List of works by Mark T. Gladwin

A 53-Year-Old Woman with Severe Carbon Monoxide Poisoning.

scientific article published in September 2017

A genetic variation associated with plasma erythropoietin and a non-coding transcript of PRKAR1A in sickle cell disease

scientific article published in October 2016

A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia

scientific article

A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response

scientific article

A network model to predict the risk of death in sickle cell disease

scientific article

A pilot study of electronic directly observed therapy to improve hydroxyurea adherence in pediatric patients with sickle-cell disease

scientific article

Abnormal pulmonary function and associated risk factors in children and adolescents with sickle cell anemia

scientific article

Acute and chronic lung infections. Novel pathogens, diagnostics, and therapeutics

scientific article

Acute hemodynamic effects of inhaled sodium nitrite in pulmonary hypertension associated with heart failure with preserved ejection fraction

scientific article published on 3 November 2016

Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease

scientific article

An electron paramagnetic resonance study of the affinity of nitrite for methemoglobin

scientific article

An emerging role for nitric oxide in sickle cell disease vascular homeostasis and therapy

scientific article

An official American Thoracic Society clinical practice guideline: diagnosis, risk stratification, and management of pulmonary hypertension of sickle cell disease

scientific article published on March 2014

Ancestry of African Americans with sickle cell disease

scientific article

Angeli's salt counteracts the vasoactive effects of elevated plasma hemoglobin

scientific article published on 23 October 2012

Angiogenic and inflammatory markers of cardiopulmonary changes in children and adolescents with sickle cell disease

scientific article

Antioxidant therapy for the treatment of pulmonary hypertension

scientific article published on 28 February 2013

Arginine Metabolism and Nitric Oxide Bioavailability in Sickle Cell Disease ⬇️

scientific article published on October 1, 2010

Association Between Hemodynamic Markers of Pulmonary Hypertension and Outcomes in Heart Failure With Preserved Ejection Fraction.

scientific article

Association of G6PD with lower haemoglobin concentration but not increased haemolysis in patients with sickle cell anaemia

scientific article

Bad blood: the risks of red cell storage

scientific article published on April 2010

Biological activity of nitric oxide in the plasmatic compartment

scholarly article

Blood mononuclear cell gene expression profiles characterize the oxidant, hemolytic, and inflammatory stress of sickle cell disease

scientific article published on 18 March 2004

Bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation

scientific article published in July 2009

CCR5 as a treatment target in pulmonary arterial hypertension

scientific article published on 3 July 2014

CT and image processing non-invasive indicators of sickle cell secondary pulmonary hypertension

scientific article published on January 2008

Carbonic anhydrase II does not regulate nitrite-dependent nitric oxide formation and vasodilation

scientific article published on 23 December 2019

Cardiopulmonary complications of sickle cell disease: role of nitric oxide and hemolytic anemia

scientific article

Cardiopulmonary function in individuals with HIV infection in the antiretroviral therapy era.

scientific article published on March 2012

Cardiovascular abnormalities in sickle cell disease

scientific article published on March 2012

Cardiovascular complications and risk of death in sickle-cell disease

scientific article

Cardiovascular complications in patients with sickle cell disease.

scientific article published in December 2017

Catalytic generation of N2O3 by the concerted nitrite reductase and anhydrase activity of hemoglobin

scientific article published on 4 November 2007

Cell-Free Plasma Hemoglobin and Male Gender Are Risk Factors for Acute Kidney Injury in Low Risk Children Undergoing Cardiopulmonary Bypass

scientific article published on 31 August 2017

Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease

scientific article

Cellular, pharmacological, and biophysical evaluation of explanted lungs from a patient with sickle cell disease and severe pulmonary arterial hypertension

scientific article

Cerebrovascular disease associated with sickle cell pulmonary hypertension

scientific article

Characterization of erythrocytic uptake and release and disposition pathways of nitrite, nitrate, methemoglobin, and iron-nitrosyl hemoglobin in the human circulation

scientific article

Characterization of whole blood gene expression profiles as a sequel to globin mRNA reduction in patients with sickle cell disease

scientific article

Chemiluminescent detection of S-nitrosated proteins: comparison of tri-iodide, copper/CO/cysteine, and modified copper/cysteine methods

scientific article published on January 2008

Chronic hyper-hemolysis in sickle cell anemia: association of vascular complications and mortality with less frequent vasoocclusive pain

scientific article

Chronic sickle cell lung disease: new insights into the diagnosis, pathogenesis and treatment of pulmonary hypertension

scientific article

Circulating blood endothelial nitric oxide synthase contributes to the regulation of systemic blood pressure and nitrite homeostasis

scientific article published on 23 May 2013

Clinical correlates of acute pulmonary events in children and adolescents with sickle cell disease

scientific article published on 03 May 2013

Combination erythropoietin-hydroxyurea therapy in sickle cell disease: experience from the National Institutes of Health and a literature review

scientific article

Computation of plasma hemoglobin nitric oxide scavenging in hemolytic anemias

scientific article

Computed tomography correlates with cardiopulmonary hemodynamics in pulmonary hypertension in adults with sickle cell disease

scientific article

Concerted nitric oxide formation and release from the simultaneous reactions of nitrite with deoxy- and oxyhemoglobin

scientific article

Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate

scientific article

Copper dependence of the biotin switch assay: modified assay for measuring cellular and blood nitrosated proteins

scientific article published on 4 January 2008

Correction to Exploring the Mechanisms of the Reductase Activity of Neuroglobin by Site-Directed Mutagenesis of the Heme Distal Pocket

scientific article published on 8 June 2015

Crises in Sickle Cell Disease.

scientific article

Cytochrome b5 Reductase 3 Modulates Soluble Guanylate Cyclase Redox State and cGMP Signaling

scientific article published on 5 June 2017

Cytoglobin at the Crossroads of Vascular Remodeling

scientific article published in October 2017

Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver

scientific article

Deconstructing endothelial dysfunction: soluble guanylyl cyclase oxidation and the NO resistance syndrome

scientific article

Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes

scientific article

Depletion of circulating blood NOS3 increases severity of myocardial infarction and left ventricular dysfunction

scientific article published on 18 December 2013

Development of a Mouse Model of Metabolic Syndrome, Pulmonary Hypertension, and Heart Failure with Preserved Ejection Fraction

scientific article published on 24 January 2017

Diastolic dysfunction is an independent risk factor for death in patients with sickle cell disease

scientific article

Dietary nitrate and nitrite modulate blood and organ nitrite and the cellular ischemic stress response

scientific article published on 20 May 2009

Differences in the clinical and genotypic presentation of sickle cell disease around the world

scientific article

Direct sGC activation bypasses NO scavenging reactions of intravascular free oxy-hemoglobin and limits vasoconstriction

scientific article published on 9 July 2013

Divergent nitric oxide bioavailability in men and women with sickle cell disease

scientific article published on January 2003

Do BRD(4)S of a Feather Flock Together? How an Inflammation-Driven Epigenetic Regulator May Link Pulmonary Hypertension and Coronary Artery Disease.

scientific article published in August 2017

Doppler-defined pulmonary hypertension in medical intensive care unit patients: Retrospective investigation of risk factors and impact on mortality

scientific article

Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease

scientific article

Echocardiographic markers of elevated pulmonary pressure and left ventricular diastolic dysfunction are associated with exercise intolerance in adults and adolescents with homozygous sickle cell anemia in the United States and United Kingdom

scientific article

Effect of eculizumab on haemolysis-associated nitric oxide depletion, dyspnoea, and measures of pulmonary hypertension in patients with paroxysmal nocturnal haemoglobinuria

scientific article published on 8 March 2010

Effects of Aged Stored Autologous Red Blood Cells on Human Endothelial Function

scientific article published on 29 July 2015

Effects of S-nitrosation and cross-linking of hemoglobin on hypoxic pulmonary vasoconstriction in isolated rat lungs

scientific article published in October 2002

Effects of a single sickling event on the mechanical fragility of sickle cell trait erythrocytes

scientific article published on January 2010

Effects of aged stored autologous red blood cells on human plasma metabolome

scientific article published on 01 March 2019

Effects of nitric oxide and its congeners on sickle red blood cell deformability

scientific article published on 23 April 2015

Elevated N-terminal pro-brain natriuretic peptide is associated with mortality in tobacco smokers independent of airflow obstruction

scientific article

Elevated NT-pro-brain natriuretic peptide level is independently associated with all-cause mortality in HIV-infected women in the early and recent HAART eras in the Women's Interagency HIV Study cohort

scientific article

Elevated tricuspid regurgitant jet velocity in children and adolescents with sickle cell disease: association with hemolysis and hemoglobin oxygen desaturation

scientific article published on 11 February 2009

Elevated tricuspid regurgitation velocity and decline in exercise capacity over 22 months of follow up in children and adolescents with sickle cell anemia

scientific article

Emerging Therapeutics in Pulmonary Hypertension

scientific article published in February 2018

Emerging role of nitrite in human biology

scientific article published on May 2004

Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling

scientific article published on 6 May 2013

Endothelin receptor antagonists for pulmonary hypertension in adult patients with sickle cell disease

scientific article published on 22 September 2009

Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health

scientific article published on 15 December 2016

Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control

scientific article

Epidermal growth factor induces p11 gene and protein expression and down-regulates calcium ionophore-induced arachidonic acid release in human epithelial cells

scientific article (publication date: 11 October 2002)

Erythrocytes and Vascular Function: Oxygen and Nitric Oxide.

scientific article published on 22 February 2018

Erythrocytic bioactivation of nitrite and its potentiation by far-red light

Erythroid DAMPs drive inflammation in SCD.

scientific article published on June 2014

Escorting α-globin to eNOS: α-globin-stabilizing protein paves the way

scientific article published on 08 October 2018

Establishment of a transgenic sickle-cell mouse model to study the pathophysiology of priapism

scientific article

Ethnicity, sex, and age are determinants of red blood cell storage and stress hemolysis: results of the REDS-III RBC-Omics study

scholarly article published 27 June 2017

Evidence mounts that red cells and deoxyhemoglobin can reduce nitrite to bioactive NO to mediate intravascular endocrine NO signaling: commentary on "Anti-platelet effects of dietary nitrate in healthy volunteers: involvement of cGMP and influence o

scientific article

Evolution of novel small-molecule therapeutics targeting sickle cell vasculopathy

scientific article

Exercise capacity and haemodynamics in patients with sickle cell disease with pulmonary hypertension treated with bosentan: results of the ASSET studies

scientific article

Exploring the mechanisms of the reductase activity of neuroglobin by site-directed mutagenesis of the heme distal pocket

scientific article published on 16 January 2015

Expression of regulatory platelet microRNAs in patients with sickle cell disease

scientific article

Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high-fat diet-induced obesity

scientific article published on 02 January 2014

First successful lung transplantation for sickle cell disease with severe pulmonary arterial hypertension and pulmonary veno-occlusive disease

scientific article published on December 2013

Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning

scientific article published on December 2016

Genetic determinants of haemolysis in sickle cell anaemia

scientific article

Genetic polymorphism of APOB is associated with diabetes mellitus in sickle cell disease

scientific article

Genetic variants and cell-free hemoglobin processing in sickle cell nephropathy

scientific article

Globin X is a six-coordinate globin that reduces nitrite to nitric oxide in fish red blood cells

scientific article

Haemoglobinuria is associated with chronic kidney disease and its progression in patients with sickle cell anaemia

scientific article published on 12 December 2013

Haldane, hot dogs, halitosis, and hypoxic vasodilation: the emerging biology of the nitrite anion

scientific article

Haptoglobin improves shock, lung injury, and survival in canine pneumonia

scholarly article by Kenneth E Remy et al published 20 September 2018 in JCI insight

Harnessing the nitrate-nitrite-nitric oxide pathway for therapy of heart failure with preserved ejection fraction.

scientific article published on 22 December 2014

Hematologic, biochemical, and cardiopulmonary effects of L-arginine supplementation or phosphodiesterase 5 inhibition in patients with sickle cell disease who are on hydroxyurea therapy

scientific article published on 10 February 2008

Heme oxygenase-1 deficiency accelerates formation of arterial thrombosis through oxidative damage to the endothelium, which is rescued by inhaled carbon monoxide

scientific article published on 20 September 2007

Hemodynamic and functional assessment of patients with sickle cell disease and pulmonary hypertension

scientific article

Hemoglobin and the paracrine and endocrine functions of nitric oxide

scientific article (publication date: 10 April 2003)

Hemoglobin as a nitrite anhydrase: modeling methemoglobin-mediated N2O3 formation

scientific article published on 17 May 2011

Hemoglobin as a nitrite reductase regulating red cell-dependent hypoxic vasodilation

scientific article published in May 2005

Hemoglobin α in Pulmonary Endothelium: Ironing Out Nitric Oxide Signaling

scientific article published in December 2017

Hemolysis and cell-free hemoglobin drive an intrinsic mechanism for human disease

scientific article published on 26 March 2012

Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin

scientific article

Hemolysis-associated hypercoagulability in sickle cell disease: the plot (and blood) thickens!

scientific article published on January 2008

Hemolysis-mediated Toxicity during Cardiopulmonary Bypass Ameliorated by Inhaled Nitric Oxide Gas

scientific article published on 01 November 2018

Hemolytic anemia-associated pulmonary hypertension in sickle cell disease

scientific article

Hemolytic anemia-associated pulmonary hypertension of sickle cell disease and the nitric oxide/arginine pathway

scientific article

Hospitalization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity

scientific article

How Red Blood Cells Process Nitric Oxide: Evidence for the Nitrite Hypothesis

scientific article published in January 2017

How do red blood cells dilate blood vessels?--Reply

scientific article published in August 2004

Human neuroglobin functions as a redox-regulated nitrite reductase

scientific article

Hydroxyurea-induced expression of glutathione peroxidase 1 in red blood cells of individuals with sickle cell anemia

scientific article

Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation

scientific article published on 29 September 2005

Imaging hemoglobin oxygen saturation in sickle cell disease patients using noninvasive visible reflectance hyperspectral techniques: effects of nitric oxide

scientific article

Impact of different standard red blood cell storage temperatures on human and canine RBC hemolysis and chromium survival

scientific article published on 01 November 2018

In vivo reduction of cell-free methemoglobin to oxyhemoglobin results in vasoconstriction in canines

scientific article published on 14 March 2013

In-gel detection of S-nitrosated proteins using fluorescence methods

scientific article published on January 2008

Increased consumption and vasodilatory effect of nitrite during exercise

scientific article published on 18 December 2015

Increased nitrite reductase activity of fetal versus adult ovine hemoglobin

scientific article

Increased pulmonary pressures and myocardial wall stress in children with severe malaria

scientific article published on September 2010

Inhalation of NO during myocardial ischemia reduces infarct size and improves cardiac function

scientific article published in June 2012

Inhaled nitric oxide decreases infarction size and improves left ventricular function in a murine model of myocardial ischemia-reperfusion injury

scientific article published on 27 January 2006

Injection drug use as a "second hit" in the pathogenesis of HIV-associated pulmonary hypertension

scientific article published on June 2012

Inorganic nitrite improves components of the metabolic syndrome independent of weight change in a murine model of obesity and insulin resistance

scientific article published on 25 June 2015

Interferon-gamma induces p11 gene and protein expression in human epithelial cells through interferon-gamma-activated sequences in the p11 promoter

scientific article (publication date: 14 March 2003)

Intradonor reproducibility and changes in hemolytic variables during red blood cell storage: results of recall phase of the REDS-III RBC-Omics study

scholarly article by Marion C. Lanteri et al published 8 November 2018 in Transfusion

Intravascular hemolysis and the pathophysiology of sickle cell disease

scientific article published on March 2017

Is nitrite the circulating endocrine effector of remote ischemic preconditioning?

scientific article published on May 2014

Isolated right ventricular dysfunction in patients with human immunodeficiency virus

scientific article

Kidney Disease among Patients with Sickle Cell Disease, Hemoglobin SS and SC.

scientific article published on 15 December 2015

Lactate dehydrogenase and hemolysis in sickle cell disease

scientific article published on August 2013

Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease

scientific article published on 15 November 2005

Levels of soluble endothelium-derived adhesion molecules in patients with sickle cell disease are associated with pulmonary hypertension, organ dysfunction, and mortality

scientific article

Low NO concentration dependence of reductive nitrosylation reaction of hemoglobin

scientific article

Markers of severe vaso-occlusive painful episode frequency in children and adolescents with sickle cell anemia

scientific article published on 3 September 2011

Measurement of circulating nitrite and S-nitrosothiols by reductive chemiluminescence

scientific article published on 5 January 2007

Measurement of nitric oxide levels in the red cell: validation of tri-iodide-based chemiluminescence with acid-sulfanilamide pretreatment

scientific article published on 14 July 2006

Measurements of nitric oxide on the heme iron and β-93 thiol of human hemoglobin during cycles of oxygenation and deoxygenation ⬇️

scientific article published on September 19, 2003

Mechanism of faster NO scavenging by older stored red blood cells

scientific article published on 10 January 2014

Mechanisms for cellular NO oxidation and nitrite formation in lung epithelial cells

scientific article published on 30 April 2013

Mechanisms of human erythrocytic bioactivation of nitrite

scientific article

Mechanisms of nitrite bioactivation

scientific article

Mechanisms of slower nitric oxide uptake by red blood cells and other hemoglobin-containing vesicles

scientific article

Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans

scientific article published on August 2012

Metabolic Syndrome and the Lung

scientific article

Methaemalbumin formation in sickle cell disease: effect on oxidative protein modification and HO-1 induction

scientific article

Methodologies for the sensitive and specific measurement of S-nitrosothiols, iron-nitrosyls, and nitrite in biological samples

scientific article

Mortality in adults with sickle cell disease and pulmonary hypertension

scientific article

Mortality increases after massive exchange transfusion with older stored blood in canines with experimental pneumonia

scientific article published on 18 December 2012

Mouse Genome-Wide Association Study of Preclinical Group II Pulmonary Hypertension Identifies Epidermal Growth Factor Receptor

scientific article published on 13 January 2017

Mutations and polymorphisms in hemoglobin genes and the risk of pulmonary hypertension and death in sickle cell disease

scientific article

Myocardial protection by nitrite: evidence that this reperfusion therapeutic will not be lost in translation

scientific article published on July 2008

N-terminal pro-brain natriuretic peptide levels and risk of death in sickle cell disease

scientific article published in July 2006

NO contest: nitrite versus S-nitroso-hemoglobin

scientific article

NO solutions?

scientific article

NT-pro brain natriuretic peptide levels and the risk of death in the cooperative study of sickle cell disease

scientific article published on 21 June 2011

NT-proBNP as a marker of cardiopulmonary status in sickle cell anaemia in Africa

scientific article

Nitrate and nitrite in biology, nutrition and therapeutics

scientific article

Nitrate-nitrite-nitric oxide pathway in pulmonary arterial hypertension therapeutics

scientific article published on 9 May 2012

Nitric Oxide-Independent Soluble Guanylate Cyclase Activation Improves Vascular Function and Cardiac Remodeling in Sickle Cell Disease.

scientific article published on 21 December 2017

Nitric oxide (NO) in normal and hypoxic vascular regulation of the spiny dogfish, Squalus acanthias

scientific article

Nitric oxide and arginine dysregulation: a novel pathway to pulmonary hypertension in hemolytic disorders

scientific article published on November 2008

Nitric oxide deficiency and endothelial dysfunction in pulmonary arterial hypertension

scientific article published on September 2013

Nitric oxide donor properties of hydroxyurea in patients with sickle cell disease

scientific article published in February 2002

Nitric oxide for inhalation in the acute treatment of sickle cell pain crisis: a randomized controlled trial

scientific article

Nitric oxide pathology and therapeutics in sickle cell disease.

scientific article published in January 2018

Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion

scientific article

Nitric oxide scavenging by red blood cells as a function of hematocrit and oxygenation

scientific article published on 25 September 2005

Nitric oxide scavenging by red cell microparticles

scientific article published on 16 September 2013

Nitric oxide's reactions with hemoglobin: a view through the SNO-storm ⬇️

scientific article published on May 1, 2003

Nitric oxide, hemolysis, and the red blood cell storage lesion: interactions between transfusion, donor, and recipient

scientific article published on July 2012

Nitrite anion provides potent cytoprotective and antiapoptotic effects as adjunctive therapy to reperfusion for acute myocardial infarction

scientific article published on 02 June 2008

Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilation

scientific article published on 23 June 2006

Nitrite as regulator of hypoxic signaling in mammalian physiology

scientific article published on September 2009

Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer

scientific article

Nitrite in pulmonary arterial hypertension: therapeutic avenues in the setting of dysregulated arginine/nitric oxide synthase signalling

scientific article published on 22 December 2010

Nitrite infusion in humans and nonhuman primates: endocrine effects, pharmacokinetics, and tolerance formation

scientific article published on 24 September 2007

Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage

scientific article published in March 2005

Nitrite mediates cytoprotection after ischemia/reperfusion by modulating mitochondrial function

scientific article published on 26 February 2009

Nitrite modulates bacterial antibiotic susceptibility and biofilm formation in association with airway epithelial cells

scientific article published on 16 September 2014

Nitrite potently inhibits hypoxic and inflammatory pulmonary arterial hypertension and smooth muscle proliferation via xanthine oxidoreductase-dependent nitric oxide generation

scientific article published on 21 December 2009

Nitrite reductase activity of cytochrome c

scientific article

Nitrite reductase activity of hemoglobin as a systemic nitric oxide generator mechanism to detoxify plasma hemoglobin produced during hemolysis

scientific article published on 13 June 2008

Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury

scholarly article

Nitrite reductase activity of nonsymbiotic hemoglobins from Arabidopsis thaliana

scientific article (publication date: 3 July 2012)

Nitrite regulates hypoxic vasodilation via myoglobin-dependent nitric oxide generation

scientific article published on 9 June 2012

Nitrite signaling in pulmonary hypertension: mechanisms of bioactivation, signaling, and therapeutics

scientific article

Nitrite therapy after cardiac arrest reduces reactive oxygen species generation, improves cardiac and neurological function, and enhances survival via reversible inhibition of mitochondrial complex I.

scientific article published on 24 August 2009

Nitrite-generated NO circumvents dysregulated arginine/NOS signaling to protect against intimal hyperplasia in Sprague-Dawley rats

scientific article

Noninfectious and Nonneoplastic Conditions Associated with Human Immunodeficiency Virus Infection

scientific article published on 14 March 2016

Normoxic cyclic GMP-independent oxidative signaling by nitrite enhances airway epithelial cell proliferation and wound healing

scientific article

Nox2-dependent glutathionylation of endothelial NOS leads to uncoupled superoxide production and endothelial barrier dysfunction in acute lung injury

scientific article

Oxidant-induced cell death in respiratory epithelial cells is due to DNA damage and loss of ATP.

scientific article published on December 2002

Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling

scientific article

Pathophysiology of Sickle Cell Disease

scientific article published on 17 October 2018

Perivascular T-Cell Infiltration Leads to Sustained Pulmonary Artery Remodeling after Endothelial Cell Damage ⬇️

scientific article published on September 2, 2010

Pharmacokinetics, pharmacodynamics, safety, and tolerability of nebulized sodium nitrite (AIR001) following repeat-dose inhalation in healthy subjects

scientific article

Physiologic changes in a nonhuman primate model of HIV-associated pulmonary arterial hypertension

scientific article published on 13 December 2012

Physiologic, pathologic and therapeutic implications for hemoglobin interactions with nitric oxide

scientific article published in February 2004

Pitfalls in measuring NO bioavailability using NOx

scientific article published on 22 October 2014

Plasma thrombospondin-1 is increased during acute sickle cell vaso-occlusive events and associated with acute chest syndrome, hydroxyurea therapy, and lower hemolytic rates

scientific article published on 8 February 2012

Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension, and nitric oxide scavenging by cell-free hemoglobin

scientific article

Platelets from pulmonary hypertension patients show increased mitochondrial reserve capacity

scientific article published on 09 March 2017

Polycythemia, HIF-1alpha and pulmonary hypertension in Chuvash.

scientific article published in June 2006

Potential therapeutic action of nitrite in sickle cell disease

scientific article

Prediction of fetal hemoglobin in sickle cell anemia using an ensemble of genetic risk prediction models

scientific article published on March 2014

Predictors of osteoclast activity in patients with sickle cell disease

scientific article

Prevalence and risk factors for pulmonary artery systolic hypertension among sickle cell disease patients in Nigeria

scientific article

Prevalence, risk factors and mortality of pulmonary hypertension defined by right heart catheterization in patients with sickle cell disease.

scientific article published in December 2011

Prospective echocardiography assessment of pulmonary hypertension and its potential etiologies in children with sickle cell disease

scientific article

Prospective evaluation of haemoglobin oxygen saturation at rest and after exercise in paediatric sickle cell disease patients

scientific article published on 19 August 2009

Pulmonary Vascular Lesions Are Common in SIV- and SHIV-env-Infected Macaques ⬇️

scientific article published on October 21, 2010

Pulmonary arterial hypertension: the clinical syndrome

scientific article

Pulmonary artery pressure and iron deficiency in patients with upregulation of hypoxia sensing due to homozygous VHL(R200W) mutation (Chuvash polycythemia).

scientific article published on 11 October 2011

Pulmonary complications of sickle cell disease

scientific article

Pulmonary hypertension and NO in sickle cell

scientific article published on August 2010

Pulmonary hypertension as a risk factor for death in patients with sickle cell disease

scientific article published in February 2004

Pulmonary hypertension in hemolytic disorders: pulmonary vascular disease: the global perspective

scientific article

Pulmonary hypertension in patients with hemoglobinopathies: could a mechanism for dysfunction provide an avenue for novel therapeutics?

scientific article published in April 2005

Pulmonary hypertension in sickle cell disease

scientific article published on November 2014

Pulmonary hypertension in sickle cell disease: mechanisms, diagnosis, and management

scientific article

Pulmonary hypertension in sickle cell disease: relevance to children

scientific article

Pulmonary hypertension: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases

scientific article

Pulmonary vascular effects of red blood cells containing S-nitrosated hemoglobin

scientific article

Pulmonary vascular endothelium: the orchestra conductor in respiratory diseases: Highlights from basic research to therapy.

scientific article published on 15 March 2018

Rates and risk factors of hypertension in adolescents and adults with sickle cell anaemia in Tanzania: 10 years' experience

scientific article

Rationale and design of mDOT-HuA study: a randomized trial to assess the effect of mobile-directly observed therapy on adherence to hydroxyurea in adults with sickle cell anemia in Tanzania

scientific article

Reactive oxygen and nitrogen species in pulmonary hypertension

scientific article published on 06 March 2012

Red blood cell endothelial nitric oxide synthase does not modulate red blood cell storage hemolysis

scientific article published on 15 August 2012

Redefining pulmonary hypertension

scientific article

Relationship of erythropoietin, fetal hemoglobin, and hydroxyurea treatment to tricuspid regurgitation velocity in children with sickle cell disease

scientific article published on September 2009

Relative systemic hypertension in patients with sickle cell disease is associated with risk of pulmonary hypertension and renal insufficiency

scientific article

Reply: Practice guideline for pulmonary hypertension in sickle cell: direct evidence needed before universal adoption

scientific article published in July 2014

Response by Lai and Gladwin to Letter Regarding Article, "SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fract

scientific article published in August 2016

Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom

scientific article

Risk factors for mortality in adult patients with sickle cell disease: a meta-analysis of studies in North America and Europe

scientific article

Role of the anion nitrite in ischemia-reperfusion cytoprotection and therapeutics

scientific article

Role of the red blood cell in nitric oxide homeostasis and hypoxic vasodilation.

scientific article published on January 2006

SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction

scientific article published on 26 January 2016

Segmentation and quantification of pulmonary artery for noninvasive CT assessment of sickle cell secondary pulmonary hypertension

scientific article

Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration

scientific article

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

scientific article published on 6 March 2019

Severe pulmonary hypertension in an adolescent with sickle cell disease

scientific article

Severity of pulmonary hypertension during vaso-occlusive pain crisis and exercise in patients with sickle cell disease

scientific article

Shining a Light on Carbon Monoxide Poisoning

scientific article published in November 2015

Sickle Cell Trait Increases Red Blood Cell Storage Hemolysis and Post-Transfusion Clearance in Mice

scientific article published on 04 August 2016

Sickle cell disease and pulmonary hypertension in Africa: a global perspective and review of epidemiology, pathophysiology, and management

scientific article published on January 2008

Sickle cell disease vasculopathy: a state of nitric oxide resistance

scientific article

Sickle-cell disease

scientific article

Sildenafil therapy in patients with sickle cell disease and pulmonary hypertension

scientific article

Sodium nitrite blocks the activity of aminoglycosides against Pseudomonas aeruginosa biofilms

scientific article published on 23 March 2015

Sodium nitrite promotes regional blood flow in patients with sickle cell disease: a phase I/II study

scientific article published on 11 July 2008

Storage lesion in banked blood due to hemolysis-dependent disruption of nitric oxide homeostasis

scientific article published in November 2009

Storage lesion: role of red blood cell breakdown

scientific article published on April 2011

Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report

scientific article

Strategies to increase nitric oxide signalling in cardiovascular disease

scientific article published on 07 August 2015

Testosterone-dependent sex differences in red blood cell hemolysis in storage, stress, and disease

scientific article published on 9 August 2016

The biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulation

scientific article published on March 2004

The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease

scientific article

The detection of the nitrite reductase and NO-generating properties of haemoglobin by mitochondrial inhibition ⬇️

scientific article published on October 14, 2010

The emerging biology of the nitrite anion

scientific article published on 01 November 2005

The functional nitrite reductase activity of the heme-globins

scientific article

The genetics of hemoglobin A2 regulation in sickle cell anemia

scientific article

The ligand binding battle at cytochrome c oxidase: how NO regulates oxygen gradients in tissue

scientific article

The new chemical biology of nitrite reactions with hemoglobin: R-state catalysis, oxidative denitrosylation, and nitrite reductase/anhydrase

scientific article published on January 2009

The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics

scientific article published on February 2008

The perfusion paradox and vascular instability in sickle cell disease

scientific article published in March 2004

The potential of Angeli's salt to decrease nitric oxide scavenging by plasma hemoglobin

scientific article published on 11 January 2008

The proverbial chicken or the egg? Dissection of the role of cell-free hemoglobin versus reactive oxygen species in sickle cell pathophysiology

scientific article published on 23 May 2008

The reaction between nitrite and deoxyhemoglobin. Reassessment of reaction kinetics and stoichiometry.

scientific article published on 18 April 2005

The reaction between nitrite and hemoglobin: the role of nitrite in hemoglobin-mediated hypoxic vasodilation

scientific article

The relationship between pulmonary emphysema and kidney function in smokers

scientific article

The relationship between the severity of hemolysis, clinical manifestations and risk of death in 415 patients with sickle cell anemia in the US and Europe

scientific article published on 14 September 2012

The role of red blood cells and hemoglobin-nitric oxide interactions on blood flow

scientific article published in February 2008

The workup of stridor: virtual bronchoscopy as a complementary technique in the diagnosis of subglottic stenosis.

scientific article published in March 2007

Therapeutics targeting of dysregulated redox equilibrium and endothelial dysfunction

scientific article published on January 2013

Thrombospondin-1 inhibits ADAMTS13 activity in sickle cell disease

scientific article published on November 2013

Towards microfluidic-based depletion of stiff and fragile human red cells that accumulate during blood storage

scientific article published on January 2015

Transfusion of older stored blood worsens outcomes in canines depending on the presence and severity of pneumonia

scientific article

Translational Advances in the Field of Pulmonary Hypertension Bench to Bedside: How Fundamental Discoveries in Science Are Advancing Our Understanding and Therapy of Pulmonary Arterial Hypertension

scientific article published in January 2017

Unraveling restrictive chronic lung disease in sickle cell disease

scientific article

Unraveling the reactions of nitric oxide, nitrite, and hemoglobin in physiology and therapeutics

scientific article

Update in Pulmonary Vascular Disease 2015.

scientific article published on June 2016

Update in Pulmonary Vascular Diseases 2014.

scientific article

Update in pulmonary vascular diseases 2012.

scientific article published on July 2013

Update on pulmonary hypertension 2009.

scientific article published on May 2010

Updated clinical classification of pulmonary hypertension.

scientific article

Vasculopathy and pulmonary hypertension in sickle cell disease

scientific article

Vasculopathy in sickle cell disease: Biology, pathophysiology, genetics, translational medicine, and new research directions

scientific article

Washing older blood units before transfusion reduces plasma iron and improves outcomes in experimental canine pneumonia

scientific article published on 23 December 2013

What is the role of screening for pulmonary hypertension in adults and children with sickle cell disease?

scientific article published in December 2017

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