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List of works by Li Xie

A unified statistical model to support local sequence order independent similarity searching for ligand-binding sites and its application to genome-based drug discovery

scientific article published on June 2009

Delineation of Polypharmacology across the Human Structural Kinome Using a Functional Site Interaction Fingerprint Approach

scientific article

Drug Discovery Using Chemical Systems Biology: Weak Inhibition of Multiple Kinases May Contribute to the Anti-Cancer Effect of Nelfinavir ⬇️

scientific article published on April 28, 2011

Drug Off-Target Effects Predicted Using Structural Analysis in the Context of a Metabolic Network Model ⬇️

scientific article published on September 23, 2010

Drug discovery using chemical systems biology: identification of the protein-ligand binding network to explain the side effects of CETP inhibitors

scientific article

Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia ⬇️

scientific article published on May 28, 2013

Novel Computational Approaches to Polypharmacology as a Means to Define Responses to Individual Drugs ⬇️

scientific article (publication date: 10 February 2012)

Quantifying reproducibility in computational biology: the case of the tuberculosis drugome

scientific article

Structure-based systems biology for analyzing off-target binding ⬇️

scientific article published on February 1, 2011

The Mycobacterium tuberculosis drugome and its polypharmacological implications

scientific article

Towards structural systems pharmacology to study complex diseases and personalized medicine

scientific article (publication date: May 2014)

Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62.

scientific article

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