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List of works by Robert C Orchard

A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells

scientific article

A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis

scientific article published on 23 May 2019

A systematic exploration of the interactions between bacterial effector proteins and host cell membranes

scientific article published on 14 September 2017

Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock

scientific article published on 25 July 2019

CD300LF polymorphisms of inbred mouse strains confer resistance to murine norovirus infection in a cell type-dependent manner

scientific article published on 24 June 2020

CD300lf conditional knockout mouse reveals strain-specific cellular tropism for murine norovirus

scientific article published on 11 November 2020

CD300lf is the primary physiologic receptor of murine norovirus but not human norovirus

scientific article published on 06 April 2020

Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival

scientific article published on 18 March 2016

Corrigendum: Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells

scientific article published on 28 September 2016

Cytidine monophosphate N-acetylneuraminic acid synthetase and solute carrier family 35 member A1 are required for reovirus binding and infection

scientific article published on 21 October 2020

Discovery of a proteinaceous cellular receptor for a norovirus

scientific article

Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection

scientific article published on 20 October 2020

Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection

scientific article published on 17 June 2020

Identification of Antinorovirus Genes in Human Cells Using Genome-Wide CRISPR Activation Screening.

article

Identification of F-actin as the dynamic hub in a microbial-induced GTPase polarity circuit.

scientific article

Mimicking GEFs: a common theme for bacterial pathogens

scientific article published on December 2011

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

scientific article

Norovirus Cell Tropism Is Determined by Combinatorial Action of a Viral Non-structural Protein and Host Cytokine.

scientific article published on 27 September 2017

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9.

scientific article published on 18 January 2016

RETRACTED ARTICLE: Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells

retracted scholarly article

Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes

scientific article published on 20 January 2020

Sphingolipid biosynthesis induces a conformational change in the murine norovirus receptor and facilitates viral infection

scholarly article by Robert C Orchard et al published October 2018 in Nature Microbiology

Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor

article published in the Proceedings of the National Academy of Sciences of the United States of America

Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics

scientific article

The assembly of a GTPase–kinase signalling complex by a bacterial catalytic scaffold

scientific article

Tropism for tuft cells determines immune promotion of norovirus pathogenesis.

scientific article

UFMylation inhibits the proinflammatory capacity of interferon-γ-activated macrophages

scientific article published on 01 January 2021

Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases.

scientific article

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