List of works - Pierre Gourdy

Natural regulatory T cells control the development of atherosclerosis in mice

article

Estrogens protect against high-fat diet-induced insulin resistance and glucose intolerance in mice.

scientific article published on 22 January 2009

The pro-Th2 cytokine IL-33 directly interacts with invariant NKT and NK cells to induce IFN-gamma production.

scientific article published in April 2009

Protective role of uncoupling protein 2 in atherosclerosis

scientific article

Mutation of the palmitoylation site of estrogen receptor α in vivo reveals tissue-specific roles for membrane versus nuclear actions.

scientific article

17Beta-estradiol promotes TLR4-triggered proinflammatory mediator production through direct estrogen receptor alpha signaling in macrophages in vivo.

scientific article published on 16 June 2010

Defective leptin/leptin receptor signaling improves regulatory T cell immune response and protects mice from atherosclerosis

scientific article

The TLR-mediated response of plasmacytoid dendritic cells is positively regulated by estradiol in vivo through cell-intrinsic estrogen receptor α signaling.

scientific article published on 16 November 2011

Estradiol enhances primary antigen-specific CD4 T cell responses and Th1 development in vivo. Essential role of estrogen receptor alpha expression in hematopoietic cells

scientific article published in February 2003

Estrogen receptors and endothelium.

scientific article published on August 2010

Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications.

scientific article

Chronic estradiol administration in vivo promotes the proinflammatory response of macrophages to TLR4 activation: involvement of the phosphatidylinositol 3-kinase pathway.

scientific article published in June 2008

Relevance of sexual dimorphism to regulatory T cells: estradiol promotes IFN-gamma production by invariant natural killer T cells.

scientific article published on 21 September 2004

Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes

scientific article published on 11 February 2008

The transactivating function 1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of 17beta-estradiol

scientific article

Internalization of microparticles by endothelial cells promotes platelet/endothelial cell interaction under flow

scientific article published on December 1, 2010

Prevalence of insulin resistance syndrome in southwestern France and its relationship with inflammatory and hemostatic markers

scientific article published in August 2002

Activation function 2 (AF2) of estrogen receptor-alpha is required for the atheroprotective action of estradiol but not to accelerate endothelial healing

scientific article

Specific abrogation of transforming growth factor-beta signaling in T cells alters atherosclerotic lesion size and composition in mice

scientific article published on 14 August 2003

Deleting TCR alpha beta+ or CD4+ T lymphocytes leads to opposite effects on site-specific atherosclerosis in female apolipoprotein E-deficient mice

scientific article

Eating frequency and body fatness in middle-aged men

scientific article published on 01 November 2002

Estrogen receptor alpha, but not beta, is required for optimal dendritic cell differentiation and [corrected] CD40-induced cytokine production

scientific article published in March 2008

Timing of the vascular actions of estrogens in experimental and human studies: why protective early, and not when delayed?

scientific article published on 16 December 2010

Endothelial estrogen receptor-alpha plays a crucial role in the atheroprotective action of 17beta-estradiol in low-density lipoprotein receptor-deficient mice.

scientific article published on 7 December 2009

The AF-1 activation function of estrogen receptor α is necessary and sufficient for uterine epithelial cell proliferation in vivo

scientific article published on 11 April 2013

Role of human smooth muscle cell progenitors in atherosclerotic plaque development and composition

article

Prevention of obesity and insulin resistance by estrogens requires ERα activation function-2 (ERαAF-2), whereas ERαAF-1 is dispensable

scientific article published on 31 July 2013

Role of fibroblast growth factor-2 isoforms in the effect of estradiol on endothelial cell migration and proliferation.

scientific article published on 8 April 2004

Specific actions of GLP-1 receptor agonists and DPP4 inhibitors for the treatment of pancreatic β-cell impairments in type 2 diabetes

scientific article

Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study

scientific article published on 29 May 2020

Prevention of skin flap necrosis by estradiol involves reperfusion of a protected vascular network.

scientific article

High-fat diet induces periodontitis in mice through lipopolysaccharides (LPS) receptor signaling: protective action of estrogens

scientific article

Estrogens in vascular biology and disease: where do we stand today?

scientific article published on October 2007

Lessons from the dissection of the activation functions (AF-1 and AF-2) of the estrogen receptor alpha in vivo

scientific article

The Pro-Th1 cytokine IL-12 enhances IL-4 production by invariant NKT cells: relevance for T cell-mediated hepatitis

scientific article published on 01 May 2007

Chronic estradiol treatment reduces platelet responses and protects mice from thromboembolism through the hematopoietic estrogen receptor α.

scientific article published on 9 July 2012

Estrogens and atherosclerosis.

scientific article published on February 2004

Measles virus nucleoprotein induces a regulatory immune response and reduces atherosclerosis in mice

scientific article published on 17 September 2007

Estrogen receptor alpha expression in both endothelium and hematopoietic cells is required for the accelerative effect of estradiol on reendothelialization.

scientific article published on 16 July 2009

A natural protective function of invariant NKT cells in a mouse model of innate-cell-driven lung inflammation

scientific article published on 11 January 2011

The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation

scientific article

Death, end-stage renal disease and renal function decline in patients with diabetic nephropathy in French cohorts of type 1 and type 2 diabetes

scientific article published on 20 October 2015

Estradiol accelerates endothelial healing through the retrograde commitment of uninjured endothelium.

scientific article published on 25 April 2008

Estradiol increases urethral tone through the local inhibition of neuronal nitric oxide synthase expression

scientific article

Essential role of bone marrow fibroblast growth factor-2 in the effect of estradiol on reendothelialization and endothelial progenitor cell mobilization.

scientific article published on November 2006

Estrogen Therapy Delays Autoimmune Diabetes and Promotes the Protective Efficiency of Natural Killer T-Cell Activation in Female Nonobese Diabetic Mice.

scientific article published on 20 October 2015

Estradiol administration controls eosinophilia through estrogen receptor-alpha activation during acute peritoneal inflammation

scientific article

Treatment of experimental murine pancreatic peritoneal carcinomatosis with fibroblasts genetically modified to express IL12: a role for peritoneal innate immunity.

scientific article published on 4 August 2006

Effectiveness and Persistence with Liraglutide Among Patients with Type 2 Diabetes in Routine Clinical Practice--EVIDENCE: A Prospective, 2-Year Follow-Up, Observational, Post-Marketing Study

scientific article

The atheroprotective effect of 17beta-estradiol depends on complex interactions in adaptive immunity

scientific article published on July 2005

List of works by Pierre Gourdy

Natural regulatory T cells control the development of atherosclerosis in mice

Estrogens protect against high-fat diet-induced insulin resistance and glucose intolerance in mice.

The pro-Th2 cytokine IL-33 directly interacts with invariant NKT and NK cells to induce IFN-gamma production.

Protective role of uncoupling protein 2 in atherosclerosis

Mutation of the palmitoylation site of estrogen receptor α in vivo reveals tissue-specific roles for membrane versus nuclear actions.

17Beta-estradiol promotes TLR4-triggered proinflammatory mediator production through direct estrogen receptor alpha signaling in macrophages in vivo.

Defective leptin/leptin receptor signaling improves regulatory T cell immune response and protects mice from atherosclerosis

The TLR-mediated response of plasmacytoid dendritic cells is positively regulated by estradiol in vivo through cell-intrinsic estrogen receptor α signaling.

Estradiol enhances primary antigen-specific CD4 T cell responses and Th1 development in vivo. Essential role of estrogen receptor alpha expression in hematopoietic cells

Estrogen receptors and endothelium.

Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications.

Chronic estradiol administration in vivo promotes the proinflammatory response of macrophages to TLR4 activation: involvement of the phosphatidylinositol 3-kinase pathway.

Relevance of sexual dimorphism to regulatory T cells: estradiol promotes IFN-gamma production by invariant natural killer T cells.

Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes

The transactivating function 1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of 17beta-estradiol

Internalization of microparticles by endothelial cells promotes platelet/endothelial cell interaction under flow

Prevalence of insulin resistance syndrome in southwestern France and its relationship with inflammatory and hemostatic markers

Activation function 2 (AF2) of estrogen receptor-alpha is required for the atheroprotective action of estradiol but not to accelerate endothelial healing

Specific abrogation of transforming growth factor-beta signaling in T cells alters atherosclerotic lesion size and composition in mice

Deleting TCR alpha beta+ or CD4+ T lymphocytes leads to opposite effects on site-specific atherosclerosis in female apolipoprotein E-deficient mice

Eating frequency and body fatness in middle-aged men

Estrogen receptor alpha, but not beta, is required for optimal dendritic cell differentiation and [corrected] CD40-induced cytokine production

Timing of the vascular actions of estrogens in experimental and human studies: why protective early, and not when delayed?

Endothelial estrogen receptor-alpha plays a crucial role in the atheroprotective action of 17beta-estradiol in low-density lipoprotein receptor-deficient mice.

The AF-1 activation function of estrogen receptor α is necessary and sufficient for uterine epithelial cell proliferation in vivo

Role of human smooth muscle cell progenitors in atherosclerotic plaque development and composition

Prevention of obesity and insulin resistance by estrogens requires ERα activation function-2 (ERαAF-2), whereas ERαAF-1 is dispensable

Role of fibroblast growth factor-2 isoforms in the effect of estradiol on endothelial cell migration and proliferation.

Specific actions of GLP-1 receptor agonists and DPP4 inhibitors for the treatment of pancreatic β-cell impairments in type 2 diabetes

Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study

Prevention of skin flap necrosis by estradiol involves reperfusion of a protected vascular network.

High-fat diet induces periodontitis in mice through lipopolysaccharides (LPS) receptor signaling: protective action of estrogens

Estrogens in vascular biology and disease: where do we stand today?

Lessons from the dissection of the activation functions (AF-1 and AF-2) of the estrogen receptor alpha in vivo

The Pro-Th1 cytokine IL-12 enhances IL-4 production by invariant NKT cells: relevance for T cell-mediated hepatitis

Chronic estradiol treatment reduces platelet responses and protects mice from thromboembolism through the hematopoietic estrogen receptor α.

Estrogens and atherosclerosis.

Measles virus nucleoprotein induces a regulatory immune response and reduces atherosclerosis in mice

Estrogen receptor alpha expression in both endothelium and hematopoietic cells is required for the accelerative effect of estradiol on reendothelialization.

A natural protective function of invariant NKT cells in a mouse model of innate-cell-driven lung inflammation

The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation

Death, end-stage renal disease and renal function decline in patients with diabetic nephropathy in French cohorts of type 1 and type 2 diabetes

Estradiol accelerates endothelial healing through the retrograde commitment of uninjured endothelium.

Estradiol increases urethral tone through the local inhibition of neuronal nitric oxide synthase expression

Essential role of bone marrow fibroblast growth factor-2 in the effect of estradiol on reendothelialization and endothelial progenitor cell mobilization.

Estrogen Therapy Delays Autoimmune Diabetes and Promotes the Protective Efficiency of Natural Killer T-Cell Activation in Female Nonobese Diabetic Mice.

Estradiol administration controls eosinophilia through estrogen receptor-alpha activation during acute peritoneal inflammation

Treatment of experimental murine pancreatic peritoneal carcinomatosis with fibroblasts genetically modified to express IL12: a role for peritoneal innate immunity.

Effectiveness and Persistence with Liraglutide Among Patients with Type 2 Diabetes in Routine Clinical Practice--EVIDENCE: A Prospective, 2-Year Follow-Up, Observational, Post-Marketing Study

The atheroprotective effect of 17beta-estradiol depends on complex interactions in adaptive immunity