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List of works by William Leenders

-mutated cancers are sensitive to the green tea polyphenol epigallocatechin-3-gallate

scientific article published on 20 May 2019

A Conjugate of an Anti-Epidermal Growth Factor Receptor (EGFR) VHH and a Cell-Penetrating Peptide Drives Receptor Internalization and Blocks EGFR Activation

scientific article published on 10 October 2017

ACLY (ATP Citrate Lyase) Mediates Radioresistance in Head and Neck Squamous Cell Carcinomas and is a Novel Predictive Radiotherapy Biomarker

scientific article published on 07 December 2019

Altered metabolic landscape in IDH-mutant gliomas affects phospholipid, energy, and oxidative stress pathways.

scientific article published on 20 October 2017

Antiangiogenic compounds interfere with chemotherapy of brain tumors due to vessel normalization.

scientific article published on 9 January 2008

Better effect of sorafenib on the rhabdoid component of a clear cell renal cell carcinoma owing to its higher level of vascular endothelial growth factor-A production

scientific article published on 01 September 2011

Characterisation of tumour vasculature in mouse brain by USPIO contrast-enhanced MRI.

scientific article published on 27 May 2008

Characterization of tumor vasculature in mouse brain by USPIO contrast-enhanced MRI.

scientific article

Cloning and production of functional active recombinant hepatitis B virus surface antigen binding protein.

scientific article published on November 1994

Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma

scientific article published on September 2016

Contrast enhanced susceptibility weighted imaging (CE-SWI) of the mouse brain using ultrasmall superparamagnetic ironoxide particles (USPIO).

scientific article published in January 2006

Design of a variant of vascular endothelial growth factor-A (VEGF-A) antagonizing KDR/Flk-1 and Flt-1

scientific article published on 01 April 2002

Development of luciferase tagged brain tumour models in mice for chemotherapy intervention studies

scientific article published on 5 October 2006

Development of the tumor vascular bed in response to hypoxia-induced VEGF-A differs from that in tumors with constitutive VEGF-A expression

scientific article published in November 2006

Effect of tyrosine kinase inhibitor treatment of renal cell carcinoma on the accumulation of carbonic anhydrase IX-specific chimeric monoclonal antibody cG250.

scientific article

Effects of dual targeting of tumor cells and stroma in human glioblastoma xenografts with a tyrosine kinase inhibitor against c-MET and VEGFR2

scientific article

Effects of targeting the VEGF and PDGF pathways in diffuse orthotopic glioma models.

scientific article

Effects of the Green Tea Polyphenol Epigallocatechin-3-Gallate on Glioma: A Critical Evaluation of the Literature.

scientific article

EpCAM-Binding DARPins for Targeted Photodynamic Therapy of Ovarian Cancer

scientific article published on 02 July 2020

Expression and clinical relevance of MET and ALK in Ewing sarcomas.

scientific article

Flow diverter implantation in a rat model of sidewall aneurysm: a feasibility study.

scientific article published on 8 February 2017

GABA, glutamine, glutamate oxidation and succinic semialdehyde dehydrogenase expression in human gliomas

scientific article published on 07 November 2018

Glioma: experimental models and reality

scientific article published on 10 January 2017

Glutamate as chemotactic fuel for diffuse glioma cells: are they glutamate suckers?

scientific article

Hepatitis delta virus attaches to human hepatocytes via human liver endonexin II, a specific HBsAg binding protein.

scientific article published in January 1994

Host and tissue tropism of hepatitis B virus ⬇️

scientific article published on April 1, 1992

Hypoxia-Mediated Mechanisms Associated with Antiangiogenic Treatment Resistance in Glioblastomas.

scientific article published on 8 March 2017

IDH1 R132H mutation generates a distinct phospholipid metabolite profile in glioma

scientific article

IN SITU METABOLIC PROFILING SHEDS LIGHT ON OXIDATIVE STRESS PATHWAYS IN IDH1 MUTANT OLIGODENDROGLIOMA.

scientific article published in July 2014

Identification of a novel MET mutation in high-grade glioma resulting in an auto-active intracellular protein

scientific article published on 11 April 2015

Identification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma.

scientific article published on 27 July 2016

Imaging liver metastases of colorectal cancer patients with radiolabelled bevacizumab: Lack of correlation with VEGF-A expression

scientific article published on 14 July 2008

Imaging of HIV-associated Kaposi sarcoma; F-18-FDG-PET/CT and In-111-bevacizumabscintigraphy

scientific article published on August 2010

In silico gene expression analysis reveals glycolysis and acetate anaplerosis in IDH1 wild-type glioma and lactate and glutamate anaplerosis in IDH1-mutated glioma

scientific article published on 13 April 2017

In vivo activities of mutants of vascular endothelial growth factor (VEGF) with differential in vitro activities.

scientific article

In vivo phage display screening for tumor vascular targets in glioblastoma identifies a llama nanobody against dynactin-1-p150Glued

scientific article

Increased mitochondrial activity in a novel IDH1-R132H mutant human oligodendroglioma xenograft model: in situ detection of 2-HG and α-KG.

scientific article published on 29 May 2013

Isocitrate dehydrogenase 1-mutated human gliomas depend on lactate and glutamate to alleviate metabolic stress

scientific article published on 12 July 2018

Isolation of targeting nanobodies against co-opted tumor vasculature.

scientific article

Legomedicine-A Versatile Chemo-Enzymatic Approach for the Preparation of Targeted Dual-Labeled Llama Antibody-Nanoparticle Conjugates

scientific article published on 3 January 2017

METB-09IDENTIFYING NOVEL VULNERABILITIES IN OXIDATIVE STRESS PATHWAYS IN IDH1 MUTANT GLIOMA.

scientific article

Mapping actionable pathways and mutations in brain tumours using targeted RNA next generation sequencing

scientific article published on 20 November 2019

Molecular Profiling of Druggable Targets in Clear Cell Renal Cell Carcinoma Through Targeted RNA Sequencing

scientific article published on 01 March 2019

Multivoxel ¹H MR spectroscopy is superior to contrast-enhanced MRI for response assessment after anti-angiogenic treatment of orthotopic human glioma xenografts and provides handles for metabolic targeting

scientific article published on 24 October 2013

Mutant IDH1 Differently Affects Redox State and Metabolism in Glial Cells of Normal and Tumor Origin

scientific article published on 16 December 2019

Mutants of basic fibroblast growth factor identify different cellular response programs

scientific article published on 01 January 1997

Nanobody-Functionalized Polymersomes for Tumor-Vessel Targeting ⬇️

scientific article published on May 21, 2013

Neoadjuvant sorafenib treatment of clear cell renal cell carcinoma and release of circulating tumor fragments

scientific article

PLEXIN-D1, a novel plexin family member, is expressed in vascular endothelium and the central nervous system during mouse embryogenesis

scientific article (publication date: November 2002)

Phenotypic and genotypic characterization of orthotopic human glioma models and its relevance for the study of anti-glioma therapy.

scientific article

Plexin D1 expression is induced on tumor vasculature and tumor cells: a novel target for diagnosis and therapy?

scientific article published in September 2005

Plexin D1 is ubiquitously expressed on tumor vessels and tumor cells in solid malignancies.

scientific article

Profiling of the metabolic transcriptome via single molecule molecular inversion probes.

scientific article published on 12 September 2017

Proteinaceous Regulators and Inhibitors of Protein Tyrosine Phosphatases.

scientific article published on 12 February 2018

Quantification and localization of oncogenic receptor tyrosine kinase variant transcripts using molecular inversion probes.

scientific article

Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198.

scientific article

Rapid and robust transgenic high-grade glioma mouse models for therapy intervention studies

scientific article

Recapitulating in vivo-like plasticity of glioma cell invasion along blood vessels and in astrocyte-rich stroma

scientific article published on 19 August 2017

Robotic injection of zebrafish embryos for high-throughput screening in disease models.

scientific article

Selective MET Kinase Inhibition in MET-Dependent Glioma Models Alters Gene Expression and Induces Tumor Plasticity.

scientific article published on 27 July 2017

Self-Assembling VHH-Elastin-Like Peptides for Photodynamic Nanomedicine.

scientific article published on 7 March 2017

Semaphorin 3E expression correlates inversely with Plexin D1 during tumor progression.

scientific article published on 30 October 2008

Specific imaging of VEGF-A expression with radiolabeled anti-VEGF monoclonal antibody

article

Synergism between temporally distinct growth factors: bFGF, insulin and lens cell differentiation

scientific article published on 01 October 1997

Targeted RNA next generation sequencing analysis of cervical smears can predict the presence of hrHPV-induced cervical lesions

scientific article published on 09 June 2022

Targeted therapies of cancer: Angiogenesis inhibition seems not enough ⬇️

scientific article published on December 18, 2010

Targeting Cyclin-Dependent Kinases in Synovial Sarcoma: Palbociclib as a Potential Treatment for Synovial Sarcoma Patients.

scientific article published on 22 June 2016

Targeting the extracellular matrix of ovarian cancer using functionalized, drug loaded lyophilisomes.

scientific article published on 26 December 2016

Targetting VEGF in anti-angiogenic and anti-tumour therapy: where are we now?

scientific article

The Importance of Wall Apposition in Flow Diverters.

scientific article published on 4 April 2018

The effect of subcellular localization on the efficiency of EGFR-targeted VHH photosensitizer conjugates

scientific article published on 20 December 2017

The endogenous anti-angiogenic VEGF isoform, VEGF165b inhibits human tumour growth in mice.

scientific article published on 18 March 2008

Tumor cells in search for glutamate: an alternative explanation for increased invasiveness of IDH1 mutant gliomas

scientific article published on 28 July 2014

Tumour control by whole brain irradiation of anti-VEGF-treated mice bearing intracerebral glioma.

scientific article

Vascular endothelial growth factor and semaphorin induce neuropilin-1 endocytosis via separate pathways.

scientific article published on 21 August 2008

Vascular endothelial growth factor in systemic capillary leak syndrome.

scientific article

Vascular endothelial growth factor receptor 2 inhibition in-vivo affects tumor vasculature in a tumor type-dependent way and downregulates vascular endothelial growth factor receptor 2 protein without a prominent role for miR-296.

scientific article

Vascular endothelial growth factor-A determines detectability of experimental melanoma brain metastasis in GD-DTPA-enhanced MRI.

scientific article published in July 2003

Vessel normalization by VEGF inhibition. A complex story.

scientific article

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