List of works - Krystyna Ossowska

3-Methoxytyramine, an extraneuronal dopamine metabolite plays a physiological role in the brain as an inhibitory regulator of catecholaminergic activity.

scientific article

6-OHDA injections into A8-A9 dopaminergic neurons modelling early stages of Parkinson's disease increase the harmaline-induced tremor in rats.

scientific article published on 10 August 2012

9-Methyl-beta-carboline has restorative effects in an animal model of Parkinson's disease

scientific article published in January 2010

A biphasic influence of globus pallidus lesions: spontaneous catalepsy followed by anticataleptic effect.

scientific article

A partial lesion of the substantia nigra pars compacta and retrorubral field decreases the harmaline-induced glutamate release in the rat cerebellum.

scientific article published on 5 September 2013

A slowly developing dysfunction of dopaminergic nigrostriatal neurons induced by long-term paraquat administration in rats: an animal model of preclinical stages of Parkinson's disease?

scientific article

Adaptation within mitochondrial oxidative phosphorylation supercomplexes and membrane viscosity during degeneration of dopaminergic neurons in an animal model of early Parkinson's disease.

scientific article published on February 2016

Adaptive down-regulation of the serotonin transporter in the 6-hydroxydopamine-induced rat model of preclinical stages of Parkinson's disease and after chronic pramipexole treatment.

scientific article published on 25 November 2015

Age-related muscle stiffness: predominance of non-reflex factors

scientific article published on 01 July 1997

Alteration of GSK-3β in the hippocampus and other brain structures after chronic paraquat administration in rats.

scientific article

Alterations of BDNF and trkB mRNA expression in the 6-hydroxydopamine-induced model of preclinical stages of Parkinson's disease: an influence of chronic pramipexole in rats.

scientific article

An influence of ligands of metabotropic glutamate receptor subtypes on parkinsonian-like symptoms and the striatopallidal pathway in rats

scientific article

Antiparkinsonian action of MK-801 on the reserpine-induced rigidity: a mechanomyographic analysis.

scientific article

Antiparkinsonian-like effects of CPL500036, a novel selective inhibitor of phosphodiesterase 10A, in the unilateral rat model of Parkinson's disease

scientific article published in November 2021

Apomorphine enhances harmaline-induced tremor in rats.

scientific article published on 27 November 2014

Blockade of adenosine A2A receptors inhibits Tremulous Jaw Movements as well as expression of zif-268 and GAD65 mRNAs in brain motor structures

scientific article published in January 2022

Blockade of the metabotropic glutamate receptor subtype 5 (mGluR5) produces antiparkinsonian-like effects in rats

scientific article

Can the supersensitivity of rodents to dopamine be regarded as a model of tardive dyskinesia?

scientific article published on January 1989

Chronic haloperidol and clozapine administration increases the number of cortical NMDA receptors in rats.

scientific article published in April 1999

Chronic treatment with haloperidol diminishes the phencyclidine-induced sensorimotor gating deficit in rats.

scientific article published in April 1998

Contralateral rotations induced by intrastriatal injections of agonists of excitatory amino acid receptors

scientific article published on 01 January 1994

Decline in motor functions in aging is related to the loss of NMDA receptors.

scientific article

Degeneration of dopaminergic mesocortical neurons and activation of compensatory processes induced by a long-term paraquat administration in rats: implications for Parkinson's disease.

scientific article

Depression in Parkinson's disease

scientific article published on 01 January 2013

Differential effects of chronic haloperidol and clozapine administration on glutamatergic transmission in the fronto-parietal cortex in rats: microdialysis and electrophysiological studies

scientific article published on 21 September 2002

Direct mechanomyographic measurement of the myorelaxant action of baclofen and diazepam in normal and reserpinized rats

scientific article published in February 1992

Disturbances in neurotransmission processes in aging and age-related diseases.

scientific article published on March 1993

Does reserpine induce parkinsonian rigidity?

scientific article published on January 1995

Dopamine receptors--the present state of research and perspectives.

scientific article published on May 1995

Dr. Gert Schulze, M.D. (1941-2013). In memoriam.

scientific article published in January 2013

Effect of the NMDA receptor antagonist, MK-801, on locomotor activity and on the metabolism of dopamine in various brain areas of mice.

scientific article

Effects of MPEP on avoidance learning in rats.

scientific article published in April 2007

Evidence for the independent role of GABA synapses of the zona incerta-lateral hypothalamic region in haloperidol-induced catalepsy

scientific article published on October 1988

Further evidence for the subsensitivity of striatal AMPA receptors, induced by chronic haloperidol administration: an autoradiographic study.

scientific article published in August 1996

GABA mechanisms of ventromedial thalamic nucleus in morphine-induced muscle rigidity

scientific article published on October 1986

Genotypic differences in locomotor stimulation and dopaminergic activity following acute ethanol administration

scientific article

Globus pallidus conveys striatal impulses connected with neuroleptic catalepsy to the lateral hypothalamus-zona incerta

scientific article published in May 1992

Glycogen synthase kinase 3β and its phosphorylated form (Y216) in the paraquat-induced model of parkinsonism

scientific article published on 9 February 2010

Haloperidol-increased muscle tone in rats as a model of parkinsonian rigidity.

scientific article published on 01 May 1996

Increased reactive oxygen species production in the brain after repeated low-dose pesticide paraquat exposure in rats. A comparison with peripheral tissues.

scientific article published on 6 April 2010

Influence of 6-hydroxydopamine lesion of the dopaminergic nigrostriatal pathway on the muscle tone and electromyographic activity measured during passive movements

scientific article published in October 1996

Influence of long-lasting administration of neuroleptics on cortical NMDA receptors and phencyclidine-induced deficit in the sensorimotor gating in rats.

scientific article

Influence of paraquat on dopaminergic transporter in the rat brain

scientific article published in May 2005

Inhibition of Excessive Glutamatergic Transmission in the Ventral Thalamic Nuclei by a Selective Adenosine A1 Receptor Agonist, 5'-Chloro-5'-Deoxy-(±)-ENBA Underlies its Tremorolytic Effect in the Harmaline-Induced Model of Essential Tremor

scientific article published on 11 January 2020

Interaction between striatal excitatory amino acid and gamma-aminobutyric acid (GABA) receptors in the turning behaviour of rats

scientific article published on 01 December 1995

Involvement of the nucleus accumbens in the myorelaxant effect of baclofen in rats.

scientific article

L-701,324, a selective antagonist at the glycine site of the NMDA receptor, counteracts haloperidol-induced muscle rigidity in rats

scientific article

LY354740, a group II metabotropic glutamate receptor agonist with potential antiparkinsonian properties in rats.

scientific article published on October 1998

Lack of a strong influence of neuroleptic decanoates on dopaminergic and GABAergic functions

scientific article published on 01 March 1995

Lateral hypothalamus-zona incerta region as an output station for the catalepsy induced by the blockade of striatal D1 and D2 dopamine receptors

scientific article

Lesion of the cerebellar noradrenergic innervation enhances the harmaline-induced tremor in rats.

scientific article published on June 2011

Lu AF21934, a positive allosteric modulator of mGlu4 receptors, reduces the harmaline-induced hyperactivity but not tremor in rats.

scientific article published on 12 April 2014

MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats.

scientific article published in September 2005

Metabotropic glutamate receptors

scientific article published on 25 January 2007

Muscle rigidity induced by fluphenazine in rats is antagonized by L-DOPA, an antiparkinsonian drug

scientific article published on June 1, 1998

Muscle rigidity induced by the opioid analgesic tramadol, but not by the non-opioid flupirtine.

scientific article

Muscle stiffness and continuous electromyographic activity in old rats; an animal model for spasticity?

scientific article published on 01 November 1992

Neuroprotective action of MPEP, a selective mGluR5 antagonist, in methamphetamine-induced dopaminergic neurotoxicity is associated with a decrease in dopamine outflow and inhibition of hyperthermia in rats.

scientific article published on September 2003

Parkinson's disease-like syndrome in rats induced by 2,9-dimethyl-beta-carbolinium ion, a beta-carboline occurring in the human brain.

scientific article published in September 2006

Partial lesion of the dopaminergic innervation of the ventral striatum induces "depressive-like" behavior of rats

scientific article

Potential antipsychotic action of the selective agonist of adenosine A1 receptors, 5'-Cl-5'-deoxy-ENBA, in amphetamine and MK-801 rat models

scientific article published on 26 March 2020

Pramipexole Reduces zif-268 mRNA Expression in Brain Structures involved in the Generation of Harmaline-Induced Tremor

scientific article published on 14 March 2020

Pramipexole at a Low Dose Induces Beneficial Effect in the Harmaline-induced Model of Essential Tremor in Rats.

scientific article

Pramipexole but not imipramine or fluoxetine reverses the "depressive-like" behaviour in a rat model of preclinical stages of Parkinson's disease.

scientific article published on 20 June 2014

Role of metabotropic glutamate receptors in animal models of Parkinson's disease.

scientific article published on November 2003

Role of the metabotropic glutamate receptor subtype 1 in the harmaline-induced tremor in rats.

scientific article published on 24 June 2009

Specific involvement of striatal D1 and D2 dopamine receptors in the neuroleptic catalepsy in rats

scientific article published on 01 July 1995

Stimulation of glutamate receptors in the intermediate/caudal striatum induces contralateral turning.

scientific article published in January 1995

Striatal and nucleus accumbens D1/D2 dopamine receptors in neuroleptic catalepsy

scientific article published in July 1990

Thalamus as a relay station for catalepsy and rigidity

scientific article published on December 1985

The effect of imipramine and mianserin on the behavior and EEG afterdischarges induced by single electric stimulation of the rabbit amygdala

scientific article published on 01 July 1980

The effect of unilateral amygdala lesion on the imipramine action in behavioural despair in rats ⬇️

scientific article published on September 1, 1979

The effect of unilateral amygdala lesion on the imipramine action in behavioural despair in rats

scientific article published in September 1979

The influence of dizocilpine (MK-801) on the reserpine-enhanced electromyographic stretch reflex in rats

scientific article published on January 1996

The influence of group III metabotropic glutamate receptor stimulation by (1S,3R,4S)-1-aminocyclo-pentane-1,3,4-tricarboxylic acid on the parkinsonian-like akinesia and striatal proenkephalin and prodynorphin mRNA expression in rats.

scientific article

The influence of long-term haloperidol- or fluphenazine decanoate treatments on striatal dopaminergic and nigral GABA-ergic functions

scientific article published in May 1992

The influence of preconditioning with low dose of LPS on paraquat-induced neurotoxicity, microglia activation and expression of α-synuclein and synphilin-1 in the dopaminergic system

scientific article published in February 2022

The involvement of cerebellar dopamine D3 receptors in locomotor activity of rats

scientific article

The neostriatal inhibition of catalepsy, but not of muscle rigidity, evoked from the substantia nigra pars reticulata

scientific article

The role of excitatory amino acids in experimental models of Parkinson's disease.

scientific article published on January 1994

The role of gamma-aminobutyric acid mechanisms of the zona incerta-lateral hypothalamus in the catalepsy and muscle rigidity evoked by morphine

scientific article

The role of glutamate receptors in antipsychotic drug action

scientific article

The role of metabotropic glutamate receptor (mGluR) ligands in parkinsonian muscle rigidity

scientific article

The role of metabotropic glutamate receptors in regulation of striatal proenkephalin expression: implications for the therapy of Parkinson's disease.

scientific article published on January 2003

The role of reflex activity in the regulation of muscle tone in rats.

scientific article published in March 1996

The role of striatal glutamate receptors in models of Parkinson's disease.

scientific article published on January 1998

The role of striatal metabotropic glutamate receptors in Parkinson's disease.

scientific article

The role of the GABA mechanisms of the globus pallidus in mediating catalepsy, stereotypy and locomotor activity.

scientific article published on December 1984

The role of the ventromedial thalamic nucleus in the catalepsy evoked from the substantia nigra pars reticulata in rats

scientific article published on 01 July 1988

The striatum as a target for anti-rigor effects of an antagonist of mGluR1, but not an agonist of group II metabotropic glutamate receptors.

scientific article published in September 2002

The striopallidal pathway is involved in antiparkinsonian-like effects of the blockade of group I metabotropic glutamate receptors in rats.

scientific article published in May 2003

The subsensitivity of striatal glutamate receptors induced by chronic haloperidol in rats

scientific article published on 01 December 1995

Toxic influence of subchronic paraquat administration on dopaminergic neurons in rats.

scientific article

Tremorolytic effect of 5'-chloro-5'-deoxy-(±)-ENBA, a potent and selective adenosine A1 receptor agonist, evaluated in the harmaline-induced model in rats

scientific article published on 29 March 2017

Zona incerta as a therapeutic target in Parkinson's disease

scientific article published on 02 August 2019

Zona incerta-lateral hypothalamus as an output structure for impulses involved in neuroleptic drug-induced catalepsy

scientific article published on April 1993

List of works by Krystyna Ossowska

3-Methoxytyramine, an extraneuronal dopamine metabolite plays a physiological role in the brain as an inhibitory regulator of catecholaminergic activity.

6-OHDA injections into A8-A9 dopaminergic neurons modelling early stages of Parkinson's disease increase the harmaline-induced tremor in rats.

9-Methyl-beta-carboline has restorative effects in an animal model of Parkinson's disease

A biphasic influence of globus pallidus lesions: spontaneous catalepsy followed by anticataleptic effect.

A partial lesion of the substantia nigra pars compacta and retrorubral field decreases the harmaline-induced glutamate release in the rat cerebellum.

A slowly developing dysfunction of dopaminergic nigrostriatal neurons induced by long-term paraquat administration in rats: an animal model of preclinical stages of Parkinson's disease?

Adaptation within mitochondrial oxidative phosphorylation supercomplexes and membrane viscosity during degeneration of dopaminergic neurons in an animal model of early Parkinson's disease.

Adaptive down-regulation of the serotonin transporter in the 6-hydroxydopamine-induced rat model of preclinical stages of Parkinson's disease and after chronic pramipexole treatment.

Age-related muscle stiffness: predominance of non-reflex factors

Alteration of GSK-3β in the hippocampus and other brain structures after chronic paraquat administration in rats.

Alterations of BDNF and trkB mRNA expression in the 6-hydroxydopamine-induced model of preclinical stages of Parkinson's disease: an influence of chronic pramipexole in rats.

An influence of ligands of metabotropic glutamate receptor subtypes on parkinsonian-like symptoms and the striatopallidal pathway in rats

Antiparkinsonian action of MK-801 on the reserpine-induced rigidity: a mechanomyographic analysis.

Antiparkinsonian-like effects of CPL500036, a novel selective inhibitor of phosphodiesterase 10A, in the unilateral rat model of Parkinson's disease

Apomorphine enhances harmaline-induced tremor in rats.

Blockade of adenosine A2A receptors inhibits Tremulous Jaw Movements as well as expression of zif-268 and GAD65 mRNAs in brain motor structures

Blockade of the metabotropic glutamate receptor subtype 5 (mGluR5) produces antiparkinsonian-like effects in rats

Can the supersensitivity of rodents to dopamine be regarded as a model of tardive dyskinesia?

Chronic haloperidol and clozapine administration increases the number of cortical NMDA receptors in rats.

Chronic treatment with haloperidol diminishes the phencyclidine-induced sensorimotor gating deficit in rats.

Contralateral rotations induced by intrastriatal injections of agonists of excitatory amino acid receptors

Decline in motor functions in aging is related to the loss of NMDA receptors.

Degeneration of dopaminergic mesocortical neurons and activation of compensatory processes induced by a long-term paraquat administration in rats: implications for Parkinson's disease.

Depression in Parkinson's disease

Differential effects of chronic haloperidol and clozapine administration on glutamatergic transmission in the fronto-parietal cortex in rats: microdialysis and electrophysiological studies

Direct mechanomyographic measurement of the myorelaxant action of baclofen and diazepam in normal and reserpinized rats

Disturbances in neurotransmission processes in aging and age-related diseases.

Does reserpine induce parkinsonian rigidity?

Dopamine receptors--the present state of research and perspectives.

Dr. Gert Schulze, M.D. (1941-2013). In memoriam.

Effect of the NMDA receptor antagonist, MK-801, on locomotor activity and on the metabolism of dopamine in various brain areas of mice.

Effects of MPEP on avoidance learning in rats.

Evidence for the independent role of GABA synapses of the zona incerta-lateral hypothalamic region in haloperidol-induced catalepsy

Further evidence for the subsensitivity of striatal AMPA receptors, induced by chronic haloperidol administration: an autoradiographic study.

GABA mechanisms of ventromedial thalamic nucleus in morphine-induced muscle rigidity

Genotypic differences in locomotor stimulation and dopaminergic activity following acute ethanol administration

Globus pallidus conveys striatal impulses connected with neuroleptic catalepsy to the lateral hypothalamus-zona incerta

Glycogen synthase kinase 3β and its phosphorylated form (Y216) in the paraquat-induced model of parkinsonism

Haloperidol-increased muscle tone in rats as a model of parkinsonian rigidity.

Increased reactive oxygen species production in the brain after repeated low-dose pesticide paraquat exposure in rats. A comparison with peripheral tissues.

Influence of 6-hydroxydopamine lesion of the dopaminergic nigrostriatal pathway on the muscle tone and electromyographic activity measured during passive movements

Influence of long-lasting administration of neuroleptics on cortical NMDA receptors and phencyclidine-induced deficit in the sensorimotor gating in rats.

Influence of paraquat on dopaminergic transporter in the rat brain

Inhibition of Excessive Glutamatergic Transmission in the Ventral Thalamic Nuclei by a Selective Adenosine A1 Receptor Agonist, 5'-Chloro-5'-Deoxy-(±)-ENBA Underlies its Tremorolytic Effect in the Harmaline-Induced Model of Essential Tremor

Interaction between striatal excitatory amino acid and gamma-aminobutyric acid (GABA) receptors in the turning behaviour of rats

Involvement of the nucleus accumbens in the myorelaxant effect of baclofen in rats.

L-701,324, a selective antagonist at the glycine site of the NMDA receptor, counteracts haloperidol-induced muscle rigidity in rats

LY354740, a group II metabotropic glutamate receptor agonist with potential antiparkinsonian properties in rats.

Lack of a strong influence of neuroleptic decanoates on dopaminergic and GABAergic functions

Lateral hypothalamus-zona incerta region as an output station for the catalepsy induced by the blockade of striatal D1 and D2 dopamine receptors

Lesion of the cerebellar noradrenergic innervation enhances the harmaline-induced tremor in rats.

Lu AF21934, a positive allosteric modulator of mGlu4 receptors, reduces the harmaline-induced hyperactivity but not tremor in rats.

MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats.

Metabotropic glutamate receptors

Muscle rigidity induced by fluphenazine in rats is antagonized by L-DOPA, an antiparkinsonian drug

Muscle rigidity induced by the opioid analgesic tramadol, but not by the non-opioid flupirtine.

Muscle stiffness and continuous electromyographic activity in old rats; an animal model for spasticity?

Neuroprotective action of MPEP, a selective mGluR5 antagonist, in methamphetamine-induced dopaminergic neurotoxicity is associated with a decrease in dopamine outflow and inhibition of hyperthermia in rats.

Parkinson's disease-like syndrome in rats induced by 2,9-dimethyl-beta-carbolinium ion, a beta-carboline occurring in the human brain.

Partial lesion of the dopaminergic innervation of the ventral striatum induces "depressive-like" behavior of rats

Potential antipsychotic action of the selective agonist of adenosine A1 receptors, 5'-Cl-5'-deoxy-ENBA, in amphetamine and MK-801 rat models

Pramipexole Reduces zif-268 mRNA Expression in Brain Structures involved in the Generation of Harmaline-Induced Tremor

Pramipexole at a Low Dose Induces Beneficial Effect in the Harmaline-induced Model of Essential Tremor in Rats.

Pramipexole but not imipramine or fluoxetine reverses the "depressive-like" behaviour in a rat model of preclinical stages of Parkinson's disease.

Role of metabotropic glutamate receptors in animal models of Parkinson's disease.

Role of the metabotropic glutamate receptor subtype 1 in the harmaline-induced tremor in rats.

Specific involvement of striatal D1 and D2 dopamine receptors in the neuroleptic catalepsy in rats

Stimulation of glutamate receptors in the intermediate/caudal striatum induces contralateral turning.

Striatal and nucleus accumbens D1/D2 dopamine receptors in neuroleptic catalepsy

Thalamus as a relay station for catalepsy and rigidity

The effect of imipramine and mianserin on the behavior and EEG afterdischarges induced by single electric stimulation of the rabbit amygdala

The effect of unilateral amygdala lesion on the imipramine action in behavioural despair in rats ⬇️

The effect of unilateral amygdala lesion on the imipramine action in behavioural despair in rats

The influence of dizocilpine (MK-801) on the reserpine-enhanced electromyographic stretch reflex in rats

The influence of group III metabotropic glutamate receptor stimulation by (1S,3R,4S)-1-aminocyclo-pentane-1,3,4-tricarboxylic acid on the parkinsonian-like akinesia and striatal proenkephalin and prodynorphin mRNA expression in rats.

The influence of long-term haloperidol- or fluphenazine decanoate treatments on striatal dopaminergic and nigral GABA-ergic functions

The influence of preconditioning with low dose of LPS on paraquat-induced neurotoxicity, microglia activation and expression of α-synuclein and synphilin-1 in the dopaminergic system

The involvement of cerebellar dopamine D3 receptors in locomotor activity of rats

The neostriatal inhibition of catalepsy, but not of muscle rigidity, evoked from the substantia nigra pars reticulata