List of works - Yuichi Tozuka

A Strategy for Co-former Selection to Design Stable Co-amorphous Formations Based on Physicochemical Properties of Non-steroidal Inflammatory Drugs.

scientific article published on 24 December 2015

A combinational supercritical CO2 system for nanoparticle preparation of indomethacin.

scientific article published on 4 November 2009

A completely solvent-free process for the improvement of erythritol compactibility

scientific article published on 25 July 2013

A mucoadhesive nanoparticulate system for the simultaneous delivery of macromolecules and permeation enhancers to the intestinal mucosa

scientific article published on 06 February 2010

A novel application of α-glucosyl hesperidin for nanoparticle formation of active pharmaceutical ingredients by dry grinding

scientific article published on 24 July 2011

A novel method for measuring rigidity of submicron-size liposomes with atomic force microscopy.

scientific article

Absorption improvement of tranilast by forming highly soluble nano-size composite structures associated with α-glucosyl rutin via spray drying

scientific article published on 26 February 2015

Adsorption and entrapment of salicylamide molecules into the mesoporous structure of folded sheets mesoporous material (FSM-16).

scientific article

Anomalous role change of tertiary amino and ester groups as hydrogen acceptors in eudragit E based solid dispersion depending on the concentration of naproxen

scientific article published on 03 March 2015

Anti-plasticizing effect of amorphous indomethacin induced by specific intermolecular interactions with PVA copolymer

scientific article published on 02 June 2014

Application of ascorbic acid 2-glucoside as a solubilizing agent for clarithromycin: solubilization and nanoparticle formation.

scientific article

Appropriate selection of an aggregation inhibitor of fine particles used for inhalation prepared by emulsion solvent diffusion.

scientific article published on 14 June 2016

Ascorbyl dipalmitate/PEG-lipid nanoparticles as a novel carrier for hydrophobic drugs.

scientific article published on 18 December 2009

Characterization of amorphous ursodeoxycholic acid prepared by spray-drying

scientific article published on 01 November 1998

Co-amorphous Formation Induced by Combination of Tranilast and Diphenhydramine Hydrochloride

scientific article published on 15 August 2016

Coloration phenomenon of mefenamic acid in mesoporous silica FSM-16.

scientific article published in February 2010

Cyclodextrins as stabilizers for the preparation of drug nanocrystals by the emulsion solvent diffusion method

scientific article published on 20 January 2008

Design and evaluation of a liposomal delivery system targeting the posterior segment of the eye.

scientific article published on 9 March 2009

Design and evaluation of novel pH-sensitive chitosan nanoparticles for oral insulin delivery

scientific article published on 21 December 2010

Development of a novel and simple method to evaluate disintegration of rapidly disintegrating tablets.

scientific article published in January 2013

Drug solubilization mechanism of α-glucosyl stevia by NMR spectroscopy.

scientific article

Edaravone-loaded liposome eyedrops protect against light-induced retinal damage in mice.

scientific article

Effect of pore size of FSM-16 on the entrapment of flurbiprofen in mesoporous structures.

scientific article published in August 2005

Effect of surface properties of liposomes coated with a modified polyvinyl alcohol (PVA-R) on the interaction with macrophage cells.

scientific article

Elucidation of solid-state complexation in ground mixtures of cholic acid and guest compounds.

scientific article

Evaluation of highly branched cyclic dextrin in inhalable particles of combined antibiotics for the pulmonary delivery of anti-tuberculosis drugs.

scientific article published on 29 November 2016

Evaluation of the Micellization Mechanism of an Amphipathic Graft Copolymer with Enhanced Solubility of Ipriflavone

scientific article published on 01 January 2016

Feasibility of highly branched cyclic dextrin as an excipient matrix in dry powder inhalers.

scientific article published on 7 September 2015

Fluorescence investigation of a specific structure formed by aggregation of transglycosylated stevias: solubilizing effect of poorly water-soluble drugs

scientific article published on 02 April 2011

Fluorescence investigation of the retinal delivery of hydrophilic compounds via liposomal eyedrops.

scientific article published on January 2011

Fluorometric Studies of Pyrene Adsorption on Porous Crystalline Cellulose

scientific article published on 01 September 1998

Formation mechanism of colloidal nanoparticles obtained from probucol/PVP/SDS ternary ground mixture.

scientific article

Formation of fine drug particle by cogrinding with cyclodextrins. Part II. The influence of moisture condition during cogrinding process on fine particle formation.

scientific article published in October 2003

Formation of fine drug particles by cogrinding with cyclodextrins. I. The use of beta-cyclodextrin anhydrate and hydrate.

scientific article published in December 2002

Formation, physical stability and in vitro antimalarial activity of dihydroartemisinin nanosuspensions obtained by co-grinding method

scientific article published in March 2008

Guest molecular size-dependent inclusion complexation of parabens with cholic acid by cogrinding.

scientific article published on 22 August 2011

Hybridization of polyvinylpyrrolidone to a binary composite of curcumin/α-glucosyl stevia improves both oral absorption and photochemical stability of curcumin.

scientific article published on 6 July 2016

Improved respirable fraction of budesonide powder for dry powder inhaler formulations produced by advanced supercritical CO2 processing and use of a novel additive

scientific article published on 2 June 2017

Improvement of dissolution and absorption properties of poorly water-soluble drug by preparing spray-dried powders with alpha-glucosyl hesperidin.

scientific article published on 20 March 2010

Improvement of physicochemical properties of N-4472. Part II: characterization of N-4472 microemulsion and the enhanced oral absorption.

scientific article

Improvement of physicochemical properties of N-4472. Part III. VC/N-4472 complex formation and self-association in aqueous solution.

scientific article

In Vitro and In Vivo Characterization of Drug Nanoparticles Prepared Using PureNano™ Continuous Crystallizer to Improve the Bioavailability of Poorly Water Soluble Drugs

scientific article published on 14 June 2016

In vitro and in vivo evaluation of WGA-carbopol modified liposomes as carriers for oral peptide delivery

scientific article published on 13 December 2010

Influence of dehydration temperature on water vapor adsorption, dissolution behavior and surface property of ampicillin.

scientific article published on 30 November 2004

Inhibition of Photodegradation of Highly Dispersed Folic Acid Nanoparticles by the Antioxidant Effect of Transglycosylated Rutin.

scientific article published on 4 April 2016

Investigation of Physiological Properties of Transglycosylated Stevia with Cationic Surfactant and Its Application to Enhance the Solubility of Rebamipide

article

Jelly containing composite based on α-glucosyl stevia and polyvinylpyrrolidone: Improved dissolution property of curcumin.

scientific article published on 8 February 2018

Kinetics of co-crystal formation with caffeine and citric acid via liquid-assisted grinding analyzed using the distinct element method.

scientific article published on 18 May 2015

Liposomal diclofenac eye drop formulations targeting the retina: formulation stability improvement using surface modification of liposomes

scientific article published on 22 July 2012

Low hygroscopic spray-dried powders with trans-glycosylated food additives enhance the solubility and oral bioavailability of ipriflavone.

scientific article

Micronization and polymorphic conversion of tolbutamide and barbital by rapid expansion of supercritical solutions

Micronization of dihydroartemisinin by rapid expansion of supercritical solutions

scientific article published in June 2008

Micronization of phenylbutazone by rapid expansion of supercritical CO2 solution.

scientific article published in August 2005

Mixed Micelle System Produced by Interaction Between Transglycosylated Stevia and an Ionic Surfactant Improves Dissolution Profile of Mefenamic Acid

scientific article published on 03 January 2017

Modification of physicochemical and mechanical properties of shellac by partial hydrolysis

scientific article published on 01 June 2004

Molecular interaction among probucol/PVP/SDS multicomponent system investigated by solid-state NMR

article

Molecular states of p-dimethylaminobenzonitrile coground with β-cyclodextrin investigated using solid-state fluorescence spectroscopy

scientific article published on 01 January 2011

N-trimethyl chitosan-modified liposomes as carriers for oral delivery of salmon calcitonin.

scientific article

NMR investigation of a novel excipient, α-glucosylhesperidin, as a suitable solubilizing agent for poorly water-soluble drugs.

scientific article

Nanocomposite formation between alpha-glucosyl stevia and surfactant improves the dissolution profile of poorly water-soluble drug

scientific article published on 14 January 2012

Nanoparticle formation from probucol/PVP/sodium alkyl sulfate co-ground mixture

scientific article

Nanoparticles of glycol chitosan and its thiolated derivative significantly improved the pulmonary delivery of calcitonin.

scientific article published on 7 July 2010

Novel channel structure of bile acid-guest inclusion complex formed between ursodeoxycholic acid and phenanthrene.

scientific article

Physicochemical properties affecting retinal drug/coumarin-6 delivery from nanocarrier systems via eyedrop administration.

scientific article published on 6 January 2010

Physicochemical, morphological and therapeutic evaluation of agarose hydrogel particles as a reservoir for basic fibroblast growth factor

scientific article published on 01 January 2008

Prednisolone multicomponent nanoparticle preparation by aerosol solvent extraction system.

scientific article

Preparation of drug nanoparticles by co-grinding with cyclodextrin: formation mechanism and factors affecting nanoparticle formation

scientific article published on 01 March 2007

Process monitoring of ultrasound compaction as a small-scale heating process

scientific article published on 11 June 2013

Pulmonary delivery of elcatonin using surface-modified liposomes to improve systemic absorption: polyvinyl alcohol with a hydrophobic anchor and chitosan oligosaccharide as effective surface modifiers.

scientific article

Pulmonary liposomal formulations encapsulated procaterol hydrochloride by a remote loading method achieve sustained release and extended pharmacological effects.

scientific article

Raman mapping for kinetic analysis of crystallization of amorphous drug based on distributional images.

scientific article published on 22 December 2013

Release profile of insulin entrapped on mesoporous materials by freeze-thaw method

scientific article published on 2 December 2009

Retinal drug delivery using eyedrop preparations of poly-L-lysine-modified liposomes.

scientific article

Salicylic acid/gamma-cyclodextrin 2:1 and 4:1 complex formation by sealed-heating method.

scientific article

Solid-state fluorescence study of naphthalene adsorption on porous material.

scientific article

Solventless dry powder coating for sustained drug release using mechanochemical treatment based on the tri-component system of acetaminophen, carnauba wax and glidant

scientific article published on 12 April 2012

Specific inclusion mode of guest compounds in the amylose complex analyzed by solid state NMR spectroscopy

scientific article published on 01 August 2006

Supercritical carbon dioxide processing of active pharmaceutical ingredients for polymorphic control and for complex formation.

scientific article published on 05 October 2007

Supercritical carbon dioxide treatment as a method for polymorph preparation of deoxycholic acid.

scientific article published in September 2003

Surface modification of liposomes using polymer-wheat germ agglutinin conjugates to improve the absorption of peptide drugs by pulmonary administration

scientific article published on 6 February 2013

Transglycosylated rutin-specific non-surface-active nanostructure affects absorption enhancement of flurbiprofen.

scientific article

Water vapor adsorption properties of amorphous cefditoren pivoxil evaluated by adsorption isotherms and microcalorimetry

pH-Sensitive nanospheres for colon-specific drug delivery in experimentally induced colitis rat model

scientific article

α-Glucosyl hesperidin induced an improvement in the bioavailability of pranlukast hemihydrate using high-pressure homogenization

scientific article published on 16 March 2011

List of works by Yuichi Tozuka

A Strategy for Co-former Selection to Design Stable Co-amorphous Formations Based on Physicochemical Properties of Non-steroidal Inflammatory Drugs.

A combinational supercritical CO2 system for nanoparticle preparation of indomethacin.

A completely solvent-free process for the improvement of erythritol compactibility

A mucoadhesive nanoparticulate system for the simultaneous delivery of macromolecules and permeation enhancers to the intestinal mucosa

A novel application of α-glucosyl hesperidin for nanoparticle formation of active pharmaceutical ingredients by dry grinding

A novel method for measuring rigidity of submicron-size liposomes with atomic force microscopy.

Absorption improvement of tranilast by forming highly soluble nano-size composite structures associated with α-glucosyl rutin via spray drying

Adsorption and entrapment of salicylamide molecules into the mesoporous structure of folded sheets mesoporous material (FSM-16).

Anomalous role change of tertiary amino and ester groups as hydrogen acceptors in eudragit E based solid dispersion depending on the concentration of naproxen

Anti-plasticizing effect of amorphous indomethacin induced by specific intermolecular interactions with PVA copolymer

Application of ascorbic acid 2-glucoside as a solubilizing agent for clarithromycin: solubilization and nanoparticle formation.

Appropriate selection of an aggregation inhibitor of fine particles used for inhalation prepared by emulsion solvent diffusion.

Ascorbyl dipalmitate/PEG-lipid nanoparticles as a novel carrier for hydrophobic drugs.

Characterization of amorphous ursodeoxycholic acid prepared by spray-drying

Co-amorphous Formation Induced by Combination of Tranilast and Diphenhydramine Hydrochloride

Coloration phenomenon of mefenamic acid in mesoporous silica FSM-16.

Cyclodextrins as stabilizers for the preparation of drug nanocrystals by the emulsion solvent diffusion method

Design and evaluation of a liposomal delivery system targeting the posterior segment of the eye.

Design and evaluation of novel pH-sensitive chitosan nanoparticles for oral insulin delivery

Development of a novel and simple method to evaluate disintegration of rapidly disintegrating tablets.

Drug solubilization mechanism of α-glucosyl stevia by NMR spectroscopy.

Edaravone-loaded liposome eyedrops protect against light-induced retinal damage in mice.

Effect of pore size of FSM-16 on the entrapment of flurbiprofen in mesoporous structures.

Effect of surface properties of liposomes coated with a modified polyvinyl alcohol (PVA-R) on the interaction with macrophage cells.

Elucidation of solid-state complexation in ground mixtures of cholic acid and guest compounds.

Evaluation of highly branched cyclic dextrin in inhalable particles of combined antibiotics for the pulmonary delivery of anti-tuberculosis drugs.

Evaluation of the Micellization Mechanism of an Amphipathic Graft Copolymer with Enhanced Solubility of Ipriflavone

Feasibility of highly branched cyclic dextrin as an excipient matrix in dry powder inhalers.

Fluorescence investigation of a specific structure formed by aggregation of transglycosylated stevias: solubilizing effect of poorly water-soluble drugs

Fluorescence investigation of the retinal delivery of hydrophilic compounds via liposomal eyedrops.

Fluorometric Studies of Pyrene Adsorption on Porous Crystalline Cellulose

Formation mechanism of colloidal nanoparticles obtained from probucol/PVP/SDS ternary ground mixture.

Formation of fine drug particle by cogrinding with cyclodextrins. Part II. The influence of moisture condition during cogrinding process on fine particle formation.

Formation of fine drug particles by cogrinding with cyclodextrins. I. The use of beta-cyclodextrin anhydrate and hydrate.

Formation, physical stability and in vitro antimalarial activity of dihydroartemisinin nanosuspensions obtained by co-grinding method

Guest molecular size-dependent inclusion complexation of parabens with cholic acid by cogrinding.

Hybridization of polyvinylpyrrolidone to a binary composite of curcumin/α-glucosyl stevia improves both oral absorption and photochemical stability of curcumin.

Improved respirable fraction of budesonide powder for dry powder inhaler formulations produced by advanced supercritical CO2 processing and use of a novel additive

Improvement of dissolution and absorption properties of poorly water-soluble drug by preparing spray-dried powders with alpha-glucosyl hesperidin.

Improvement of physicochemical properties of N-4472. Part II: characterization of N-4472 microemulsion and the enhanced oral absorption.

Improvement of physicochemical properties of N-4472. Part III. VC/N-4472 complex formation and self-association in aqueous solution.

In Vitro and In Vivo Characterization of Drug Nanoparticles Prepared Using PureNano™ Continuous Crystallizer to Improve the Bioavailability of Poorly Water Soluble Drugs

In vitro and in vivo evaluation of WGA-carbopol modified liposomes as carriers for oral peptide delivery

Influence of dehydration temperature on water vapor adsorption, dissolution behavior and surface property of ampicillin.

Inhibition of Photodegradation of Highly Dispersed Folic Acid Nanoparticles by the Antioxidant Effect of Transglycosylated Rutin.

Investigation of Physiological Properties of Transglycosylated Stevia with Cationic Surfactant and Its Application to Enhance the Solubility of Rebamipide

Jelly containing composite based on α-glucosyl stevia and polyvinylpyrrolidone: Improved dissolution property of curcumin.

Kinetics of co-crystal formation with caffeine and citric acid via liquid-assisted grinding analyzed using the distinct element method.

Liposomal diclofenac eye drop formulations targeting the retina: formulation stability improvement using surface modification of liposomes

Low hygroscopic spray-dried powders with trans-glycosylated food additives enhance the solubility and oral bioavailability of ipriflavone.

Micronization and polymorphic conversion of tolbutamide and barbital by rapid expansion of supercritical solutions

Micronization of dihydroartemisinin by rapid expansion of supercritical solutions

Micronization of phenylbutazone by rapid expansion of supercritical CO2 solution.

Mixed Micelle System Produced by Interaction Between Transglycosylated Stevia and an Ionic Surfactant Improves Dissolution Profile of Mefenamic Acid

Modification of physicochemical and mechanical properties of shellac by partial hydrolysis

Molecular interaction among probucol/PVP/SDS multicomponent system investigated by solid-state NMR

Molecular states of p-dimethylaminobenzonitrile coground with β-cyclodextrin investigated using solid-state fluorescence spectroscopy

N-trimethyl chitosan-modified liposomes as carriers for oral delivery of salmon calcitonin.

NMR investigation of a novel excipient, α-glucosylhesperidin, as a suitable solubilizing agent for poorly water-soluble drugs.

Nanocomposite formation between alpha-glucosyl stevia and surfactant improves the dissolution profile of poorly water-soluble drug

Nanoparticle formation from probucol/PVP/sodium alkyl sulfate co-ground mixture

Nanoparticles of glycol chitosan and its thiolated derivative significantly improved the pulmonary delivery of calcitonin.

Novel channel structure of bile acid-guest inclusion complex formed between ursodeoxycholic acid and phenanthrene.

Physicochemical properties affecting retinal drug/coumarin-6 delivery from nanocarrier systems via eyedrop administration.

Physicochemical, morphological and therapeutic evaluation of agarose hydrogel particles as a reservoir for basic fibroblast growth factor

Prednisolone multicomponent nanoparticle preparation by aerosol solvent extraction system.

Preparation of drug nanoparticles by co-grinding with cyclodextrin: formation mechanism and factors affecting nanoparticle formation

Process monitoring of ultrasound compaction as a small-scale heating process

Pulmonary delivery of elcatonin using surface-modified liposomes to improve systemic absorption: polyvinyl alcohol with a hydrophobic anchor and chitosan oligosaccharide as effective surface modifiers.

Pulmonary liposomal formulations encapsulated procaterol hydrochloride by a remote loading method achieve sustained release and extended pharmacological effects.

Raman mapping for kinetic analysis of crystallization of amorphous drug based on distributional images.

Release profile of insulin entrapped on mesoporous materials by freeze-thaw method

Retinal drug delivery using eyedrop preparations of poly-L-lysine-modified liposomes.

Salicylic acid/gamma-cyclodextrin 2:1 and 4:1 complex formation by sealed-heating method.

Solid-state fluorescence study of naphthalene adsorption on porous material.

Solventless dry powder coating for sustained drug release using mechanochemical treatment based on the tri-component system of acetaminophen, carnauba wax and glidant

Specific inclusion mode of guest compounds in the amylose complex analyzed by solid state NMR spectroscopy

Supercritical carbon dioxide processing of active pharmaceutical ingredients for polymorphic control and for complex formation.

Supercritical carbon dioxide treatment as a method for polymorph preparation of deoxycholic acid.