List of works - Domenico Accili

A Foxo/Notch pathway controls myogenic differentiation and fiber type specification

scientific article

A MEMS differential viscometric sensor for affinity glucose detection in continuous glucose monitoring

scientific article published on May 2013

A differential dielectric affinity glucose sensor

scientific article published on 13 November 2013

Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity

scientific article published on 5 March 2015

Alain Ktorza, PhD.

scientific article published in September 2017

Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice

scientific article published on 30 August 2016

All roads lead to FoxO.

scientific article published in April 2005

Altered Plasma Profile of Antioxidant Proteins as an Early Correlate of Pancreatic β Cell Dysfunction

scientific article published on 25 February 2016

Anorexia and impaired glucose metabolism in mice with hypothalamic ablation of Glut4 neurons

scientific article

Application of combined omics platforms to accelerate biomedical discovery in diabesity

scientific article published on 09 May 2013

Biochemical and cellular properties of insulin receptor signalling

scientific article published on 4 October 2017

Blunted refeeding response and increased locomotor activity in mice lacking FoxO1 in synapsin-Cre-expressing neurons

scientific article published on 08 July 2013

Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ

scientific article

Calcium Signaling through CaMKII Regulates Hepatic Glucose Production in Fasting and Obesity ⬇️

scientific article published on April 12, 2012

Continuous Monitoring of Glucose in Subcutaneous Tissue Using Microfabricated Differential Affinity Sensors ⬇️

scientific article published on November 1, 2012

Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor

scientific article

Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Endothelial Cells Accelerates Atherosclerosis in Mice

scientific article published on 19 May 2016

Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans

scientific article

Diabetes in mice with selective impairment of insulin action in Glut4-expressing tissues

scientific article

Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance.

scientific article

Distinct roles of systemic and local actions of insulin on pancreatic β-cells

scientific article published on 7 January 2018

Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons

scientific article

Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism

scientific article

Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance

scientific journal article

Erratum: Corrigendum: Structure-based prediction of protein–protein interactions on a genome-wide scale

scientific article published in Nature

Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes

scientific article published on 29 December 2015

Expanded granulocyte/monocyte compartment in myeloid-specific triple FoxO knockout increases oxidative stress and accelerates atherosclerosis in mice

scientific article published on 18 February 2013

Expression of Concern. The IR1152 Mutant Insulin Receptor Selectively Impairs Insulin Action in Skeletal Muscle but Not in Liver. Diabetes 2000;49:1194-1202. DOI: https://doi.org/10.2337/diabetes.49.7.1194. PMID: 10909978.

scientific article published on 6 November 2017

FGF21 and the second coming of PPARγ.

scientific article published on February 2012

FOXO1 inhibition yields functional insulin-producing cells in human gut organoid cultures

scientific article

Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake

scientific journal article

Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress

scientific article published on 26 August 2008

FoxO Feedback Control of Basal IRS-2 Expression in Pancreatic β-Cells Is Distinct From That in Hepatocytes ⬇️

scientific article published on September 20, 2011

FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake

FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction

scientific article published on September 2005

FoxO1 target Gpr17 activates AgRP neurons to regulate food intake

scientific article

FoxOs Integrate Pleiotropic Actions of Insulin in Vascular Endothelium to Protect Mice from Atherosclerosis ⬇️

scientific article published on March 7, 2012

FoxOs at the crossroads of cellular metabolism, differentiation, and transformation

scientific article published on May 2004

FoxOs function synergistically to promote glucose production

scientific article

Foxo1 links hyperglycemia to LDL oxidation and endothelial nitric oxide synthase dysfunction in vascular endothelial cells

scientific article published on 07 July 2009

Functional characterization of the matrix metalloproteinase-1 cigarette smoke-responsive region and association with the lung health study

scientific article

Generation of functional insulin-producing cells in the gut by Foxo1 ablation ⬇️

scientific article published on March 11, 2012

Genetic Analysis of Type-1 Insulin-like Growth Factor Receptor Signaling through Insulin Receptor Substrate-1 and -2 in Pancreatic β Cells ⬇️

scientific article published on October 14, 2010

Glut4 expression defines an insulin-sensitive hypothalamic neuronal population

scientific article

Gpr17 in AgRP Neurons Regulates Feeding and Sensitivity to Insulin and Leptin

scientific article

Hepatic FoxO1 ablation exacerbates lipid abnormalities during hyperglycemia

scientific article

Hepatic FoxO1 integrates glucose utilization and lipid synthesis through regulation of Chrebp O-glycosylation

scientific article

Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions

scientific article published on 11 June 2015

Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice

scientific article published on 09 March 2009

Homozygosity for an Allele Encoding Deacetylated FoxO1 Protects Macrophages From Cholesterol-Induced Inflammation Without Increasing Apoptosis ⬇️

scientific article published on September 22, 2011

Hormonal regulation of hepatic glucose production in health and disease

scientific article published on July 2011

How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited

scientific article published on May 2011

Human insulin resistance is associated with increased plasma levels of 12α-hydroxylated bile acids

scientific article published on 24 July 2013

Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor ⬇️

scientific article published on June 6, 2011

Hypoglycemia Secondary to Sulfonylurea Ingestion in a Patient with End Stage Renal Disease: Results from a 72-Hour Fast

scientific article published on 17 November 2015

Hypoxia converts the myogenic action of insulin-like growth factors into mitogenic action by differentially regulating multiple signaling pathways

scientific article

Identification of Insulin-Responsive Transcription Factors That Regulate Glucose Production by Hepatocytes

scientific article published on 01 April 2019

Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia

scientific article published on 22 December 2011

Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver

scientific article published in September 2007

In vivo mutagenesis of the insulin receptor

scientific article

Inactivation of arf-bp1 Induces p53 Activation and Diabetic Phenotypes in Mice ⬇️

scientific article published on December 20, 2011

Increased Atherosclerosis and Endothelial Dysfunction in Mice Bearing Constitutively Deacetylated Alleles of Foxo1 Gene ⬇️

scientific article published on March 2, 2012

Increased CD36 protein as a response to defective insulin signaling in macrophages

scientific article published on March 2004

Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner

scientific article

Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability

scientific article published on 7 July 2013

InsR/FoxO1 signaling curtails hypothalamic POMC neuron number

scientific article

Insulin Action Research and the Future of Diabetes Treatment: The 2017 Banting Medal for Scientific Achievement Lecture

Insulin receptor knockout mice

scientific article

Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity

scientific article

Legacy Effect of Foxo1 in Pancreatic Endocrine Progenitors on Adult β-Cell Mass and Function

scientific article published on 17 March 2015

Lilly lecture 2003: the struggle for mastery in insulin action: from triumvirate to republic

scientific article

Liver sinusoidal endothelial cells link hyperinsulinemia to hepatic insulin resistance

scientific article published on 24 January 2013

Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay

scientific article published on 12 February 2013

Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions.

scientific article

Mechanisms of disease: using genetically altered mice to study concepts of type 2 diabetes

scientific article published on 22 January 2008

Metabolic inflexibility impairs insulin secretion and results in MODY-like diabetes in triple FoxO-deficient mice

scientific article published on 25 September 2014

Metformin and AMP Kinase Activation Increase Expression of the Sterol Transporters ABCG5/8 (ATP-Binding Cassette Transporter G5/G8) With Potential Antiatherogenic Consequences.

scientific article

Mosaic analysis of insulin receptor function

scientific article published on January 2004

Mouse models of insulin resistance

scientific article

New insights into the integrated physiology of insulin action

scientific article published on May 2004

Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression

scientific article

Nuclear forkhead box O1 controls and integrates key signaling pathways in hepatocytes

scientific article published on 15 February 2007

Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes

scientific article published on 22 March 2005

Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia

scientific article

Pair Feeding, but Not Insulin, Phloridzin, or Rosiglitazone Treatment, Curtails Markers of β-Cell Dedifferentiation in db/db Mice

scientific article published on 15 May 2017

Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure

scientific article

Pathogenesis of selective insulin resistance in isolated hepatocytes

scientific article published on 14 April 2015

Preserved energy balance in mice lacking FoxO1 in neurons of Nkx2.1 lineage reveals functional heterogeneity of FoxO1 signaling within the hypothalamus

scientific article published on 31 January 2014

Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through Creb deacetylation

scientific journal article

Proinsulin in girls: relationship to obesity, hyperinsulinemia, and puberty

scientific article

RETRACTED: Turning up the heat in the fat cell

retracted scientific article

Reconstitution of Insulin Action in Muscle, White Adipose Tissue, and Brain of Insulin Receptor Knock-out Mice Fails to Rescue Diabetes ⬇️

scientific article published on January 14, 2011

Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

scientific article

Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.

scientific article

Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors

scientific article

Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1.

scientific article published on 8 June 2009

Respective Contributions of Maternal Insulin Resistance and Diet to Metabolic and Hypothalamic Phenotypes of Progeny ⬇️

scientific article published on October 14, 2010

Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action

scientific article

Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance

scientific article published on 16 February 2006

Signalling through IGF-I and insulin receptors: where is the specificity?

scientific article

SirT1 gain of function increases energy efficiency and prevents diabetes in mice

scientific article

Structure-based prediction of protein–protein interactions on a genome-wide scale

scientific article (publication date: 30 September 2012)

Testis determination requires insulin receptor family function in mice

scientific journal article

The double life of Irs.

scientific article published on July 2008

The effect of insulin signaling on female reproductive function independent of adiposity and hyperglycemia

scientific article

The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells

scientific article

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

scientific journal article

The forkhead transcription factor Foxo1 regulates adipocyte differentiation

scientific article

The impact of insulin resistance on macrophage death pathways in advanced atherosclerosis

scientific article published on January 2007

The impact of macrophage insulin resistance on advanced atherosclerotic plaque progression

scientific article

The new biology of diabetes

scientific article

The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake

scientific article published on 20 September 2009

The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities

scientific article

The tangled path to glucose production

scientific article published in January 2006

Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha

scientific article

Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass.

scientific article

Transgenic rescue of insulin receptor-deficient mice

scientific article published in July 2004

n-3 Fatty Acids Decrease Arterial Low-Density Lipoprotein Cholesterol Delivery and Lipoprotein Lipase Levels in Insulin-Resistant Mice ⬇️

scientific article published on October 7, 2010

List of works by Domenico Accili

A Foxo/Notch pathway controls myogenic differentiation and fiber type specification

A MEMS differential viscometric sensor for affinity glucose detection in continuous glucose monitoring

A differential dielectric affinity glucose sensor

Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity

Alain Ktorza, PhD.

Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice

All roads lead to FoxO.

Altered Plasma Profile of Antioxidant Proteins as an Early Correlate of Pancreatic β Cell Dysfunction

Anorexia and impaired glucose metabolism in mice with hypothalamic ablation of Glut4 neurons

Application of combined omics platforms to accelerate biomedical discovery in diabesity

Biochemical and cellular properties of insulin receptor signalling

Blunted refeeding response and increased locomotor activity in mice lacking FoxO1 in synapsin-Cre-expressing neurons

Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ

Calcium Signaling through CaMKII Regulates Hepatic Glucose Production in Fasting and Obesity ⬇️

Continuous Monitoring of Glucose in Subcutaneous Tissue Using Microfabricated Differential Affinity Sensors ⬇️

Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor

Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Endothelial Cells Accelerates Atherosclerosis in Mice

Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans

Diabetes in mice with selective impairment of insulin action in Glut4-expressing tissues

Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance.

Distinct roles of systemic and local actions of insulin on pancreatic β-cells

Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons

Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism

Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance

Erratum: Corrigendum: Structure-based prediction of protein–protein interactions on a genome-wide scale

Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes

Expanded granulocyte/monocyte compartment in myeloid-specific triple FoxO knockout increases oxidative stress and accelerates atherosclerosis in mice

Expression of Concern. The IR1152 Mutant Insulin Receptor Selectively Impairs Insulin Action in Skeletal Muscle but Not in Liver. Diabetes 2000;49:1194-1202. DOI: https://doi.org/10.2337/diabetes.49.7.1194. PMID: 10909978.

FGF21 and the second coming of PPARγ.

FOXO1 inhibition yields functional insulin-producing cells in human gut organoid cultures

Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake

Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress

FoxO Feedback Control of Basal IRS-2 Expression in Pancreatic β-Cells Is Distinct From That in Hepatocytes ⬇️

FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake

FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction

FoxO1 target Gpr17 activates AgRP neurons to regulate food intake

FoxOs Integrate Pleiotropic Actions of Insulin in Vascular Endothelium to Protect Mice from Atherosclerosis ⬇️

FoxOs at the crossroads of cellular metabolism, differentiation, and transformation

FoxOs function synergistically to promote glucose production

Foxo1 links hyperglycemia to LDL oxidation and endothelial nitric oxide synthase dysfunction in vascular endothelial cells

Functional characterization of the matrix metalloproteinase-1 cigarette smoke-responsive region and association with the lung health study

Generation of functional insulin-producing cells in the gut by Foxo1 ablation ⬇️

Genetic Analysis of Type-1 Insulin-like Growth Factor Receptor Signaling through Insulin Receptor Substrate-1 and -2 in Pancreatic β Cells ⬇️

Glut4 expression defines an insulin-sensitive hypothalamic neuronal population

Gpr17 in AgRP Neurons Regulates Feeding and Sensitivity to Insulin and Leptin

Hepatic FoxO1 ablation exacerbates lipid abnormalities during hyperglycemia

Hepatic FoxO1 integrates glucose utilization and lipid synthesis through regulation of Chrebp O-glycosylation

Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions

Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice

Homozygosity for an Allele Encoding Deacetylated FoxO1 Protects Macrophages From Cholesterol-Induced Inflammation Without Increasing Apoptosis ⬇️

Hormonal regulation of hepatic glucose production in health and disease

How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited

Human insulin resistance is associated with increased plasma levels of 12α-hydroxylated bile acids

Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor ⬇️

Hypoglycemia Secondary to Sulfonylurea Ingestion in a Patient with End Stage Renal Disease: Results from a 72-Hour Fast

Hypoxia converts the myogenic action of insulin-like growth factors into mitogenic action by differentially regulating multiple signaling pathways

Identification of Insulin-Responsive Transcription Factors That Regulate Glucose Production by Hepatocytes

Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia

Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver

In vivo mutagenesis of the insulin receptor

Inactivation of arf-bp1 Induces p53 Activation and Diabetic Phenotypes in Mice ⬇️

Increased Atherosclerosis and Endothelial Dysfunction in Mice Bearing Constitutively Deacetylated Alleles of Foxo1 Gene ⬇️

Increased CD36 protein as a response to defective insulin signaling in macrophages

Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner

Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability

InsR/FoxO1 signaling curtails hypothalamic POMC neuron number

Insulin Action Research and the Future of Diabetes Treatment: The 2017 Banting Medal for Scientific Achievement Lecture

Insulin receptor knockout mice

Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity

Legacy Effect of Foxo1 in Pancreatic Endocrine Progenitors on Adult β-Cell Mass and Function

Lilly lecture 2003: the struggle for mastery in insulin action: from triumvirate to republic

Liver sinusoidal endothelial cells link hyperinsulinemia to hepatic insulin resistance

Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay

Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions.

Mechanisms of disease: using genetically altered mice to study concepts of type 2 diabetes

Metabolic inflexibility impairs insulin secretion and results in MODY-like diabetes in triple FoxO-deficient mice

Metformin and AMP Kinase Activation Increase Expression of the Sterol Transporters ABCG5/8 (ATP-Binding Cassette Transporter G5/G8) With Potential Antiatherogenic Consequences.

Mosaic analysis of insulin receptor function

Mouse models of insulin resistance