Search filters

List of works by David Rowitch

A FOXO-Pak1 transcriptional pathway controls neuronal polarity

scientific journal article

A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment.

scientific article

A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2.

scientific article

A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons

scientific article

A dramatic increase of C1q protein in the CNS during normal aging.

scientific article published on August 2013

A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development

scientific journal article

A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool

scientific article

A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injury

scientific article

Ablation of NG2 proteoglycan leads to deficits in brown fat function and to adult onset obesity

scientific article

Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma

scientific article published on August 2008

An amino terminal phosphorylation motif regulates intranuclear compartmentalization of Olig2 in neural progenitor cells

scientific article

Astrocyte development and heterogeneity

scientific article

Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map

scientific article published on 16 March 2020

Astrocyte-encoded positional cues maintain sensorimotor circuit integrity.

scientific article published on 28 April 2014

Astrocytes: The Final Frontier….

scientific article published in January 2016

Beta-catenin function is required for cerebellar morphogenesis

scientific article published on 7 July 2006

CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination.

scientific article

Cerebellar 'transcriptome' reveals cell-type and stage-specific expression during postnatal development and tumorigenesis

scientific article published on 8 September 2006

Cerebellar abnormalities following hypoxia alone compared to hypoxic-ischemic forebrain injury in the developing rat brain.

scientific article published on 16 September 2010

Cerebellar cortical lamination and foliation require cyclin A2

scientific article (publication date: 15 January 2014)

Challenges to curing primary brain tumours

scientific article published on 01 August 2019

Characterization of Pax-2 regulatory sequences that direct transgene expression in the Wolffian duct and its derivatives.

scientific article published in January 2001

Concise Review: Stem Cell-Based Treatment of Pelizaeus-Merzbacher Disease.

scientific article

Cooperative interactions of BRAF V600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy ⬇️

scientific article published on May 14, 2012

Corridors of migrating neurons in the human brain and their decline during infancy.

scientific article

Development of NG2 neural progenitor cells requires Olig gene function

scientific article (published 2006-05-16)

Development of mice expressing a single D-type cyclin.

scientific article published on December 2002

Developmental genetics of vertebrate glial-cell specification.

scientific article

Dexamethasone destabilizes Nmyc to inhibit the growth of hedgehog-associated medulloblastoma

scientific article

Disease specific therapies in leukodystrophies and leukoencephalopathies

scientific article

Dlx1 and Dlx2 Promote Interneuron GABA Synthesis, Synaptogenesis, and Dendritogenesis.

scientific article published on 28 September 2017

Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain

scientific journal article

Dysregulation of astrocyte extracellular signaling in Costello syndrome

scientific article published on May 2015

Dysregulation of locus coeruleus development in congenital central hypoventilation syndrome

scientific article published on 15 May 2015

Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS

scientific journal article

Effect of coat protein mutations in bacteriophage fd studied by sedimentation analysis.

scientific article published on November 1992

Evidence that nuclear factor IA inhibits repair after white matter injury

scientific article

Evolving concepts of gliogenesis: a look way back and ahead to the next 25 years

scientific article

Expression and function of Nkx6.3 in vertebrate hindbrain.

scientific article published on 6 May 2008

Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: use of YKL-40, ApoE, ASCL1, and NKX2-2.

scientific article published in December 2006

Expression pattern of the transcription factor Olig2 in response to brain injuries: implications for neuronal repair

scientific article

Expression profiling of Aldh1l1‐precursors in the developing spinal cord reveals glial lineage‐specific genes and direct Sox9‐Nfe2l1 interactions ⬇️

scientific article published on July 10, 2013

Extensive migration of young neurons into the infant human frontal lobe

scientific article

Ferret brain possesses young interneuron collections equivalent to human postnatal migratory streams

scientific article published on 15 May 2019

Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage.

scientific article published on 19 October 2017

Forkhead transcription factor FoxM1 regulates mitotic entry and prevents spindle defects in cerebellar granule neuron precursors.

scientific article published on 24 September 2007

Functional diversity of astrocytes in neural circuit regulation

scientific article published on December 2016

GDNF induces branching and increased cell proliferation in the ureter of the mouse.

scientific article published in December 1997

Glial specification in the vertebrate neural tube

scientific article published on May 2004

Glioma stem cells: a midterm exam.

scientific article published on June 2008

Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors.

scientific article published on 3 December 2003

Hedgehog signaling has a protective effect in glucocorticoid-induced mouse neonatal brain injury through an 11betaHSD2-dependent mechanism.

scientific article published on 26 January 2009

Heparan sulfate sulfatase SULF2 regulates PDGFRα signaling and growth in human and mouse malignant glioma ⬇️

scientific article published on February 1, 2012

Hypomyelinating leukodystrophies: translational research progress and prospects

scientific article

Identification of molecular compartments and genetic circuitry in the developing mammalian kidney ⬇️

scientific article

Identification of proliferative progenitors associated with prominent postnatal growth of the pons.

scientific article published on 18 May 2016

Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination.

scientific article

Inhibition of phosphatidylinositol 3-kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma.

scientific article published on August 2006

Insulin-like growth factor type 1 receptor signaling in the cells of oligodendrocyte lineage is required for normal in vivo oligodendrocyte development and myelination

scientific article published on March 2007

Interactions between DNA and coat protein in the structure and assembly of filamentous bacteriophage fd.

scientific article published on May 1987

Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength.

scientific article published on 5 April 2018

Lineage-Restricted OLIG2-RTK Signaling Governs the Molecular Subtype of Glioma Stem-like Cells.

scientific article published on September 2016

Malignant glioma: genetics and biology of a grave matter.

scientific article published in June 2001

Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells

scientific article published on August 2008

Missense mutation in mouse GALC mimics human gene defect and offers new insights into Krabbe disease ⬇️

scientific article published on April 24, 2013

Moderate-Grade Germinal Matrix Haemorrhage Activates Cell Division in the Neonatal Mouse Subventricular Zone

scientific article

Molecular diversity of astrocytes with implications for neurological disorders

scholarly article

Mouse brain organization revealed through direct genome-scale TF expression analysis

scientific article published on 01 December 2004

Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination

scientific article

Myelin regeneration in multiple sclerosis: targeting endogenous stem cells

scientific article published on October 2011

Myelin regeneration: a recapitulation of development?

scientific article published on January 2011

Myelin restoration: progress and prospects for human cell replacement therapies.

scientific article published on 02 April 2011

Myeloid cell interferon secretion restricts Zika flavivirus infection of developing and malignant human neural progenitor cells

scientific article published in 2022

N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth.

scientific article published in September 2006

NIH Consensus Development Conference statement: inhaled nitric-oxide therapy for premature infants.

scientific article published on 10 January 2011

Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination ⬇️

scientific article published on December 12, 2011

Neuronal vulnerability and multilineage diversity in multiple sclerosis

scientific article published on 17 July 2019

Neurotoxic reactive astrocytes are induced by activated microglia

scientific article

New Recipes for Myelinating Oligodendrocytes

scientific article published on 01 October 2018

Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination.

scholarly article

Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress

scientific article published on 30 April 2013

OLIG2 is differentially expressed in pediatric astrocytic and in ependymal neoplasms.

scientific article

Olig1 function is required for remyelination potential of transplanted neural progenitor cells in a model of viral-induced demyelination ⬇️

scientific article published on March 17, 2012

Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain

scientific article published on February 2014

Olig1 is required for noggin-induced neonatal myelin repair

scientific article published on 2 March 2017

Olig2 expression, GFAP, p53 and 1p loss analysis contribute to glioma subclassification

scientific article published on 01 February 2005

Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination

scientific article

Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors

scientific article

Oligodendrocyte regeneration after neonatal hypoxia requires FoxO1-mediated p27Kip1 expression

scientific article

Oligodendrocyte-encoded HIF function couples postnatal myelination and white matter angiogenesis

scientific article

Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity

scientific article published on 11 September 2018

On-chip perivascular <i>niche</i> supporting stemness of patient-derived glioma cells in a serum-free, flowable culture

scientific article published on 01 June 2021

Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas.

scientific article published on 12 January 2010

Origin and dynamics of oligodendrocytes in the developing brain: Implications for perinatal white matter injury.

scientific article published on 14 November 2017

Origin of oligodendrocytes in the subventricular zone of the adult brain.

scientific article

Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer

scientific article published on 09 March 2014

Phosphorylation state of Olig2 regulates proliferation of neural progenitors

scientific article

Postnatal growth of the human pons: a morphometric and immunohistochemical analysis.

scientific article

Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases.

scientific article

Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase

scientific article (publication date: 15 June 2001)

Reactive astrocyte COX2-PGE2 production inhibits oligodendrocyte maturation in neonatal white matter injury

scientific article published on 30 August 2017

Regional astrocyte allocation regulates CNS synaptogenesis and repair.

scientific article published on 28 June 2012

Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord.

scientific article

Reply to 'Assembling the brain trust: the multidisciplinary imperative in neuro-oncology'

scientific article published on 01 August 2019

Role of academic medical centers in cell-based therapeutic clinical trials ⬇️

scientific article published on January 25, 2011

Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2 ⬇️

scientific article published on December 1, 2012

Single-cell genomics identifies cell type-specific molecular changes in autism

scientific article

Single-cell reconstruction of the early maternal–fetal interface in humans

scientific article published in Nature

Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury.

scientific article published on 19 December 2016

Six3 promotes the formation of ectopic optic vesicle-like structures in mouse embryos

scientific journal article

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

scientific article published on 05 August 2009

Smaller inner ear sensory epithelia in Neurog 1 null mice are related to earlier hair cell cycle exit

scientific journal article

Sonic Hedgehog Agonist Protects Against Complex Neonatal Cerebellar Injury

scientific article

Sonic Hedgehog Is Required during an Early Phase of Oligodendrocyte Development in Mammalian Brain ⬇️

scientific article published on October 1, 2001

Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex.

scientific article published on May 2012

Sustaining careers of physician-scientists in neonatology and pediatric critical care medicine: formulating supportive departmental policies.

scientific article published on 19 July 2016

Synchronization of goat fibroblast cells at quiescent stage and determination of their transition from G0 to G1 by detection of cyclin D1 mRNA.

scientific article published on January 2004

Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes

scientific article published on 27 November 2017

Targeted therapy for BRAFV600E malignant astrocytoma.

scientific article published on 28 October 2011

The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors.

scientific article published on September 2005

The Role of the Neurointensive Care Nursery for Neonatal Encephalopathy.

scientific article

The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma

scientific article

The proneural gene Mash1 specifies an early population of telencephalic oligodendrocytes.

scientific article

The role of Tal2 and Tal1 in the differentiation of midbrain GABAergic neuron precursors.

scientific article published on 9 August 2013

The role of prenatal steroids at 34-36 weeks of gestation

scientific article published on 4 April 2017

Towards improved animal models of neonatal white matter injury associated with cerebral palsy.

scientific article published on November 2010

Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics

scientific article

Paulina is supported by:

About Paulina

Help