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List of works by Esra A Akbay

Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors

scientific article published on 27 September 2013

Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints.

scientific article

Assessing Therapeutic Efficacy of MEK Inhibition in a KRASG12C-Driven Mouse Model of Lung Cancer

scientific article published on 26 June 2018

Autochthonous murine models for the study of smoker and never-smoker associated lung cancers

scientific article published on 01 August 2018

Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer

scientific article published on 09 March 2021

Clinical implications of monitoring nivolumab immunokinetics in non-small cell lung cancer patients

scientific article published on 04 October 2018

Co-clinical quantitative tumor volume imaging in ALK-rearranged NSCLC treated with crizotinib.

scientific article published on 26 December 2016

Co-clinical trials demonstrate superiority of crizotinib to chemotherapy in ALK-rearranged non-small cell lung cancer and predict strategies to overcome resistance

scientific article published on 10 December 2013

Cooperation between p53 and the telomere-protecting shelterin component Pot1a in endometrial carcinogenesis.

scientific article

Corrigendum: Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer

scientific article published in Nature

D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice

scientific article published on March 2014

Development of Selective Covalent Janus Kinase 3 Inhibitors.

scientific article published on 10 August 2015

Differential roles of telomere attrition in type I and II endometrial carcinogenesis.

scientific article published on 3 July 2008

Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase

scientific article published on 15 June 2020

Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer

scientific article published on 17 September 2013

Erratum: Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2.

scientific article published on 9 June 2017

Genomewide discovery and classification of candidate ovarian fertility genes in the mouse

scientific article

Identification and characterization of an alternative cancer-derived PD-L1 splice variant

scientific article published on 18 December 2018

Image-guided radiotherapy platform using single nodule conditional lung cancer mouse models

scientific article

Interleukin-17A Promotes Lung Tumor Progression through Neutrophil Attraction to Tumor Sites and Mediating Resistance to PD-1 Blockade

scientific article published on 5 May 2017

JAK2/IDH-mutant-driven myeloproliferative neoplasm is sensitive to combined targeted inhibition

scientific article published on 17 September 2018

JAK2/IDH-mutant-driven myeloproliferative neoplasm is sensitive to combined targeted inhibition.

scientific article published on 22 January 2018

Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a Pan-FGFR inhibitor in a mouse model of NSCLC

scientific article

Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2.

scientific article published on 7 April 2017

Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression

scientific article

Multiple interaction domains in FtsL, a protein component of the widely conserved bacterial FtsLBQ cell division complex.

scientific article

Polymerase-mediated ultramutagenesis in mice produces diverse cancers with high mutational load.

scientific article published on 20 August 2018

STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment.

scientific article published on February 2016

Somatic LKB1 mutations promote cervical cancer progression

scientific article

Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity

scientific article published on 06 February 2019

Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor

scientific article

The impact of the MYB-NFIB fusion proto-oncogene in vivo.

scientific article published on 18 May 2016

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