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Authors whose works are in public domain in at least one jurisdiction

List of works by Talal A Chatila

A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1

scientific article

A Jagged1-Notch4 Molecular Switch Mediates Airway Inflammation by Ultrafine Particles

scientific article published on 5 April 2018

A central role for induced regulatory T cells in tolerance induction in experimental colitis

scientific article published on March 2009

A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis

scientific article

A protein of the AP-1 family is a component of nuclear factor of activated T cells

scientific article published on 01 April 1993

A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity

scientific article published on 01 June 2018

A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma

scientific article published on 14 September 2020

A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity

scientific article

A simple twist of phosphate: Immunological synapse formation and T cell receptor signaling outcome in regulatory T cells.

scientific article published in December 2017

A syndrome involving immunodeficiency and multiple intestinal atresias

scientific article published on 01 January 1995

A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR.

scientific article

A young girl with severe cerebral fungal infection due to card 9 deficiency.

scientific article published on 4 January 2018

Activator protein-1 (AP-1) is stimulated by microbial superantigens in human monocytic cells.

scientific article published on September 1993

Advances in food allergy oral immunotherapy: toward tolerance.

scientific article

Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice

scientific article

Alternatively Activated Macrophages Boost Induced Regulatory T and Th17 Cell Responses during Immunotherapy for Colitis

scientific article published on 29 February 2016

An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells

scientific article published on August 2016

An immunodeficiency characterized by defective signal transduction in T lymphocytes

scientific article published on 01 March 1989

Antigen-specific Treg cells in immunological tolerance: implications for allergic diseases.

scientific article

Association of neuronal pp60c-src with growth cone glycoproteins of rat brain

scientific article published on September 1, 1992

Author Correction: A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma

scientific article published on 19 November 2020

Author Correction: Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy

scientific article published on 01 September 2019

CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes

scientific article

CD4(+)CD25(hi)Foxp3(+) Cells Exacerbate Bleomycin-Induced Pulmonary Fibrosis

scientific article published on 15 June 2016

CTLA-4 haploinsufficiency in a patient with an autoimmune lymphoproliferative disorder

scientific article published on 30 March 2017

Ca(2+)-dependent gene expression mediated by MEF2 transcription factors.

scientific article

Calcium calmodulin-dependent protein kinase IV is required for fear memory

scientific article published in June 2002

Calcium-dependent activation of TNF family gene expression by Ca2+/calmodulin kinase type IV/Gr and calcineurin

scientific article published on 01 February 1999

Cellular and molecular mechanisms of immune activation by microbial superantigens: studies using toxic shock syndrome toxin-1

scientific article published on January 1, 1992

Clinical, Immunological and Genetic Spectrum of 696 Patients with Combined Immunodeficiency.

scientific article published on 12 September 2017

Clinical, immunologic and genetic profiles of DOCK8-deficient patients in Kuwait

scientific article published on 30 March 2012

Contribution of CaMKIV to injury and fear-induced ultrasonic vocalizations in adult mice.

scientific article

Control of cortical axon elongation by a GABA-driven Ca2+/calmodulin-dependent protein kinase cascade.

scientific article published on October 2009

Control of peripheral tolerance by regulatory T cell-intrinsic Notch signaling.

scientific article

Correction: Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome

scientific article published on 01 June 2020

Corrigendum: Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56bright NKG2A+++ Cells, and Yet Display Increased Degranulation and Higher Perforin Conten

scientific article published on 10 October 2017

Corrigendum: Primary Immunodeficiency Diseases: An Update on the Classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency.

scientific article

Critical function of the CD40 pathway in parvovirus B19 infection revealed by a hypomorphic CD40 ligand mutation

scientific article published on 05 October 2005

Crouching tigers, hidden dragons: the interplay of pathogens and hosts.

scientific article published in May 2009

Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation

scientific article

DOCK8 Deficiency Presenting as an IPEX-Like Disorder.

scientific article

DOCK8 and STAT3 dependent inhibition of IgE isotype switching by TLR9 ligation in human B cells.

scientific article published on 4 September 2017

DOCK8 deficiency: Insights into pathophysiology, clinical features and management.

scientific article

DOCK8 deficiency: clinical and immunological phenotype and treatment options - a review of 136 patients

scientific article

DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation

scientific article

DOCK8 immune deficiency as a model for primary cytoskeletal dysfunction.

scientific article published on January 2010

Deciphering the black box of food allergy mechanisms.

scientific article published on January 2017

Dedicator of cytokinesis 8 regulates signal transducer and activator of transcription 3 activation and promotes TH17 cell differentiation.

scientific article published on 24 May 2016

Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells

scientific article

Defective expression of early activation genes in cartilage-hair hypoplasia (CHH) with severe combined immunodeficiency (SCID)

scientific article published on 01 October 1995

Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM

scientific article

Defects along the T(H)17 differentiation pathway underlie genetically distinct forms of the hyper IgE syndrome

scientific article

Deficient T Cell Receptor Excision Circles (TRECs) in autosomal recessive hyper IgE syndrome caused by DOCK8 mutation: implications for pathogenesis and potential detection by newborn screening.

scientific article

Developmental regulation of transmembrane signaling via the T cell antigen receptor/CD3 complex in human T lymphocytes.

scientific article published in March 1992

Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy ⬇️

scientific article published on November 14, 2012

Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome

scientific article published on 01 June 2020

EROS mutations: decreased NADPH oxidase function and chronic granulomatous disease

scientific article published on 09 October 2018

Early activation events induced by the staphylococcal superantigen toxic shock syndrome toxin-1 in human peripheral blood monocytes

scientific article published on 01 February 1994

Editorial: Optimizing iTreg differentiation: STATs in the balance

scientific article published on 01 February 2014

Engagement of MHC class II molecules by staphylococcal superantigens activates src-type protein tyrosine kinases

scientific article published on 01 March 1994

Engagement of MHC-class II molecules by staphylococcal exotoxins delivers a comitogenic signal to human B cells

scientific article published on 01 March 1991

Engagement of the common leukocyte antigen CD45 induces homotypic adhesion of activated human T cells

scientific article published on 01 August 1994

Epitope-specific crosslinking of CD45 down-regulates membrane-associated tyrosine phosphatase activity and triggers early signalling events in human activated T cells

scientific article published in December 2004

Evidence for a role of CaMKIV in the development of opioid analgesic tolerance.

scientific article published in April 2006

Exaggerated follicular helper T-cell responses in patients with LRBA deficiency caused by failure of CTLA4-mediated regulation.

scientific article published on 7 June 2017

Extra-intestinal manifestations of gastro-intestinal allergy: effector and regulatory T cells in the balance

scientific article published on 01 October 2007

FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune disease.

scientific article

Flow cytometry biomarkers distinguish DOCK8 deficiency from severe atopic dermatitis.

scientific article published on 31 December 2013

Flow cytometry diagnosis of dedicator of cytokinesis 8 (DOCK8) deficiency.

scientific article published in April 2014

Food allergy: Insights into etiology, prevention, and treatment provided by murine models.

scientific article published on February 2014

Fox family ties.

scientific article published on 15 January 2013

Foxp3: shades of tolerance

scientific article published on May 2012

Functional reprogramming of regulatory T cells in the absence of Foxp3

scientific article published on 05 August 2019

GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells

scientific article

Gene-environment interaction between an IL4R variant and school endotoxin exposure contributes to asthma symptoms in inner-city children

scientific article published on 21 September 2017

Genetics of atopic diseases

scientific article published on 01 December 1998

Glucagon regulates ACC activity in adipocytes through the CAMKKβ/AMPK pathway

scientific article

HIV glycoprotein gp120 inhibits TCR-CD3-mediated activation of fyn and lck

scientific article published on 01 January 1997

Hematopoietic Stem Cell Transplantation in Patients with Heterozygous STAT1 Gain-of-Function Mutation.

scientific article published on 13 December 2018

Hematopoietic stem cell transplantation outcomes for 11 patients with dedicator of cytokinesis 8 deficiency

scientific article published on 6 April 2016

IL-10 produced by induced regulatory T cells (iTregs) controls colitis and pathogenic ex-iTregs during immunotherapy

scientific article published on 2 November 2012

IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function.

scientific article published on 18 April 2016

ILC3 deficiency and generalized ILC abnormalities in DOCK8-deficient patients

scientific article published on 09 October 2019

Identification of a novel mutation in ZAP70 and prenatal diagnosis in a Turkish family with severe combined immunodeficiency disorder

scientific article published on 2 November 2012

Identification of an interleukin 13-induced epigenetic signature in allergic airway inflammation.

scientific article

Idiopathic systemic capillary leak syndrome: novel therapy for acute attacks.

scientific article published on 22 August 2009

IgE-mediated systemic anaphylaxis and impaired tolerance to food antigens in mice with enhanced IL-4 receptor signaling

scientific article

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-related disorders: an evolving web of heritable autoimmune diseases.

scientific article

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome associated with neonatal epidermolysis bullosa acquisita.

scientific article published on 17 March 2015

Immunoglobulin E signal inhibition during allergen ingestion leads to reversal of established food allergy and induction of regulatory T cells

scientific article

Immunoglobulin replacement therapy in children

scientific article published on November 2008

Immunotherapy with iTreg and nTreg Cells in a Murine Model of Inflammatory Bowel Disease

scientific article published in January 2016

Impaired memory of eyeblink conditioning in CaMKIV KO mice.

scientific article

Impaired synaptic plasticity and cAMP response element-binding protein activation in Ca2+/calmodulin-dependent protein kinase type IV/Gr-deficient mice

scientific journal article

In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif

scientific article

Increased prevalence of mutations in the cystic fibrosis transmembrane conductance regulator in children with chronic rhinosinusitis

scientific article published on 01 January 2002

Induction of interleukin-6 after stimulation of human B-cell CD21 by Epstein-Barr virus glycoproteins gp350 and gp220.

scientific article published on January 1996

Inhaled alpha1-antitrypsin administered to treat pneumatocele in autosomal dominant hyperimmunoglobulin E syndrome

scientific article published in January 2013

Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections

scientific article published on June 2015

Innate Immunity in Asthma.

scientific article published on August 2016

Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis

scientific article

Interleukin-4 receptor signaling pathways in asthma pathogenesis

scientific article

International Union of Immunological Societies: 2017 Primary Immunodeficiency Diseases Committee Report on Inborn Errors of Immunity.

scientific article published on 11 December 2017

Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome

scientific article

Light microscopic, immunophenotypic, and molecular genetic study of autoimmune lymphoproliferative syndrome caused by fas mutation

scientific article published on 01 January 2000

Long-term memory deficits in Pavlovian fear conditioning in Ca2+/calmodulin kinase kinase alpha-deficient mice

scientific article

Mechanism of mononuclear cell activation by an anti-CD43 (sialophorin) agonistic antibody

scientific article published on 01 June 1989

Mechanisms of Dupilumab

scientific article published on 30 September 2019

Mechanisms of T cell activation by the calcium ionophore ionomycin.

scientific article published in August 1989

Microbial superantigens induce NF-kappa B in the human monocytic cell line THP-1.

scientific article

Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy

scientific article published on 24 June 2019

Molecular basis of a multiple lymphokine deficiency in a patient with severe combined immunodeficiency

scientific article

Molecular mechanisms of regulatory T cell development.

scientific article published on 2 September 2008

Molecular mechanisms of regulatory T-cell development.

scientific article published on January 2008

Monogenic Hashimoto thyroiditis associated with a variant in the thyroglobulin (TG) gene

scientific article

Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease

scientific article published on 01 March 2000

MyD88 Adaptor-Dependent Microbial Sensing by Regulatory T Cells Promotes Mucosal Tolerance and Enforces Commensalism

scientific article

MyD88 is critically involved in immune tolerance breakdown at environmental interfaces of Foxp3-deficient mice

scientific article published on 2 April 2012

NF-kappaB and the innate immune response in the respiratory distress syndrome of the newborn: commentary on the article by Cheah et al. on page 616.

scientific article published on 17 March 2005

Natural Killer (NK) cell deficiency associated with an epitope-deficient Fc receptor type IIIA (CD16-II)

scientific article published on 01 March 1996

Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56bright NKG2A+++ Cells, and Yet Display Increased Degranulation and Higher Perforin Content

scientific article

Novel immune deficiencies: defective transcription of lymphokine genes

scientific article published on 01 November 1991

Novel immune deficiencies: defective transcription of lymphokine genes

scientific article published on 01 January 1991

Oral immunotherapy induces IgG antibodies that act through FcγRIIb to suppress IgE-mediated hypersensitivity

scientific article

Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma

scientific article published on 21 September 2009

Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects

scientific article published on 04 May 2018

Phenotypic and Functional Characterization of Regulatory T Cell Populations

scientific article published on 15 November 2018

Phosphorylation of T cell membrane proteins by activators of protein kinase C

scientific article published on 01 June 1988

Plasmacytoid dendritic cell depletion in DOCK8 deficiency: rescue of severe herpetic infections with IFN-α 2b therapy

scientific article

Primary Immune Deficiency Treatment Consortium (PIDTC) report

scientific article published on 15 October 2013

Primary Immunodeficiency Diseases: an Update on the Classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency 2015.

scientific article

Primary combined immunodeficiency resulting from defective transcription of multiple T-cell lymphokine genes.

scientific article

Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency

scientific article published in 2014

Reactivation of Epstein-Barr virus: regulation and function of the BZLF1 gene.

scientific article published on October 1997

Recombinant interleukin 2 therapy in severe combined immunodeficiency disease

scientific article

Regulation of microtubule dynamics by Ca2+/calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18

scientific article

Regulation of osteoclast differentiation and function by the CaMK-CREB pathway.

scientific article published on 26 November 2006

Regulatory T Cells: the Many Faces of Foxp3

scientific article published on 02 September 2019

Regulatory T cell development in the absence of functional Foxp3.

scientific article published on 2 February 2007

Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy

scientific article

Regulatory T cells dynamically control the primary immune response to foreign antigen

scientific article published on 01 March 2007

Regulatory T cells in allergic diseases.

scientific article

Regulatory T cells: exosomes deliver tolerance

scientific article

Regulatory T cells: key players in tolerance and autoimmunity.

scientific article published on June 2009

Regulatory T-cell deficiency and immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like disorder caused by loss-of-function mutations in LRBA.

scientific article

Renal involvement in the immunodysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) disorder

scientific article published on 25 April 2015

Requirement for Ca2+/calmodulin-dependent kinase type IV/Gr in setting the thymocyte selection threshold.

scientific article published in December 2001

Requirement for mitogen, T cell-accessory cell contact, and interleukin 1 in the induction of resting T-cell proliferation

scientific article published on 01 August 1987

Requirements for activation of human peripheral blood T cells by mouse monoclonal antibodies to CD3

scientific article published on 01 April 1987

Response of refractory Kawasaki disease to pulse steroid and cyclosporin A therapy

scientific article (publication date: June 2001)

Role of protein kinase activation in the induction of B cell adhesion by MHC class II ligands

scientific article published on 01 September 1992

Role of protein tyrosine phosphorylation in monokine induction by the staphylococcal superantigen toxic shock syndrome toxin-1 ⬇️

scientific article published on April 1, 1992

Role of regulatory T cells in human diseases.

scientific article

Ruxolitinib reverses dysregulated T helper cell responses and controls autoimmunity caused by a novel signal transducer and activator of transcription 1 (STAT1) gain-of-function mutation.

scientific article published on 23 January 2017

Selective engagement of plasticity mechanisms for motor memory storage.

scientific article published in September 2006

Severe Early-Onset Combined Immunodeficiency due to Heterozygous Gain-of-Function Mutations in STAT1

scientific article

Severe combined immunodeficiency with selective T-cell cytokine genes

scientific article published on 01 January 1993

Signal transduction by microbial superantigens via MHC class II molecules.

scientific article published on February 1993

Signal transduction via leukocyte antigen CD43 (sialophorin). Feedback regulation by protein kinase C

scientific article published on 01 February 1990

Signals delivered via MHC class II molecules synergize with signals delivered via TCR/CD3 to cause proliferation and cytokine gene expression in T cells

scientific article published on 01 July 1992

Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4<sup>+</sup> T cell perturbations

scientific article published on 08 April 2021

Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses.

scientific article published on 14 June 2010

Successful engraftment of donor marrow after allogeneic hematopoietic cell transplantation in autosomal-recessive hyper-IgE syndrome caused by dedicator of cytokinesis 8 deficiency.

scientific article

Successful interferon-alpha 2b therapy for unremitting warts in a patient with DOCK8 deficiency

scientific article

Superantigens

scientific article published on 01 February 1992

T Regulatory Cell Biology in Health and Disease.

scientific article published on March 2016

T cell receptor (TCR)-transgenic CD8 lymphocytes rendered insensitive to transforming growth factor beta (TGFβ) signaling mediate superior tumor regression in an animal model of adoptive cell therapy

scientific article

T cell receptor transgenic lymphocytes infiltrating murine tumors are not induced to express foxp3.

scientific article published on 23 November 2011

T-cell effector pathways in allergic diseases: transcriptional mechanisms and therapeutic targets.

scientific article published on April 2008

T-regulatory cells in primary immune deficiencies

scientific article

Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation

scientific article

Temporal Regulation by Innate Type 2 Cytokines in Food Allergies

scientific article

The 2015 IUIS Phenotypic Classification for Primary Immunodeficiencies

scientific article

The 2017 IUIS Phenotypic Classification for Primary Immunodeficiencies

scientific article published on 11 December 2017

The Association of Atopy with a Gain-of-Function Mutation in the α Subunit of the Interleukin-4 Receptor ⬇️

scientific article published on December 11, 1997

The Epstein-Barr virus-induced Ca2+/calmodulin-dependent kinase type IV/Gr promotes a Ca(2+)-dependent switch from latency to viral replication.

scientific article

The T cell receptor associated CD3-epsilon protein is phosphorylated upon T cell activation in the two tyrosine residues of a conserved signal transduction motif

scientific article published on 01 July 1993

The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency

scientific article

The regulatory T cell transcriptosome: E pluribus unum

scientific article

The role of the gut microbiota in food allergy.

scientific article published on 28 September 2016

Toxic Shock Syndrome Toxin-1, Toxic Shock, and the Immune System ⬇️

scientific article published on January 1, 1991

Toxic shock syndrome toxin-1 induces inositol phospholipid turnover, protein kinase C translocation, and calcium mobilization in human T cells

scientific article published on 01 February 1988

Transcriptional activation of the human TNF-alpha promoter by superantigen in human monocytic cells: role of NF-kappa B ⬇️

scientific article published on July 15, 1995

Vehicular exhaust particles promote allergic airway inflammation through an aryl hydrocarbon receptor-notch signaling cascade

scientific article

WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis

scientific article

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