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List of works by Edward Darżynkiewicz

7-methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (DcpS) enzymes and potently inhibits their activity

scientific article

A cap binding protein that may mediate nuclear export of RNA polymerase II-transcribed RNAs

scientific article published on September 1992

A direct method for the synthesis of nucleoside 5′-methylenebis(phosphonate)s from nucleosides

A novel approach to solid phase chemical synthesis of oligonucleotide mRNA cap analogs

scientific article

Affinity of dinucleotide cap analogues for human decapping scavenger (hDcpS).

scientific article published in January 2007

Affinity resins containing enzymatically resistant mRNA cap analogs--a new tool for the analysis of cap-binding proteins

scientific article

Assignment of the absolute configuration of P-chiral 5' mRNA cap analogues containing phosphorothioate moiety

scientific article published in January 2007

Binding specificities and potential roles of isoforms of eukaryotic initiation factor 4E in Leishmania

scientific article

Binding studies of eukaryotic initiation factor eIF4E with novel mRNA dinucleotide cap analogues

scientific article published in May 2003

Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins

scientific article

Bisphosphonate modification in tetraphosphate 5'mRNA cap analogs – synthesis and biochemical properties

Cap analog substrates reveal three clades of cap guanine-N2 methyltransferases with distinct methyl acceptor specificities

scientific article

Cap analogs modified with 1,2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential

scientific article published on 07 October 2016

Cap-binding activity of an eIF4E homolog from Leishmania

scientific article published on 23 September 2004

Characterization of hMTr1, a human Cap1 2'-O-ribose methyltransferase

scientific article

Charge distribution in 7-methylguanine regarding cation-pi interaction with protein factor eIF4E.

scientific article published on September 2003

ChemInform Abstract: Synthetic mRNA Cap Analogues with a Modified Triphosphate Bridge - Synthesis, Applications and Prospects

Chemical synthesis and binding activity of the trypanosomatid cap-4 structure

scientific article

Contribution of trans-splicing, 5' -leader length, cap-poly(A) synergism, and initiation factors to nematode translation in an Ascaris suum embryo cell-free system

scientific article

Cross-talk between snurportin1 subdomains

scientific article

Deaggregation of eIF4E induced by mRNA 5' cap binding

scientific article

Differential inhibition of mRNA degradation pathways by novel cap analogs

scientific article

Discrimination between mono- and trimethylated cap structures by two isoforms of Caenorhabditis elegans eIF4E.

scientific article

Distinct features of cap binding by eIF4E1b proteins

scientific article

Diverse role of three tyrosines in binding of the RNA 5' cap to the human nuclear cap binding complex

scientific article published on 8 November 2008

Diversity in the signals required for nuclear accumulation of U snRNPs and variety in the pathways of nuclear transport

scientific article published on May 1991

Drosophila miR2 primarily targets the m7GpppN cap structure for translational repression

scientific article

Effect of different N7 substitution of dinucleotide cap analogs on the hydrolytic susceptibility towards scavenger decapping enzymes (DcpS).

scientific article published on 04 June 2015

Establishment of an in vitro trans-splicing system in Trypanosoma brucei that requires endogenous spliced leader RNA.

scientific article

Evolutionary changes in the Leishmania eIF4F complex involve variations in the eIF4E-eIF4G interactions

scientific article published on 24 March 2009

Five eIF4E isoforms from Arabidopsis thaliana are characterized by distinct features of cap analogs binding

scientific article published on 18 November 2014

Hydrolytic activity of human Nudt16 enzyme on dinucleotide cap analogs and short capped oligonucleotides

scientific article published on 26 February 2018

Identification of the HIT-45 protein from Trypanosoma brucei as an FHIT protein/dinucleoside triphosphatase: substrate specificity studies on the recombinant and endogenous proteins

scientific article published on 18 June 2009

In vivo translation and stability of trans-spliced mRNAs in nematode embryos

scientific article published on 21 February 2007

Influence of electric charge variation at residues 209 and 159 on the interaction of eIF4E with the mRNA 5' terminus

scientific article

Interaction between yeast eukaryotic initiation factor eIF4E and mRNA 5' cap analogues differs from that for murine eIF4E.

scientific article published in May 2003

Interaction of human decapping scavenger with 5′ mRNA cap analogues: structural requirements for catalytic activity

Interaction of three Caenorhabditis elegans isoforms of translation initiation factor eIF4E with mono- and trimethylated mRNA 5' cap analogues.

scientific article published in January 2002

Investigating the consequences of eIF4E2 (4EHP) interaction with 4E-transporter on its cellular distribution in HeLa cells

scientific article

Kinetics of C. elegans DcpS cap hydrolysis studied by fluorescence spectroscopy

scientific article published in January 2007

Molecular recognition of mRNA 5' cap by 3' poly(A)-specific ribonuclease (PARN) differs from interactions known for other cap-binding proteins.

scientific article published on 6 January 2016

Nematode m7GpppG and m3(2,2,7)GpppG decapping: activities in Ascaris embryos and characterization of C. elegans scavenger DcpS

scientific article

New affinity resin for purification of cap-binding proteins

scientific article (publication date: 2005)

Novel "anti-reverse" cap analogs with superior translational properties

scientific article

Novel cap analogs for in vitro synthesis of mRNAs with high translational efficiency

scientific article

Novel dinucleoside 5',5'-triphosphate cap analogues. Synthesis and affinity for murine translation factor eIF4E.

scientific article

Partial Molar Volumes of mRNA 5′ Cap Analogues ⬇️

scientific article published on May 1, 2003

Phosphate-modified analogues of m(7)GTP and m(7)Gppppm(7)G-Synthesis and biochemical properties

scientific article published on 29 July 2015

Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation

scientific article published on 21 February 2009

Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo

scientific article published on 22 April 2010

Phosphorothioate cap analogs stabilize mRNA and increase translational efficiency in mammalian cells

scientific article

Phosphorylation of eIF4E attenuates its interaction with mRNA 5' cap analogs by electrostatic repulsion: intein-mediated protein ligation strategy to obtain phosphorylated protein

scientific article published in January 2003

Proximity of mRNA5′-region and 18S rRNA in eukaryotic initiation complexes

scientific article published in Nature

Significance of the first transcribed nucleoside of capped RNA for ligand-induced folding of the cap-binding complex

Solid-supported synthesis of 5'-mRNA CAP-4 from Trypanosomatids

scientific article published in January 2007

Specificity of recognition of mRNA 5' cap by human nuclear cap-binding complex

scientific article published on 25 July 2005

Stopped-flow kinetic analysis of eIF4E and phosphorylated eIF4E binding to cap analogs and capped oligoribonucleotides: evidence for a one-step binding mechanism

scientific article published on 15 March 2006

Structural Insights into Parasite eIF4E Binding Specificity for m7G and m2,2,7G mRNA Caps

scientific article

Structural analysis of 5′-mRNA–cap interactions with the human AGO2 MID domain

scientific article

Structural analysis of human 2′-O-ribose methyltransferases involved in mRNA cap structure formation

scientific article

Structural basis for nematode eIF4E binding an m2,2,7G-Cap and its implications for translation initiation

scientific article

Structural changes of eIF4E upon binding to the mRNA 5' monomethylguanosine and trimethylguanosine Cap.

scientific article published on 26 January 2008

Structural requirements for Caenorhabditis elegans DcpS substrates based on fluorescence and HPLC enzyme kinetic studies

scientific article

Study of the 2719 mutant of the c-H-ras oncogene in a bi-intronic alternative splicing system.

scientific article

Synthesis and biochemical studies of tetraphosphate 5' mRNA cap analogs bearing bisphosphonate modification

scientific article

Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS

scientific article published on 22 April 2008

Synthesis and enzymatic characterization of methylene analogs of adenosine 5'-tetraphosphate (P4A).

scientific article

Synthesis and evaluation of fluorescent cap analogues for mRNA labelling

scientific article published on January 2013

Synthesis of 3H and 13C labeled mRNA cap dinucleotides--useful tools for NMR, biochemical, and biological studies

scientific article published in January 2007

Synthesis of Leishmania cap-4 intermediates, cap-2 and cap-3.

scientific article published in January 2007

Synthesis of anti-reverse cap analogs (ARCAs) and their applications in mRNA translation and stability

scientific article published on January 2007

Synthesis of novel mRNA 5' cap-analogues: dinucleoside P1, P3-tri-, P1, P4-tetra-, and P1, P5-pentaphosphates

scientific article published in May 2003

Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes

scientific article

Synthetic dinucleotide mRNA cap analogs with tetraphosphate 5',5' bridge containing methylenebis(phosphonate) modification

scientific article published on 7 September 2009

Synthetic mRNA cap analogs with a modified triphosphate bridge – synthesis, applications and prospects

The TbMTr1 spliced leader RNA cap 1 2'-O-ribose methyltransferase from Trypanosoma brucei acts with substrate specificity

scientific article published on 29 November 2007

The antiviral drug ribavirin does not mimic the 7-methylguanosine moiety of the mRNA cap structure in vitro

scientific article

The first examples of mRNA cap analogs bearing boranophosphate modification.

scientific article

The g5R (D250) gene of African swine fever virus encodes a Nudix hydrolase that preferentially degrades diphosphoinositol polyphosphates

scientific article published on February 2002

The nematode eukaryotic translation initiation factor 4E/G complex works with a trans-spliced leader stem-loop to enable efficient translation of trimethylguanosine-capped RNAs

scientific article

Thermodynamics and conformational changes related to binding of eIF4E protein to mRNA 5′ cap

Thermodynamics of 7-methylguanosine cation stacking with tryptophan upon mRNA 5' cap binding to translation factor eIF4E.

scientific article published in May 2003

Thermodynamics of mRNA 5' cap binding by eukaryotic translation initiation factor eIF4E.

scientific article published in October 2004

Thermodynamics of molecular recognition of mRNA 5' cap by yeast eukaryotic initiation factor 4E.

scientific article published on 22 June 2011

Towards mRNA with superior translational activity: synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications

scientific article

Translation, stability, and resistance to decapping of mRNAs containing caps substituted in the triphosphate chain with BH3, Se, and NH

scientific article

Triazole-containing monophosphate mRNA cap analogs as effective translation inhibitors

scientific article

Trypanosoma brucei translation initiation factor homolog EIF4E6 forms a tripartite cytosolic complex with EIF4G5 and a capping enzyme homolog

scientific article

Weak binding affinity of human 4EHP for mRNA cap analogs

scientific article

eIF4F-like complexes formed by cap-binding homolog TbEIF4E5 with TbEIF4G1 or TbEIF4G2 are implicated in post-transcriptional regulation in Trypanosoma brucei

scientific article

m7GTP alphaS is a strong and stable inhibitor of cap-dependent translation

scientific article

mRNA decapping is promoted by an RNA-binding channel in Dcp2

scientific article

mRNAs containing the histone 3' stem-loop are degraded primarily by decapping mediated by oligouridylation of the 3' end.

scientific article

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