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List of works by Barbara Kahn

A LC-MS-based workflow for measurement of branched fatty acid esters of hydroxy fatty acids

scientific article published on 17 March 2016

A Postsynaptic AMPK→p21-Activated Kinase Pathway Drives Fasting-Induced Synaptic Plasticity in AgRP Neurons

scientific article published on 15 June 2016

A guide to analysis of mouse energy metabolism

scientific article published on 28 December 2011

A high-fat, ketogenic diet induces a unique metabolic state in mice

scientific article published on 13 February 2007

A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism

scientific journal article

AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs

scientific article (publication date: May 2016)

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

scientific article

Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport

scientific article

Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat.

scientific article published in January 2018

Activation of the Ras Mitogen-activated Protein Kinase-Ribosomal Protein Kinase Pathway Is Not Required for the Repression of Phosphoenolpyruvate Carboxykinase Gene Transcription by Insulin

scientific article published in Journal of Biological Chemistry

Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis

scientific article

Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes

scientific article

Adipose Tissue, Inter-Organ Communication, and the Path to Type 2 Diabetes: The 2016 Banting Medal for Scientific Achievement Lecture

scientific article published on 01 January 2019

Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels.

scientific article

Adipose tissue dysfunction is associated with low levels of the novel Palmitic Acid Hydroxystearic Acids

scientific article published in Scientific Reports

Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells ⬇️

scientific article published on September 19, 2012

Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance

scientific article

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

scientific article (publication date: 8 February 2001)

Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo

scientific article

Antigen Presentation and T-Cell Activation Are Critical for RBP4-Induced Insulin Resistance

scientific article published on 2 March 2016

Application of combined omics platforms to accelerate biomedical discovery in diabesity

scientific article published on 09 May 2013

Biguanide therapy for diabetes and cancer & a novel methyltransferase that regulates energy expenditure and adiposity and is elevated in many cancers.

scientific article published on 28 May 2014

Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses

scientific article published on 29 August 2016

Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase

scientific article

Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin

scholarly article by Xingxing Kong published in October 2018

CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability

scientific article (publication date: 30 September 2011)

Ca2+/calmodulin-dependent protein kinase kinase is not involved in hypothalamic AMP-activated protein kinase activation by neuroglucopenia

scientific article (publication date: 2012)

Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart

scientific article

Cathepsin L activity controls adipogenesis and glucose tolerance

scientific article

Challenges and opportunities of defining clinical leptin resistance

scientific article published on February 2012

Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP

scientific journal article

Data-driven synthesis of proteolysis-resistant peptide hormones

scientific article

Decreased clearance of serum retinol-binding protein and elevated levels of transthyretin in insulin-resistant ob/ob mice

scientific article published on 19 February 2008

Decreased in vivo glucose uptake but normal expression of GLUT1 and GLUT4 in skeletal muscle of diabetic rats

scientific article

Deletion of cd39/entpd1 results in hepatic insulin resistance

scientific article published on 20 June 2008

Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle

scientific article

Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes

scientific article published on January 1997

Differential regulation of two glucose transporters in adipose cells from diabetic and insulin-treated diabetic rats

scientific article

Discovery of FAHFA-Containing Triacylglycerols and Their Metabolic Regulation

scientific article published on 13 May 2019

Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects.

scientific article

Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance.

scientific article

Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats

scientific article published on 01 May 2000

Downregulation of STRA6 in adipocytes and adipose stromovascular fraction in obesity and effects of adipocyte-specific STRA6 knockdown in vivo

scientific article published on 13 January 2014

Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in middle-aged men.

scientific article published in January 2002

Effects of genetic variation in the human retinol binding protein-4 gene (RBP4) on insulin resistance and fat depot-specific mRNA expression

scientific article published on 29 August 2007

Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance

Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance

scientific article published on 13 October 2011

Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity ⬇️

scientific article published on September 1, 1995

Faster Protocol for Endogenous Fatty Acid Esters of Hydroxy Fatty Acid (FAHFA) Measurements

scientific article published on 26 March 2018

Fatty acid infusion selectively impairs insulin action on Akt1 and protein kinase C lambda /zeta but not on glycogen synthase kinase-3.

scientific article published on 2 July 2002

GLUT4 Expression in Adipocytes Regulates De Novo Lipogenesis and Levels of a Novel Class of Lipids With Antidiabetic and Anti-inflammatory Effects

scientific article published on 10 June 2016

GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization.

scientific article published on December 2004

GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor-stimulated muscle glucose utilization

scientific article

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice

scientific article published on 26 July 2009

Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4

scientific article

Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony

scientific article

High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control

scientific article published on 29 November 2021

Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B.

scientific article

Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

scientific article published in August 2000

Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogen-activated protein kinase signaling pathway

scientific article

Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling

scientific article published on 21 December 2004

Insulin-mediated pseudoacromegaly: clinical and biochemical characterization of a syndrome of selective insulin resistance.

scientific article published in June 1993

Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: reversal with weight reduction

scientific article published in August 2003

Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression

scientific article

Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice

scientific article published in January 2004

Lactate induces insulin resistance in skeletal muscle by suppressing glycolysis and impairing insulin signaling

scientific article

Leptin and insulin act on POMC neurons to promote the browning of white fat.

scientific article published on January 2015

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

scientific article (publication date: 17 January 2002)

Leptin, GABA, and glucose control

scientific article

Lessons on conditional gene targeting in mouse adipose tissue

scientific article published on 15 January 2013

Leveraging leptin for type I diabetes?

scientific article

Lipid Extraction from Mouse Feces.

scientific article

Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress

scientific article published on 15 December 2008

Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice

scientific article published on 7 February 2005

Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis

scientific article published on 13 October 2009

Metabolites as regulators of insulin sensitivity and metabolism

scientific article published on 01 October 2018

Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects

scientific article published on 20 September 2018

Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice

scientific article published on 20 May 2013

Multiple signal transduction pathways link Na+/K+-ATPase to growth-related genes in cardiac myocytes. The roles of Ras and mitogen-activated protein kinases

scientific article published in June 1998

Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism

scientific article

Neuronal PTP1B regulates body weight, adiposity and leptin action.

scientific article published on 16 July 2006

Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues

scientific article published on 15 June 2009

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.

scientific article

Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes

scientific article

Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression.

scientific article

Novel mechanisms by which fat cells regulate systemic insulin sensitivity and diabetes risk.

scientific article published in June 2012

Nutrient sensor links obesity with diabetes risk

scientific article published in October 2004

Obesity and insulin resistance

scientific article

Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3

scientific article published on 11 September 2020

Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance

scientific article published on 27 February 2017

Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance

scientific article

PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice

scientific article published on 05 August 2019

PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms

scientific article published on 01 October 2019

PTP1B regulates leptin signal transduction in vivo

scientific article

Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis.

scientific article published in February 2018

Peripheral signals set the tone for central regulation of metabolism

scientific article published in September 2004

Plasma retinol-binding protein 4 (RBP4) levels and risk of coronary heart disease: a prospective analysis among women in the nurses' health study

scientific article published on 12 April 2013

Protein kinase C isoforms epsilon, eta, delta and zeta in murine adipocytes: expression, subcellular localization and tissue-specific regulation in insulin-resistant states

scientific article published on June 1996

Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance

scientific article published on 01 June 2007

Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo

scientific article published on 14 February 2008

Quantitative Measurement of Full-Length and C-Terminal Proteolyzed RBP4 in Serum of Normal and Insulin-Resistant Humans using a Novel Mass Spectrometry Immunoassay ⬇️

scientific article published on January 17, 2012

RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance

scientific article

RBP4 increases lipolysis in human adipocytes and is associated with increased lipolysis and hepatic insulin resistance in obese women

scientific article published on 13 March 2020

Recombinant methionyl human leptin administration activates signal transducer and activator of transcription 3 signaling in peripheral blood mononuclear cells in vivo and regulates soluble tumor necrosis factor-alpha receptor levels in humans with r

scientific article published on 21 December 2004

Reduction of elevated serum retinol binding protein in obese children by lifestyle intervention: association with subclinical inflammation

scientific article published on 6 March 2007

Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2.

scientific article

Regulation of gluconeogenesis by Krüppel-like factor 15

scientific article published in April 2007

Regulation of glucose transporter-specific mRNA levels in rat adipose cells with fasting and refeeding. Implications for in vivo control of glucose transporter number

scientific article

Retinol binding protein 4 primes the NLRP3 inflammasome by signaling through Toll-like receptors 2 and 4

scientific article published on 19 November 2020

Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects

scientific article

Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism

scientific article published on 19 March 2012

Reversible transdifferentiation of secretory epithelial cells into adipocytes in the mammary gland

scholarly article

Role of Rho-kinase in regulation of insulin action and glucose homeostasis.

scientific article published on August 2005

Role of hypothalamic adenosine 5'-monophosphate-activated protein kinase in the impaired counterregulatory response induced by repetitive neuroglucopenia

scientific article

Rosiglitazone, PPARγ, and Type 2 Diabetes ⬇️

scientific article published on December 30, 2010

Sequential evaluation of islet cell responses to glucose in the transplanted pancreas in humans

scientific article

Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

scientific article

Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass

scientific article published on 01 July 2007

Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation

scientific article published on 28 March 2017

The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance

scientific article published on 16 July 2007

The relationship of retinol binding protein 4 to changes in insulin resistance and cardiometabolic risk in overweight black adolescents

scientific article published on 10 September 2008

The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome

scholarly article

Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis

scientific article

Tissue-specific nutritional regulation of angiotensinogen in adipose tissue

scientific article published on April 1, 1992

Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action

scientific article published on 18 March 2004

Transthyretin Antisense Oligonucleotides Lower Circulating RBP4 Levels and Improve Insulin Sensitivity in Obese Mice

scientific article published on 18 December 2014

Troglitazone but not metformin restores insulin-stimulated phosphoinositide 3-kinase activity and increases p110beta protein levels in skeletal muscle of type 2 diabetic subjects

scientific article published in February 2002

Type 2 diabetes — who is conducting the orchestra? ⬇️

scientific article published on November 1, 1998

Uncoupling protein 3 (UCP3) stimulates glucose uptake in muscle cells through a phosphoinositide 3-kinase-dependent mechanism.

scientific article published on 12 January 2001

Ventromedial hypothalamus-specific Ptpn1 deletion exacerbates diet-induced obesity in female mice

scientific article

mTOR tells the brain that the body is hungry

scientific article published in June 2006

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