age and Obesity on Insulin Binding to Isolated Adipocytes1212 ⬇️

scientific article published on June 1, 1975

Effects of Nonesterified Fatty Acids on Glucose Metabolism After Glucose Ingestion ⬇️

scientific article published on October 1, 1997

Effects of Streptozotocin-induced Diabetes on Insulin Binding, Glucose Transport, and Intracellular Glucose Metabolism in Isolated Rat Adipocytes ⬇️

scientific article published on February 1, 1979

Effects of aging on glucose-mediated glucose disposal and glucose transport

scientific article published on June 1986

Effects of fasting on insulin binding, glucose transport, and glucose oxidation in isolated rat adipocytes: relationships between insulin receptors and insulin action ⬇️

scientific article published on December 1, 1976

Effects of general receptor for phosphoinositides 1 on insulin and insulin-like growth factor I-induced cytoskeletal rearrangement, glucose transporter-4 translocation, and deoxyribonucleic acid synthesis

scientific article published on December 1998

Effects of glucocorticoids on carbohydrate metabolism

scientific article

Effects of growth and insulin treatment on the levels of insulin receptors and their mRNA in Hep G2 cells.

scientific article published in April 1989

Effects of insulin and insulin-like agents on the glucose transport system of cultured human fibroblasts

scientific article published on 01 June 1981

Effects of insulin incubation on insulin binding, glucose transport, and insulin degradation by isolated rat adipocytes. Evidence for hormone-induced desensitization at the receptor and postreceptor level

scientific article published on October 1980

Effects of lysosomotropic agents on insulin interactions with adipocytes. Evidence for a lysosomal pathway for insulin processing and degradation ⬇️

scientific article published on October 25, 1979

Effects of oral fructose in normal, diabetic, and impaired glucose tolerance subjects

scientific article published on 01 September 1980

Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer

scientific article

Effects of prednisolone and dexamethasone in vivo and in vitro: studies of insulin binding, deoxyglucose uptake and glucose oxidation in rat adipocytes

scientific article

Effects of sulfonylurea therapy on insulin binding to mononuclear leukocytes of diabetic patients ⬇️

scientific article published on January 1, 1976

Effects of troglitazone on blood concentrations of plasminogen activator inhibitor 1 in patients with type 2 diabetes and in lean and obese normal subjects

scientific article published on April 2000

Effects of weight loss on mechanisms of hyperglycemia in obese non-insulin-dependent diabetes mellitus

scientific article published in September 1986

Effects of weight reduction on obesity. Studies of lipid and carbohydrate metabolism in normal and hyperlipoproteinemic subjects

scientific article

Endocrine-metabolic relationships in patients with leprechaunism

scientific article published on December 1982

Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer

scientific article (publication date: 18 September 2014)

Endocytotic uptake, processing, and retroendocytosis of human biosynthetic proinsulin by rat fibroblasts transfected with the human insulin receptor gene

scientific article published on May 1988

Endothelin-1-induced GLUT4 translocation is mediated via Galpha(q/11) protein and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes

scientific article published on November 1999

Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp

scientific article

Erratum: Corrigendum: Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer

scientific article published in Nature

Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor

scientific journal article

Evidence for an insulin receptor substrate 1 independent insulin signaling pathway that mediates insulin-responsive glucose transporter (GLUT4) translocation

scientific article published on August 1996

Evidence for decreased splanchnic glucose uptake after oral glucose administration in non-insulin-dependent diabetes mellitus ⬇️

scientific article published on November 1, 1997

Evidence for insulin-induced internalization and degradation of insulin receptors in rat adipocytes

scientific article

Evidence for recycling of insulin receptors in isolated rat adipocytes.

scientific article published on November 1981

Evidence for two independent pathways of insulin-receptor internalization in hepatocytes and hepatoma cells

scientific article published on June 1988

Evidence that glucose transport is rate-limiting for in vivo glucose uptake ⬇️

scientific article published on 01 August 1992

Exercise and thiazolidinedione therapy normalize insulin action in the obese Zucker fatty rat.

scientific article

Exercise-stimulated glucose turnover in the rat is impaired by glucosamine infusion

scientific article

Expression of dominant negative mutant SHPTP2 attenuates phosphatidylinositol 3'-kinase activity via modulation of phosphorylation of insulin receptor substrate-1.

scientific article published on May 1996

FOXO1 transrepresses peroxisome proliferator-activated receptor gamma transactivation, coordinating an insulin-induced feed-forward response in adipocytes

scientific article

Factitious hypoglycemia. Diagnosis by measurement of serum C-peptide immunoreactivity and insulin-binding antibodies

scientific article

Fat talks, liver and muscle listen

scientific article published in September 2008

Fat-Induced Inflammation Unchecked ⬇️

scientific article published on December 1, 2010

Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylation

scientific article published in January 2002

Female rats do not exhibit free fatty acid-induced insulin resistance

scientific article

Food fallacies and blood sugar

scientific article published on 01 July 1983

FoxO1 haploinsufficiency protects against high-fat diet-induced insulin resistance with enhanced peroxisome proliferator-activated receptor gamma activation in adipose tissue

scientific article

FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages

scientific article

Free Fatty Acids Induce Lhb mRNA but Suppress Fshb mRNA in Pituitary LβT2 Gonadotropes and Diet-Induced Obesity Reduces FSH Levels in Male Mice and Disrupts the Proestrous LH/FSH Surge in Female Mice ⬇️

scientific article published on March 22, 2013

Functional and structural differences in human and rat-derived insulin receptors: characterization of the beta-subunit kinase activity

scientific article

Functional characterization of hybrid receptors composed of a truncated insulin receptor and wild type insulin-like growth factor 1 or insulin receptors

scientific article

Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice

scientific article

Functional roles of the Shc phosphotyrosine binding and Src homology 2 domains in insulin and epidermal growth factor signaling

scientific article published on October 1996

Further Evidence for Functional Heterogeneity of Adipocyte Insulin Receptors* ⬇️

scientific article published on February 1, 1979

Further evidence that insulin resistance exists in patients with chemical diabetes.

scientific article

G alpha-q/11 protein plays a key role in insulin-induced glucose transport in 3T3-L1 adipocytes

scientific article

G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice

scientific journal article

G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes

scientific article published on 30 June 2005

G protein-coupled receptors as targets for anti-diabetic therapeutics

scientific article published on 29 January 2016

GPR105 ablation prevents inflammation and improves insulin sensitivity in mice with diet-induced obesity

scientific article

GPR43 Potentiates β-Cell Function in Obesity

scientific article published on 28 May 2015

GRK2 is an endogenous protein inhibitor of the insulin signaling pathway for glucose transport stimulation

scientific article published on 08 July 2004

Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects

scientific journal article

Glucocorticoids and thiazolidinediones interfere with adipocyte-mediated macrophage chemotaxis and recruitment

scientific article published on 09 September 2009

Glucose and insulin co-regulate the glucose transport system in primary cultured adipocytes. A new mechanism of insulin resistance.

scientific article

Glucose kinetics in leprechaunism: accelerated fasting due to insulin resistance

scientific article published in November 1980

Glucose-induced phosphorylation of the insulin receptor. Functional effects and characterization of phosphorylation sites

scientific article published on February 1996

Glycemic effects of intensive caloric restriction and isocaloric refeeding in noninsulin-dependent diabetes mellitus

scientific article

GnRH activates ERK1/2 leading to the induction of c-fos and LHbeta protein expression in LbetaT2 cells

scientific article published on March 2002

Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology [...]

scientific article published on March 20, 1998

Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice

scientific article

Hepatic insulin responsiveness in patients with endogenous hypertriglyceridaemia ⬇️

scientific article published on April 1, 1978

Hepatic ultrastructure in leprechaunism. Hepatic ultrastructural evidence suggesting a syndrome with defective hepatic glucose release

scientific article published in January 1982

High fat diet causes depletion of intestinal eosinophils associated with intestinal permeability

scientific article published on 2 April 2015

Hormonal and substrate responses to a standard meal in normal and hypertriglyceridemic subjects

scientific article published in April 1981

Human adipocyte glucose transport system. Biochemical and functional heterogeneity of hexose carriers

scientific article

Hybrid formation between endogenous mouse and transfected human tyrosine kinase-deficient (A/K1018) insulin receptors leads to decreased insulin sensitivity in 3T3-L1 adipocytes

scientific article published on June 1994

Hyperinsulinemia does not compensate for peripheral insulin resistance in obesity

scientific article published on March 1987

IKK-beta links inflammation to obesity-induced insulin resistance

scientific article (publication date: February 2005)

IKKepsilon: a bridge between obesity and inflammation

scientific article published in September 2009

Impaired insulin secretion in a mouse model of ataxia telangiectasia

scientific article published on 13 March 2007

Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency

scientific article published on February 2000

Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone

scientific article

In Vitro Characterization of Biosynthetic Human Proinsulin ⬇️

scientific article published on February 1, 1984

In vitro studies on the action of CS-045, a new antidiabetic agent

scientific article published on October 1990

In vivo deactivation of peripheral, hepatic, and pancreatic insulin action in man

scientific article published on 01 October 1982

In vivo kinetics of insulin action on peripheral glucose disposal and hepatic glucose output in normal and obese subjects

scientific article

In vivo regulation of non-insulin-mediated and insulin-mediated glucose uptake by epinephrine

scientific article published on 01 May 1987

In vivo stimulation of the insulin receptor kinase in human skeletal muscle. Correlation with insulin-stimulated glucose disposal during euglycemic clamp studies ⬇️

scientific article published on June 1, 1991

Increased Macrophage Migration Into Adipose Tissue in Obese Mice ⬇️

scientific article published on December 21, 2011

Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity

scientific article

Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects

scientific article

Increased phosphorylation of ribosomal protein S6 following microinjection of insulin receptor-kinase into Xenopus oocytes

scientific article published in Nature

Induction of Hypertriglyceridemia by a Low-Fat Diet ⬇️

scientific article published on April 1, 1976

Induction of insulin resistance in vivo by amylin and calcitonin gene-related peptide

scientific article published on February 1990

Inflamed fat: what starts the fire?

scientific article

Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet–Induced Insulin Resistance ⬇️

scientific article published on September 12, 2011

Inflammation and lipid signaling in the etiology of insulin resistance ⬇️

scientific article published on May 2, 2012

Inflammatory mechanisms linking obesity and metabolic disease

scientific article published on 3 January 2017

Influence of hyperglycemia on insulin's in vivo effects in type II diabetes ⬇️

scientific article published on March 1, 1984

Inhibition of PLC-gamma1 activity converts nerve growth factor from an anti-mitogenic to a mitogenic signal in CHO cells

scientific article published on September 1999

Inhibition of Phosphatidylinositol 3-Kinase Activity by Adenovirus-mediated Gene Transfer and Its Effect on Insulin Action ⬇️

scientific article published on July 17, 1998

Inhibition of mitochondrial Na+-Ca2+ exchanger increases mitochondrial metabolism and potentiates glucose-stimulated insulin secretion in rat pancreatic islets

scientific article published on April 2003

Insensitivity of large rat adipocytes to the antilipolytic effects of insulin ⬇️

scientific article published on July 1, 1977

Insulin Binding to Erythrocytes Incubatedin Vitroat Physiological Temperature ⬇️

scientific article published on 01 July 1983

Insulin Sensitivity of Isolated Perfused Rat Liver ⬇️

scientific article published on 01 February 1975

Insulin action and resistance in obesity and noninsulin-dependent type II diabetes mellitus.

scientific article

Insulin action kinetics in adipocytes from obese and noninsulin-dependent diabetes mellitus subjects: identification of multiple cellular defects in glucose transport

scientific article published on April 1991

Insulin activates p21Ras and guanine nucleotide releasing factor in cells expressing wild type and mutant insulin receptors.

scientific article published on September 1993

Insulin activation of insulin receptor tyrosine kinase in intact rat adipocytes. An in vitro system to measure histone kinase activity of insulin receptors activated in vivo

scientific article published on 01 April 1986

Insulin and Glucose Responses to Identical Oral Glucose Tolerance Tests Performed Forty-eight Hours Apart ⬇️

scientific article published on May 1, 1974

Insulin and epidermal growth factor influence guanine nucleotide-releasing factor by distinct mechanisms

scientific article published on December 1994

Insulin and insulin-like growth factor I receptors utilize different G protein signaling components

scientific article published on 8 February 2001

Insulin and insulin-like growth factor-I signal transduction requires p21ras.

scientific article published on February 1994

Insulin binding in diabetes. Relationships with plasma insulin levels and insulin sensitivity

scientific article published on July 1977

Insulin binding in human pregnancy: comparisons to the postpartum, luteal, and follicular states

scientific article published on 01 May 1981

Insulin binding to adipocytes. Evidence for functionally distinct receptors

scientific article published in September 1978

Insulin binding to isolated human adipocytes

scientific article published in July 1974

Insulin binding to monocytes and total mononuclear leukocytes from normal and diabetic patients

scientific article published in July 1976

Insulin binding, internalization, and insulin receptor regulation in fibroblasts from type II, non-insulin-dependent diabetic subjects

scientific article published on July 1981

Insulin binding, internalization, and receptor regulation in cultured human fibroblasts

scientific article published on September 1981

Insulin can regulate GLUT4 internalization by signaling to Rab5 and the motor protein dynein ⬇️

scientific article published on October 30, 2001

Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes

scientific article published on September 2005

Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1.

scientific article

Insulin induces progressive insulin resistance in cultured rat adipocytes. Sequential effects at receptor and multiple postreceptor sites

scientific article

Insulin inhibits nuclear phosphatase activity: requirement for the C-terminal domain of the insulin receptor

scientific article published on June 1995

Insulin internalization and degradation in adipocytes from normal and type II diabetic subjects

scientific article published on February 1986

Insulin receptor down-regulation is linked to an insulin-induced postreceptor defect in the glucose transport system in rat adipocytes

scientific article

Insulin receptor kinase activity in rat liver. Regulation by fasting and high carbohydrate feeding

scientific article

Insulin receptor kinase following internalization in isolated rat adipocytes

scientific article published on 01 August 1987

Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction

scientific article

Insulin receptors in isolated human adipocytes. Characterization by photoaffinity labeling and evidence for internalization and cellular processing ⬇️

scientific article published on December 1, 1983

Insulin receptors of skeletal muscle: Specific insulin binding sites and demonstration of decreased numbers of sites in obese rats ⬇️

scientific article published on February 1, 1976

Insulin receptors with defective tyrosine kinase inhibit normal receptor function at the level of substrate phosphorylation

scientific article published in September 1988

Insulin resistance and diabetes due to a genetic defect in insulin receptors

scientific article

Insulin resistance and diabetes due to different mutations in the tyrosine kinase domain of both insulin receptor gene alleles

scientific article published in March 1991

Insulin resistance and non-insulin-dependent diabetes mellitus: cellular and molecular mechanisms

scientific article published on April 1995

Insulin resistance and the pathogenesis of non-insulin dependent diabetes mellitus: cellular and molecular mechanisms.

scientific article

Insulin resistance due to a defect distal to the insulin receptor: Demonstration in a patient with leprechaunism ⬇️

scientific article published on July 1, 1978

Insulin resistance in humans.

scientific article

Insulin resistance in non-insulin dependent (type II) and insulin dependent (type I) diabetes mellitus

scientific article published in January 1985

Insulin resistance in non-insulin-dependent, type II diabetes mellitus

scientific article published on July 1982

Insulin resistance in noninsulin-dependent diabetes mellitus: impact of sulfonylurea agents in vivo and in vitro

scientific article published on January 1983

Insulin sensitivity: modulation by nutrients and inflammation

scientific article published on September 2008

Insulin signals to prenyltransferases via the Shc branch of intracellular signaling

scientific article published on 25 January 2001

Insulin stimulates the tyrosine dephosphorylation of pp125 focal adhesion kinase

scientific article

Insulin treatment reverses the insulin resistance of type II diabetes mellitus.

scientific article

Insulin treatment reverses the postreceptor defect in adipocyte 3-O-methylglucose transport in type II diabetes mellitus

scientific article published on June 1983

Insulin-Receptor cDNA Sequence in NIDDM Patient Homozygous for Insulin-Receptor Gene RFLP ⬇️

scientific article published on February 1, 1991

Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin

scientific article

Insulin-induced beta-arrestin1 Ser-412 phosphorylation is a mechanism for desensitization of ERK activation by Galphai-coupled receptors

scientific article published in November 2004

Insulin-mediated cellular insulin resistance decreases osmotic shock-induced glucose transport in 3T3-L1 adipocytes

scientific article

Insulin-receptor autophosphorylation and endogenous substrate phosphorylation in human adipocytes from control, obese, and NIDDM subjects

scientific article published on February 1990

Insulin-responsive human adipocytes express two glucose transporter isoforms and target them to different vesicles

scientific article published in July 1993

Insulin-stimulated GLUT4 translocation is mediated by a divergent intracellular signaling pathway

scientific article published on November 1995

Insulin-stimulated glucose transport in cultured fibroblasts from normal and noninsulin-dependent (type II) diabetic human subjects

scientific article published on December 1982

Insulin-stimulated glucose transport in human adipocytes ⬇️

scientific article published on June 1, 1979

Insulin-stimulated glucose transport minireview series

scientific article published in January 1999

Interaction between insulin receptors and glucose transport: effect of prostaglandin E2

scientific article published on March 21, 1977

Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling

scientific article

Interactions Between Insulin and Its Receptors After the Initial Binding Event: Functional Heterogeneity and Relationships to Insulin Degradation ⬇️

scientific article published on May 1, 1979

Internalization and degradation of a low affinity insulin ([LeuB24]insulin) by rat adipocytes

scientific article published on August 1982

Internalization and intracellular processing of insulin and insulin receptors in adipocytes

scientific article published on July 1982

Internalization and molecular processing of insulin receptors in isolated rat adipocytes

scientific article

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

scientific article

Intracellular insulin-receptor dissociation and segregation in a rat fibroblast cell line transfected with a human insulin receptor gene

scientific article published on May 1988

Intracellular signaling by a mutant human insulin receptor lacking the carboxyl-terminal tyrosine autophosphorylation sites ⬇️

scientific article published on May 5, 1992

Inverse regulation of inflammation and mitochondrial function in adipose tissue defines extreme insulin sensitivity in morbidly obese patients

scientific article published on 6 December 2012

Involvement of ErbB2 in the signaling pathway leading to cell cycle progression from a truncated epidermal growth factor receptor lacking the C-terminal autophosphorylation sites

scientific article published on April 1996

Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells

scientific journal article

Islet amyloid polypeptide (amylin) increases the renal excretion of calcium in the conscious dog.

scientific article published in October 1994

JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes

scientific article

JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity

scientific article

Kinetic relationships between insulin receptor binding and effects on glucose transport in isolated rat adipocytes

scientific article published on 01 July 1982

Kinetics of biosynthetic human proinsulin action in isolated rat adipocytes

scientific article published on 01 March 1986

Kinetics of in vivo muscle insulin-mediated glucose uptake in human obesity

scientific article published in August 1990

Kinetics of insulin action in vivo. Identification of rate-limiting steps

scientific article published in August 1995

Kinetics of insulin-mediated and non-insulin-mediated glucose uptake in humans

scientific article

LIlly lecture 1980. Insulin resistance and insulin action. An in vitro and in vivo perspective

scientific article published on February 1981

LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes

scientific article published on 23 February 2015

Lack of Effect of Islet Amyloid Polypeptide in Causing Insulin Resistance in Conscious Dogs During Euglycemic Clamp Studies ⬇️

scientific article published on August 1, 1991

Lack of in Vivo Insulin Resistance in Controlled Insulin-Dependent, Type I, Diabetic Patients* ⬇️

scientific article published on 01 February 1984

Lack of insulin resistance in fibroblasts from subjects with polycystic ovary syndrome ⬇️

scientific article published on August 1, 1998

Length of Acute Exposure to Insulin Regulates the Rate of Deactivation of Stimulated Glucose Transport in Isolated Rat Adipocytes* ⬇️

scientific article published on 01 November 1983

Lentiviral short hairpin ribonucleic acid-mediated knockdown of GLUT4 in 3T3-L1 adipocytes

scientific article published on 23 February 2006

Ligand-Independent GLUT4 Translocation Induced by Guanosine 5′-O-(3-Thiotriphosphate) Involves Tyrosine Phosphorylation* ⬇️

scientific article published on January 1, 1998

Liver-specific p70 S6 Kinase Depletion Protects against Hepatic Steatosis and Systemic Insulin Resistance ⬇️

scientific article published on April 9, 2012

Localization of the Insulin-like Growth Factor I Receptor Binding Sites for the SH2 Domain Proteins p85, Syp, and GTPase Activating Protein ⬇️

scientific article published on August 11, 1995

Localization of the insulin receptor binding sites for the SH2 domain proteins p85, Syp, and GAP.

scientific article published in November 1994

Locating the site(s) of insulin resistance in patients with nonketotic diabetes mellitus

scientific article published in August 1976

Long-term regulation of adipocyte glucose transport capacity by circulating insulin in rats

scientific article published on July 1978

Low pH accelerates dissociation of receptor-bound insulin

scientific article published on July 1983

Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones

scientific article published on 24 May 2007

Macrophages, immunity, and metabolic disease

scientific article published on July 2014

Macrophages, inflammation, and insulin resistance

scientific article (publication date: 2010)

Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3

scientific journal article

Mechanism of SHIP-mediated inhibition of insulin- and platelet-derived growth factor-stimulated mitogen-activated protein kinase activity in 3T3-L1 adipocytes

scientific article published on 14 October 2004

Mechanism of activation of guanine nucleotide exchange factor by insulin ⬇️

scientific article published on July 1, 1995

Mechanism of defective insulin-receptor kinase activity in NIDDM. Evidence for two receptor populations

scientific article published in March 1989

Mechanism of hypertriglyceridaemia in diabetic patients with fasting hyperglycaemia

scientific article published in June 1980

Mechanism of impaired metabolic signaling by a truncated human insulin receptor. Decreased activation of protein phosphatase 1 by insulin.

scientific article published on April 1993

Mechanism of the postreceptor defect in insulin action in human obesity. Decrease in glucose transport system activity

scientific article published on October 1981

Mechanisms of Insulin Resistance in Aging ⬇️

scientific article published on June 1, 1983

Mechanisms of decreased insulin responsiveness of large adipocytes

scientific article published on April 1, 1977

Mechanisms of enhanced transmembrane signaling by an insulin receptor lacking a cytoplasmic beta-subunit domain

scientific article published on May 1995

Mechanisms of insulin degradation by isolated rat adipocytes

scientific article published on August 1982

Mechanisms of insulin resistance in experimental hyperinsulinemic dogs ⬇️

scientific article published on January 1, 1998

Mechanisms of insulin resistance in human obesity: evidence for receptor and postreceptor defects

scientific article published on June 1980

Mechanisms of insulin resistance in non-insulin-dependent (type II) diabetes

scientific article published in September 1985

Mechanisms of insulin resistance in obesity and noninsulin-dependent (type II) diabetes.

scientific article

Mechanisms of the Fasting-Induced Increase in Insulin Binding to Rat Adipocytes ⬇️

scientific article published on February 1, 1978

Mechanisms of the ability of insulin to activate the glucose-transport system in rat adipocytes ⬇️

scientific article published on April 15, 1978

Mechanisms of the kinetic defect in insulin action in obesity and NIDDM.

scientific article published in June 1997

Medicine. Wnt fans the flames in obesity.

scientific article

Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance

scientific article published on May 1999

Metabolic consequences of very-low-calorie diet therapy in obese non-insulin-dependent diabetic and nondiabetic subjects

scientific article published in February 1986

Metabolic effects of increased caloric intake in man ⬇️

scientific article published on April 1, 1975

Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects

scientific article published on February 1, 1992

Metabolic effects of troglitazone monotherapy in type 2 diabetes mellitus. A randomized, double-blind, placebo-controlled trial

scientific article published in February 1998

Metabolic effects of troglitazone on fat-induced insulin resistance in the rat.

scientific article

Metabolic effects of troglitazone on fructose-induced insulin resistance in the rat.

scientific article published in December 1994

Metabolic effects of troglitazone therapy in type 2 diabetic, obese, and lean normal subjects

scientific article published on January 2000

Metabolic requirements for deactivation of insulin-stimulated glucose transport in isolated rat adipocytes

scientific article published on 01 May 1981

Metabolism of photoaffinity-labeled insulin receptors by adipocytes. Role of internalization, degradation, and recycling ⬇️

scientific article published on May 25, 1984

Microbiota-Produced N-Formyl Peptide fMLF Promotes Obesity-Induced Glucose Intolerance

scientific article published on 22 April 2019

Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression

scientific article published on November 1994

Moderate ethanol ingestion and plasma triglyceride levels. A study in normal and hypertriglyceridemic persons

scientific article published in February 1974

Modulation of insulin secretion by insulin and glucose in type II diabetes mellitus

scientific article published on 01 March 1985

Muscle-specific Pparg deletion causes insulin resistance

scientific journal article

Mutation of the two carboxyl-terminal tyrosines in the insulin receptor results in enhanced activation of mitogen-activated protein kinase.

scientific article published in April 1994

Mutation of the two carboxyl-terminal tyrosines results in an insulin receptor with normal metabolic signaling but enhanced mitogenic signaling properties

scientific article published on May 1991

Myosin 5a is an insulin-stimulated Akt2 (protein kinase Bbeta) substrate modulating GLUT4 vesicle translocation

scientific article

NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids

scientific article

NPXY motif in the insulin-like growth factor-I receptor is required for efficient ligand-mediated receptor internalization and biological signaling

scientific article

Negative Feedback Regulation and Desensitization of Insulin- and Epidermal Growth Factor-stimulated p21ras Activation ⬇️

scientific article published on October 27, 1995

Nerve Growth Factor Processing and Trafficking Events Following TrkA-Mediated Endocytosis1 ⬇️

scientific article published on July 1, 1998

Neuronal SIRT1 Regulates Metabolic and Reproductive Function and the Response to Caloric Restriction

Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues

scientific article published on March 2013

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

scientific article

Non-insulin-mediated glucose uptake predominates in postabsorptive dogs

scientific article published in May 1987

Nonketotic diabetes mellitus: insulin deficiency or insulin resistance?

scientific article published in January 1976

Nuclear receptor minireview series

scientific article (publication date: 5 October 2001)

Nuclear translocation of the insulin receptor. A possible mediator of insulin's long term effects

scientific article published on 01 March 1987

Obese Neuronal PPARγ Knockout Mice Are Leptin Sensitive but Show Impaired Glucose Tolerance and Fertility

scientific article published on 14 November 2016

Obesity Modulates Intestinal Intraepithelial T Cell Persistence, CD103 and CCR9 Expression, and Outcome in Dextran Sulfate Sodium-Induced Colitis

scientific article published on 11 November 2019

Omega 3 fatty acids and GPR120.

scientific article published on May 2012

PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.

scientific article published on 25 April 2004

PPAR gamma and the treatment of insulin resistance

scientific article

PPARG regulates gonadotropin-releasing hormone signaling in LbetaT2 cells in vitro and pituitary gonadotroph function in vivo in mice

scientific article

PPARdelta regulates glucose metabolism and insulin sensitivity

scientific article

PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization

scientific article published on 16 December 2009

Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport ⬇️

scientific article published on August 14, 2011

Persistent activation of phosphatidylinositol 3-kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 adipocytes

scientific article published on June 2000

Pertussis toxin-sensitive and -insensitive thrombin stimulation of Shc phosphorylation and mitogenesis are mediated through distinct pathways

scientific article

Phorbol ester-mediated protein kinase C interaction with wild-type and COOH-terminal truncated insulin receptors

scientific article published on November 1991

Phosphatidylinositol 3-kinase is necessary and sufficient for insulin-stimulated stress fiber breakdown

scientific article published on November 1996

Phosphatidylinositol 3-kinase is required for insulin-stimulated tyrosine phosphorylation of Shc in 3T3-L1 adipocytes

scientific article published on 15 March 2002

Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance

scientific article

Photoaffinity labeling of insulin receptors in viable cultured human lymphocytes. Demonstration of receptor shedding and degradation

scientific article published on 01 May 1982

Photolabeling of the adipocyte hexose carrier with an aryl azide derivative of maltose

scientific article published on 01 February 1987

Plasma glucose and insulin responses to orally administered simple and complex carbohydrates

scientific article published on 01 September 1976

Platelet-derived Growth Factor Inhibits Insulin Stimulation of Insulin Receptor Substrate-1-associated Phosphatidylinositol 3-Kinase in 3T3-L1 Adipocytes without Affecting Glucose Transport ⬇️

scientific article published on September 25, 1998

Post binding events in insulin action

scientific article

Post-binding events in insulin action

scientific article

Postprandial hormonal responses to different types of complex carbohydrate in individuals with impaired glucose tolerance

scientific article

Postprandial plasma triglyceride and cholesterol responses to a low-fat meal ⬇️

scientific article published on May 1, 1976

Postprandial plasma-glucose and -insulin responses to different complex carbohydrates

scientific article

Postprandial plasma-glucose and -insulin responses to different complex carbohydrates

article

Preparation of N epsilon B28-monoazidobenzoyl insulin-like growth factor I and photoaffinity labeling of insulin-like growth factor I receptor

scientific article published on March 1993

Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-alpha: implications for insulin resistance

scientific article published in November 2002

Prolonged vs transient roles for early cell cycle signaling components

scientific article published on August 1998

Properties of a human insulin receptor with a COOH-terminal truncation. I. Insulin binding, autophosphorylation, and endocytosis

scientific article published in June 1988

Properties of a human insulin receptor with a COOH-terminal truncation. II. Truncated receptors have normal kinase activity but are defective in signaling metabolic effects

scientific article published in June 1988

Prospects for research in diabetes mellitus

scientific article

Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling

scientific journal article

Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes

scientific article published on October 2004

Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes

scientific article (publication date: 21 May 2004)

Protein tyrosine phosphatase 1B interacts with the activated insulin receptor

scientific article

Protein tyrosine phosphatase 1B interacts with the activated insulin receptor

article published in 1996

Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signaling

scientific article

Putting the brakes on FOXO1 in fat ⬇️

scientific article published on April 17, 2012

Quantification of plasma cholesterol and triglyceride levels in hypercholesterolemic subjects receiving ascorbic acid supplements ⬇️

scientific article published on June 1, 1975

Quantitative proteomic and functional analysis of liver mitochondria from high fat diet (HFD) diabetic mice

scientific article published on 12 September 2013

Rates of noninsulin-mediated glucose uptake are elevated in type II diabetic subjects

scientific article

Reappraisal of the role of insulin in hypertriglyceridemia.

scientific article

Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus ⬇️

scientific article published on October 1, 1981

Recycling of photoaffinity-labeled insulin receptors in rat adipocytes. Dissociation of insulin-receptor complexes is not required for receptor recycling

scientific article published on July 1986

Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups

scientific article

Regulation of epidermal growth factor receptor number and phosphorylation by fasting in rat liver

scientific article

Regulation of glucose transport in cultured muscle cells by novel hypoglycemic agents ⬇️

scientific article published on August 1, 1995

Regulation of insulin receptors in cultured human fibroblasts

scientific article published on 01 November 1981

Regulation of insulin receptors: evidence for involvement of an endocytotic internalization pathway ⬇️

scientific article published on October 1, 1980

Regulation of metabolism by the innate immune system

scientific article

Regulation of protein tyrosine phosphatases by insulin and insulin-like growth factor I.

scientific article published on December 1993

Regulation of receptor tyrosine kinase signaling by GRKs and beta-arrestins

scientific article published on January 2007

Regulation of skeletal muscle hexokinase II by insulin in nondiabetic and NIDDM subjects ⬇️

scientific article published on July 1, 1998

Regulation of the insulin receptor by protein kinase C isoenzymes: preferential interaction with β isoenzymes and interaction with the catalytic domain of βII ⬇️

scientific article published on January 1, 2004

Relationship Between Fasting Plasma Insulin Level and Resistance to Insulin-Mediated Glucose Uptake in Normal and Diabetic Subjects ⬇️

scientific article published on July 1, 1973

Relationship between deactivation of insulin-stimulated glucose transport and insulin dissociation in isolated rat adipocytes

scientific article published on 01 January 1980

Relationship between fasting plasma lipid levels and adipose tissue morphology ⬇️

scientific article published on October 1, 1973

Relationship between heterogeneity of insulin responses and insulin resistance in normal subjects and patients with chemical diabetes

scientific article published on May 1, 1977

Relationship between in Vivo Insulin Resistance and Decreased Insulin Receptors in Obese Man* ⬇️

scientific article published on March 1, 1979

Relationship between insulin response during the intravenous glucose tolerance test, rate of fractional glucose removal and the degree of insulin resistance in normal adults

scientific article published in May 1974

Relationship between negative cooperativity and insulin action

scientific article published on 01 July 1981

Relationship between serum glucose level and the metabolic clearance rate of glucose in non-insulin-dependent diabetes mellitus

scientific article published on 01 July 1983

Relative expression of insulin receptor isoforms does not differ in lean, obese, and noninsulin-dependent diabetes mellitus subjects ⬇️

scientific article published on May 1, 1993

Removal of insulin by perfused rat liver: Effect of concentration ⬇️

scientific article published on 01 February 1975

Restoration of Euglycemia After Duodenal Bypass Surgery Is Reliant on Central and Peripheral Inputs in Zucker fa/fa Rats ⬇️

scientific article published on December 17, 2012

Restriction-fragment-length polymorphism in insulin-receptor gene and insulin resistance in NIDDM.

scientific article

Retroendocytosis of insulin in rat adipocytes

scientific article published on 01 August 1986

Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss

scientific article published on October 1988

Role of Host GPR120 in Mediating Dietary Omega-3 Fatty Acid Inhibition of Prostate Cancer

scientific article published on 01 January 2019

Role of glucose transport in the postreceptor defect of non-insulin-dependent diabetes mellitus.

scientific article

Role of glucose transporters in the cellular insulin resistance of type II non-insulin-dependent diabetes mellitus

scientific article published on May 1988

Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of noninsulin-dependent diabetes mellitus and obesity.

scientific article published in February 1994

SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes

scientific article published on 22 December 2008

SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity

scientific article

SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis

scientific article

Selective modulation of promoter recruitment and transcriptional activity of PPARgamma

scientific article published on 18 October 2007

Selective suppression of hepatic glucose output by human proinsulin in the dog

scientific article published on 01 February 1987

Semisynthesis and biological activity of porcine [LeuB24]insulin and [LeuB25]insulin

scientific article

Separate intracellular pathways for insulin receptor recycling and insulin degradation in isolated rat adipocytes ⬇️

scientific article published on November 1, 1983

Sex difference in the kinetics of triglyceride metabolism in normal and hypertriglyceridaemic human subjects

scientific article published on 01 April 1974

Shc is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21ras-GTP formation.

scientific article

Signal transduction pathways leading to insulin-induced early gene induction

scientific article

SirT1 regulates adipose tissue inflammation

scientific article published on December 2011

Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction

scientific article

Skeletal muscle peroxisome proliferator- activated receptor-gamma expression in obesity and non- insulin-dependent diabetes mellitus ⬇️

scientific article published on February 1, 1998

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

scientific article

Spatial Cognition in Adult and Aged Mice Exposed to High-Fat Diet

scientific article

Src homology 2 domains of protein tyrosine phosphatase are associated in vitro with both the insulin receptor and insulin receptor substrate-1 via different phosphotyrosine motifs

scientific article published on 01 March 1994

Stressed out about obesity and insulin resistance

scientific article published in January 2006

Structural differences between insulin receptors in the brain and peripheral target tissues.

scientific article

Substrate specificities of insulin and epidermal growth factor receptor kinases

scientific article published on 01 February 1985

Suppression of Egr-1 transcription through targeting of the serum response factor by oncogenic H-Ras

scientific article

Suppression of PPAR-gamma attenuates insulin-stimulated glucose uptake by affecting both GLUT1 and GLUT4 in 3T3-L1 adipocytes

scientific article published on 27 March 2007

Surface binding and rates of internalization of 125I-insulin in adipocytes and IM-9 lymphocytes.

scientific article published on August 1982

Synthesis and evaluation of photolabile insulin prodrugs

scientific article published on September 2005

Synthesis of an organoinsulin molecule that can be activated by antibody catalysis ⬇️

scientific article published on November 13, 2001

Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction

scientific article published in August 1994

TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis

scientific article

TNF-α-Induced Insulin Resistance In Vivo and Its Prevention by Troglitazone ⬇️

scientific article published on November 1, 1997

Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases ⬇️

scientific article published on June 12, 2011

The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) initiative: rationale and design

scientific article published on 3 February 2013

The Effects of Acute and Chronic Starvation on Insulin Binding to Isolated Human Adipocytes* ⬇️

scientific article published on May 1, 1979

The Fractalkine/CX3CR1 System Regulates β Cell Function and Insulin Secretion ⬇️

scientific article published on April 11, 2013

The G12 coupled thrombin receptor stimulates mitogenesis through the Shc SH2 domain ⬇️

scientific article published on July 31, 1997

The Metabolic Effects of Biosynthetic Human Proinsulin in Individuals with Type I Diabetes* ⬇️

scientific article published on 01 June 1984

The Origins and Drivers of Insulin Resistance ⬇️

scientific article published on February 14, 2013

The Physiological Significance of the Glucose Intolerance of Aging ⬇️

scientific article published on 01 May 1984

The Role of Insulin Resistance in the Pathogenesis of Diabetes Mellitus ⬇️

scientific article published on January 1, 1978

The Small Guanosine Triphosphate-Binding Protein Rab4 Is Involved in Insulin-Induced GLUT4 Translocation and Actin Filament Rearrangement in 3T3-L1 Cells* ⬇️

scientific article published on November 1, 1997

The US's changing competitiveness in the biomedical sciences

scientific article published on January 2007

The acute and chronic effects of sulfonylurea therapy in type II diabetic subjects

scientific article published in April 1984

The acute and chronic stimulatory effects of endothelin-1 on glucose transport are mediated by distinct pathways in 3T3-L1 adipocytes

scientific article

The cellular and signaling networks linking the immune system and metabolism in disease ⬇️

scientific article published on 06 March 2012

The effect of insulin concentration on retroendocytosis in isolated rat adipocytes

scientific article published on 01 February 1987

The effect of insulin treatment on insulin secretion and insulin action in type II diabetes mellitus

scientific article published in March 1985

The effect of oral glucosamine sulfate on insulin sensitivity in human subjects

scientific article published in June 2003

The effect of ten days of fasting on various aspects of carbohydrate metabolism in obese diabetic subjects with significant fasting hyperglycemia

scientific article published on December 1, 1978

The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects

scientific article

The effects of acute and chronic dexamethasone administration on insulin binding to isolated rat hepatocytes and adipocytes ⬇️

scientific article published on April 1, 1975

The effects of biosynthetic human proinsulin on carbohydrate metabolism in non-insulin-dependent diabetes mellitus

scientific article published in February 1987

The effects of dietary carbohydrate content on insulin binding and glucose metabolism by isolated rat adipocytes

scientific article published on December 1, 1978

The effects of intracellular calcium depletion on insulin signaling in 3T3-L1 adipocytes

scientific article published on February 2002

The effects of oral fructose, sucrose, and glucose in subjects with reactive hypoglycemia

scientific article published on 01 September 1982

The effects of proinsulin pretreatment on the combined actions of insulin and proinsulin in normal man

scientific article published on 01 April 1986

The effects of spontaneous obesity on insulin binding, glucose transport, and glucose oxidation of isolated rat adipocytes ⬇️

scientific article published on April 1, 1976

The endocytotic-internalization pathway of insulin metabolism: relationship to insulin degradation and activation of glucose transport

scientific article published on December 1980

The functional role of CrkII in actin cytoskeleton organization and mitogenesis

scientific article

The genetics of non-insulin-dependent diabetes mellitus.

scientific article published on January 1995

The impact of sulfonylurea treatment upon the mechanisms responsible for the insulin resistance in type II diabetes

scientific article published on May 1, 1984

The insulin receptor. A multifunctional protein

scientific article published on September 1990

The insulin receptor: its role in insulin resistance of obesity and diabetes

scientific article published on December 1976

The ligand binding characteristics of a kinase-defective A/K1018 human insulin receptor expressed in Rat 1 fibroblasts

scientific article published on July 1990

The metabolic clearance of insulin and the feedback inhibition of insulin secretion are altered with aging

scientific article published in March 1985

The osmotic shock-induced glucose transport pathway in 3T3-L1 adipocytes is mediated by gab-1 and requires Gab-1-associated phosphatidylinositol 3-kinase activity for full activation

scientific article

The proto-oncogene product p120(cbl) links c-Src and phosphatidylinositol 3'-kinase to the integrin signaling pathway.

scientific article published in February 1997

The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities

scientific article published on 13 December 2019

The role of the glucose transport system in the postreceptor defect in insulin action associated with human aging

scientific article published on April 1984

The signaling pathway coupling epidermal growth factor receptors to activation of p21ras

scientific article

The trafficking and processing of insulin and insulin receptors in cultured rat hepatocytes

scientific article published on December 1987

The tumor suppressor PTEN negatively regulates insulin signaling in 3T3-L1 adipocytes

scientific article

Thiazolidinedione treatment prevents free fatty acid-induced insulin resistance in male wistar rats

scientific article

Thiazolidinediones in the treatment of insulin resistance and type II diabetes

scientific article

Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice

scientific article

Topiramate is an insulin-sensitizing compound in vivo with direct effects on adipocytes in female ZDF rats

scientific article published on 9 November 2004

Topiramate treatment causes skeletal muscle insulin sensitization and increased Acrp30 secretion in high-fat-fed male Wistar rats

scientific article published on 19 July 2005

Trans-resveratrol inhibits phosphorylation of Smad2/3 and represses FSHβ gene expression by a SirT1-independent pathway in LβT2 gonadotrope cells ⬇️

scientific article published on June 6, 2011

Transdominant inhibition of tyrosine kinase activity in mutant insulin/insulin-like growth factor I hybrid receptors ⬇️

scientific article published on January 1, 1991

Transmembrane signaling by an insulin receptor lacking a cytoplasmic beta-subunit domain

scientific article

Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists

scientific article

Tris (hydroxmethyl) aminomethane permits the expression of insulin-induced receptor loss in isolated rat adipocytes

scientific article published on 01 September 1981

Tumor necrosis factor receptor-1 can function through a G alpha q/11-beta-arrestin-1 signaling complex

scientific article published on 30 July 2007

Tyrosine kinase-defective insulin receptors undergo decreased endocytosis but do not affect internalization of normal endogenous insulin receptors ⬇️

scientific article published on June 1, 1992

Tyrosine kinase-defective insulin receptors undergo insulin-induced microaggregation but do not concentrate in coated pits

scientific article published on 01 September 1991

Use of a variable tracer infusion method to determine glucose turnover in humans

scientific article published in January 1990

VAMPIRE microarray suite: a web-based platform for the interpretation of gene expression data

scientific article

Variance-modeled posterior inference of microarray data: detecting gene-expression changes in 3T3-L1 adipocytes

scientific article

Variation in the gene for muscle-specific AMP deaminase is associated with insulin clearance, a highly heritable trait

scientific article published in April 2005

Weighing in on the lean genes

scientific article

beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport

scientific journal article

beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1.

scientific article published on October 2004

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