List of works by Rachel F Tyndale

"Target-Site" Drug Metabolism and Transport.

scientific article

A Comparison of Direct and Indirect Analytical Approaches to Measuring Total Nicotine Equivalents in Urine

scientific article published on 31 May 2018

A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism

scientific article published on 25 September 2015

A clinical trial to examine disparities in quitting between African-American and White adult smokers: Design, accrual, and baseline characteristics

scientific article published on 5 December 2015

A cluster of three GABAA receptor subunit genes is deleted in a neurological mutant of the mouse p locus.

scientific article published in July 1993

A common genetic defect in nicotine metabolism decreases risk for dependence and lowers cigarette consumption

scientific article

A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes.

scientific article published in September 1997

A novel CYP2A6 allele (CYP2A6*35) resulting in an amino-acid substitution (Asn438Tyr) is associated with lower CYP2A6 activity in vivo

scientific article

A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent

scientific article

A systems biology network model for genetic association studies of nicotine addiction and treatment.

scientific article published on July 2009

Acute effects of a very low nicotine content cigarette on laboratory smoking lapse: Impacts of nicotine metabolism and nicotine dependence

scientific article published on 23 June 2020

Alaska Native smokers and smokeless tobacco users with slower CYP2A6 activity have lower tobacco consumption, lower tobacco-specific nitrosamine exposure and lower tobacco-specific nitrosamine bioactivation

scientific article

An association of CYP2A6 genotype and smoking topography

scientific article published on 01 April 2007

An in vivo pilot study characterizing the new CYP2A6*7, *8, and *10 alleles

scientific article published in January 2002

Analyses of nicotine metabolism biomarker genetics stratified by sex in African and European Americans

scientific article published on 01 October 2021

Assessment of nicotine dependence symptoms in adolescents: a comparison of five indicators.

scientific article published on December 2002

Association between daily cigarette consumption and hypertension moderated by CYP2A6 genotypes in Chinese male current smokers.

scientific article

Association of CHRNA5-A3-B4 SNP rs2036527 with smoking cessation therapy response in African-American smokers

scientific article

Association of Reduced Nicotine Content Cigarettes With Smoking Behaviors and Biomarkers of Exposure Among Slow and Fast Nicotine Metabolizers: A Nonrandomized Clinical Trial

scientific article published on 24 August 2018

Association of nicotine metabolite ratio and CYP2A6 genotype with smoking cessation treatment in African-American light smokers

scientific article published on 11 March 2009

Association of the nicotine metabolite ratio and CHRNA5/CHRNA3 polymorphisms with smoking rate among treatment-seeking smokers

scientific article

Associations of CYP2A6 genotype with smoking behaviors in southern China

scientific article

Attitudes toward Precision Treatment of Smoking in the Southern Community Cohort Study

scientific article published on 03 June 2019

Beyond quitting: Any additional impact of mailing free nicotine patches to current smokers?

scientific article

Biomarkers for smoking cessation

scientific article published on 18 March 2013

Black Light Smokers: How Nicotine Intake and Carcinogen Exposure Differ Across Various Biobehavioral Factors

scientific article published on 11 May 2019

Brain CYP2B induction can decrease nicotine levels in the brain

scientific article published on 27 May 2016

Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics.

scientific article

Brain Responses to Smoking Cues Differ Based on Nicotine Metabolism Rate

scientific article published on 26 November 2015

Brain drug-metabolizing cytochrome P450 enzymes are active in vivo, demonstrated by mechanism-based enzyme inhibition.

scientific article published on 30 July 2008

Breaking barriers in the genomics and pharmacogenetics of drug addiction

scientific article

Bupropion for smoking cessation in African American light smokers: a randomized controlled trial

scientific article published on 25 January 2012

C57BL/6 Substrain Differences in Pharmacological Effects after Acute and Repeated Nicotine Administration

scientific article published on 21 September 2019

CHRNA5-A3-B4 genetic variants alter nicotine intake and interact with tobacco use to influence body weight in Alaska Native tobacco users.

scientific article published on 05 July 2013

CYP-mediated drug metabolism in the brain impacts drug response

scientific article published on 9 October 2017

CYP2A6 Genetic Variation Alters Striatal-Cingulate Circuits, Network Hubs, and Executive Processing in Smokers

scientific article published on 28 September 2016

CYP2A6 and CYP2B6 genetic variation and its association with nicotine metabolism in South Western Alaska Native people

scientific article

CYP2A6 genetic variation and dexmedetomidine disposition

scientific article

CYP2A6 genetic variation and potential consequences

scientific article (publication date: 18 November 2002)

CYP2A6 genotype and the metabolism and disposition kinetics of nicotine.

scientific article

CYP2A6 genotype but not age determines cotinine half-life in infants and children.

scientific article published on 29 May 2013

CYP2A6 genotype, phenotype, and the use of nicotine metabolites as biomarkers during ad libitum smoking.

scientific article published in October 2006

CYP2A6 genotyping methods and strategies using real-time and end point PCR platforms. ⬇️

scientific article published on 15 December 2015

CYP2A6 reduced activity gene variants confer reduction in lung cancer risk in African American smokers--findings from two independent populations

scientific article

CYP2A6 slow nicotine metabolism is associated with increased quitting by adolescent smokers

scientific article published on April 2013

CYP2B6 and bupropion's smoking-cessation pharmacology: the role of hydroxybupropion

scientific article

CYP2B6 genotype alters abstinence rates in a bupropion smoking cessation trial.

scientific article published on 16 January 2007

CYP2B6 genotype does not alter nicotine metabolism, plasma levels, or abstinence with nicotine replacement therapy.

scientific article published in June 2007

CYP2B6 is expressed in African Green monkey brain and is induced by chronic nicotine treatment

scientific article published on 23 November 2005

CYP2D6 and CYP2A6 biotransform dietary tyrosol into hydroxytyrosol.

scientific article published on 7 September 2016

CYP2D6 phenotype and genotype in a Canadian Native Indian population

scientific article published in April 1997

CYP2E1*1D regulatory polymorphism: association with alcohol and nicotine dependence

scientific article published in June 2003

Canadian Native Indians exhibit unique CYP2A6 and CYP2C19 mutant allele frequencies*

article

Cannabinoids: Friend or foe?

scientific article published on June 2015

Cardiovascular benefits of tyrosol and its endogenous conversion into hydroxytyrosol in humans. A randomized, controlled trial

scientific article published on 31 August 2019

Changes in Nicotine Metabolite Ratio Among Daily Smokers Receiving Treatment for Alcohol Use Disorder

scientific article published on 01 February 2020

Characterising the nicotine metabolite ratio and its association with treatment choice: A cross sectional analysis of Stop Smoking Services in England.

scientific article published on 14 December 2017

Characterization and comparison of nicotine and cotinine metabolism in vitro and in vivo in DBA/2 and C57BL/6 mice.

scientific article published on 7 December 2006

Characterization of cytochrome P-450 2D1 activity in rat brain: high-affinity kinetics for dextromethorphan.

scientific article

Characterization of the novel CYP2A6*21 allele using in vivo nicotine kinetics

scientific article published on 28 April 2006

Chronic nicotine treatment induces rat CYP2D in the brain but not in the liver: an investigation of induction and time course

scientific journal article

Chronic oral nicotine treatment protects against striatal degeneration in MPTP-treated primates.

scientific article published in August 2006

Cigarette consumption and biomarkers of nicotine exposure during pregnancy and postpartum

scientific article published on 23 July 2018

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2B6 and Efavirenz-containing Antiretroviral Therapy

scientific article published on 05 July 2019

Cohort Profile: The Nicotine Dependence in Teens (NDIT) Study

scientific article

Comparison of three CYP2D6 probe substrates and genotype in Ghanaians, Chinese and Caucasians

scientific article

Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of [...]

scientific journal article

Cytochrome P450 2D6 and treatment of codeine dependence.

scientific article

Cytochrome P450 2D6 enzyme neuroprotects against 1-methyl-4-phenylpyridinium toxicity in SH-SY5Y neuronal cells.

scientific article published on 22 March 2010

Cytochrome P450 2D6.1 and cytochrome P450 2D6.10 differ in catalytic activity for multiple substrates.

scientific article

Cytochrome P450 enzymes in the brain: emerging evidence of biological significance

scientific article published on 3 October 2011

Cytochrome P450-mediated drug metabolism in the brain

scientific article

Cytochrome P4502C9 (CYP2C9) allele frequencies in Canadian Native Indian and Inuit populations

scientific article

D3 dopamine receptors and a missense mutation of fatty acid amide hydrolase linked in mouse and men: implication for addiction

scientific article published on 27 November 2019

DRD1 associations with smoking abstinence across slow and normal nicotine metabolizers

scientific article

Data on the endogenous conversion of tyrosol into hydroxytyrosol in humans

scientific article published on 12 November 2019

Decreased Nicotinic Receptor Availability in Smokers with Slow Rates of Nicotine Metabolism

scientific article

Decreasing smoking behaviour and risk through CYP2A6 inhibition.

scientific article

Deficient C-oxidation of nicotine continued.

scientific article published in December 2001

Design, baseline characteristics, and retention of African American light smokers into a randomized trial involving biological data.

scientific article

Designer Drugs 2.0.

scientific article published in February 2017

Designer drugs that are potent inhibitors of CYP2D6

scientific article (publication date: June 2002)

Developmental hippocampal neuroplasticity in a model of nicotine replacement therapy during pregnancy and breastfeeding

scientific article (publication date: 2012)

Differences in pharmacogenetics of nicotine and alcohol metabolism: review and recommendations for future research.

scientific article published on September 2007

Differences in the rate of nicotine metabolism among smokers with and without HIV

scientific article published on 01 May 2019

Differential effects of nicotine treatment and ethanol self-administration on CYP2A6, CYP2B6 and nicotine pharmacokinetics in African green monkeys

scientific article

Differential induction of ethanol-metabolizing CYP2E1 and nicotine-metabolizing CYP2B1/2 in rat liver by chronic nicotine treatment and voluntary ethanol intake

scientific article published on 13 March 2009

Disposition kinetics and metabolism of nicotine and cotinine in African American smokers: impact of CYP2A6 genetic variation and enzymatic activity

scientific article published on 31 March 2016

Dissecting the genetic overlap of smoking behaviors, lung cancer, and chronic obstructive pulmonary disease: A focus on nicotinic receptors and nicotine metabolizing enzyme

scientific article published on 16 August 2020

Does cannabis use moderate smoking cessation outcomes in treatment-seeking tobacco smokers? Analysis from a large multi-center trial.

scientific article published on 17 May 2016

Does coffee consumption impact on heaviness of smoking?

scientific article published on 27 May 2017

Does menthol cigarette use moderate the effect of nicotine metabolism on short-term smoking cessation?

scientific article

Does the nicotine metabolite ratio moderate smoking cessation treatment outcomes in real-world settings? A prospective study

scientific article published on 30 October 2018

Dopamine genes and nicotine dependence in treatment-seeking and community smokers

scientific article published on 3 June 2009

Dopaminergic signaling mediates the motivational response underlying the opponent process to chronic but not acute nicotine

scientific article published on 23 December 2009

Dose-independent kinetics with low level exposure to nicotine and cotinine

scientific article published on January 2013

Down-regulation of hepatic nicotine metabolism and a CYP2A6-like enzyme in African green monkeys after long-term nicotine administration

scientific article

Drug Metabolizing Enzyme and Transporter Gene Variation, Nicotine Metabolism, Prospective Abstinence, and Cigarette Consumption

scientific article

Drugs and genotypes: how pharmacogenetic information could improve smoking cessation treatment.

scientific article published on July 2006

Duplications and defects in the CYP2A6 gene: identification, genotyping, and in vivo effects on smoking

scientific article

Effect of Brain CYP2B Inhibition on Brain Nicotine Levels and Nicotine Self-Administration.

scientific article

Effect of Mailing Nicotine Patches on Tobacco Cessation Among Adult Smokers: A Randomized Clinical Trial

scientific article published on 25 January 2016

Effect of UGT2B10, UGT2B17, FMO3, and OCT2 genetic variation on nicotine and cotinine pharmacokinetics and smoking in African Americans

scientific article published on 7 February 2017

Effect of cytochrome P450 2D1 inhibition on hydrocodone metabolism and its behavioral consequences in rats.

scientific article

Effect of food training and training dose on nicotine self-administration in rats.

scientific article

Effect of metabolic blockade on the psychoactive effects of dextromethorphan

scientific article published in January 2010

Effects of Menthol on Nicotine Pharmacokinetic, Pharmacology and Dependence in Mice.

scientific article published on 10 September 2015

Effects of Nicotine Metabolic Rate on Cigarette Reinforcement

scientific article published on 14 November 2019

Effects of Nicotine Metabolic Rate on Withdrawal Symptoms and Response to Cigarette Smoking After Abstinence

scientific article published on 25 October 2018

Effects of methoxsalen, a CYP2A5/6 inhibitor, on nicotine dependence behaviors in mice

scientific article

Effects of varenicline on cognitive function in non-smokers with schizophrenia.

scientific article published on 10 March 2017

Elevated CYP2C19 expression is associated with depressive symptoms and hippocampal homeostasis impairment

scientific article published on 29 November 2016

Elevated CYP2C19 expression is associated with depressive symptoms and hippocampal homeostasis impairment

scientific article published on 18 April 2017

Epigenome-wide association study of serum cotinine in current smokers reveals novel genetically driven loci

scientific article published on 05 January 2019

Ethanol self-administration and nicotine treatment increase brain levels of CYP2D in African green monkeys

scientific article

Ethanol self-administration and nicotine treatment induce brain levels of CYP2B6 and CYP2E1 in African green monkeys

scientific article

Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians.

scientific article published in September 2004

Ethnic variation in CYP2A6*7, CYP2A6*8 and CYP2A6*10 as assessed with a novel haplotyping method.

scientific article published in March 2005

Evaluating metronidazole as a novel, safe CYP2A6 phenotyping probe in healthy adults

scientific article published on 12 March 2019

Evaluating the temporal relationships between withdrawal symptoms and smoking relapse

scientific article published on 07 January 2019

Evaluation of a weighted genetic risk score for the prediction of biomarkers of CYP2A6 activity

scientific article published on 27 February 2019

Evaluation of methoxsalen, tranylcypromine, and tryptamine as specific and selective CYP2A6 inhibitors in vitro.

scientific article

Evaluation of nicotine patch adherence measurement using self-report and saliva cotinine among abstainers in a smoking cessation trial

scientific article published on 20 March 2020

Evidence of association between smoking and alpha7 nicotinic receptor subunit gene in schizophrenia patients

scientific article published in August 2004

Exposure to nicotine and carcinogens among Southwestern Alaskan Native cigarette smokers and smokeless tobacco users

scientific article

Factors That Explain Differences in Abstinence Between Black and White Smokers: A Prospective Intervention Study

scientific article published on 01 October 2019

Factors associated with discontinuation of bupropion and counseling among African American light smokers in a randomized clinical trial.

scientific article published on December 2013

Factors influencing cotinine half-life during smoking abstinence in African American and Caucasian women.

scientific article

Fatty Acid Amide Hydrolase Binding in Brain of Cannabis Users: Imaging With the Novel Radiotracer [11C]CURB.

scientific article

Fatty acid amide hydrolase is lower in young cannabis users

scientific article published on 20 January 2020

Functional Connectivity of the Raphe Nuclei: Link to Tobacco Withdrawal in Smokers

scientific article published on 01 September 2018

Functional characterization of novel rare CYP2A6 variants and potential implications for clinical outcomes

scientific article published on 25 September 2021

Gender-stratified gene and gene-treatment interactions in smoking cessation

scientific article published on 2 August 2011

Gene variants in CYP2C19 are associated with altered in vivo bupropion pharmacokinetics but not bupropion-assisted smoking cessation outcomes

scientific article (publication date: November 2014)

Gene-gene interactions between CYP2B6 and CYP2A6 in nicotine metabolism

scientific article published in December 2007

Genetic Relationship between Schizophrenia and Nicotine Dependence

scientific article published on 10 May 2016

Genetic and environmental influences on the ratio of 3'hydroxycotinine to cotinine in plasma and urine

scientific article

Genetic and pharmacokinetic determinants of response to transdermal nicotine in white, black, and Asian nonsmokers

scientific article published on 09 August 2013

Genetic and phenotypic variation in UGT2B17, a testosterone-metabolizing enzyme, is associated with BMI in males

scientific article

Genetic influences on smoking: a brief review

scientific article

Genetic variation in CYP2A6-mediated nicotine metabolism alters smoking behavior

scientific article (publication date: February 2002)

Genetic variation in nicotine metabolism predicts the efficacy of extended-duration transdermal nicotine therapy

scientific article published on 24 March 2010

Genetically decreased CYP2A6 and the risk of tobacco dependence: a prospective study of novice smokers.

scientific article published on December 2004

Genetically deficient CYP2D6 metabolism provides protection against oral opiate dependence.

scientific article published in October 1997

Genetics of alcohol and tobacco use in humans.

scientific article

Genetics of smoking behavior in American Indians

scientific article published on 27 August 2020

Genome-Wide Meta-Analyses of FTND and TTFC Phenotypes

scientific article published on 11 July 2019

Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2.

scientific article published on February 2016

Genome-wide association meta-analysis of nicotine metabolism and cigarette consumption measures in smokers of European descent

scientific article published on 10 March 2020

Genome-wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences

scientific article

Genomewide Association Studies in Pharmacogenomics: Meeting Report of the NIH Pharmacogenomics Research Network-RIKEN (PGRN-RIKEN) Collaboration

scientific article published on 03 June 2016

Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities

scientific article published on 06 November 2019

Guidelines on nicotine dose selection for in vivo research.

scientific article published on 9 August 2006

Hepatic CYP2A6 levels and nicotine metabolism: impact of genetic, physiological, environmental, and epigenetic factors.

scientific article

High dose transdermal nicotine for fast metabolizers of nicotine: a proof of concept placebo-controlled trial.

scientific article published on 15 May 2012

Human CYP2D6 Is Functional in Brain In Vivo: Evidence from Humanized CYP2D6 Transgenic Mice

scientific article published on 18 March 2020

Human CYP2D6 and mouse CYP2Ds: organ distribution in a humanized mouse model

scientific article published on 20 July 2005

Human CYP2D6 in the Brain Is Protective Against Harmine-Induced Neurotoxicity: Evidence from Humanized CYP2D6 Transgenic Mice

scientific article published on 06 August 2020

Identification of novel CYP2A6*1B variants: the CYP2A6*1B allele is associated with faster in vivo nicotine metabolism.

scientific article

Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk

scientific article published in Nature Communications

Imaging Brain Fatty Acid Amide Hydrolase in Untreated Patients With Psychosis

scientific article published on 12 March 2020

Imaging changes in synaptic acetylcholine availability in living human subjects.

scientific article published on 15 November 2012

Impact of CYP2A6 Activity on Nicotine Reinforcement and Cue-Reactivity in Daily Smokers

scientific article published on 01 August 2021

Impact of CYP2A6 genotype on pretreatment smoking behaviour and nicotine levels from and usage of nicotine replacement therapy

scientific article published in April 2006

Impact of early nausea on varenicline adherence and smoking cessation

scientific article published on 05 November 2019

Impact of self-reported lifetime depression or anxiety on effectiveness of mass distribution of nicotine patches

scientific article published on 19 August 2016

Implications of CYP2A6 genetic variation for smoking behaviors and nicotine dependence.

scientific article

Improvement of the association between self-reported pill count and varenicline levels following exclusion of participants with misreported pill count: A commentary on Peng et al. (2017).

scientific article published on 2 December 2017

In vivo and in vitro characterization of chlorzoxazone metabolism and hepatic CYP2E1 levels in African Green monkeys: induction by chronic nicotine treatment

scientific article

Incorporation of pharmacogenomics into routine clinical practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development process

scientific article

Independent and combined effects of ethanol self-administration and nicotine treatment on hepatic CYP2E1 in African green monkeys.

scientific article published on 25 August 2011

Inducing rat brain CYP2D with nicotine increases the rate of codeine tolerance; predicting the rate of tolerance from acute analgesic response.

scientific article published on 21 August 2017

Induction and recovery time course of rat brain CYP2E1 after nicotine treatment.

scientific article published on 24 January 2006

Induction of CYP2B1/2 and nicotine metabolism by ethanol in rat liver but not rat brain

scientific article

Induction of the drug metabolizing enzyme CYP2D in monkey brain by chronic nicotine treatment

scientific article published on 19 July 2008

Influence of CYP2B6 genetic variants on plasma and urine concentrations of bupropion and metabolites at steady state.

scientific article published on March 2013

Influence of Nicotine Metabolism Ratio on [11C]-(+)-PHNO PET binding in Tobacco Smokers

scientific article published on 13 January 2018

Influence of a dopamine pathway additive genetic efficacy score on smoking cessation: results from two randomized clinical trials of bupropion

scientific article published on 18 September 2013

Infusion of brain-derived neurotrophic factor into the ventral tegmental area switches the substrates mediating ethanol motivation.

scientific article published on 21 December 2012

Inhibition of cytochrome P450 2A6 increases nicotine's oral bioavailability and decreases smoking

scientific article published on 01 July 2000

Inhibition of cytochrome P450 2D6 modifies codeine abuse liability

scientific article (publication date: August 2000)

Inhibition of cytochromes P450 by antifungal imidazole derivatives

scientific article published in March 2002

Inhibition of nicotine metabolism by methoxysalen: Pharmacokinetic and pharmacological studies in mice.

scientific article

Interaction between heavy smoking and CYP2A6 genotypes on type 2 diabetes and its possible pathways

scientific article

Interaction of buprenorphine and its metabolite norbuprenorphine with cytochromes p450 in vitro

scientific article

Interactions between age and the aversive effects of nicotine withdrawal under mecamylamine-precipitated and spontaneous conditions in male Wistar rats.

scientific article published on 3 April 2008

Intercellular calcium waves in neurons.

scientific article published on May 1996

Intracerebroventricularly and systemically delivered inhibitor of brain CYP2B (C8-Xanthate), even following chlorpyrifos exposure, reduces chlorpyrifos activation and toxicity in male rats.

scientific article

Known and novel sources of variability in the nicotine metabolite ratio in a large sample of treatment-seeking smokers

scientific article

Lack of Associations of CHRNA5-A3-B4 Genetic Variants with Smoking Cessation Treatment Outcomes in Caucasian Smokers despite Associations with Baseline Smoking

scientific article published on 26 May 2015

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

scientific article published on 12 June 2017

Letrozole concentration is associated with CYP2A6 variation but not with arthralgia in patients with breast cancer

scientific article published on 09 August 2018

Leveraging genomic data in smoking cessation trials in the era of Precision Medicine: Why and how.

scientific article

Long-term effectiveness of mailed nicotine replacement therapy: study protocol of a randomized controlled trial 5-year follow-up

scientific article

Longitudinal Influence of Pregnancy on Nicotine Metabolic Pathways.

scientific article

Low doses of nicotine and ethanol induce CYP2E1 and chlorzoxazone metabolism in rat liver

scientific article

Lower brain fatty acid amide hydrolase in treatment-seeking patients with alcohol use disorder: a positron emission tomography study with [C-11]CURB

scientific article published on 07 January 2020

Lymphoma-Associated Biomarkers Are Increased in Current Smokers in Twin Pairs Discordant for Smoking

scientific article

Measures and predictors of varenicline adherence in the treatment of nicotine dependence.

scientific article

Metabolism of 18-methoxycoronaridine, an ibogaine analog, to 18-hydroxycoronaridine by genetically variable CYP2C19.

scientific article

Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation

scientific article published on 15 July 2016

Molecular genetics of nicotine metabolism.

scientific article published on January 2009

NAD(P)H:quinone oxidoreductase: polymorphisms and allele frequencies in Caucasian, Chinese and Canadian Native Indian and Inuit populations.

scientific article

Neural basis of smoking-induced relief of craving and negative affect: Contribution of nicotine

scientific article published on 11 October 2018

Neurodegenerative diseases: a growing challenge.

scientific article published in October 2010

Neuroimaging in psychiatric pharmacogenetics research: the promise and pitfalls

scientific article

New CYP2A6 gene deletion and conversion variants in a population of Black African descent.

scientific article published on February 2010

Nicotine Dependence, Nicotine Metabolism, and the Extent of Compensation in Response to Reduced Nicotine Content Cigarettes.

scientific article

Nicotine Increases Codeine Analgesia Through the Induction of Brain CYP2D and Central Activation of Codeine to Morphine.

scientific article published on 29 January 2015

Nicotine Metabolism-informed Care for Smoking Cessation: A Pilot Precision RCT.

scientific article published on 14 October 2017

Nicotine dependence as a moderator of genetic influences on smoking cessation treatment outcome

scientific article

Nicotine dependence pharmacogenetics: role of genetic variation in nicotine-metabolizing enzymes

scientific article published on 23 January 2009

Nicotine induces brain CYP enzymes: relevance to Parkinson's disease

scientific article published on January 2006

Nicotine kinetics in zebra finches in vivo and in vitro.

scientific article published on 25 March 2013

Nicotine metabolic rate predicts successful smoking cessation with transdermal nicotine: a validation study

scientific article published on 31 October 2008

Nicotine metabolism and CYP2A6 activity in a population of black African descent: impact of gender and light smoking.

scientific article published on 8 December 2006

Nicotine metabolism defect reduces smoking

scientific article published in June 1998

Nicotine metabolism: the impact of CYP2A6 on estimates of additive genetic influence

scientific article published in February 2005

Nicotine metabolite ratio (3-hydroxycotinine/cotinine) in plasma and urine by different analytical methods and laboratories: implications for clinical implementation

scientific article published on 26 May 2015

Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity

scientific article

Nicotine metabolite ratio predicts efficacy of transdermal nicotine for smoking cessation

scientific article published on 11 May 2006

Nicotine metabolite ratio predicts smoking topography and carcinogen biomarker level

scientific article

Nicotine metabolite ratio: Comparison of the three urinary versions to the plasma version and nicotine clearance in three clinical studies

scientific article published on 20 April 2021

Nicotine pharmacokinetics in rats is altered as a function of age, impacting the interpretation of animal model data.

scientific article

Nicotine physical dependence and tolerance in the mouse following chronic oral administration.

scientific article

Nicotine-dependence symptoms are associated with smoking frequency in adolescents

scientific article published in October 2003

Nicotine-motivated behavior in Caenorhabditis elegans requires the nicotinic acetylcholine receptor subunits acr-5 and acr-15.

scientific article published on 25 January 2013

Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation

scientific article published on July 2008

Nicotinic acetylcholine receptor variation and response to smoking cessation therapies

scientific article published on February 2013

Non-nicotinic therapies for smoking cessation.

scientific article

Novel CYP2A6 diplotypes identified through next-generation sequencing are associated with in-vitro and in-vivo nicotine metabolism

scientific article published in January 2018

Novel CYP2A6 variants identified in African Americans are associated with slow nicotine metabolism in vitro and in vivo

scientific article published on February 2014

Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent.

scientific article

Opioids: The Painful Public Health Reality

scientific article published on 01 June 2018

Organic cation transporter variation and response to smoking cessation therapies

scientific article

Paroxetine Steady-State Plasma Concentration in Relation to CYP2D6 Genotype in Extensive Metabolizers

scientific article published on 01 October 1999

Patterns of lapses and recoveries during a quit attempt using varenicline and behavioral counseling among smokers with and without HIV

scientific article published on 20 July 2020

Perceptions of pharmacogenetic research to guide tobacco cessation by patients, providers and leaders in a tribal healthcare setting

scientific article published on 12 February 2016

Personalized dosing of nicotine replacement therapy versus standard dosing for the treatment of individuals with tobacco dependence: study protocol for a randomized placebo-controlled trial

scientific article published on 29 June 2020

PharmGKB summary: very important pharmacogene information for cytochrome P-450, family 2, subfamily A, polypeptide 6

scientific article

Pharmacogenetic Optimization of Smoking Cessation Treatment

scientific article

Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting.

scientific article published on 19 October 2015

Pharmacogenetics of drug dependence: role of gene variations in susceptibility and treatment.

scientific article published on January 2010

Pharmacogenetics of nicotine and associated smoking behaviors

scientific article published on January 2015

Pharmacogenetics of nicotine metabolism in twins: methods and procedures.

scientific article

Pharmacogenomics at the tipping point: challenges and opportunities

scientific article published on 01 March 2011

Pharmacogenomics of nicotine metabolism: novel CYP2A6 and CYP2B6 genetic variation patterns in Alaska Native and American Indian populations

scientific article published on 25 June 2019

Pharmacokinetic and pharmacodynamics studies of nicotine after oral administration in mice: effects of methoxsalen, a CYP2A5/6 inhibitor.

scientific article published on 24 July 2013

Phenobarbital induces monkey brain CYP2E1 protein but not hepatic CYP2E1, in vitro or in vivo chlorzoxazone metabolism

scientific article published on 16 September 2006

Pilot study of CYP2B6 genetic variation to explore the contribution of nitrosamine activation to lung carcinogenesis.

scientific article published on 16 April 2013

Plasma letrozole concentrations in postmenopausal women with breast cancer are associated with CYP2A6 genetic variants, body mass index, and age.

scientific article

Predicting smoking abstinence with biological and self-report measures of adherence to varenicline: Impact on pharmacogenetic trial outcomes

scientific article published on 26 June 2018

Predictors of Variation in CYP2A6 mRNA, Protein, and Enzyme Activity in a Human Liver Bank: Influence of Genetic and Nongenetic Factors.

scientific article

Predictors of cessation in African American light smokers enrolled in a bupropion clinical trial

scientific article published on 29 November 2012

Pregnancy-Induced Increases in the Nicotine Metabolite Ratio: Examining Changes During Antepartum and Postpartum

scientific article published on 01 November 2019

Pregnant Smokers Receiving Opioid Agonist Therapy Have an Elevated Nicotine Metabolite Ratio: A Replication Study

scientific article published on 18 April 2020

Preparing the Way: Exploiting Genomic Medicine to Stop Smoking

scientific article published on 4 January 2018

Progress in pharmacogenomics: bridging the gap from research to practice

scientific article published on 01 March 2014

Propranolol is a mechanism-based inhibitor of CYP2D and CYP2D6 in humanized CYP2D6-transgenic mice: Effects on activity and drug responses

scientific article published on 06 January 2020

Psychotropic effects of dextromethorphan are altered by the CYP2D6 polymorphism: a pilot study.

scientific article

Quinidine: potent inhibition of sparteine and debrisoquine oxidation in vivo.

scientific article

RNA sequencing of transcriptomes in human brain regions: protein-coding and non-coding RNAs, isoforms and alleles

scientific article published on 23 November 2015

Racial differences in the relationship between rate of nicotine metabolism and nicotine intake from cigarette smoking.

scientific article

Randomized controlled trial of mailed Nicotine Replacement Therapy to Canadian smokers: study protocol.

scientific article

Rat brain CYP2B induction by nicotine is persistent and does not involve nicotinic acetylcholine receptors.

scientific article published on 20 June 2010

Rat brain CYP2D activity alters in vivo central oxycodone metabolism, levels and resulting analgesia

scientific article published on 21 December 2017

Rat hepatic CYP2E1 is induced by very low nicotine doses: an investigation of induction, time course, dose response, and mechanism

scientific article published on 15 May 2003

Rate of Nicotine Metabolism and Tobacco Use among Persons with HIV: Implications for Treatment and Research

article

Rate of nicotine metabolism and smoking cessation outcomes in a community-based sample of treatment-seeking smokers.

scientific article

Rational design of novel CYP2A6 inhibitors

scientific article published on 13 October 2014

Reduced (+/-)-3,4-methylenedioxymethamphetamine ("Ecstasy") metabolism with cytochrome P450 2D6 inhibitors and pharmacogenetic variants in vitro.

scientific article

Reduced-Nicotine Cigarettes in Young Smokers: Impact of Nicotine Metabolism on Nicotine Dose Effects.

scientific article published on 24 January 2017

Regional and cellular distribution of CYP2D subfamily members in rat brain.

scientific article published in June 2000

Regional and cellular expression of CYP2D6 in human brain: higher levels in alcoholics.

scientific article

Regional and cellular induction of nicotine-metabolizing CYP2B1 in rat brain by chronic nicotine treatment

scientific article

Relating individual differences in nicotine dependence severity to underpinning motivational and pharmacological processes among smokers from vulnerable populations

scientific article published on 03 July 2020

Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk

scientific article published on 11 July 2011

Relationship between amounts of daily cigarette consumption and abdominal obesity moderated by CYP2A6 genotypes in Chinese male current smokers.

scientific article

Relationship between skin melanin index and nicotine pharmacokinetics in African American smokers

scientific article published on 30 August 2019

Relationships between smoking behaviors and cotinine levels among two American Indian populations with distinct smoking patterns

scientific article

Reproducibility of the nicotine metabolite ratio in cigarette smokers

scientific article

Risk factors for tobacco dependence in adolescent smokers.

scientific article published on June 2006

S265. Endocannabinoid Metabolism and Alcohol Consumption in Youth: A PET Study With the Fatty Acid Amide Hydrolase Radioligand [11C]CURB

Selegiline is a mechanism-based inactivator of CYP2A6 inhibiting nicotine metabolism in humans and mice

scientific article

Sex differences in tobacco withdrawal and responses to smoking reduced-nicotine cigarettes in young smokers.

scientific article published on 11 October 2017

Simultaneous determination of haloperidol and reduced haloperidol by gas chromatography using a megabore column with electron-capture detection: application to microsomal oxidation of reduced haloperidol

scientific article published on 01 July 1990

Simultaneous gas chromatographic determination of methamphetamine, amphetamine and their p-hydroxylated metabolites in plasma and urine.

scientific article published in March 1997

Sleep Disturbance During Smoking Cessation: Withdrawal or Side Effect of Treatment?

scientific article published on 12 April 2016

Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain

scientific article

Socioeconomic and drug use determinants of smoking status in an urban adult population of Black African descent

scientific article

Sparteine metabolism capacity in human liver: structural variants of human P450IID6 as assessed by immunochemistry

scientific article published on 01 July 1990

T76. Involvement of the Endocannabinoid Enzyme Fatty Acid Amide Hydrolase in the Neurobiology of Impulsivity: Positron Emission Tomography Studies With [11C]CURB

Test-Retest Reliability and Stability of the Nicotine Metabolite Ratio Among Treatment-Seeking Smokers

scientific article

The DRD4 exon III VNTR, bupropion, and associations with prospective abstinence

scientific article published on 03 December 2012

The Late Positive Potentials Evoked by Cigarette-Related and Emotional Images Show no Gender Differences in Smokers

scientific article published on 01 March 2019

The Nicotine Metabolite Ratio is Associated With Early Smoking Abstinence Even After Controlling for Factors That Influence the Nicotine Metabolite Ratio.

scientific article published on 11 June 2015

The Value of Biosamples in Smoking Cessation Trials: A Review of Genetic, Metabolomic, and Epigenetic Findings

scientific article published on 3 May 2017

The ability of plasma cotinine to predict nicotine and carcinogen exposure is altered by differences in CYP2A6: the influence of genetics, race, and sex

scientific article

The association between self-reported varenicline adherence and varenicline blood levels in a sample of cancer patients receiving treatment for tobacco dependence.

scientific article published on 4 July 2018

The discriminative stimulus effects of i.v. nicotine in rhesus monkeys: Pharmacokinetics and apparent pA2 analysis with dihydro-β-erythroidine

scientific article published on 8 December 2016

The dopamine transporter and cytochrome P45OIID1 (debrisoquine 4-hydroxylase) in brain: resolution and identification of two distinct [3H]GBR-12935 binding proteins

scientific article published in February 1990

The effect of methoxsalen on nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in vivo

scientific article

The effect of tobacco use on the expression of placental transporters in Alaska Native women

scientific article published in 2022

The fatty acid amide hydrolase C385A (P129T) missense variant in cannabis users: studies of drug use and dependence in Caucasians.

scientific article published in July 2007

The fatty acid amide hydrolase C385A variant affects brain binding of the positron emission tomography tracer [11C]CURB.

scientific article published on 3 June 2015

The human dopamine D5 receptor gene: cloning and characterization of the 5'-flanking and promoter region

scientific article

The influence of tobacco smoke/nicotine on CYP2A expression in Human and African Green Monkey Lungs

scientific article published on 14 October 2020

The neuroprotective enzyme CYP2D6 increases in the brain with age and is lower in Parkinson's disease patients.

scientific article

The pharmacogenetics research network: from SNP discovery to clinical drug response.

scientific article published on March 2007

The potential role of the cytochrome P-450 2D6 pharmacogenetic polymorphism in drug abuse

scientific article published on January 1, 1997

The relationship between the nicotine metabolite ratio and three self-report measures of nicotine dependence across sex and race

scientific article

The role of CYP2A6 in the emergence of nicotine dependence in adolescents

scientific article published on 27 November 2006

The role of cytochrome P450 2C19 activity in flunitrazepam metabolism in vivo

scientific article published in April 2003

The role of pharmacogenetically-variable cytochrome P450 enzymes in drug abuse and dependence.

scientific article

The unique regulation of brain cytochrome P450 2 (CYP2) family enzymes by drugs and genetics.

scientific article published in May 2004

The γ-aminobutyric acid receptor γ3 subunit gene (GABRG3) is tightly linked to the α5 subunit gene (GABRA5) on human chromosome 15q11–q13 and is transcribed in the same orientation ⬇️

scientific article published on March 20, 1995

Three-dimensional culture and cAMP signaling promote the maturation of human pluripotent stem cell-derived hepatocytes.

scientific article published on August 2013

Tobacco use among southwestern Alaska Native people

scientific article published on 4 September 2012

Toward Precision Medicine for Smoking Cessation: Developing a Neuroimaging-Based Classification Algorithm to Identify Smokers at Higher Risk for Relapse

scientific article published on 14 November 2019

Toward personalized therapy for smoking cessation: a randomized placebo-controlled trial of bupropion.

scientific article published on 2 April 2008

Transferability Of Ancestry-Specific And Cross-Ancestry CYP2A6 Activity Genetic Risk Scores In African And European Populations

scientific article published on 09 December 2020

Treatment of codeine dependence with inhibitors of cytochrome P450 2D6

scientific article (publication date: June 2002)

Twenty-first-century neuroscience: the potential for innovative therapies for brain disorders.

scientific article published in February 2012

UGT1A and UGT2B genetic variation alters nicotine and nitrosamine glucuronidation in european and african american smokers

scientific article

Use of the nicotine metabolite ratio as a genetically informed biomarker of response to nicotine patch or varenicline for smoking cessation: a randomised, double-blind placebo-controlled trial

scientific article published on 12 January 2015

Utility and relationships of biomarkers of smoking in African-American light smokers.

scientific article published on December 2009

Varenicline-Induced Elevation of Dopamine in Smokers: A Preliminary [(11)C]-(+)-PHNO PET Study.

scientific article published on 7 October 2015

Variable CYP2A6-mediated nicotine metabolism alters smoking behavior and risk.

scientific article published in April 2001

Variation in CYP2A6 Activity and Personalized Medicine

scientific article published in December 2017

Variation in CYP2A6 and nicotine metabolism among two American Indian tribal groups differing in smoking patterns and risk for tobacco-related cancer

scientific article

Variation in CYP2A6 and tobacco dependence throughout adolescence and in young adult smokers

scientific article

Variation in P450 oxidoreductase (POR) A503V and flavin-containing monooxygenase (FMO)-3 E158K is associated with minor alterations in nicotine metabolism, but does not alter cigarette consumption.

scientific article published on March 2014

Variation in trans-3'-hydroxycotinine glucuronidation does not alter the nicotine metabolite ratio or nicotine intake.

scientific article

Paulina is supported by:

About Paulina

Help