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List of works by Ignacio Melero, MD-PhD

106 Interferon-Producing Killer Dendritic Cells and Natural Killer Cells Response to Interleukin-15 Liver Gene Transfer

article

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

scientific article (publication date: November 2016)

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two: National Harbor, MD, USA. 9-13 November 2016

scientific article published oln 16 November 2016

4-1BB (CD137) in anticancer chimeras

scientific article published on 01 December 2020

A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C.

scientific article published on 4 March 2013

A network analysis of the human T-cell activation gene network identifies JAGGED1 as a therapeutic target for autoimmune diseases

scientific article

A randomized phase II clinical trial of dendritic cell vaccination following complete resection of colon cancer liver metastasis

scientific article published on 29 September 2018

A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity

scientific article published in Nature Communications

Abscopal Effects of Radiotherapy Are Enhanced by Combined Immunostimulatory mAbs and Are Dependent on CD8 T Cells and Crosspriming.

scientific article published on 22 August 2016

Abstract 4387: Antiviral and antitumoral effects of the anti-CTLA4 agent tremelimumab in patients with hepatocellular carcinoma (HCC) and chronic hepatitis C virus (HCV) infection: Results from a phase II clinical trial

Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes.

scientific article published on 25 January 2011

Agonist antibodies to TNFR molecules that costimulate T and NK cells

scientific article

Agonists of Co-stimulation in Cancer Immunotherapy Directed Against CD137, OX40, GITR, CD27, CD28, and ICOS.

scientific article published on 11 June 2015

An Integrative Approach to Inform Optimal Administration of OX40 Agonist Antibodies in Patients with Advanced Solid Tumors

scientific article published on 01 October 2019

An RNA toolbox for cancer immunotherapy

scientific article published on 07 September 2018

An anti-ICAM-2 (CD102) monoclonal antibody induces immune-mediated regressions of transplanted ICAM-2-negative colon carcinomas

scientific article

Anti-CD137 and PD-1/PD-L1 Antibodies En Route toward Clinical Synergy

scientific article published on 8 August 2017

Anti-CD137 monoclonal antibodies and adoptive T cell therapy: a perfect marriage?

scientific article published on 12 March 2016

Anti-ICAM-2 monoclonal antibody synergizes with intratumor gene transfer of interleukin-12 inhibiting activation-induced T-cell death

scientific article published on September 2003

Anti-PD1 associated fulminant myocarditis after a single pembrolizumab dose: the role of occult pre-existing autoimmunity.

scientific article published on 12 April 2018

Antibody-dependent cell cytotoxicity: immunotherapy strategies enhancing effector NK cells.

scientific article published on 31 January 2017

Antigen Cross-Presentation and T-Cell Cross-Priming In Cancer Immunology And Immunotherapy

scientific article published on September 2017

Antitumor immunotherapeutic and toxic properties of an HDL-conjugated chimeric IL-15 fusion protein.

scientific article

Association of inflammatory biomarkers with clinical outcomes in nivolumab-treated patients with advanced hepatocellular carcinoma

scientific article published on 22 July 2020

Awareness and understanding of cancer immunotherapy in Europe

scientific article

B7-H3 Promotes Pathogenesis of Autoimmune Disease and Inflammation by Regulating the Activity of Different T Cell Subsets

scientific article published on 11 June 2015

Better performance of CARs deprived of the PD-1 brake

scientific article published on 4 September 2013

Biologic therapy of liver tumors

scientific article published on April 2004

Bone-marrow-derived cell differentiation into microglia: a study in a progressive mouse model of Parkinson's disease.

scientific article

Brachytherapy attains abscopal effects when combined with immunostimulatory monoclonal antibodies

scientific article published on 21 August 2017

CD137 (4-1BB) Costimulation Modifies DNA Methylation in CD8+ T Cell-Relevant Genes.

scientific article published on 13 November 2017

CD137 (4-1BB) Signalosome: Complexity Is a Matter of TRAFs

scientific article published on 15 November 2018

CD137 on inflamed lymphatic endothelial cells enhances CCL21-guided migration of dendritic cells

scientific article published on 16 May 2012

CD4+/CD25+ regulatory cells inhibit activation of tumor-primed CD4+ T cells with IFN-gamma-dependent antiangiogenic activity, as well as long-lasting tumor immunity elicited by peptide vaccination.

scientific article published on December 2003

CD69 is a direct HIF-1α target gene in hypoxia as a mechanism enhancing expression on tumor-infiltrating T lymphocytes.

scientific article published on 19 January 2017

CD8 T cell priming in the presence of IFN-α renders CTLs with improved responsiveness to homeostatic cytokines and recall antigens: important traits for adoptive T cell therapy.

scientific article

CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity

scientific article published on 06 April 2020

Cancer Immunosurveillance Caught in the Act

scientific article published on 01 March 2016

Cancer Immunotherapy with Immunomodulatory Anti-CD137 and Anti-PD-1 Monoclonal Antibodies Requires BATF3-Dependent Dendritic Cells

scientific article published on 22 October 2015

Cancer Treatment with Anti-PD-1/PD-L1 Agents: Is PD-L1 Expression a Biomarker for Patient Selection?

scientific article published on 26 May 2016

Cancer immunotherapy resistance based on immune checkpoints inhibitors: Targets, biomarkers, and remedies

scientific article published on 15 July 2020

Carcinoma-derived interleukin-8 disorients dendritic cell migration without impairing T-cell stimulation

scientific article

Cardiotrophin-1 determines liver engraftment of syngenic colon carcinoma cells through an immune system-mediated mechanism

scientific article published on December 2012

Cell tracking using multimodal imaging.

scientific article

Cellular immunotherapies for cancer

scientific article

Cellular liaisons of natural killer lymphocytes in immunology and immunotherapy of cancer

scientific article published on May 2007

Changing the Tumor Microenvironment: New Strategies for Immunotherapy ⬇️

scientific article published on July 23, 2012

Científicos españoles con los Dres. Greg Winter y Richard A. Lerner, premios Príncipe de Asturias en Investigación Científica y Técnica 2012

article

Classification of current anticancer immunotherapies

scientific article

Clinical Experiences With Anti-CD137 and Anti-PD1 Therapeutic Antibodies ⬇️

scientific article published on October 1, 2010

Clinical benefit associated with idiotypic vaccination in patients with follicular lymphoma

scientific article published on 01 September 2006

Clinical development of combination strategies in immunotherapy: are we ready for more than one investigational product in an early clinical trial?

scientific article published on September 2009

Clinical development of immunostimulatory monoclonal antibodies and opportunities for combination.

scientific article published on March 2013

Clinical implications of antigen transfer mechanisms from malignant to dendritic cells. exploiting cross-priming.

scientific article

Combinations of immunostimulatory antibodies with synergistic effects against spontaneous cancer

scientific article published on 16 January 2014

Combined immunostimulatory monoclonal antibodies extend survival in an aggressive transgenic hepatocellular carcinoma mouse model.

scientific article published on 12 September 2013

Consensus nomenclature for CD8(+) T cell phenotypes in cancer

scientific article published on 25 February 2015

Cytokines in clinical cancer immunotherapy

scientific article published on 09 November 2018

Daratumumab in combination with urelumab to potentiate anti-myeloma activity in lymphocyte-deficient mice reconstituted with human NK cells

scientific article published on 13 April 2019

Deciphering CD137 (4-1BB) signaling in T-cell costimulation for translation into successful cancer immunotherapy

scientific article

Defining the critical hurdles in cancer immunotherapy

scientific article published on 14 December 2011

Delivery of immunostimulatory monoclonal antibodies by encapsulated hybridoma cells

scientific article published on 06 July 2010

Dendritic cells adhere to and transmigrate across lymphatic endothelium in response to IFN-α

scientific article published on 27 October 2010

Dendritic cells delivered inside human carcinomas are sequestered by interleukin-8.

scientific article

Dendritic cells in cancer immunology and immunotherapy

scientific article published on 29 August 2019

Dendritic cells take up and present antigens from viable and apoptotic polymorphonuclear leukocytes

scientific article

Deubiquitinases A20 and CYLD modulate costimulatory signaling via CD137 (4-1BB).

scientific article published on 21 September 2017

Direct effects of type I interferons on cells of the immune system

scientific article published on 03 March 2011

Diverse immune environments in human lung tuberculosis granulomas assessed by quantitative multiplexed immunofluorescence

scientific article published on 26 June 2020

Effective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigen

scholarly article by Stefanie K Wculek et al published 8 April 2019 in Journal for Immunotherapy of Cancer

Effective tumor immunotherapy: start the engine, release the brakes, step on the gas pedal,...and get ready to face autoimmunity

scientific article

Effects of IFN-α as a signal-3 cytokine on human naïve and antigen-experienced CD8(+) T cells

scientific article published in December 2010

Efficacy and Safety of Nivolumab Plus Ipilimumab in Patients With Advanced Hepatocellular Carcinoma Previously Treated With Sorafenib: The CheckMate 040 Randomized Clinical Trial

scientific article published on 01 October 2020

Efficacy and safety of nivolumab in patients with advanced hepatocellular carcinoma analyzed by patient age: A sub-analysis of the CheckMate 040 study

scientific article published on 01 June 2017

Emerging Opportunities and Challenges in Cancer Immunotherapy.

scientific article published on April 2016

Endoscopical and pathological dissociation in severe colitis induced by immune-checkpoint inhibitors

scientific article published on 13 May 2020

Engineering bionic T cells: signal 1, signal 2, signal 3, reprogramming and the removal of inhibitory mechanisms

scientific article published on 20 May 2020

Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells

scientific article

Enhancement of CD4 and CD8 immunity by anti-CD137 (4-1BB) monoclonal antibodies during hepatitis C vaccination with recombinant adenovirus

scientific article published in May 2005

Enhancement of antibody-dependent cellular cytotoxicity of cetuximab by a chimeric protein encompassing interleukin-15.

scientific article published on 13 November 2017

Epistatic Oncogenic Interactions Determine Cancer Susceptibility to Immunotherapy

scientific article published on 01 July 2018

Essential complicity of perforin-granzyme and FAS-L mechanisms to achieve tumor rejection following treatment with anti-CD137 mAb

scientific article published on 29 May 2013

Evolving synergistic combinations of targeted immunotherapies to combat cancer.

scientific article published on July 2015

Exploiting TCR Recognition of Shared Hotspot Oncogene-encoded Neoantigens

scientific article published on 30 January 2020

Expression Analysis and Significance of PD-1, LAG-3, and TIM-3 in Human Non-Small Cell Lung Cancer Using Spatially Resolved and Multiparametric Single-Cell Analysis

scientific article published on 03 May 2019

Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3

scientific article published on 20 December 2018

Focusing and sustaining the antitumor CTL effector killer response by agonist anti-CD137 mAb.

scientific article published on June 2015

Focusing and sustaining the antitumor CTL effector killer response by agonist anti-CD137 mAb.

scientific article published on 6 November 2014

For Whom the Cell Tolls? Intratumoral Treatment Links Innate and Adaptive Immunity

scientific article published on 27 September 2018

Functional expression of CD137 (4-1BB) on T helper follicular cells.

scientific article

Future perspectives in melanoma research: meeting report from the "Melanoma Bridge", Napoli, December 5th-8th 2013.

scientific article

Future perspectives in melanoma research: meeting report from the "Melanoma Bridge": Napoli, December 3rd-6th 2014.

scientific article published on 30 November 2015

Gene therapy of cancer based on interleukin 12.

scientific article

Gene therapy of cancer with interleukin-12.

scientific article published in January 2003

Genetic basis for clinical response to CTLA-4 blockade

scientific article published on 01 February 2015

Genomic characterization of individuals presenting extreme phenotypes of high and low risk to develop tobacco-induced lung cancer.

scientific article published on 15 May 2018

Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint

scientific article published on 19 May 2020

Hepatitis C Virus Structural Proteins Impair Dendritic Cell Maturation and Inhibit In Vivo Induction of Cellular Immune Responses

scientific article

High-density lipoproteins delivering interleukin-15.

scientific article published on April 2013

Human CD8 T cells are susceptible to TNF-mediated activation-induced cell death ⬇️

scientific article published on 15 March 2020

Hypoxia-induced soluble CD137 in malignant cells blocks CD137L-costimulation as an immune escape mechanism

scientific article published on 24 June 2015

Hypoxia-induced soluble CD137 in malignant cells blocks CD137L-costimulation as an immune escape mechanism.

scientific article published on 6 November 2014

ICAM-1-LFA-1 Dependent CD8+ T-Lymphocyte Aggregation in Tumor Tissue Prevents Recirculation to Draining Lymph Nodes

IL-10 suppressor activity andex vivo Tr1 cell function are impaired in multiple sclerosis

scientific article published on 01 February 2008

Identification of mutations associated with acquired resistance to sunitinib in renal cell cancer

scientific article published on 30 March 2019

Imiquimod enhances the systemic immunity attained by local cryosurgery destruction of melanoma lesions

scientific article published on 22 March 2007

Immune Desertic Landscapes in Hepatocellular Carcinoma Shaped by β-Catenin Activation

scientific article published on 01 August 2019

Immune mechanisms mediating abscopal effects in radioimmunotherapy

scientific article published on 05 December 2018

Immune response regulation in the tumor microenvironment by hypoxia.

scientific article published on 13 February 2015

Immunodivergence in Metastatic Colorectal Cancer

scientific article published on 01 December 2018

Immunodynamics: a cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials

scientific article

Immunogenic cell death and cross-priming are reaching the clinical immunotherapy arena

scientific article published on 01 April 2006

Immunological Mechanisms Responsible for Radiation-Induced Abscopal Effect

scientific article published on 11 July 2018

Immunological impact of cell death signaling driven by radiation on the tumor microenvironment

scientific article published on 23 December 2019

Immunological landscape and immunotherapy of hepatocellular carcinoma

scientific article

Immunology and gene therapy: shoulder to shoulder into the fray

scientific article published on March 2010

Immunostimulatory Monoclonal Antibodies and Immunomodulation: Harvesting the Crop

scientific article published on 2 May 2016

Immunostimulatory monoclonal antibodies for cancer therapy

scientific article published on February 2007

Immunosuppression routed via the kynurenine pathway: a biochemical and pathophysiologic approach.

scientific article published on January 2008

Immunotherapeutic Synergy Between Anti-CD137 mAb and Intratumoral Administration of a Cytopathic Semliki Forest Virus Encoding IL-12 ⬇️

scientific article published on June 26, 2012

Immunotherapy and immunoescape in colorectal cancer.

scientific article published on November 2007

Immunotherapy in Non-Small Cell Lung Cancer: Facts and Hopes

scientific article published on 01 March 2019

Immunotherapy of Cancer Visualized by Live Microscopy: Seeing Is Believing

scientific article published on 21 June 2016

Immunotherapy of Hepatocellular Carcinoma: Facts and Hopes

scientific article published on 14 November 2017

Immunotherapy of hepatocellular carcinoma

Immunotherapy targeting 4-1BB: mechanistic rationale, clinical results, and future strategies

scientific article

Impact of prophylactic TNF blockade in the dual PD-1 and CTLA-4 immunotherapy efficacy and toxicity

scientific article published on 27 June 2019

Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer

scientific article published on 12 October 2017

Improving efficacy of interleukin-12-transfected dendritic cells injected into murine colon cancer with anti-CD137 monoclonal antibodies and alloantigens.

scientific article published on May 2004

In vivo depletion of DC impairs the anti-tumor effect of agonistic anti-CD137 mAb.

scientific article

Initial afferent lymphatic vessels controlling outbound leukocyte traffic from skin to lymph nodes.

scientific article published on 09 December 2013

Initial efficacy of anti-lymphocyte activation gene-3 (anti–LAG-3; BMS-986016) in combination with nivolumab (nivo) in pts with melanoma (MEL) previously treated with anti–PD-1/PD-L1 therapy

article

Innate functions of immunoglobulin M lessen liver gene transfer with helper-dependent adenovirus

scientific article published on 21 January 2014

Innate immune mediators in cancer: between defense and resistance

scientific article

Intensive pharmacological immunosuppression allows for repetitive liver gene transfer with recombinant adenovirus in nonhuman primates

scientific article

Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule Are Induced by Ionizing Radiation on Lymphatic Endothelium

scientific article published on 7 November 2016

Interleukin-12 message in a bottle

scientific article published on 01 October 2020

Interleukin-15 in gene therapy of cancer.

scientific article published on February 2013

Interleukin-8 in cancer pathogenesis, treatment and follow-up

scientific article published on 31 August 2017

Interleukin-8, Neutrophils, and NETs in a Collusion against Cancer Immunity and Immunotherapy

scientific article published on 29 December 2020

International symposium on CTL and immunostimulation, Pamplona (Spain), October 26th and 27th 2010.

scientific article published on 5 March 2011

Intratumor Adoptive Transfer of IL-12 mRNA Transiently Engineered Antitumor CD8+ T Cells

scientific article published on 21 November 2019

Intratumoral Delivery of Immunotherapy-Act Locally, Think Globally

scientific article published on January 2017

Intratumoral immunotherapy with XCL1 and sFlt3L encoded in recombinant Semliki Forest Virus-derived vectors fosters dendritic cell-mediated T cell cross-priming

Intratumoral injection of dendritic cells engineered to secrete interleukin-12 by recombinant adenovirus in patients with metastatic gastrointestinal carcinomas.

scientific article published on 14 December 2004

Intratumoral injection of dendritic cells transduced by an SV40-based vector expressing interleukin-15 induces curative immunity mediated by CD8+ T lymphocytes and NK cells

scientific article

Intratumoral injection of interferon-α and systemic delivery of agonist anti-CD137 monoclonal antibodies synergize for immunotherapy.

scientific article published on January 2011

Intratumoral nanoplexed poly I:C BO-112 in combination with systemic anti-PD-1 for patients with anti-PD-1-refractory tumors

scientific article published on 01 October 2020

Intratumoural administration of dendritic cells: hostile environment and help by gene therapy

scientific article

Introducing a New Series: Immunotherapy Facts and Hopes

scientific article published on 23 February 2018

Liver gene transfer of interkeukin-15 constructs that become part of circulating high density lipoproteins for immunotherapy

scientific article

Low surface expression of B7-1 (CD80) is an immunoescape mechanism of colon carcinoma

scientific article published on February 2006

Lymphatic endothelium forms integrin-engaging 3D structures during DC transit across inflamed lymphatic vessels

scientific article published on 25 March 2013

Lysine 63 polyubiquitination in immunotherapy and in cancer-promoting inflammation.

scientific article

MAGE antigens: therapeutic targets in hepatocellular carcinoma?

scientific article published on 01 January 2004

Making the Most of Cancer Surgery with Neoadjuvant Immunotherapy

scientific article published on 01 December 2016

Melanoma: From Incurable Beast to a Curable Bet. The Success of Immunotherapy

scientific article

Metabolic Consequences of T-cell Costimulation in Anticancer Immunity

scientific article published on 01 October 2019

Mitochondrial morphological and functional reprogramming following CD137 (4-1BB) co-stimulation.

scientific article published on 20 April 2018

Molecular and cellular basis for immunomodulation with monoclonal antibodies

scientific article published on 15 January 2015

Molecular pathways: hypoxia response in immune cells fighting or promoting cancer

scientific article

Multi-layered action mechanisms of CD137 (4-1BB)-targeted immunotherapies.

scientific article published on July 2008

Neoadjuvant immunotherapy in non-small cell lung cancer: the sooner the better?

scientific article published on 01 December 2018

New emerging targets in cancer immunotherapy: CD137/4-1BB costimulatory axis

scientific article published on 01 July 2020

New trends in immunotherapy

scholarly article by Luis Álvarez-Vallina et al published October 2011 in Inmunologia (Barcelona, Spain : 1987)

Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2-/-IL2Rγnull Immunodeficient Mice.

scientific article published on 25 June 2015

Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial

scientific article published on 20 April 2017

OX40 Agonist BMS-986178 Alone or in Combination With Nivolumab and/or Ipilimumab in Patients With Advanced Solid Tumors

scientific article published on 04 November 2020

Orchestrating immune check-point blockade for cancer immunotherapy in combinations

scientific article published on 28 January 2014

PD-L1 expression as a potential predictive biomarker

scientific article published on 01 October 2015

PS1-010. CD8 T cell priming in the presence of IFNα improves memory differentiation and the efficacy of adoptive immunotherapy

scholarly article by Sandra Hervas-Stubbs et al published October 2011 in Cytokine

Palettes of vaccines and immunostimulatory monoclonal antibodies for combination.

scientific article published on 24 February 2009

Perspectives in immunotherapy: meeting report from the Immunotherapy Bridge (29-30 November, 2017, Naples, Italy).

scientific article published on 11 July 2018

Perspectives in immunotherapy: meeting report from the “Immunotherapy Bridge”, Napoli, December 5th 2015.

scientific article published on 18 October 2016

Phase I trial of intratumoral injection of an adenovirus encoding interleukin-12 for advanced digestive tumors.

scientific article published on April 2004

Pilot clinical trial of type 1 dendritic cells loaded with autologous tumor lysates combined with GM-CSF, pegylated IFN, and cyclophosphamide for metastatic cancer patients.

scientific article published on 2 November 2011

Porphobilinogen deaminase over-expression in hepatocytes, but not in erythrocytes, prevents accumulation of toxic porphyrin precursors in a mouse model of acute intermittent porphyria

scientific article published on 23 September 2009

Potentiation of therapeutic immune responses against malignancies with monoclonal antibodies.

scientific article published on November 2003

Premortem Tumor Stress in Radioimmunotherapy

scientific article published on 27 January 2020

Prognostic value of macrophage polarization markers in epithelial neoplasms and melanoma. A systematic review and meta-analysis

scientific article published on 14 April 2020

Prophylactic TNF blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy

scientific article published on 01 May 2019

Quantitative and qualitative impairments in dendritic cell subsets of patients with ovarian or prostate cancer

scientific article published on 23 June 2020

Radiation effects on antitumor immune responses: current perspectives and challenges

scientific article published on 18 January 2018

Rapid isolation and enrichment of mouse NK cells for experimental purposes

scientific article published on 20 November 2019

Recombinant adenoviral vectors turn on the type I interferon system without inhibition of transgene expression and viral replication.

scientific article published on 19 April 2006

Repurposing infectious disease vaccines for intratumoral immunotherapy

scientific article published on 01 February 2020

Results from an Integrated Safety Analysis of Urelumab, an Agonist Anti-CD137 Monoclonal Antibody

scientific article

Revisiting Interleukin-12 as a Cancer Immunotherapy Agent

scientific article published on 16 March 2018

Routing cancer immunology and immunotherapy from the lab to the clinic 4-5 th March 2014, Center for Applied Medical Research and University Clinic, Pamplona, Spain

scientific article published on 24 July 2014

Safety and Tolerability of Immune Checkpoint Inhibitors (PD-1 and PD-L1) in Cancer

scientific article published on 01 February 2019

Scavenger Receptor class B type I is Required for 25-Hydroxycholecalciferol Cellular Uptake and Signaling in Myeloid Cells

scientific article published on 25 June 2020

Serum interleukin-8 reflects tumor burden and treatment response across malignancies of multiple tissue origins.

scientific article published on 15 September 2014

Short-Term Local Expression of a PD-L1 Blocking Antibody from a Self-Replicating RNA Vector Induces Potent Antitumor Responses

scientific article published on 16 September 2019

SimB16: modeling induced immune system response against B16-melanoma

scientific article

Strategies to design clinical studies to identify predictive biomarkers in cancer research.

scientific article published on 30 December 2016

Strict requirement for vector-induced type I interferon in efficacious antitumor responses to virally encoded IL12.

scientific article published on 19 December 2014

Successful Immunotherapy against a Transplantable Mouse Squamous Lung Carcinoma with Anti-PD-1 and Anti-CD137 Monoclonal Antibodies.

scientific article published on February 2016

Synergistic effects of CTLA-4 blockade with tremelimumab and elimination of regulatory T lymphocytes in vitro and in vivo

article

T Cell Migration from Inflamed Skin to Draining Lymph Nodes Requires Intralymphatic Crawling Supported by ICAM-1/LFA-1 Interactions

scientific article published in January 2017

T cell costimulation with anti-CD137 monoclonal antibodies is mediated by K63-polyubiquitin-dependent signals from endosomes.

scientific article published on 20 May 2013

T-cell and NK-cell infiltration into solid tumors: a key limiting factor for efficacious cancer immunotherapy

scientific article published on May 2014

TGFβ Blockade Enhances Radiotherapy Abscopal Efficacy Effects in Combination with Anti-PD1 and Anti-CD137 Immunostimulatory Monoclonal Antibodies

scientific article published on 25 January 2019

Targeting NK-cell checkpoints for cancer immunotherapy

scientific article published on 22 February 2017

The HIF-1α Hypoxia Response in Tumor-Infiltrating T Lymphocytes Induces Functional CD137 (4-1BB) for Immunotherapy

scientific article published on 19 June 2012

The clinical application of cancer immunotherapy based on naturally circulating dendritic cells

scientific article published on 18 April 2019

The combined actions of NK and T lymphocytes are necessary to reject an EGFP+ mesenchymal tumor through mechanisms dependent on NKG2D and IFN gamma.

scientific article published on September 2007

The liver, liver metastasis and liver cancer: a special case for immunotherapy with cytokines and immunostimulatory monoclonal antibodies

scientific article published on 01 November 2012

The many sounds of T lymphocyte silence.

scientific article

Therapeutic activity of a combination of immunostimulatory monoclonal antibodies (anti-B7-H1, CD137 and OX40) on a c-myc-driven spontaneous transgenic model of hepatocellular carcinoma.

scientific article published on 7 November 2013

Therapeutic antitumor efficacy of anti-CD137 agonistic monoclonal antibody in mouse models of myeloma

scientific article published on November 2008

Therapeutic vaccines for cancer: an overview of clinical trials

scientific article published on 08 July 2014

Transient and intensive pharmacological immunosuppression fails to improve AAV-based liver gene transfer in non-human primates

scientific article

Treatment with anti-CD137 mAbs causes intense accumulations of liver T cells without selective antitumor immunotherapeutic effects in this organ

scientific article published on 25 March 2010

Tumor-Produced Interleukin-8 Attracts Human Myeloid-Derived Suppressor Cells and Elicits Extrusion of Neutrophil Extracellular Traps (NETs).

scientific article

Twists and turns to translating 4-1BB cancer immunotherapy

scientific article published on 01 June 2019

Upregulation of natural killer cells functions underlies the efficacy of intratumorally injected dendritic cells engineered to produce interleukin-12.

scientific article published in March 2002

Vaccination for Pancreatic Ductal Adenocarcinoma: A Hard Nut to Crack

scientific article published on 17 July 2019

Virotherapy with a Semliki Forest Virus-Based Vector Encoding IL12 Synergizes with PD-1/PD-L1 Blockade

scientific article

Virotherapy, gene transfer and immunostimulatory monoclonal antibodies.

scientific article

Workshop on immunotherapy combinations. Society for immunotherapy of cancer annual meeting Bethesda, November 3, 2011 ⬇️

scientific article published on May 28, 2012

[Role of interleukin-12 in cancer immunotherapy]

scientific article published on 01 January 2004

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