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List of works by Kohji Seio

'Protected DNA Probes' capable of strong hybridization without removal of base protecting groups.

scientific article published on 13 February 2008

(+)-3-[2-(Benzo[b]thiophen-2-yl)-2-oxoethyl]-1-azabicyclo[2.2.2]octane as potent agonists for the alpha7 nicotinic acetylcholine receptor.

scientific article

4,5-bis(ethoxycarbonyl)-[1,3]dioxolan-2-yl as a new orthoester-type protecting group for the 2'-hydroxyl function in the chemical synthesis of RNA.

scientific article

7-(Benzofuran-2-yl)-7-deazadeoxyguanosine as a fluorescence turn-ON probe for single-strand DNA binding protein

scientific article published on 11 February 2016

A new method for the synthesis of oligodeoxyribonucleotides containing 4-N-alkoxycarbonyldeoxycytidine derivatives and their hybridization properties.

scientific article published in January 2002

A new modified cytosine base capable of base pairing with guanine using four hydrogen bonds

scientific article published on 01 April 2014

A new protecting group for the 5'-hydroxyl group having O-S single bond oxidatively cleavable under mild conditions.

scientific article

A new route to 2'-O-alkyl-2-thiouridine derivatives via 4-O-protection of the uracil base and hybridization properties of oligonucleotides incorporating these modified nucleoside derivatives.

scientific article published in December 2003

A pyrimidopyrimidoindole nucleoside (dC PPI): photophysical properties and thermal stability of the modified DNA duplexes.

scientific article published in January 2007

An effective method for the in situ synthesis of DNA-CPG conjugates using chemical ligation technology as tools for SNP analysis

scientific article published on 21 August 2007

Application of 2'-O-(2-N-Methylcarbamoylethyl) Nucleotides in RNase H-Dependent Antisense Oligonucleotides

scholarly article by Yoshiaki Masaki published in October 2018

Assembly of pyrene-modified DNA/RNA duplexes incorporating a G-rich single strand region.

scientific article

Base recognition of gap sites in DNA-DNA and DNA-RNA duplexes by short oligonucleotides

scientific article published on 26 March 2013

Biochemical behavior of N-oxidized cytosine and adenine bases in DNA polymerase-mediated primer extension reactions.

scientific article

Chemical Synthesis and Properties of Conformationally Fixed Diuridine Monophosphates as Building Blocks of the RNA Turn Motif

Chemical Synthesis of a 5'-Terminal TMG-Capped Triribonucleotide m(3)(2,2,7)G(5)(')pppAmpUmpA of U1 RNA

scientific article published on 01 June 1996

Chemical synthesis of U1 snRNA derivatives.

scientific article published on 16 August 2013

Chemically stabilized phenylboranylidene groups having a dimethoxytrityl group as a colorimetrically detectable protecting group designed for cis-1,2-diol functions of ribonucleosides in the solid-phase synthesis of m2(2,2)G5'ppT.

scientific article

Computational evaluation of intermolecular interactions of a universal base 3-nitropyrrole in stacked dimers and DNA duplexes.

scientific article

Convenient synthesis of N-unprotected deoxynucleoside 3'-phosphoramidite building blocks by selective deacylation of N-acylated species and their facile conversion to other N-functionalized derivatives

scientific article published on 01 November 2005

DNA duplexes and triplex-forming oligodeoxynucleotides incorporating modified nucleosides forming stable and selective triplexes

scientific article published on 06 December 2011

DNA-maleimide: an improved maleimide compound for electrophoresis-based titration of reactive thiols in a specific protein.

scientific article published on 26 January 2013

Deoxynucleoside Triphosphate Containing Pyridazin-3-one Aglycon as a Thymidine Triphosphate Substitute for Primer Extension and Chain Elongation by Klenow Fragments

scientific article published on 19 July 2018

Design, Synthesis, and Properties of Phosphoramidate 2',5'-Linked Branched RNA: Toward the Rational Design of Inhibitors of the RNA Lariat Debranching Enzyme

scientific article published on 17 September 2015

Development of an efficient method for phosphorodiamidate bond formation by using inorganic salts

scientific article published on 08 December 2011

Effective Strategy for Conformer-Selective Detection of Short-Lived Excited State Species: Application to the IR Spectroscopy of the N1H Keto Tautomer of Guanine.

scientific article

Efficient synthesis of functionalized oligodeoxyribonucleotides with base-labile groups using a new silyl linker.

scientific article published on 29 February 2008

Enhanced stereoselectivity in internucleotidic bond formation by the use of the chiral ribose moiety of thymidine.

scientific article published in May 2003

Enzymatic synthesis and reverse transcription of RNAs incorporating 2'-O-carbamoyl uridine triphosphate.

scientific article published in October 2016

First synthesis and anticancer activity of phosmidosine and its related compounds.

scientific article

Fluorescence enhancement of oligodeoxynucleotides modified with green fluorescent protein chromophore mimics upon triplex formation.

scientific article published on 13 January 2017

Fluorescence properties of pyrimidopyrimidoindole nucleoside dC(PPI) incorporated into oligodeoxynucleotides.

scientific article

Fluorescent properties of oligonucleotides doubly modified with an indole-fused cytosine analog and 2-aminopurine.

scientific article published on 30 March 2013

Fluorescent pyrimidopyrimidoindole nucleosides: control of photophysical characterizations by substituent effects

scientific article published on 08 June 2007

Formation of new base pairs between inosine and 5-methyl-2-thiocytidine derivatives

scientific article published on 27 January 2012

Highly selective recognition of cytosine over uracil and adenine by a guanine analogue, 2-N-acetyl-3-deazaguanine, in 2'-O-methyl-RNA/RNA and DNA duplexes

scientific article published on 01 February 2007

Hybridization-dependent fluorescence of oligodeoxynucleotides incorporating new pyrene-modified adenosine residues.

scientific article published on 22 May 2008

Introduction of 3'-terminal nucleosides having a silyl-type linker into polymer supports without base protection.

scientific article published in April 2009

Linear relationship between deformability and thermal stability of 2'-O-modified RNA hetero duplexes.

scientific article published on February 2010

Microwave-assisted synthesis of 2'-O-aryluridine derivatives

scientific article published on 01 December 2009

Modified oligodeoxynucleotide primers for reverse-transcription of target RNAs that can discriminate among length variants at the 3'-terminus

scientific article published on 30 October 2013

New nucleotide pairs for stable DNA triplexes stabilized by stacking interaction.

scientific article published on 9 July 2008

New thermolytic carbamoyl groups for the protection of nucleobases.

scientific article published on 7 January 2009

O-selective condensation using P-N bond cleavage in RNA synthesis without base protection.

scientific article

O-selectivity and utility of phosphorylation mediated by phosphite triester intermediates in the N-unprotected phosphoramidite method.

scientific article published in September 2004

Oligonucleotide synthesis involving deprotection of amidine-type protecting groups for nucleobases under acidic conditions.

scientific article published in June 2010

Photo-controlled binding of MutS to photo-caged DNA duplexes incorporating 4-O-(2-nitrobenzyl) or 4-O-[2-(2-nitrophenyl)propyl]thymidine.

scientific article published on 30 July 2016

Prediction of the stability of modified RNA duplexes based on deformability analysis: oligoribonucleotide derivatives modified with 2'-O-cyanoethyl-5-propynyl-2-thiouridine as a promising component

scientific article published on 18 June 2012

Properties of 5- and/or 2-modified 2'-O-cyanoethyl uridine residue: 2'-O-cyanoethyl-5-propynyl-2-thiouridine as an efficient duplex stabilizing component

scientific article published on 01 February 2014

Remarkable stabilization of antiparallel DNA triplexes by strong stacking effects of consecutively modified nucleobases containing thiocarbonyl groups.

scientific article published in December 2012

Short-RNA selective binding of oligonucleotides modified using adenosine and guanosine derivatives that possess cyclohexylphosphates as substituents ⬇️

scientific article published on December 5, 2011

Stable triplex formation using the strong stacking effect of consecutive thionucleoside moieties

scientific article published on 26 October 2011

Study of the base discrimination ability of DNA and 2'-O-methylated RNA oligomers containing 2-thiouracil bases towards complementary RNA or DNA strands and their application to single base mismatch detection.

scientific article published on 25 April 2008

Synthesis and Properties of Conformationally Rigid Cyclouridylic Acids Having Covalent Bonding Linkers Between the Uracil 5-Position and the 5′-Phosphate Group

Synthesis and biological properties of new phosmidosine analogs having an N-acylsulfamate linkage.

scientific article published on January 2006

Synthesis and fluorescent properties of bi- and tricyclic 4-N-carbamoyldeoxycytidine derivatives

scientific article published on 01 January 2007

Synthesis and hybridization properties of 2'-O-methylated oligoribonucleotides incorporating 2'-O-naphthyluridines

scientific article published on 29 October 2010

Synthesis and properties of a new fluorescent bicyclic 4-N-carbamoyldeoxycytidine derivative

scientific article published on 01 April 2006

Synthesis and properties of cationic 2'-O-[N-(4-aminobutyl)carbamoyl] modified oligonucleotides

scientific article published on 13 February 2012

Synthesis and properties of oligodeoxynucleotides containing 5-carboxy-2'-deoxycytidines.

scientific article published on 30 October 2007

Synthesis and properties of oligodeoxynucleotides incorporating a conformationally rigid uridine unit having a cyclic structure at the 5'-terminal site.

scientific article published in June 2000

Synthesis and properties of oligonucleotides having a phosphorus chiral center by incorporation of conformationally rigid 5'-cyclouridylic acid derivatives

scientific article published on 01 October 2000

Synthesis and properties of oligonucleotides modified with 2'-O-(2-carboxyethyl)nucleotides and their carbamoyl derivatives

scientific article published on 01 September 2014

Synthesis and properties of oligonucleotides with iodo-substituted aromatic aglycons: investigation of possible halogen bonding base pairs.

scientific article published on 15 December 2007

Synthesis and triplex-forming properties of oligonucleotides capable of recognizing corresponding DNA duplexes containing four base pairs.

scientific article published on 26 May 2015

Synthesis of 2'-O-[2-(N-methylcarbamoyl)ethyl]ribonucleosides using oxa-Michael reaction and chemical and biological properties of oligonucleotide derivatives incorporating these modified ribonucleosides

scientific article published on 23 March 2011

Synthesis of 2'-O-methyl-RNAs incorporating a 3-deazaguanine, and UV melting and computational studies on its hybridization properties.

scientific article published on 26 August 2006

Synthesis of 5'-terminal capped oligonucleotides using O-N phosphoryl migration of phosphoramidite derivatives

scientific article published on 14 December 2011

Synthesis of 5-[3-(2-aminopyrimidin-4-yl)aminopropyn-1-yl]uracil derivative that recognizes Ade-Thy base pairs in double-stranded DNA

scientific article published on 02 November 2015

Synthesis of 6-N-(benzothiazol-2-yl)deoxyadenosine and its exciton-coupled circular dichroism.

scientific article published on 11 December 2009

Synthesis of Deoxypseudouridine 5'-Triphosphate Bearing the Photoremovable Protecting Group at the N1 Position Capable of Enzymatic Incorporation to DNA

scientific article published on 07 January 2020

Synthesis of N-labeled peptidyl AMP.

scientific article

Synthesis of and triplex formation in oligonucleotides containing 2'-deoxy-6-thioxanthosine

scientific article published on 05 June 2018

Synthesis of branched oligonucleotides with three different sequences using an oxidatively removable tritylthio group.

scientific article published on 27 September 2007

Synthesis of chemically stabilized phosmidosine analogues and the structure--activity relationship of phosmidosine.

scientific article

Synthesis of oligodeoxynucleotides incorporating 2-N-carbamoylguanine and evaluation of the hybridization properties.

scientific article published on 24 November 2008

Synthesis of oligodeoxynucleotides using fully protected deoxynucleoside 3'-phosphoramidite building blocks and base recognition of oligodeoxynucleotides incorporating N3-cyano-ethylthymine.

scientific article published on 27 October 2010

Synthesis of oligonucleotides containing 2-N-heteroarylguanine residues and their effect on duplex/triplex stability

scientific article published on 22 September 2017

Synthesis of peptide nucleic acids containing pyridazine derivatives as cytosine and thymine analogs, and their duplexes with complementary oligodeoxynucleotides

scientific article published on 10 March 2015

Synthesis of photocaged 6-O-(2-nitrobenzyl)guanosine and 4-O-(2-nitrobenzyl) uridine triphosphates for photocontrol of the RNA transcription reaction

scientific article

Synthesis of terminally modified oligonucleotides and their hybridization dependence on the size of the target RNAs.

scientific article

Transcription of DNA duplex containing deoxypseudouridine and deoxypseudoisocytidine, and inhibition of transcription by triplex forming oligonucleotide that recognizes the modified duplex

scientific article published on 04 March 2020

Use of ferrocene scaffolds as pendant groups in hairpin-type pyrrole-imidazole polyamide molecules showing sequence-selective binding to DNA duplexes.

scientific article published on December 2005

cis-Tetrahydrofuran-3,4-diol structure as a key skeleton of new protecting groups removable by self-cyclization under oxidative conditions

scientific article published on 01 September 2006

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