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List of works by Ohara Augusto

A ditryptophan cross-link is responsible for the covalent dimerization of human superoxide dismutase 1 during its bicarbonate-dependent peroxidase activity

scientific article

A role for peroxymonocarbonate in the stimulation of biothiol peroxidation by the bicarbonate/carbon dioxide pair

scientific article published on 01 November 2006

Albumin oxidation to diverse radicals by the peroxidase activity of Cu,Zn-superoxide dismutase in the presence of bicarbonate or nitrite: diffusible radicals produce cysteinyl and solvent-exposed and -unexposed tyrosyl radicals.

scientific article

Argininosuccinate synthetase is a functional target for a snake venom anti-hypertensive peptide: role in arginine and nitric oxide production

scientific article

Aromatic thiol-mediated cleavage of N-O bonds enables chemical ubiquitylation of folded proteins

scientific article (publication date: 29 September 2016)

Association between nitric oxide synthesis and vaccination-acquired resistance to murine hepatitis virus by spf mice

scientific article published on 16 August 2006

Bicarbonate modulates oxidative and functional damage in ischemia-reperfusion.

scientific article

Carbon dioxide-catalyzed peroxynitrite reactivity - The resilience of the radical mechanism after two decades of research

scientific article published on 25 February 2019

Catalytic Thr or Ser Residue Modulates Structural Switches in 2-Cys Peroxiredoxin by Distinct Mechanisms

scientific article

Cholesterol secosterol aldehyde adduction and aggregation of Cu,Zn-superoxide dismutase: Potential implications in ALS

article published in 2018

Connecting the Chemical and Biological Properties of Nitric Oxide ⬇️

scientific article published on 06 April 2012

Cyclic nitroxides inhibit the toxicity of nitric oxide-derived oxidants: mechanisms and implications

scientific article published on March 2008

Cytochrome c reacts with cholesterol hydroperoxides to produce lipid- and protein-derived radicals.

scientific article published on 27 April 2015

Decreased arginine and nitrite levels in nitrate reductase-deficient Arabidopsis thaliana plants impair nitric oxide synthesis and the hypersensitive response to Pseudomonas syringae

article

Detection of C8-(1-hydroxyethyl)guanine in liver RNA and DNA from control and ethanol-treated rats

scientific article

Dynamics of Dinitrosyl Iron Complex (DNIC) Formation with Low Molecular Weight Thiols

scientific article published on 19 September 2019

EPR detection of glutathiyl and hemoglobin-cysteinyl radicals during the interaction of peroxynitrite with human erythrocytes

scientific article

EPR studies of in vivo radical production by lipopolysaccharide: potential role of iron mobilized from iron-nitrosyl complexes

scientific article published in March 2003

Effects of hyperbaric oxygen on Pseudomonas aeruginosa susceptibility to imipenem and macrophages

scientific article published on January 2015

Erratum to <Lipid aldehyde hydrophobicity affects apo-SOD1 modification and aggregation>

scientific article published on 05 November 2020

Even free radicals should follow some rules: a guide to free radical research terminology and methodology

scientific article

Evidence of a Ca(2+)-(*)NO-cGMP signaling pathway controlling zoospore biogenesis in the aquatic fungus Blastocladiella emersonii.

scientific article published on 23 April 2009

Formation of protein tyrosine ortho-semiquinone radical and nitrotyrosine from cytochrome c-derived tyrosyl radical

scientific article published on 4 February 2004

Horseradish peroxidase compound I as a tool to investigate reactive protein-cysteine residues: from quantification to kinetics

scientific article published on 24 February 2011

Human cataractous lenses contain cross-links produced by crystallin-derived tryptophanyl and tyrosyl radicals

scientific article published on 25 August 2020

Increased SOD1 association with chromatin, DNA damage, p53 activation, and apoptosis in a cellular model of SOD1-linked ALS.

scientific article published on 25 January 2010

Influence of quinoline-containing antimalarials in the catalase activity of ferriprotoporphyrin IX

Inhibition of in vivo leishmanicidal mechanisms by tempol: nitric oxide down-regulation and oxidant scavenging

scientific article published on 12 February 2008

Inhibition of myeloperoxidase-mediated protein nitration by tempol: Kinetics, mechanism, and implications

scholarly article

Inhibition of the chlorinating activity of myeloperoxidase by tempol: revisiting the kinetics and mechanisms ⬇️

scientific article published on 01 November 2011

Inhibitory effect of chloroquine on the peroxidase activity of ferriprotoporphyrin IX

Kinetics, subcellular localization, and contribution to parasite virulence of a Trypanosoma cruzi hybrid type A heme peroxidase (TcAPx-CcP).

scientific article published on 8 February 2017

Linoleic acid hydroperoxide reacts with hypochlorous acid, generating peroxyl radical intermediates and singlet molecular oxygen

scientific article

Lipid aldehyde hydrophobicity affects apo-SOD1 modification and aggregation

scientific article published on 26 June 2020

MPO Inhibitors Selected by Virtual Screening

scientific article published on 28 June 2011

Mechanism of the peroxidase activity of superoxide dismutase 1

scientific article published on 27 May 2010

New antibacterial agents: Hybrid bioisoster derivatives as potential E. coli FabH inhibitors.

scientific article published on 30 June 2016

Nitrated lipids decompose to nitric oxide and lipid radicals and cause vasorelaxation

scientific article published in August 2005

Nitrite as the major source of nitric oxide production by Arabidopsis thaliana in response to Pseudomonas syringae

scientific article published in July 2005

Nitrogen dioxide and carbonate radical anion: two emerging radicals in biology.

scientific article

Nitroxides attenuate carrageenan-induced inflammation in rat paws by reducing neutrophil infiltration and the resulting myeloperoxidase-mediated damage

scientific article published on 14 September 2012

Ohr plays a central role in bacterial responses against fatty acid hydroperoxides and peroxynitrite.

scientific article published on 27 December 2016

Oligomerization of Cu,Zn-Superoxide Dismutase (SOD1) by Docosahexaenoic Acid and Its Hydroperoxides In Vitro: Aggregation Dependence on Fatty Acid Unsaturation and Thiols.

scientific article

Oxidation and nitration of ribonuclease and lysozyme by peroxynitrite and myeloperoxidase

scientific article published on 30 December 2008

Oxidation of the tryptophan 32 residue of human superoxide dismutase 1 caused by its bicarbonate-dependent peroxidase activity triggers the non-amyloid aggregation of the enzyme

scientific article published on 18 September 2014

Oxidation, inactivation and aggregation of protein disulfide isomerase promoted by the bicarbonate-dependent peroxidase activity of human superoxide dismutase

scientific article published on 20 June 2014

Peptides that activate the 20S proteasome by gate opening increased oxidized protein removal and reduced protein aggregation

scientific article published on 27 November 2013

Peroxymonocarbonate and carbonate radical displace the hydroxyl-like oxidant in the Sod1 peroxidase activity under physiological conditions

scientific article published in April 2009

Peroxynitrite preferentially oxidizes the dithiol redox motifs of protein disulfide isomerase.

scientific article published on 30 November 2017

Production of lysozyme and lysozyme-superoxide dismutase dimers bound by a ditryptophan cross-link in carbonate radical-treated lysozyme

scientific article published on 18 July 2015

Production of the carbonate radical anion during xanthine oxidase turnover in the presence of bicarbonate

scientific article

Radical production from free and peptide-bound methionine sulfoxide oxidation by peroxynitrite and hydrogen peroxide/iron(II).

scientific article

Reaction of human hemoglobin with peroxynitrite. Isomerization to nitrate and secondary formation of protein radicals

scientific article published on 13 August 2003

Reactions of yeast thioredoxin peroxidases I and II with hydrogen peroxide and peroxynitrite: rate constants by competitive kinetics

scientific article

Reduction of 1-Cys peroxiredoxins by ascorbate changes the thiol-specific antioxidant paradigm, revealing another function of vitamin C

scientific article

Restricted bioreductive metabolism of a nitroimidazole-thiadiazole derivative with curative action in experimental Trypanosoma cruzi infections

scientific article published in 1989

Saccharomyces cerevisiae coq10 null mutants are responsive to antimycin A.

scientific article

Singlet oxygen generation by the reaction of acrolein with peroxynitrite via a 2-hydroxyvinyl radical intermediate

scientific article published on 04 March 2020

Spin trapping of glutathiyl and protein radicals produced from nitric oxide-derived oxidants

scientific article published on May 2004

Superoxide dismutase 1-mediated production of ethanol- and DNA-derived radicals in yeasts challenged with hydrogen peroxide: molecular insights into the genome instability of peroxiredoxin-null strains

scientific article

Tempol ameliorates murine viral encephalomyelitis by preserving the blood-brain barrier, reducing viral load, and lessening inflammation

scientific article published on 24 December 2009

Tempol diverts peroxynitrite/carbon dioxide reactivity toward albumin and cells from protein-tyrosine nitration to protein-cysteine nitrosation.

scientific article published in January 2005

Tempol moderately extends survival in a hSOD1(G93A) ALS rat model by inhibiting neuronal cell loss, oxidative damage and levels of non-native hSOD1(G93A) forms

scientific article

Tempol reduces inflammation and oxidative damage in cigarette smoke-exposed mice by decreasing neutrophil infiltration and activating the Nrf2 pathway

scientific article published on 26 July 2020

The Mechanism by which 4-hydroxy-2,2,6,6-tetramethylpiperidene-1-oxyl (tempol) diverts peroxynitrite decomposition from nitrating to nitrosating species

scientific article

The Peroxidatic Thiol of Peroxiredoxin 1 is Nitrosated by Nitrosoglutathione but Coordinates to the Dinitrosyl Iron Complex of Glutathione

scientific article published on 25 March 2020

The bicarbonate/carbon dioxide pair increases hydrogen peroxide-mediated hyperoxidation of human peroxiredoxin 1

scientific article published on 30 July 2019

The carbonate radical and related oxidants derived from bicarbonate buffer

scientific article published on April 2007

The carbonylation and covalent dimerization of human superoxide dismutase 1 caused by its bicarbonate-dependent peroxidase activity is inhibited by the radical scavenger tempol.

scientific article

The labile iron pool attenuates peroxynitrite-dependent damage and can no longer be considered solely a pro-oxidative cellular iron source

scientific article published on 16 April 2018

Thioredoxin-1 promotes survival in cells exposed to S-nitrosoglutathione: Correlation with reduction of intracellular levels of nitrosothiols and up-regulation of the ERK1/2 MAP Kinases

scientific article published on 13 August 2008

Thiyl radicals are co-products of dinitrosyl iron complex (DNIC) formation

scientific article published on 15 July 2019

Toxicological issues in Brazil range from long-standing problems to novel challenges

scientific article published on 18 February 2008

Urate hydroperoxide oxidizes human peroxiredoxin 1 and peroxiredoxin 2.

scientific article published on 27 March 2017

Where do we aspire to publish? A position paper on scientific communication in biochemistry and molecular biology

scientific article published on 29 August 2019

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