List of works by Lucy R Wedderburn

A Bayesian semiparametric Markov regression model for juvenile dermatomyositis

scientific article published on 20 February 2018

A novel dried blood spot-LCMS method for the quantification of methotrexate polyglutamates as a potential marker for methotrexate use in children

scientific article

A subgroup of juvenile idiopathic arthritis patients who respond well to methotrexate are identified by the serum biomarker MRP8/14 protein.

scientific article published on 25 April 2013

Adaptation of the methotrexate in rheumatoid arthritis knowledge questionnaire (MiRAK) for use with parents of children with juvenile idiopathic arthritis: a qualitative study

scientific article published on 03 July 2013

Adult and juvenile dermatomyositis: are the distinct clinical features explained by our current understanding of serological subgroups and pathogenic mechanisms?

scientific article published on 8 April 2013

Advances in the treatment of polyarticular juvenile idiopathic arthritis

scientific article

Age-dependent inhibition of ectopic calcification: a possible role for fetuin-A and osteopontin in patients with juvenile dermatomyositis with calcinosis

scientific article published on 29 April 2008

Agreement between proxy and adolescent assessment of disability, pain, and well-being in juvenile idiopathic arthritis

scientific article published in February 2011

Allogeneic hematopoietic stem cell transplantation for severe, refractory juvenile idiopathic arthritis

scientific article published on 01 April 2018

An extra molecule in addition to human tapasin is required for surface expression of beta2m linked HLA-B4402 on murine cell.

scientific article published on 10 May 2007

Analysis of the T-cell receptor repertoire of synovial T-cells

scientific article published on 01 January 2007

Anti-BiP antibody levels in juvenile idiopathic arthritis (JIA)

scientific article published on 01 October 2004

Anti-HMGCR Autoantibodies in Juvenile Idiopathic Inflammatory Myopathies Identify a Rare but Clinically Important Subset of Patients.

scientific article

Anti-MDA5 autoantibodies in juvenile dermatomyositis identify a distinct clinical phenotype: a prospective cohort study

scientific article

Association between duration of symptoms and severity of disease at first presentation to paediatric rheumatology: results from the Childhood Arthritis Prospective Study

scientific article published on 16 April 2008

Association of the 5-aminoimidazole-4-carboxamide ribonucleotide transformylase gene with response to methotrexate in juvenile idiopathic arthritis

scientific article

Association of the IL-10 gene family locus on chromosome 1 with juvenile idiopathic arthritis (JIA).

scientific article

Autoantibodies in juvenile-onset myositis: Their diagnostic value and associated clinical phenotype in a large UK cohort

scientific article published on 26 June 2017

Autoantibodies to a 140-kd protein in juvenile dermatomyositis are associated with calcinosis.

scientific article published on June 2009

Autologous haematopoeitic stem cell rescue (AHSCR) for severe rheumatic disease in children: guidance for BSPAR members--executive summary

scientific article published on 31 October 2006

Autologous stem cell transplantation for paediatric-onset polyarteritis nodosa: changes in autoimmune phenotype in the context of reduced diversity of the T- and B-cell repertoires, and evidence for reversion from the CD45RO(+) to RA(+) phenotype

scientific article published on 01 November 2001

Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: analysis of clinical effects, mortality, and transplant related morbidity

scientific article published on October 2004

Biologic predictors of extension of oligoarticular juvenile idiopathic arthritis as determined from synovial fluid cellular composition and gene expression.

scientific article

Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: a cross-sectional study.

scientific article

Brief Report: Innate lymphoid cells and T-cells contribute to the IL-17A signature detected in the synovial fluid of patients with Juvenile Idiopathic Arthritis

article

Brief Report: The Genetic Profile of Rheumatoid Factor-Positive Polyarticular Juvenile Idiopathic Arthritis Resembles That of Adult Rheumatoid Arthritis.

scientific article published on 9 February 2018

CD161 defines the subset of FoxP3+ T cells capable of producing proinflammatory cytokines.

scientific article published on 25 January 2013

CD161+ Tconv and CD161+ Treg Share a Transcriptional and Functional Phenotype despite Limited Overlap in TCRβ Repertoire

scientific article published on 06 March 2017

CD19+CD24hiCD38hi B Cells Are Expanded in Juvenile Dermatomyositis and Exhibit a Pro-Inflammatory Phenotype After Activation Through Toll-Like Receptor 7 and Interferon-α.

scientific article published on 22 June 2018

CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis.

scientific article published in May 2004

Calcinosis in juvenile dermatomyositis is influenced by both anti-NXP2 autoantibody status and age at disease onset

scientific article

Chronic shoulder pain in rheumatoid arthritis: Authors' Reply.

scientific article

Clinical associations of autoantibodies to a p155/140 kDa doublet protein in juvenile dermatomyositis

scientific article published on 30 January 2008

Clonal Expansions in Acute EBV Infection Are Detectable in the CD8 and not the CD4 Subset and Persist with a Variable CD45 Phenotype

scientific article published on 01 November 2000

Comparing and contrasting clinical and serological features of juvenile and adult-onset myositis: implications for pathogenesis and outcomes

scientific article published on 08 September 2015

Comparison of the utility and validity of three scoring tools to detect skin disease in patients with juvenile dermatomyositis.

scientific article published on 17 September 2014

Consensus-based recommendations for the management of juvenile dermatomyositis.

scientific article published on 11 August 2016

Correlation of low CD73 expression on synovial lymphocytes with reduced adenosine generation and higher disease severity in juvenile idiopathic arthritis.

scientific article published on February 2015

Crystallization and preliminary X-ray analysis of mouse RANK and its complex with RANKL ⬇️

scientific article published on 22 May 2009

Current developments in the use of biomarkers for juvenile idiopathic arthritis.

scientific article published on March 2014

Delineation of the innate and adaptive T-cell immune outcome in the human host in response to Campylobacter jejuni infection.

scientific article

Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis.

scientific article

Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups

scientific article published on 11 September 2015

Depressive symptoms, pain and disability for adolescent patients with juvenile idiopathic arthritis: results from the Childhood Arthritis Prospective Study.

scientific article

Developing and Evaluating JIApp: Acceptability and Usability of a Smartphone App System to Improve Self-Management in Young People With Juvenile Idiopathic Arthritis

scientific article published on 15 August 2017

Development of an internationally agreed minimal dataset for juvenile dermatomyositis (JDM) for clinical and research use.

scientific article published on 12 June 2015

Disease activity and disability in children with juvenile idiopathic arthritis one year following presentation to paediatric rheumatology. Results from the Childhood Arthritis Prospective Study

scientific article

Divergence in the degree of clonal expansions in inflammatory T cell subpopulations mirrors HLA-associated risk alleles in genetically and clinically distinct subtypes of childhood arthritis

scientific article published on 01 December 2001

Do mothers and fathers hold similar views about their child's arthritis?

scientific article published in December 2009

Duration of etanercept treatment and reasons for discontinuation in a cohort of juvenile idiopathic arthritis patients.

scientific article published on 3 November 2010

Efficacy and safety of cyclophosphamide treatment in severe juvenile dermatomyositis shown by marginal structural modelling

scientific article published on 17 January 2018

Enhancing translational research in paediatric rheumatology through standardization

scientific article published on 22 September 2016

Expression of miRNAs miR-133b and miR-206 in the Il17a/f locus is co-regulated with IL-17 production in αβ and γδ T cells

scientific article published on 26 May 2011

Expression of myxovirus-resistance protein A: a possible marker of muscle disease activity and autoantibody specificities in juvenile dermatomyositis

scientific article published on 4 June 2018

Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells

scientific article

Factors affecting TCR-repertoire diversity

scientific article published on 01 January 1994

Failure to over express MHC-CLASS-1 on muscle biopsy in a case of amyopathic juvenile dermatomyositis

scientific article published on 01 January 2007

Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases

scientific article published on 20 December 2016

Focused HLA analysis in Caucasians with myositis identifies significant associations with autoantibody subgroups

scientific article published on 28 May 2019

Generation of novel pharmacogenomic candidates in response to methotrexate in juvenile idiopathic arthritis: correlation between gene expression and genotype.

scientific article

Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications

article

Genetic association study of NF-κB genes in UK Caucasian adult and juvenile onset idiopathic inflammatory myopathy.

scientific article published on 30 December 2011

Genetics: Mapping autoimmune disease epigenetics: what's on the horizon?

scientific article published on 16 December 2014

Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes.

scientific article

Genome-wide association study of dermatomyositis reveals genetic overlap with other autoimmune disorders

scientific article published on December 2013

Genotyping of immune-related genetic variants identifies TYK2 as a novel associated locus for idiopathic inflammatory myopathies.

scientific article published on 7 May 2014

Gold-induced colitis

scientific article published on 01 June 1989

Growth patterns in early juvenile idiopathic arthritis: Results from the Childhood Arthritis Prospective Study (CAPS).

scientific article published on 7 November 2017

HLA class II haplotype and autoantibody associations in children with juvenile dermatomyositis and juvenile dermatomyositis-scleroderma overlap.

scientific article published on 14 November 2007

HLA-DPB1 associations differ between DRB1*03 positive anti-Jo-1 and anti-PM-Scl antibody positive idiopathic inflammatory myopathy

scientific article published on 18 August 2009

HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis

scientific article

Histological heterogeneity in a large clinical cohort of juvenile idiopathic inflammatory myopathy: analysis by myositis autoantibody and pathological features

scientific article published on 11 March 2019

How common is clinically inactive disease in a prospective cohort of patients with juvenile idiopathic arthritis? The importance of definition

scientific article published on 7 April 2017

Hsp60 in inflamed muscle tissue is the target of regulatory autoreactive T cells in patients with juvenile dermatomyositis

scientific article published on 01 February 2008

Human dendritic cells infected with an adenoviral vector suppress proliferation of autologous and allogeneic T cells

scientific article

Hypomethylation at the regulatory T cell-specific demethylated region in CD25hi T cells is decoupled from FOXP3 expression at the inflamed site in childhood arthritis.

scientific article

IL1RN Variation Influences both Disease Susceptibility and Response to Human Recombinant IL-1RA Therapy in Systemic Juvenile Idiopathic Arthritis.

scientific article published on 2 April 2018

Immunological characteristics and T-cell receptor clonal diversity in children with systemic juvenile idiopathic arthritis undergoing T-cell-depleted autologous stem cell transplantation

scientific article

Increased presence of FOXP3+ regulatory T cells in inflamed muscle of patients with active juvenile dermatomyositis compared to peripheral blood

scientific article

Influence of past breast feeding on pattern and severity of presentation of juvenile idiopathic arthritis

scientific article published on 14 September 2015

Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers.

scientific article published on March 2008

International consensus on a proposed score system for muscle biopsy evaluation in patients with juvenile dermatomyositis: a tool for potential use in clinical trials.

scientific article published on October 2007

Juvenile arthritis disease activity score is a better reflector of active disease than the disease activity score 28 in adults with polyarticular juvenile idiopathic arthritis.

scientific article published on 29 December 2015

Juvenile chronic arthritis

scientific article published on 01 March 1998

Juvenile chronic arthritis and Wegener's granulomatosis

scientific article published on 01 February 1992

Juvenile dermatomyositis: Latest advances

scientific article published on 01 August 2017

Juvenile dermatomyositis: new developments in pathogenesis, assessment and treatment.

scientific article

Juvenile dermatomyositis: new insights and new treatment strategies.

scientific article

Juvenile dermatomyositis: novel treatment approaches and outcomes

scientific article published on 01 November 2018

Juvenile-onset inflammatory arthritis: a study of adolescents' beliefs about underlying cause

scientific article

Labeling antigen-specific CD4(+) T cells with class II MHC oligomers.

scientific article

Long-Term Outcomes Following Achievement of Clinically Inactive Disease in Juvenile Idiopathic Arthritis: The Importance of Definition

scientific article published on 22 July 2018

Long-term follow-up of autologous stem cell transplantation for refractory juvenile idiopathic arthritis.

scientific article published in August 2003

MHC Class I overexpression on muscles in early juvenile dermatomyositis

scientific article published on 01 March 2004

MRP8/14 serum levels as a predictor of response to starting and stopping anti-TNF treatment in juvenile idiopathic arthritis.

scientific article published on 7 August 2015

Methotrexate polyglutamates as a potential marker of adherence to long-term therapy in children with juvenile idiopathic arthritis and juvenile dermatomyositis: an observational, cross-sectional study

scientific article

Methotrexate withdrawal at 6 vs 12 months in juvenile idiopathic arthritis in remission: a randomized clinical trial

scientific article

Modelling disease activity in juvenile dermatomyositis: A Bayesian approach.

scientific article published on January 2017

Morphometric analyses of normal pediatric brachial biceps and quadriceps muscle tissue.

scientific article published on 08 February 2013

Muscle Biopsy Findings in Combination With Myositis-Specific Autoantibodies Aid Prediction of Outcomes in Juvenile Dermatomyositis

scientific article published on 23 May 2016

Outcome assessment after epidural corticosteroid injection for low back pain and sciatica

scientific article published on 01 August 1993

Overexpression of MHC class I heavy chain protein in young skeletal muscle leads to severe myositis: implications for juvenile myositis

scientific article published on 21 August 2009

Paediatric idiopathic inflammatory muscle disease: recognition and management.

scientific article

Paediatric rheumatology: a bright future in the UK and Europe

scientific article published on 16 February 2005

Patient-reported wellbeing and clinical disease measures over time captured by multivariate trajectories of disease activity in individuals with juvenile idiopathic arthritis in the UK: a multicentre prospective longitudinal study

scientific article published on 04 December 2020

Patterns of pain over time among children with juvenile idiopathic arthritis

scientific article published on 25 November 2017

Pediatric rheumatic disease: can molecular profiling predict the future in JIA?

scientific article published on 01 November 2009

Phagocyte-specific S100 proteins and high-sensitivity C reactive protein as biomarkers for a risk-adapted treatment to maintain remission in juvenile idiopathic arthritis: a comparative study

scientific article published on 11 June 2012

Quantification of normal range of inflammatory changes in morphologically normal pediatric muscle

scientific article published on 01 February 2008

Quantitative assessment of MRI T2 relaxation time of thigh muscles in juvenile dermatomyositis.

scientific article published on 24 February 2004

Response to: 'Antisynthetase syndrome or what else? Different perspectives indicate the need for new classification criteria' by Cavagna et al.

scientific article published on 19 December 2017

S100A12 Is Associated with Response to Therapy in Juvenile Idiopathic Arthritis.

scientific article published on 15 January 2018

SHARE – workpackage 5: evidence based recommendations for diagnosis and treatment of juvenile dermatomyositis.

scientific article published on 17 September 2014

Selective recruitment of polarized T cells expressing CCR5 and CXCR3 to the inflamed joints of children with juvenile idiopathic arthritis

scientific article published on 01 April 2000

Single-step immunosorbent preparation of F-protein from mouse liver with conservation of the allo-antigenic site, and determination of concentration in liver and serum

scientific article published on 01 October 1984

Strategies for the prevention and management of methotrexate-related nausea and vomiting in juvenile idiopathic arthritis: results of a UK Paediatric Rheumatology prescriber survey.

scientific article published on 23 July 2015

Structural and functional insights of RANKL-RANK interaction and signaling

scientific article

Synovial Regulatory T Cells Occupy a Discrete TCR Niche in Human Arthritis and Require Local Signals To Stabilize FOXP3 Protein Expression

scientific article

Synovial dendritic cells in juvenile idiopathic arthritis (JIA) express receptor activator of NF-kappaB (RANK)

scientific article published on 01 April 2003

T cell activation by coxsackievirus B4 antigens in type 1 diabetes mellitus: evidence for selective TCR Vbeta usage without superantigenic activity

scientific article published on 01 September 2001

T cell expression of granulocyte-macrophage colony-stimulating factor in juvenile arthritis is contingent upon Th17 plasticity.

scientific article

T cells at the turn of the twenty-first century

scientific article published on 01 March 2000

T regulatory cells in childhood arthritis--novel insights

scientific article published on 03 December 2013

T-cell control of Epstein–Barr virus-infected B cells is lost during P. falciparum malaria ⬇️

scientific article published on December 29, 1984

TCR dynamics on the surface of living T cells

scientific article published on 01 December 2001

Th1 and Th17 cell subpopulations are enriched in the peripheral blood of patients with systemic juvenile idiopathic arthritis

scientific article

Th17 and regulatory T cells: rebalancing pro- and anti-inflammatory forces in autoimmune arthritis.

scientific article published on 05 March 2009

Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment

scientific article

The EuroMyositis registry: an international collaborative tool to facilitate myositis research.

scientific article published on 30 August 2017

The Toll-like receptor 4 agonist MRP8/14 protein complex is a sensitive indicator for disease activity and predicts relapses in systemic-onset juvenile idiopathic arthritis.

scientific article published on 20 January 2012

The Vasculopathy of Juvenile Dermatomyositis: endothelial injury, hypercoagulability, and increased arterial stiffness

scientific article published on 04 January 2021

The association between low socioeconomic status with high physical limitations and low illness self-perception in patients with juvenile idiopathic arthritis: results from the Childhood Arthritis Prospective Study.

scientific article published on March 2015

The coming of age of adolescent rheumatology

scientific article published on 07 January 2014

The experience of taking methotrexate for juvenile idiopathic arthritis: results of a cross-sectional survey with children and young people.

scientific article

The lived experience of juvenile idiopathic arthritis in young people receiving etanercept.

scientific article

The protein tyrosine phosphatase N22 gene is associated with juvenile and adult idiopathic inflammatory myopathy independent of the HLA 8.1 haplotype in British Caucasian patients

scientific article

The transcription factor CREM drives an inflammatory phenotype of T cells in oligoarticular juvenile idiopathic arthritis.

scientific article published on 20 June 2018

Treatment of Juvenile Dermatomyositis: An Update.

scientific article published on 26 May 2017

Treatment prescribing patterns in patients with juvenile idiopathic arthritis (JIA): Analysis from the UK Childhood Arthritis Prospective Study (CAPS).

scientific article published on 08 June 2016

Trends in paediatric rheumatology referral times and disease activity indices over a ten-year period among children and young people with Juvenile Idiopathic Arthritis: results from the childhood arthritis prospective Study

scientific article published on 25 March 2016

Update in juvenile myositis

scientific article

Upregulation of MHC class I in transgenic mice results in reduced force-generating capacity in slow-twitch muscle.

scientific article published on May 2009

Validation of Relapse Risk Biomarkers for Routine Use in Patients With Juvenile Idiopathic Arthritis

scientific article published on 01 June 2014

Validity of a three-variable Juvenile Arthritis Disease Activity Score in children with new-onset juvenile idiopathic arthritis

scientific article published on 20 December 2012

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