List of works by Claire Palles

A candidate gene study of capecitabine-related toxicity in colorectal cancer identifies new toxicity variants at DPYD and a putative role for ENOSF1 rather than TYMS

scientific article

A colorectal cancer genome-wide association study in a Spanish cohort identifies two variants associated with colorectal cancer risk at 1p33 and 8p12.

scientific article

A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer

scientific article published on 20 May 2015

A panoply of errors: polymerase proofreading domain mutations in cancer

scientific article

Author Correction: Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases

scientific article published on 04 December 2019

BMP2/BMP4 colorectal cancer susceptibility loci in northern and southern European populations

scientific article published on 16 November 2012

CYP3A variation, premenopausal estrone levels, and breast cancer risk

scientific article published on 3 April 2012

Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta-analysis of individual patient data

scientific article

Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus

scientific article

Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

scientific article

Correspondence: SEMA4A variation and risk of colorectal cancer

scientific article

Counting potentially functional variants in BRCA1, BRCA2 and ATM predicts breast cancer susceptibility

DNA polymerase ε and δ exonuclease domain mutations in endometrial cancer

scientific article

Deciphering the genetic architecture of low-penetrance susceptibility to colorectal cancer

scientific article published on 30 July 2013

Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy

scientific article published on 5 April 2016

Erratum: A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer

scientific article published on 3 August 2015

Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication

scientific article published on 06 July 2021

Five endometrial cancer risk loci identified through genome-wide association analysis

scientific article published on 02 May 2016

Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases

scientific article published on 16 September 2019

Genetic markers of toxicity from capecitabine and other fluorouracil-based regimens: investigation in the QUASAR2 study, systematic review, and meta-analysis

scientific article

Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis ⬇️

scientific article

Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci

scientific article published on 28 September 2017

Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas ⬇️

scientific article

Germline variation in inflammation-related pathways and risk of Barrett's oesophagus and oesophageal adenocarcinoma

scientific article published on 2 August 2016

Identification of genetic variants that influence circulating IGF1 levels: a targeted search strategy

Identification of nine new susceptibility loci for endometrial cancer

scientific article published in Nature Communications

Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis

scientific article

Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer

scientific article published on 23 June 2016

Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer

scientific article

Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

scientific article

Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer

scientific article

Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series

article

Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study

scientific article published on 24 January 2011

POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer

scientific article

Pharmacogenomics in colorectal cancer: a genome-wide association study to predict toxicity after 5-fluorouracil or FOLFOX administration

scientific article

Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus ⬇️

scientific article

Pro-inflammatory fatty acid profile and colorectal cancer risk: A Mendelian randomisation analysis

scientific article

Rare disruptive mutations and their contribution to the heritable risk of colorectal cancer. ⬇️

scientific article

Re: Role of the oxidative DNA damage repair gene OGG1 in colorectal tumorigenesis

scientific article

Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer ⬇️

scientific article

Signatures of TOP1 transcription-associated mutagenesis in cancer and germline

scientific article published on 09 February 2022

Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response.

scientific article published on 31 March 2018

The HABP2 G534E variant is an unlikely cause of familial non-medullary thyroid cancer.

scientific article published on 21 December 2015

The evolutionary landscape of colorectal tumorigenesis ⬇️

scientific article published on 31 August 2018

Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease

scientific article published on 22 March 2016

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