List of works - Ian Sayers

A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample

scientific article

A genome-wide association study to identify genetic determinants of atopy in subjects from the United Kingdom

article

A tailored approach to asthma management: Arg16 holds the key? ⬇️

scientific article published on 01 April 2013

Airway and peripheral urokinase plasminogen activator receptor is elevated in asthma, and identifies a severe, nonatopic subset of patients.

scientific article

Allelic association and functional studies of promoter polymorphism in the leukotriene C4 synthase gene (LTC4S) in asthma

scientific article published on May 2003

Alternative promoter use and splice variation in the human histamine H1 receptor gene.

scientific article published on 16 February 2006

Amino acid residues that influence Fc epsilon RI-mediated effector functions of human immunoglobulin E

scientific article published on 01 November 1998

Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

scientific article published on 01 June 2019

Can lineage-specific markers be identified to characterize mesenchyme-derived cell populations in the human airways?

scientific article published on 30 April 2010

Characterisation of urokinase plasminogen activator receptor variants in human airway and peripheral cells

scientific article published on 28 July 2009

Characterization of protocadherin-1 expression in primary bronchial epithelial cells: association with epithelial cell differentiation

scientific article published on 07 October 2011

Cigarette Smoke and the Induction of Urokinase Plasminogen Activator Receptor In Vivo: Selective Contribution of Isoforms to Bronchial Epithelial Phenotype

scientific article published on August 2015

Clonally expanded human airway smooth muscle cells exhibit morphological and functional heterogeneity

scientific article

Copy number variation of the beta-defensin genes in europeans: no supporting evidence for association with lung function, chronic obstructive pulmonary disease or asthma

scientific article published on 03 January 2014

Defining the contribution of SNPs identified in asthma GWAS to clinical variables in asthmatic children

scientific article

Defining the inflammatory signature of human lung explant tissue in the presence and absence of glucocorticoid

scientific article published on 11 April 2017

Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function

scientific article

Effects of atopy and grass pollen season on histamine H₄ receptor expression in human leukocytes.

scientific article

Evidence of a genetic contribution to lung function decline in asthma.

scientific article published on 12 July 2011

Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12.

scientific article published on 25 February 2016

Expression of polycomb protein BMI-1 maintains the plasticity of basal bronchial epithelial cells

scientific article published on August 2016

Functional polymorphism and differential regulation of CYSLTR1 transcription in human airway smooth muscle and monocytes

scientific article published on 01 January 2007

GSTCD and INTS12 regulation and expression in the human lung

scientific article

Genes associated with polymorphic variants predicting lung function are differentially expressed during human lung development.

scientific article published on 29 July 2016

Genetic risk factors for the development of allergic disease identified by genome-wide association

scientific article published on January 2015

Genetic risk factors for the development of pulmonary disease identified by genome-wide association

scientific article published on 13 November 2018

Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study.

scientific article published on 20 October 2017

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

scientific article published on 6 February 2017

Genome-wide association analysis identifies six new loci associated with forced vital capacity

scientific article

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

scientific article

Genome-wide association study identifies five loci associated with lung function

scientific article

Genome-wide association study to identify genetic determinants of severe asthma.

scientific article

Genome-wide protein QTL mapping identifies human plasma kallikrein as a post-translational regulator of serum uPAR levels.

scientific article

Identification of the high affinity receptor binding region in human immunoglobulin E.

scientific article

Leukotriene pathway genetics and pharmacogenetics in allergy.

scientific article published on 26 March 2009

Lung function associated gene Integrator Complex subunit 12 regulates protein synthesis pathways

scientific article

Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study

scientific article published on 11 December 2018

Mouse protocadherin-1 gene expression is regulated by cigarette smoke exposure in vivo.

scientific article

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

scientific article published on 25 February 2019

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

scholarly article published 12 June 2018

Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank

scientific article

PLAUR polymorphisms and lung function in UK smokers

scientific article

Pharmacogenetic approaches in the treatment of asthma.

scientific article

Pharmacogenetic characterization of indacaterol, a novel beta 2-adrenoceptor agonist.

scientific article

Pharmacogenetics and asthma: false hope or new dawn?

scientific article published on June 2007

Polymorphisms in IL13 pathway genes in asthma and chronic obstructive pulmonary disease.

scientific article

Polymorphisms in the interleukin-4 and interleukin-4 receptor alpha chain genes confer susceptibility to asthma and atopy in a Caucasian population.

scientific article published in August 2003

Response

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

scientific article

Structure/function studies on IgE as a basis for the development of rational IgE antagonists

scientific article published on 01 January 1998

Targeted Sequencing of Lung Function Loci in Chronic Obstructive Pulmonary Disease Cases and Controls

scientific article

The challenge of measuring IL-33 in serum using commercial ELISA: lessons from asthma

scientific article published on 6 February 2016

The cysteinyl-leukotriene type 1 receptor polymorphism 927T/C is associated with atopy severity but not with asthma.

scientific article published in June 2006

The differential effects of azithromycin on the airway epithelium in vitro and in vivo

scientific article published on September 2016

The effect of beta2-adrenoceptor agonists on phospholipase C (beta1) signalling in human airway smooth muscle cells.

scientific article published on 17 January 2006

The impact of azithromycin therapy on the airway microbiota in asthma

scientific article published on 28 November 2013

The role of ALOX5AP, LTA4H and LTB4R polymorphisms in determining baseline lung function and COPD susceptibility in UK smokers.

scientific article

The role of LTA4H and ALOX5AP polymorphism in asthma and allergy susceptibility.

scientific article published on 10 June 2008

The secretory tailpiece isoform of IgE is not associated with allergy.

scientific article published in July 2008

Traditional and emerging indicators of cardiovascular risk in chronic obstructive pulmonary disease.

scientific article

Translating Lung Function Genome-Wide Association Study (GWAS) Findings: New Insights for Lung Biology.

scientific article published on 9 February 2016

Urokinase plasminogen activator receptor polymorphisms and airway remodelling in asthma

scientific article published on 11 February 2016

Urokinase receptor orchestrates the plasminogen system in airway epithelial cell function.

scientific article published on 14 February 2013

Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction.

scientific article

uPAR regulates bronchial epithelial repair in vitro and is elevated in asthmatic epithelium.

scientific article published on 3 December 2011

β2-adrenoceptor polymorphisms and asthma from childhood to middle age in the British 1958 birth cohort: a genetic association study

scientific article published in The Lancet

List of works by Ian Sayers

A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample

A genome-wide association study to identify genetic determinants of atopy in subjects from the United Kingdom

A tailored approach to asthma management: Arg16 holds the key? ⬇️

Airway and peripheral urokinase plasminogen activator receptor is elevated in asthma, and identifies a severe, nonatopic subset of patients.

Allelic association and functional studies of promoter polymorphism in the leukotriene C4 synthase gene (LTC4S) in asthma

Alternative promoter use and splice variation in the human histamine H1 receptor gene.

Amino acid residues that influence Fc epsilon RI-mediated effector functions of human immunoglobulin E

Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

Can lineage-specific markers be identified to characterize mesenchyme-derived cell populations in the human airways?

Characterisation of urokinase plasminogen activator receptor variants in human airway and peripheral cells

Characterization of protocadherin-1 expression in primary bronchial epithelial cells: association with epithelial cell differentiation

Cigarette Smoke and the Induction of Urokinase Plasminogen Activator Receptor In Vivo: Selective Contribution of Isoforms to Bronchial Epithelial Phenotype

Clonally expanded human airway smooth muscle cells exhibit morphological and functional heterogeneity

Copy number variation of the beta-defensin genes in europeans: no supporting evidence for association with lung function, chronic obstructive pulmonary disease or asthma

Defining the contribution of SNPs identified in asthma GWAS to clinical variables in asthmatic children

Defining the inflammatory signature of human lung explant tissue in the presence and absence of glucocorticoid

Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function

Effects of atopy and grass pollen season on histamine H₄ receptor expression in human leukocytes.

Evidence of a genetic contribution to lung function decline in asthma.

Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12.

Expression of polycomb protein BMI-1 maintains the plasticity of basal bronchial epithelial cells

Functional polymorphism and differential regulation of CYSLTR1 transcription in human airway smooth muscle and monocytes

GSTCD and INTS12 regulation and expression in the human lung

Genes associated with polymorphic variants predicting lung function are differentially expressed during human lung development.

Genetic risk factors for the development of allergic disease identified by genome-wide association

Genetic risk factors for the development of pulmonary disease identified by genome-wide association

Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study.

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

Genome-wide association analysis identifies six new loci associated with forced vital capacity

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

Genome-wide association study identifies five loci associated with lung function

Genome-wide association study to identify genetic determinants of severe asthma.

Genome-wide protein QTL mapping identifies human plasma kallikrein as a post-translational regulator of serum uPAR levels.

Identification of the high affinity receptor binding region in human immunoglobulin E.

Leukotriene pathway genetics and pharmacogenetics in allergy.

Lung function associated gene Integrator Complex subunit 12 regulates protein synthesis pathways

Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study

Mouse protocadherin-1 gene expression is regulated by cigarette smoke exposure in vivo.

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank

PLAUR polymorphisms and lung function in UK smokers

Pharmacogenetic approaches in the treatment of asthma.

Pharmacogenetic characterization of indacaterol, a novel beta 2-adrenoceptor agonist.

Pharmacogenetics and asthma: false hope or new dawn?

Polymorphisms in IL13 pathway genes in asthma and chronic obstructive pulmonary disease.

Polymorphisms in the interleukin-4 and interleukin-4 receptor alpha chain genes confer susceptibility to asthma and atopy in a Caucasian population.

Response

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

Structure/function studies on IgE as a basis for the development of rational IgE antagonists

Targeted Sequencing of Lung Function Loci in Chronic Obstructive Pulmonary Disease Cases and Controls

The challenge of measuring IL-33 in serum using commercial ELISA: lessons from asthma

The cysteinyl-leukotriene type 1 receptor polymorphism 927T/C is associated with atopy severity but not with asthma.

The differential effects of azithromycin on the airway epithelium in vitro and in vivo

The effect of beta2-adrenoceptor agonists on phospholipase C (beta1) signalling in human airway smooth muscle cells.

The impact of azithromycin therapy on the airway microbiota in asthma

The role of ALOX5AP, LTA4H and LTB4R polymorphisms in determining baseline lung function and COPD susceptibility in UK smokers.

The role of LTA4H and ALOX5AP polymorphism in asthma and allergy susceptibility.

The secretory tailpiece isoform of IgE is not associated with allergy.

Traditional and emerging indicators of cardiovascular risk in chronic obstructive pulmonary disease.

Translating Lung Function Genome-Wide Association Study (GWAS) Findings: New Insights for Lung Biology.

Urokinase plasminogen activator receptor polymorphisms and airway remodelling in asthma

Urokinase receptor orchestrates the plasminogen system in airway epithelial cell function.

Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction.

uPAR regulates bronchial epithelial repair in vitro and is elevated in asthmatic epithelium.

β2-adrenoceptor polymorphisms and asthma from childhood to middle age in the British 1958 birth cohort: a genetic association study