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List of works by David S Park

A novel arylsulfatase A protein variant and genotype in two patients with major depression

scientific article published on 01 October 1996

APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death.

scientific article

Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy

scientific article

Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival.

scientific article published on April 2014

Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila.

scientific article published on 12 July 2010

Amyloid-beta42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism.

scientific article

Animal models of Parkinson's disease

scientific article published on 18 December 2011

Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms

scientific journal article

Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

scientific article

Arylsulfatase A: relationship of genotype to variant electrophoretic properties

scientific article published on 01 April 1996

Association of alcoholism with the N-glycosylation polymorphism of pseudodeficient human arylsulfatase A.

scientific article published in April 1996

Attenuation of MPTP-induced neurotoxicity and behavioural impairment in NSE-XIAP transgenic mice.

scientific article published in March 2003

BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for Mitochondrial Translocation of PARKIN and Neuronal Survival

scientific article

CDK5 phosphorylates DRP1 and drives mitochondrial defects in NMDA-induced neuronal death.

scientific article published on 22 May 2015

CDKs: taking on a role as mediators of dopaminergic loss in Parkinson's disease.

scientific article published in September 2004

CITED2 signals through peroxisome proliferator-activated receptor-gamma to regulate death of cortical neurons after DNA damage.

scientific article published in May 2008

Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2.

scientific article published in January 2006

Calpains mediate p53 activation and neuronal death evoked by DNA damage.

scientific article published on 29 April 2003

Cdc25A Is a Critical Mediator of Ischemic Neuronal Death In Vitro and In Vivo

scientific article

Cdk5: Links to DNA damage ⬇️

scientific article published on August 9, 2010

Cell cycle machinery and stroke.

scientific article published on 5 December 2006

Cell cycle regulator E2F4 is essential for the development of the ventral telencephalon.

scientific article

Cell cycle regulators in neuronal death evoked by excitotoxic stress: implications for neurodegeneration and its treatment.

scientific article published in November 2000

Comparative analysis of Parkinson's disease-associated genes reveals altered survival and bioenergetics of parkin-deficient dopamine neurons in mice

scientific article published on 26 April 2018

Comparison of rectilinear biphasic waveform energy versus truncated exponential biphasic waveform energy for transthoracic cardioversion of atrial fibrillation

scientific article published in December 2004

Conditional Disruption of Calpain in the CNS Alters Dendrite Morphology, Impairs LTP, and Promotes Neuronal Survival following Injury ⬇️

scientific article published on March 27, 2013

Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease ⬇️

scientific article published on October 31, 2003

Cyclin-dependent kinase 5 mediates neurotoxin-induced degradation of the transcription factor myocyte enhancer factor 2.

scientific article published in May 2005

Cyclin-dependent kinases as a therapeutic target for stroke.

scientific article published on August 2000

Cyclin-dependent kinases as potential targets to improve stroke outcome.

scientific article

Cyclin-dependent kinases participate in death of neurons evoked by DNA-damaging agents

scientific article

DJ-1 interacts with and regulates paraoxonase-2, an enzyme critical for neuronal survival in response to oxidative stress.

scientific article

DJ-1 modulates the unfolded protein response and cell death via upregulation of ATF4 following ER stress

scientific article published on 12 February 2019

DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway.

scientific article

Delayed combinatorial treatment with flavopiridol and minocycline provides longer term protection for neuronal soma but not dendrites following global ischemia.

scientific article

Differential roles of nuclear and cytoplasmic cyclin-dependent kinase 5 in apoptotic and excitotoxic neuronal death

scientific journal article

Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis

scientific article

E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3.

scientific article published in April 2000

Effects of calpain inhibition on dopaminergic markers and motor function following intrastriatal 6-hydroxydopamine administration in rats.

scientific article

Essential role of cytoplasmic cdk5 and Prx2 in multiple ischemic injury models, in vivo.

scientific article

Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.

scientific article

Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

scientific article

Inactivation of Pink1 Gene in Vivo Sensitizes Dopamine-producing Neurons to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and Can Be Rescued by Autosomal Recessive Parkinson Disease Genes, Parkin or DJ-1 ⬇️

scientific article published on April 17, 2012

Induction and modulation of cerebellar granule neuron death by E2F-1

scientific article published on 01 August 2000

Induction of CPP32-like activity in PC12 cells by withdrawal of trophic support. Dissociation from apoptosis

scientific article published on 01 November 1996

Induction of protein deletion through in utero electroporation to define deficits in neuronal migration in transgenic models.

scientific article

Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons

scientific article published on 01 April 1996

Inhibitors of trypsin-like serine proteases prevent DNA damage-induced neuronal death by acting upstream of the mitochondrial checkpoint and of p53 induction.

scientific article published in January 2001

Involvement of caspase 3 in apoptotic death of cortical neurons evoked by DNA damage.

scientific article published in April 2000

Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons.

scientific article published in March 2007

Involvement of the Fc gamma receptor in a chronic N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of dopaminergic loss.

scientific article

LRRK2(I2020T) functional genetic interactors that modify eye degeneration and dopaminergic cell loss in Drosophila.

scientific article published on 2 February 2017

LXCXE-independent chromatin remodeling by Rb/E2f mediates neuronal quiescence ⬇️

scientific article published on April 9, 2013

Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease

scientific article

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

scientific article

Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner

scientific article published on 01 September 2019

MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner ⬇️

scientific article published on December 7, 2010

MCL-1Matrix maintains neuronal survival by enhancing mitochondrial integrity and bioenergetic capacity under stress conditions

scientific article published on 05 May 2020

MPTP induces intranuclear rodlet formation in midbrain dopaminergic neurons.

scientific article published in December 2005

Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program

scientific article published on 25 May 2016

Mitochondrial dysfunction underlies cognitive defects as a result of neural stem cell depletion and impaired neurogenesis.

scientific article published on 08 June 2017

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment ⬇️

scientific article published on April 1, 2012

Mitofusin 2 protects cerebellar granule neurons against injury-induced cell death.

scientific article published on 30 May 2007

Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo.

scientific article

NAIP protects the nigrostriatal dopamine pathway in an intrastriatal 6-OHDA rat model of Parkinson's disease.

scientific article

NFkappaB in neurons? The uncertainty principle in neurobiology

scientific article

Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA ⬇️

scientific journal article

Nuclear factor-(kappa)B modulates the p53 response in neurons exposed to DNA damage.

scientific article published in March 2004

OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand

scientific article

Opposing Regulation of Sox2 by Cell-Cycle Effectors E2f3a and E2f3b in Neural Stem Cells ⬇️

scientific article published on March 14, 2013

Ordering the Multiple Pathways of Apoptosis ⬇️

scientific article published on November 1, 1997

PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress

scientific article published on 9 November 2017

Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress

scientific article

Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures

scientific article

Parkinson's disease: to live or die by autophagy.

scientific article published on 07 April 2009

Pathological axonal death through a MAPK cascade that triggers a local energy deficit

scientific article published on January 2015

Perturbation of Transcription Factor Nur77 Expression Mediated by Myocyte Enhancer Factor 2D (MEF2D) Regulates Dopaminergic Neuron Loss in Response to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) ⬇️

scientific article published on March 27, 2013

Pink1 regulates FKBP5 interaction with AKT/PHLPP and protects neurons from neurotoxin stress induced by MPP

scientific article published on 02 April 2019

Pocket proteins pRb and p107 are required for cortical lamination independent of apoptosis.

scientific article published on 19 September 2013

Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease ⬇️

scientific article published on September 10, 2012

RB regulates the production and the survival of newborn neurons in the embryonic and adult dentate gyrus.

scientific article published on 20 June 2016

ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons.

scientific article

Rb/E2F Regulates Expression of Neogenin during Neuronal Migration ⬇️

scientific article published on November 8, 2010

Regulation of dopaminergic loss by Fas in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.

scientific article published on February 2004

Regulation of ischemic neuronal death by E2F4-p130 protein complexes

scientific journal article

Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson's disease

scientific article published on 14 May 2018

Regulation of the VHL/HIF-1 pathway by DJ-1

scientific article

Required roles of Bax and JNKs in central and peripheral nervous system death of retinoblastoma-deficient mice.

scientific article published on 5 November 2007

Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1.

scientific article published on 6 April 2011

Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease.

scientific article

Role of cyclooxygenase-2 induction by transcription factor Sp1 and Sp3 in neuronal oxidative and DNA damage response

scientific article published on 28 September 2006

Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system.

scientific article published on 10 November 2011

Sertad1 plays an essential role in developmental and pathological neuron death.

scientific article published on March 2010

Structural characterization of variant forms of arylsulfatase A that associate with alcoholism

scientific article published on 01 April 1996

The Chk1/Cdc25A pathway as activators of the cell cycle in neuronal death induced by camptothecin.

scientific article

The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage.

scholarly article

The Rb-CDK4/6 signaling pathway is critical in neural precursor cell cycle regulation

scientific article published on 01 October 2000

The Rb/E2F pathway modulates neurogenesis through direct regulation of the Dlx1/Dlx2 bigene cluster.

scientific article published in June 2012

The Retinoblastoma family member p107 regulates the rate of progenitor commitment to a neuronal fate.

scientific article

The mitochondrial inner membrane GTPase, optic atrophy 1 (Opa1), restores mitochondrial morphology and promotes neuronal survival following excitotoxicity.

scientific article published on November 2010

The nuclear localization of SET mediated by impalpha3/impbeta attenuates its cytosolic toxicity in neurons.

scientific article

The pro-death role of Cited2 in stroke is regulated by E2F1/4 transcription factors

scientific article published on 09 April 2019

The retinoblastoma protein is essential for survival of postmitotic neurons

scientific article published on 01 October 2012

Unaltered striatal dopamine release levels in young Parkin knockout, Pink1 knockout, DJ-1 knockout and LRRK2 R1441G transgenic mice.

scientific article

Unique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle-independent functions

scientific article published on 23 April 2007

c-Jun N-terminal kinase 3 deficiency protects neurons from axotomy-induced death in vivo through mechanisms independent of c-Jun phosphorylation.

scientific article published on 4 November 2004

c-Jun mediates axotomy-induced dopamine neuron death in vivo ⬇️

scientific article published on October 30, 2001

p53 activation domain 1 is essential for PUMA upregulation and p53-mediated neuronal cell death

scientific article published on 01 November 2004

β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson's disease.

scientific article

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