List of works - Klaus Brandenburg

A new class of synthetic anti-lipopolysaccharide peptides inhibits influenza A virus replication by blocking cellular attachment.

scientific article

A new class of synthetic peptide inhibitors blocks attachment and entry of human pathogenic viruses

scientific article

Analysis of cytokine immune response profile in response to inflammatory stimuli in mice with genetic defects in fetal and adult hemoglobin chain expression

scientific article published on 4 January 2018

Antimicrobial Peptides and Their Therapeutic Potential for Bacterial Skin Infections and Wounds

scientific article published on 28 March 2018

Antimicrobial peptides and the enteric mucus layer act in concert to protect the intestinal mucosa

scientific article

Antimicrobial peptides and their potential application in inflammation and sepsis ⬇️

scientific article published on December 12, 2012

Bacterial Cell Wall Compounds as Promising Targets of Antimicrobial Agents I. Antimicrobial Peptides and Lipopolyamines ⬇️

scientific article published on August 1, 2012

Bacterial cell wall compounds as promising targets of antimicrobial agents II. Immunological and clinical aspects

scientific article

Bartonella quintana lipopolysaccharide (LPS): structure and characteristics of a potent TLR4 antagonist for in-vitro and in-vivo applications

scientific article

Biologically active lipid A antagonist embedded in a multilayered polyelectrolyte architecture

scientific article published on 20 October 2005

Biophysical Analysis of Lipopolysaccharide Formulations for an Understanding of the Low Endotoxin Recovery (LER) Phenomenon

scientific article published on 16 December 2017

Biophysical Mechanisms of Endotoxin Neutralization by Cationic Amphiphilic Peptides ⬇️

scientific article published on June 8, 2011

Biophysical analysis of the interaction of granulysin-derived peptides with enterobacterial endotoxins

scientific article

Biophysical analysis of the interaction of the serum protein human β2GPI with bacterial lipopolysaccharide

scientific article

Biophysical characterization of endotoxin inactivation by NK-2, an antimicrobial peptide derived from mammalian NK-lysin

scientific article published on May 2004

Biophysical characterization of synthetic rhamnolipids

scientific article published on 24 October 2006

Biophysical characterization of the interaction of Limulus polyphemus endotoxin neutralizing protein with lipopolysaccharide

scientific article

Biophysical characterization of the interaction of endotoxins with hemoglobins

scientific article

Biophysical characterization of the interaction of high-density lipoprotein (HDL) with endotoxins

scientific article

Biophysical characterization of triacyl monosaccharide lipid a partial structures in relation to bioactivity

scientific article published on July 2002

Biophysical investigations into the interactions of endotoxins with bile acids ⬇️

scientific article published on September 27, 2011

Biophysical mechanisms of the neutralization of endotoxins by lipopolyamines

scientific article published on 30 September 2013

Biophysical study of the non-steroidal anti-inflammatory drugs (NSAID) ibuprofen, naproxen and diclofenac with phosphatidylserine bilayer membranes

scientific article

Cellular distribution of lipid A and LPS R595 after in vitro application to isolated human monocytes by freeze-fracture replica immunogold-labelling ⬇️

scientific article published on February 12, 2013

Characterization of the N-terminal segment used by the barley yellow dwarf virus movement protein to promote interaction with the nuclear membrane of host plant cells

scientific article published on 21 August 2007

Chemical synthesis of a glycolipid library by a solid-phase strategy allows elucidation of the structural specificity of immunostimulation by rhamnolipids

scientific article

Combinational clustering of receptors following stimulation by bacterial products determines lipopolysaccharide responses

scientific article published on July 2004

Comparative analysis of selected methods for the assessment of antimicrobial and membrane-permeabilizing activity: a case study for lactoferricin derived peptides

scientific article

Corrigendum to “The membrane-activity of Ibuprofen, Diclofenac, and Naproxen: A physico-chemical study with lecithin phospholipids” [Biochim. Biophys. Acta 1788 (2009) 1296–1303]

scholarly article published in BBA - Biomembranes

Cross-linked hemoglobin converts endotoxically inactive pentaacyl endotoxins into a physiologically active conformation

scientific article published on 17 September 2003

Crucial roles of charged saccharide moieties in survival of gram negative bacteria against protamine revealed by combination of grazing incidence x-ray structural characterizations and Monte Carlo simulations

scientific article published on 2 April 2010

Cyclic antimicrobial peptides based on Limulus anti-lipopolysaccharide factor for neutralization of lipopolysaccharide

scientific article published in October 2004

Divalent cations affect chain mobility and aggregate structure of lipopolysaccharide from Salmonella minnesota reflected in a decrease of its biological activity

scientific article published in September 2005

Domain V of m-calpain shows the potential to form an oblique-orientated alpha-helix, which may modulate the enzyme's activity via interactions with anionic lipid

scientific article published in November 2002

Effects of specific versus nonspecific ionic interactions on the structure and lateral organization of lipopolysaccharides

scientific article published on May 2011

Endotoxins: relationships between structure, function, and activity

scientific article published in January 2004

Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide

scientific article published on January 2005

Enhancing actions of peptides derived from the γ-chain of fetal human hemoglobin on the immunostimulant activities of monophosphoryl lipid A.

scientific article published on 25 February 2016

Evaluation of Crystallographic Data with the Program DIAMOND

scientific article

Galleria mellonella native and analogue peptides Gm1 and ΔGm1. I) biophysical characterization of the interaction mechanisms with bacterial model membranes

scientific article

Galleria mellonella native and analogue peptides Gm1 and ΔGm1. II) anti-bacterial and anti-endotoxic effects

scientific article

Hemoglobin enhances the biological activity of synthetic and natural bacterial (endotoxic) virulence factors: a general principle

scientific article

Innate recognition of bacteria: engagement of multiple receptors.

scientific article

Interaction between the movement protein of barley yellow dwarf virus and the cell nuclear envelope: role of a putative amphiphilic alpha-helix at the N-terminus of the movement protein

scientific article published on October 2005

Interaction of lipopolysaccharide and phospholipid in mixed membranes: solid-state 31P-NMR spectroscopic and microscopic investigations

scientific article published on 2 May 2008

Interaction of quorum signals with outer membrane lipids: insights into prokaryotic membrane vesicle formation

scientific article published on July 2008

Intestinal mucus affinity and biological activity of an orally administered antibacterial and anti-inflammatory peptide

scientific article

Investigation into the interaction of recombinant human serum albumin with Re-lipopolysaccharide and lipid A.

scientific article published in January 2002

Investigation into the interaction of the bacterial protease OmpT with outer membrane lipids and biological activity of OmpT:lipopolysaccharide complexes

scientific article published on 6 July 2004

Investigation into the interaction of the phosphoporin PhoE with outer membrane lipids: physicochemical characterization and biological activity

scientific article

Investigations into the ability of an oblique alpha-helical template to provide the basis for design of an antimicrobial anionic amphiphilic peptide.

scientific article

Investigations into the mechanisms used by the C-terminal anchors of Escherichia coli penicillin-binding proteins 4, 5, 6 and 6b for membrane interaction.

scientific article

Investigations into the membrane interactions of m-calpain domain V.

scientific article

Lack of new antiinfective agents: Passing into the pre-antibiotic age?

scientific article published on August 2015

Lipopolysaccharide regions involved in the activation of Escherichia coli outer membrane protease OmpT.

scientific article published in March 2002

Lipoproteins/peptides are sepsis-inducing toxins from bacteria that can be neutralized by synthetic anti-endotoxin peptides

scientific article

MARCKS as a negative regulator of lipopolysaccharide signaling.

scientific article

Mechanical diagnosis of human erythrocytes by ultra-high speed manipulation unraveled critical time window for global cytoskeletal remodeling

scientific article published on 24 February 2017

Mechanical properties of interacting lipopolysaccharide membranes from bacteria mutants studied by specular and off-specular neutron scattering

scientific article published on 28 October 2009

Mechanism of Hbγ-35-induced an increase in the activation of the human immune system by endotoxins

scientific article published on 16 July 2014

Mechanism of interaction of optimized Limulus-derived cyclic peptides with endotoxins: thermodynamic, biophysical and microbiological analysis

scientific article published on September 2007

Mechanisms of endotoxin neutralization by synthetic cationic compounds

scientific article published on January 2006

Molecular basis for endotoxin neutralization by amphipathic peptides derived from the alpha-helical cationic core-region of NK-lysin

scientific article published on 29 January 2010

Molecular basis for membrane selectivity of NK-2, a potent peptide antibiotic derived from NK-lysin.

scientific article

Molecular interactions of mefenamic acid with lipid bilayers and red blood cells

Morphology, size distribution, and aggregate structure of lipopolysaccharide and lipid A dispersions from enterobacterial origin ⬇️

scientific article published on August 3, 2010

New antiseptic peptides to protect against endotoxin-mediated shock

scientific article

Novel Synthetic, Host-defense Peptide Protects Against Organ Injury/Dysfunction in a Rat Model of Severe Hemorrhagic Shock.

scientific article published on 10 March 2017

Novel integrated and portable endotoxin detection system based on an electrochemical biosensor.

scientific article published in January 2015

Peptide 19-2.5 inhibits heparan sulfate-triggered inflammation in murine cardiomyocytes stimulated with human sepsis serum

scientific article published on 29 May 2015

Peptide drug stability: The anti-inflammatory drugs Pep19-2.5 and Pep19-4LF in cream formulation

scientific article published on 11 January 2018

Peptide-based treatment of sepsis ⬇️

scientific article published on 03 March 2011

Peptides with dual mode of action: Killing bacteria and preventing endotoxin-induced sepsis

scientific article

Physical interactions of fish protamine and antisepsis peptide drugs with bacterial membranes revealed by combination of specular x-ray reflectivity and grazing-incidence x-ray fluorescence

scientific article published on 8 July 2013

Physical mechanisms of bacterial survival revealed by combined grazing-incidence X-ray scattering and Monte Carlo simulation

scientific article published in January 2009

Physico-chemical and biophysical study of the interaction of hexa- and heptaacyl lipid A from Erwinia carotovora with magainin 2-derived antimicrobial peptides

scientific article published on 6 April 2008

Physicochemical Interaction Study of Non-Steroidal Anti-Inflammatory Drugs with Dimyristoylphosphatidylethanolamine Liposomes

Physicochemical and Biological Analysis of Synthetic Bacterial Lipopeptides

scientific article published in Journal of Biological Chemistry

Physicochemical and Biological Characterization of Anti-Endotoxin Peptides and Their Influence on Lipid Properties ⬇️

scientific article published on November 1, 2010

Physicochemical characterization and biological activity of a glycoglycerolipid from Mycoplasma fermentans

scientific article published in August 2003

Physicochemical characterization and biological activity of lipooligosaccharides and lipid A from Neisseria meningitidis

scientific article published on January 2007

Physicochemical characterization of carboxymethyl lipid A derivatives in relation to biological activity

scientific article published in January 2005

Physicochemical characterization of the endotoxins from Coxiella burnetii strain Priscilla in relation to their bioactivities

scientific article

Physicochemical properties of bacterial glycopolymers in relation to bioactivity

scientific article published on November 2003

Preclinical investigations reveal the broad-spectrum neutralizing activity of peptide Pep19-2.5 on bacterial pathogenicity factors

scientific article published on 14 January 2013

Pulmonary surfactant protein A-induced changes in the molecular conformation of bacterial deep-rough LPS lead to reduced activity on human macrophages

scientific article published on 11 October 2013

Quantification of the Influence of Endotoxins on the Mechanics of Adult and Neonatal Red Blood Cells

scientific article published on 11 June 2015

Quantitative determination of ion distributions in bacterial lipopolysaccharide membranes by grazing-incidence X-ray fluorescence

scientific article

Rationale for the design of shortened derivatives of the NK-lysin-derived antimicrobial peptide NK-2 with improved activity against Gram-negative pathogens.

scientific article published on 27 March 2007

Self-Organisation, Thermotropic and Lyotropic Properties of Glycolipids Related to their Biological Implications

scientific article

Structural features governing the activity of lactoferricin-derived peptides that act in synergy with antibiotics against Pseudomonas aeruginosa in vitro and in vivo

scientific article

Structural investigations into the interaction of hemoglobin and part structures with bacterial endotoxins

scientific article published in February 2008

Structural polymorphism of hydrated ether-linked dimyristyl maltoside and melibioside

scientific article published on 25 September 2007

Structural polymorphism of hydrated monoacylated maltose glycolipids

scientific article published on 10 July 2008

Structural requirements of the Pseudomonas quinolone signal for membrane vesicle stimulation

scientific article published on 13 March 2009

Supramolecular structure of enterobacterial wild-type lipopolysaccharides (LPS), fractions thereof, and their neutralization by Pep19-2.5.

scientific article published on 29 January 2016

Synthesis and mesomorphic properties of glycosyl dialkyl- and diacyl-glycerols bearing saturated, unsaturated and methyl branched fatty acid and fatty alcohol chains. Part I. Synthesis

scientific article published on 16 February 2005

Synthesis and mesomorphic properties of glycosyl dialkyl- and diacyl-glycerols bearing saturated, unsaturated and methyl branched fatty acid and fatty alcohol chains. Part II. Mesomorphic properties

scientific article published on 2 March 2005

Synthetic anti-endotoxin peptides inhibit cytoplasmic LPS-mediated responses

scientific article

Synthetic antimicrobial and LPS-neutralising peptides suppress inflammatory and immune responses in skin cells and promote keratinocyte migration

scientific article

Temperature dependence of the binding of endotoxins to the polycationic peptides polymyxin B and its nonapeptide

scientific article published on 13 December 2004

Temperature-induced changes in the lipopolysaccharide of Yersinia pestis affect plasminogen activation by the pla surface protease

scientific article

The Synthetic Antimicrobial Peptide 19-2.5 Interacts with Heparanase and Heparan Sulfate in Murine and Human Sepsis

scientific article published on 23 November 2015

The acyl group as the central element of the structural organization of antimicrobial lipopeptide

scientific article

The anti-inflammatory effect of the synthetic antimicrobial peptide 19-2.5 in a murine sepsis model: a prospective randomized study

scientific article published on 9 January 2013

The expression of endotoxic activity in the Limulus test as compared to cytokine production in immune cells

scientific article published on January 2009

The generalized endotoxic principle

scientific article published in June 2003

The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition

scientific article

The lipopolysaccharide of Brucella abortus BvrS/BvrR mutants contains lipid A modifications and has higher affinity for bactericidal cationic peptides

scientific article published on August 2005

The membrane-activity of Ibuprofen, Diclofenac, and Naproxen: a physico-chemical study with lecithin phospholipids

scientific article

The physicochemistry of endotoxins in relation to bioactivity

scientific article published on 23 April 2007

The synthetic antimicrobial peptide 19-2.5 attenuates mitochondrial dysfunction in cardiomyocytes stimulated with human sepsis serum

scientific article published on 13 September 2016

The synthetic antimicrobial peptide 19-2.5 attenuates septic cardiomyopathy and prevents down-regulation of SERCA2 in polymicrobial sepsis

scientific article

Thermodynamic analysis of the lipopolysaccharide-dependent resistance of gram-negative bacteria against polymyxin B.

scientific article published on 19 January 2007

List of works by Klaus Brandenburg

A new class of synthetic anti-lipopolysaccharide peptides inhibits influenza A virus replication by blocking cellular attachment.

A new class of synthetic peptide inhibitors blocks attachment and entry of human pathogenic viruses

Analysis of cytokine immune response profile in response to inflammatory stimuli in mice with genetic defects in fetal and adult hemoglobin chain expression

Antimicrobial Peptides and Their Therapeutic Potential for Bacterial Skin Infections and Wounds

Antimicrobial peptides and the enteric mucus layer act in concert to protect the intestinal mucosa

Antimicrobial peptides and their potential application in inflammation and sepsis ⬇️

Bacterial Cell Wall Compounds as Promising Targets of Antimicrobial Agents I. Antimicrobial Peptides and Lipopolyamines ⬇️

Bacterial cell wall compounds as promising targets of antimicrobial agents II. Immunological and clinical aspects

Bartonella quintana lipopolysaccharide (LPS): structure and characteristics of a potent TLR4 antagonist for in-vitro and in-vivo applications

Biologically active lipid A antagonist embedded in a multilayered polyelectrolyte architecture

Biophysical Analysis of Lipopolysaccharide Formulations for an Understanding of the Low Endotoxin Recovery (LER) Phenomenon

Biophysical Mechanisms of Endotoxin Neutralization by Cationic Amphiphilic Peptides ⬇️

Biophysical analysis of the interaction of granulysin-derived peptides with enterobacterial endotoxins

Biophysical analysis of the interaction of the serum protein human β2GPI with bacterial lipopolysaccharide

Biophysical characterization of endotoxin inactivation by NK-2, an antimicrobial peptide derived from mammalian NK-lysin

Biophysical characterization of synthetic rhamnolipids

Biophysical characterization of the interaction of Limulus polyphemus endotoxin neutralizing protein with lipopolysaccharide

Biophysical characterization of the interaction of endotoxins with hemoglobins

Biophysical characterization of the interaction of high-density lipoprotein (HDL) with endotoxins

Biophysical characterization of triacyl monosaccharide lipid a partial structures in relation to bioactivity

Biophysical investigations into the interactions of endotoxins with bile acids ⬇️

Biophysical mechanisms of the neutralization of endotoxins by lipopolyamines

Biophysical study of the non-steroidal anti-inflammatory drugs (NSAID) ibuprofen, naproxen and diclofenac with phosphatidylserine bilayer membranes

Cellular distribution of lipid A and LPS R595 after in vitro application to isolated human monocytes by freeze-fracture replica immunogold-labelling ⬇️

Characterization of the N-terminal segment used by the barley yellow dwarf virus movement protein to promote interaction with the nuclear membrane of host plant cells

Chemical synthesis of a glycolipid library by a solid-phase strategy allows elucidation of the structural specificity of immunostimulation by rhamnolipids

Combinational clustering of receptors following stimulation by bacterial products determines lipopolysaccharide responses

Comparative analysis of selected methods for the assessment of antimicrobial and membrane-permeabilizing activity: a case study for lactoferricin derived peptides

Corrigendum to “The membrane-activity of Ibuprofen, Diclofenac, and Naproxen: A physico-chemical study with lecithin phospholipids” [Biochim. Biophys. Acta 1788 (2009) 1296–1303]

Cross-linked hemoglobin converts endotoxically inactive pentaacyl endotoxins into a physiologically active conformation

Crucial roles of charged saccharide moieties in survival of gram negative bacteria against protamine revealed by combination of grazing incidence x-ray structural characterizations and Monte Carlo simulations

Cyclic antimicrobial peptides based on Limulus anti-lipopolysaccharide factor for neutralization of lipopolysaccharide

Divalent cations affect chain mobility and aggregate structure of lipopolysaccharide from Salmonella minnesota reflected in a decrease of its biological activity

Domain V of m-calpain shows the potential to form an oblique-orientated alpha-helix, which may modulate the enzyme's activity via interactions with anionic lipid

Effects of specific versus nonspecific ionic interactions on the structure and lateral organization of lipopolysaccharides

Endotoxins: relationships between structure, function, and activity

Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide

Enhancing actions of peptides derived from the γ-chain of fetal human hemoglobin on the immunostimulant activities of monophosphoryl lipid A.

Evaluation of Crystallographic Data with the Program DIAMOND

Galleria mellonella native and analogue peptides Gm1 and ΔGm1. I) biophysical characterization of the interaction mechanisms with bacterial model membranes

Galleria mellonella native and analogue peptides Gm1 and ΔGm1. II) anti-bacterial and anti-endotoxic effects

Hemoglobin enhances the biological activity of synthetic and natural bacterial (endotoxic) virulence factors: a general principle

Innate recognition of bacteria: engagement of multiple receptors.

Interaction between the movement protein of barley yellow dwarf virus and the cell nuclear envelope: role of a putative amphiphilic alpha-helix at the N-terminus of the movement protein

Interaction of lipopolysaccharide and phospholipid in mixed membranes: solid-state 31P-NMR spectroscopic and microscopic investigations

Interaction of quorum signals with outer membrane lipids: insights into prokaryotic membrane vesicle formation

Intestinal mucus affinity and biological activity of an orally administered antibacterial and anti-inflammatory peptide

Investigation into the interaction of recombinant human serum albumin with Re-lipopolysaccharide and lipid A.

Investigation into the interaction of the bacterial protease OmpT with outer membrane lipids and biological activity of OmpT:lipopolysaccharide complexes

Investigation into the interaction of the phosphoporin PhoE with outer membrane lipids: physicochemical characterization and biological activity

Investigations into the ability of an oblique alpha-helical template to provide the basis for design of an antimicrobial anionic amphiphilic peptide.

Investigations into the mechanisms used by the C-terminal anchors of Escherichia coli penicillin-binding proteins 4, 5, 6 and 6b for membrane interaction.

Investigations into the membrane interactions of m-calpain domain V.

Lack of new antiinfective agents: Passing into the pre-antibiotic age?

Lipopolysaccharide regions involved in the activation of Escherichia coli outer membrane protease OmpT.

Lipoproteins/peptides are sepsis-inducing toxins from bacteria that can be neutralized by synthetic anti-endotoxin peptides

MARCKS as a negative regulator of lipopolysaccharide signaling.

Mechanical diagnosis of human erythrocytes by ultra-high speed manipulation unraveled critical time window for global cytoskeletal remodeling

Mechanical properties of interacting lipopolysaccharide membranes from bacteria mutants studied by specular and off-specular neutron scattering

Mechanism of Hbγ-35-induced an increase in the activation of the human immune system by endotoxins

Mechanism of interaction of optimized Limulus-derived cyclic peptides with endotoxins: thermodynamic, biophysical and microbiological analysis

Mechanisms of endotoxin neutralization by synthetic cationic compounds

Molecular basis for endotoxin neutralization by amphipathic peptides derived from the alpha-helical cationic core-region of NK-lysin

Molecular basis for membrane selectivity of NK-2, a potent peptide antibiotic derived from NK-lysin.

Molecular interactions of mefenamic acid with lipid bilayers and red blood cells

Morphology, size distribution, and aggregate structure of lipopolysaccharide and lipid A dispersions from enterobacterial origin ⬇️

New antiseptic peptides to protect against endotoxin-mediated shock

Novel Synthetic, Host-defense Peptide Protects Against Organ Injury/Dysfunction in a Rat Model of Severe Hemorrhagic Shock.

Novel integrated and portable endotoxin detection system based on an electrochemical biosensor.

Peptide 19-2.5 inhibits heparan sulfate-triggered inflammation in murine cardiomyocytes stimulated with human sepsis serum

Peptide drug stability: The anti-inflammatory drugs Pep19-2.5 and Pep19-4LF in cream formulation

Peptide-based treatment of sepsis ⬇️

Peptides with dual mode of action: Killing bacteria and preventing endotoxin-induced sepsis

Physical interactions of fish protamine and antisepsis peptide drugs with bacterial membranes revealed by combination of specular x-ray reflectivity and grazing-incidence x-ray fluorescence

Physical mechanisms of bacterial survival revealed by combined grazing-incidence X-ray scattering and Monte Carlo simulation

Physico-chemical and biophysical study of the interaction of hexa- and heptaacyl lipid A from Erwinia carotovora with magainin 2-derived antimicrobial peptides

Physicochemical Interaction Study of Non-Steroidal Anti-Inflammatory Drugs with Dimyristoylphosphatidylethanolamine Liposomes

Physicochemical and Biological Analysis of Synthetic Bacterial Lipopeptides

Physicochemical and Biological Characterization of Anti-Endotoxin Peptides and Their Influence on Lipid Properties ⬇️