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List of works by Pierre Gourdy

17Beta-estradiol promotes TLR4-triggered proinflammatory mediator production through direct estrogen receptor alpha signaling in macrophages in vivo.

scientific article published on 16 June 2010

A natural protective function of invariant NKT cells in a mouse model of innate-cell-driven lung inflammation

scientific article published on 11 January 2011

Activation function 2 (AF2) of estrogen receptor-alpha is required for the atheroprotective action of estradiol but not to accelerate endothelial healing

scientific article

Adaptive Beta-Cell Neogenesis in the Adult Mouse in Response to Glucocorticoid-Induced Insulin Resistance

scientific article published on 16 October 2018

Apelin administration improves insulin sensitivity in overweight men during hyperinsulinaemic-euglycaemic clamp.

scientific article

Association Between Diabetic Macular Edema and Cardiovascular Events in Type 2 Diabetes Patients: A Multicenter Observational Study.

scientific article

Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case-control study.

scientific article

Association of estrogens and selective estrogens receptors modulators: towards a renewal of the hormonal treatment?

scientific article published on 13 August 2015

Associations between hepatic miRNA expression, liver triacylglycerols and gut microbiota during metabolic adaptation to high-fat diet in mice

scientific article

Author Correction: Dimorphic metabolic and endocrine disorders in mice lacking the constitutive androstane receptor

scientific article published on 03 March 2020

Blood glucose levels and COVID-19. Reply to Sardu C, D'Onofrio N, Balestrieri ML et al [letter] and Lepper PM, Bals R, Jüni P et al [letter]

scientific article published on 20 August 2020

Calcineurin Inhibitors Downregulate HNF-1β and May Affect the Outcome of HNF1B Patients After Renal Transplantation

scientific article published on 01 September 2016

Chronic estradiol administration in vivo promotes the proinflammatory response of macrophages to TLR4 activation: involvement of the phosphatidylinositol 3-kinase pathway.

scientific article published in June 2008

Chronic estradiol treatment reduces platelet responses and protects mice from thromboembolism through the hematopoietic estrogen receptor α.

scientific article published on 9 July 2012

Consensus statement on the care of the hyperglycaemic/diabetic patient during and in the immediate follow-up of acute coronary syndrome

Correction to: Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study

scientific article published on 02 July 2020

Correction: High-Fat Diet Induces Periodontitis in Mice through Lipopolysaccharides (LPS) Receptor Signaling: Protective Action of Estrogens.

scientific article

Death, end-stage renal disease and renal function decline in patients with diabetic nephropathy in French cohorts of type 1 and type 2 diabetes

scientific article published on 20 October 2015

Defective leptin/leptin receptor signaling improves regulatory T cell immune response and protects mice from atherosclerosis

scientific article

Deleting TCR alpha beta+ or CD4+ T lymphocytes leads to opposite effects on site-specific atherosclerosis in female apolipoprotein E-deficient mice

scientific article

Diabetes and oral contraception.

scientific article published on 19 December 2012

Dimorphic metabolic and endocrine disorders in mice lacking the constitutive androstane receptor

scientific article published on 27 December 2019

Direct comparison of the specialised blood fibrosis tests FibroMeterV2G and Enhanced Liver Fibrosis score in patients with non-alcoholic fatty liver disease from tertiary care centres

scientific article published on 15 October 2019

Eating frequency and body fatness in middle-aged men

scientific article published on 01 November 2002

Effect of raloxifene -- a selective oestrogen receptor modulator -- on kidney function in post-menopausal women with Type 2 diabetes: results from a randomized, placebo-controlled pilot trial

scientific article published on 19 April 2007

Effectiveness and Persistence of Liraglutide Treatment Among Patients with Type 2 Diabetes Treated in Primary Care and Specialist Settings: A Subgroup Analysis from the EVIDENCE Study, a Prospective, 2-Year Follow-up, Observational, Post-Marketing S

scientific article published on 30 January 2017

Effectiveness and Persistence with Liraglutide Among Patients with Type 2 Diabetes in Routine Clinical Practice--EVIDENCE: A Prospective, 2-Year Follow-Up, Observational, Post-Marketing Study

scientific article

Efficacy and Safety of Switching Patients Inadequately Controlled on Basal Insulin to Insulin Glargine 300 U/mL: The TRANSITION 2 Study

scientific article published on 28 November 2019

Endothelial estrogen receptor-alpha plays a crucial role in the atheroprotective action of 17beta-estradiol in low-density lipoprotein receptor-deficient mice.

scientific article published on 7 December 2009

Essential role of bone marrow fibroblast growth factor-2 in the effect of estradiol on reendothelialization and endothelial progenitor cell mobilization.

scientific article published on November 2006

Estradiol accelerates endothelial healing through the retrograde commitment of uninjured endothelium.

scientific article published on 25 April 2008

Estradiol administration controls eosinophilia through estrogen receptor-alpha activation during acute peritoneal inflammation

scientific article

Estradiol enhances primary antigen-specific CD4 T cell responses and Th1 development in vivo. Essential role of estrogen receptor alpha expression in hematopoietic cells

scientific article published in February 2003

Estradiol increases urethral tone through the local inhibition of neuronal nitric oxide synthase expression

scientific article

Estrogen Therapy Delays Autoimmune Diabetes and Promotes the Protective Efficiency of Natural Killer T-Cell Activation in Female Nonobese Diabetic Mice.

scientific article published on 20 October 2015

Estrogen receptor alpha expression in both endothelium and hematopoietic cells is required for the accelerative effect of estradiol on reendothelialization.

scientific article published on 16 July 2009

Estrogen receptor alpha, but not beta, is required for optimal dendritic cell differentiation and [corrected] CD40-induced cytokine production

scientific article published in March 2008

Estrogen receptor subcellular localization and cardiometabolism

scientific article published on 16 May 2018

Estrogen receptors and endothelium.

scientific article published on August 2010

Estrogens and atherosclerosis.

scientific article published on February 2004

Estrogens in vascular biology and disease: where do we stand today?

scientific article published on October 2007

Estrogens protect against high-fat diet-induced insulin resistance and glucose intolerance in mice.

scientific article published on 22 January 2009

Failure of L-nitroarginine to inhibit the activity of aortic inducible nitric oxide synthase.

scientific article published in May 2001

From in vivo gene targeting of oestrogen receptors to optimization of their modulation in menopause.

scientific article published on January 2012

From the Women's Health Initiative to the combination of estrogen and selective estrogen receptor modulators to avoid progestin addition

scientific article published on 26 July 2015

GLP-1-based strategies: a physiological analysis of differential mode of action

scientific article

Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes

scientific article published on 11 February 2008

Gestational diabetes and acromegaly: Single-centre experience of 14 pregnancies

scientific article published on 14 October 2019

Glucose Profiles in Pregnant Women After a Gastric Bypass : Findings from Continuous Glucose Monitoring

scientific article published on 01 September 2016

Harnessing glucagon-like peptide-1 receptor agonists for the pharmacological treatment of overweight and obesity.

scientific article published on 16 September 2016

Hepatic PPARα is critical in the metabolic adaptation to sepsis

scientific article published on 21 January 2019

High-fat diet induces periodontitis in mice through lipopolysaccharides (LPS) receptor signaling: protective action of estrogens

scientific article

Hormonal contraception in women at risk of vascular and metabolic disorders: guidelines of the French Society of Endocrinology.

scientific article

In vivo dissection of the estrogen receptor alpha: uncoupling of its physiological effects and medical perspectives

scientific article published on 06 April 2013

Influence of sildenafil on micturition and urethral tone in ovariectomized and non-ovariectomized mice.

scientific article published on 6 December 2011

Internalization of microparticles by endothelial cells promotes platelet/endothelial cell interaction under flow ⬇️

scientific article published on December 1, 2010

Lessons from the dissection of the activation functions (AF-1 and AF-2) of the estrogen receptor alpha in vivo

scientific article

Lixisenatide as add-on to oral anti-diabetic therapy: an effective treatment for glycaemic control with body weight benefits in type 2 diabetes

scientific article published in November 2014

Lixisenatide as add-on treatment among patients with different β-cell function levels as assessed by HOMA-β index

scientific article

MFN2-associated lipomatosis: Clinical spectrum and impact on adipose tissue

scientific article published on 25 July 2018

Macrophage-derived HMGB1 is dispensable for tissue fibrogenesis

scientific article published on 12 February 2019

Measles virus nucleoprotein induces a regulatory immune response and reduces atherosclerosis in mice

scientific article published on 17 September 2007

Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications.

scientific article

Membrane expression of the estrogen receptor ERα is required for intercellular communications in the mammary epithelium

scientific article published on 11 March 2020

Mutation of the palmitoylation site of estrogen receptor α in vivo reveals tissue-specific roles for membrane versus nuclear actions.

scientific article

Natural regulatory T cells control the development of atherosclerosis in mice

article

Nuclear and Membrane Actions of Estrogen Receptor Alpha: Contribution to the Regulation of Energy and Glucose Homeostasis.

scientific article published in January 2017

Omapatrilat, a dual angiotensin-converting enzyme and neutral endopeptidase inhibitor, prevents fatty streak deposit in apolipoprotein E-deficient mice.

scientific article published in April 2001

Periodontal treatment to improve glycaemic control in diabetic patients: study protocol of the randomized, controlled DIAPERIO trial

scientific article published on 02 August 2009

Phenotypic Characteristics and Development of a Hospitalization Prediction Risk Score for Outpatients with Diabetes and COVID-19: The DIABCOVID Study

scientific article published on 20 November 2020

Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study

scientific article published on 29 May 2020

Plasma Apelin and Risk of Type 2 Diabetes in a Cohort From the Community

scientific article published on 05 December 2019

Predominant Role of Nuclear Versus Membrane Estrogen Receptor α in Arterial Protection: Implications for Estrogen Receptor α Modulation in Cardiovascular Prevention/Safety

scientific article published on 29 June 2018

Prevalence of insulin resistance syndrome in southwestern France and its relationship with inflammatory and hemostatic markers

scientific article published in August 2002

Prevention of obesity and insulin resistance by estrogens requires ERα activation function-2 (ERαAF-2), whereas ERαAF-1 is dispensable

scientific article published on 31 July 2013

Prevention of skin flap necrosis by estradiol involves reperfusion of a protected vascular network.

scientific article

Protective role of uncoupling protein 2 in atherosclerosis

scientific article

Rationale and methodology for a European pooled analysis of postmarketing interventional and observational studies of insulin glargine 300 U/mL in diabetes: protocol of REALI project

scientific article published on 28 April 2020

Relationship between obesity and severe COVID-19 outcomes in patients with type 2 diabetes: results from the CORONADO study

scientific article published on 14 October 2020

Relevance of sexual dimorphism to regulatory T cells: estradiol promotes IFN-gamma production by invariant natural killer T cells.

scientific article published on 21 September 2004

Role of fibroblast growth factor-2 isoforms in the effect of estradiol on endothelial cell migration and proliferation.

scientific article published on 8 April 2004

Role of human smooth muscle cell progenitors in atherosclerotic plaque development and composition

article

Role of inflammatory cytokines in the effect of estradiol on atheroma.

scientific article

Selective Activation of Estrogen Receptor α Activation Function-1 Is Sufficient to Prevent Obesity, Steatosis, and Insulin Resistance in Mouse

scientific article

Selective Liver Estrogen Receptor α Modulation Prevents Steatosis, Diabetes, and Obesity Through the Anorectic Growth Differentiation Factor 15 Hepatokine in Mice ⬇️

scientific article published on 29 April 2019

Sex differences in metabolic regulation and diabetes susceptibility

scientific article published on 21 November 2019

Sex hormone levels are not associated with progression of renal disease in male patients with T2DM.

scientific article published on 22 June 2016

Specific abrogation of transforming growth factor-beta signaling in T cells alters atherosclerotic lesion size and composition in mice

scientific article published on 14 August 2003

Specific actions of GLP-1 receptor agonists and DPP4 inhibitors for the treatment of pancreatic β-cell impairments in type 2 diabetes

scientific article

Structure-function relationship of estrogen receptors in cardiovascular pathophysiological models

scientific article published on October 2012

Tamoxifen elicits atheroprotection through estrogen receptor α AF-1 but does not accelerate reendothelialization

scientific article published on 10 May 2013

The AF-1 activation function of estrogen receptor α is necessary and sufficient for uterine epithelial cell proliferation in vivo

scientific article published on 11 April 2013

The Activation Function-1 of Estrogen Receptor Alpha Prevents Arterial Neointima Development Through a Direct Effect on Smooth Muscle Cells.

scientific article

The Pro-Th1 cytokine IL-12 enhances IL-4 production by invariant NKT cells: relevance for T cell-mediated hepatitis

scientific article published on 01 May 2007

The TLR-mediated response of plasmacytoid dendritic cells is positively regulated by estradiol in vivo through cell-intrinsic estrogen receptor α signaling.

scientific article published on 16 November 2011

The atheroprotective effect of 17 beta-estradiol is not altered in P-selectin- or ICAM-1-deficient hypercholesterolemic mice.

scientific article published in January 2003

The atheroprotective effect of 17beta-estradiol depends on complex interactions in adaptive immunity

scientific article published on July 2005

The effects of periodontal treatment on diabetic patients: The DIAPERIO randomized controlled trial

scientific article published on 14 September 2018

The estrogen effects on endothelial repair and mitogen-activated protein kinase activation are abolished in endothelial nitric-oxide (NO) synthase knockout mice, but not by NO synthase inhibition by N-nitro-L-arginine methyl ester

scientific article

The pro-Th2 cytokine IL-33 directly interacts with invariant NKT and NK cells to induce IFN-gamma production.

scientific article published in April 2009

The tissue-specific effects of different 17β-estradiol doses reveal the key sensitizing role of AF1 domain in ERα activity

scientific article published on 28 January 2020

The transactivating function 1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of 17beta-estradiol

scientific article

The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation

scientific article

Timing of the vascular actions of estrogens in experimental and human studies: why protective early, and not when delayed?

scientific article published on 16 December 2010

Towards optimization of estrogen receptor modulation in medicine

scientific article published on 03 May 2018

Transforming growth factor activity is a key determinant for the effect of estradiol on fatty streak deposit in hypercholesterolemic mice

scientific article published on 09 August 2007

Treatment of experimental murine pancreatic peritoneal carcinomatosis with fibroblasts genetically modified to express IL12: a role for peritoneal innate immunity.

scientific article published on 4 August 2006

Understanding the oestrogen action in experimental and clinical atherosclerosis.

scientific article published on December 2006

Urinary and genital infections in patients with diabetes: How to diagnose and how to treat.

scientific article published on 28 August 2015

Urinary lysophopholipids are increased in diabetic patients with nephropathy

scientific article

Use of local estrogenotherapy in urology and pelviperineology: A systematic review

scientific article published on 11 February 2015

Usefulness of experimental models to understand the vascular effects of estrogens

scientific article published in December 2003

Vaginal lubrication after cervicovaginal stimulation is facilitated by phosphodiesterase type 5 inhibition in ovariectomized mice.

scientific article

[French Society of Endocrinology's 33th Congress in Bordeaux]

scientific article published on 18 August 2016

[Management of dyslipidemia in adult]

scientific article published on 01 September 2016

[Menopause and cardiovascular risk]

scientific article published on 05 October 2012

[Tissue-specific membrane effects of estrogen receptor alpha]

scientific article published on 16 December 2015

[Towards an optimization of the modulation of the estrogen receptor during menopausal hormonal therapy]

scientific article published on 01 December 2018

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