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List of works by Oksana Lockridge

A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters

scientific article published on 16 April 2008

A medical health report on individuals with silent butyrylcholinesterase in the Vysya community of India

scientific article published on 17 November 2006

A mutation linked with autism reveals a common mechanism of endoplasmic reticulum retention for the alpha,beta-hydrolase fold protein family

scientific journal article

A novel method for purifying recombinant human host defense cathelicidin LL-37 by utilizing its inherent property of aggregation.

scientific article published on 15 February 2007

Adaptation to excess acetylcholine by downregulation of adrenoceptors and muscarinic receptors in lungs of acetylcholinesterase knockout mice

scientific article published on 06 September 2007

Adenovirus-transduced human butyrylcholinesterase in mouse blood functions as a bioscavenger of chemical warfare nerve agents.

scientific article published on 19 June 2009

Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation

scientific article

Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry

scientific article

Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry

scientific article published on 3 November 2004

Altered hippocampal muscarinic receptors in acetylcholinesterase-deficient mice

scientific article

Altered striatal function and muscarinic cholinergic receptors in acetylcholinesterase knockout mice

scientific journal article

Application of chromosomal DNA and protein targeting for the identification of Yersinia pestis

scientific article published on 10 May 2013

Aromatic amino‐acid residues at the active and peripheral anionic sites control the binding of E2020 (Aricept®) to cholinesterases ⬇️

scientific article published on November 1, 2003

Aryl acylamidase activity of human serum albumin with o-nitrotrifluoroacetanilide as the substrate

scientific article

Binding and hydrolysis of soman by human serum albumin

scientific article published on 29 December 2007

Biomarkers of organophosphorus (OP) exposures in humans ⬇️

scientific article published on July 8, 2011

Butyrylcholinesterase for protection from organophosphorus poisons: catalytic complexities and hysteretic behavior

scientific article

Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasma

scientific article

Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase.

scientific article published on 21 June 2008

Carbofuran poisoning detected by mass spectrometry of butyrylcholinesterase adduct in human serum.

scientific article

Characteristic fragment ions associated with dansyl cadaverine and biotin cadaverine adducts on glutamine

scientific article published on 23 April 2020

Characteristic mass spectral fragments of the organophosphorus agent FP-biotin and FP-biotinylated peptides from trypsin and bovine albumin (Tyr410).

scientific article published in October 2005

Characterization of a novel BCHE "silent" allele: point mutation (p.Val204Asp) causes loss of activity and prolonged apnea with suxamethonium.

scientific article

Characterization of a novel butyrylcholinesterase point mutation (p.Ala34Val), "silent" with mivacurium

scientific article

Characterization of butyrylcholinesterase from porcine milk

scientific article published on 15 June 2018

Characterization of butyrylcholinesterase in bovine serum

scientific article published on 8 February 2017

Chlorpyrifos Oxon-Induced Isopeptide Bond Formation in Human Butyrylcholinesterase

scientific article published on 25 January 2020

Chlorpyrifos oxon promotes tubulin aggregation via isopeptide cross-linking between diethoxyphospho-Lys and Glu or Asp: Implications for neurotoxicity

scientific article published on 13 July 2018

Choline availability and acetylcholine synthesis in the hippocampus of acetylcholinesterase-deficient mice

scientific article published on 16 October 2007

Cocrystallization studies of full-length recombinant butyrylcholinesterase (BChE) with cocaine ⬇️

scientific article published on March 24, 2011

Comparison of 5 monoclonal antibodies for immunopurification of human butyrylcholinesterase on Dynabeads: KD values, binding pairs, and amino acid sequences

scientific article published on 02 September 2015

Computer-designed active human butyrylcholinesterase double mutant with a new catalytic triad

scientific article published on 19 April 2019

Contributions of selective knockout studies to understanding cholinesterase disposition and function.

scientific article

Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine

scientific article

Cresyl Saligenin Phosphate, an Organophosphorus Toxicant, Makes Covalent Adducts with Histidine, Lysine, and Tyrosine Residues of Human Serum Albumin ⬇️

scientific article published on July 26, 2012

Cresyl saligenin phosphate makes multiple adducts on free histidine, but does not form an adduct on histidine 438 of human butyrylcholinesterase ⬇️

scientific article published on August 8, 2012

Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly

scientific article published on 11 December 2018

Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products

scientific article

Crystallization and X-ray structure of full-length recombinant human butyrylcholinesterase

scientific article

DNA sequence of butyrylcholinesterase from the rat: expression of the protein and characterization of the properties of rat butyrylcholinesterase

scientific article

Damped oscillatory hysteretic behaviour of butyrylcholinesterase with benzoylcholine as substrate

scientific article published in January 2004

Delivery of human acetylcholinesterase by adeno-associated virus to the acetylcholinesterase knockout mouse.

scientific article published on 21 October 2005

Detectable organophosphorus pesticide exposure in the blood of Nebraska and Iowa residents measured by mass spectrometry of butyrylcholinesterase adducts.

scientific article

Detection of adduct on tyrosine 411 of albumin in humans poisoned by dichlorvos

scientific article

Detection of cresyl phosphate-modified butyrylcholinesterase in human plasma for chemical exposure associated with aerotoxic syndrome

scientific article

Development of diagnostics in the search for an explanation of aerotoxic syndrome

scientific article

Dichlorvos, chlorpyrifos oxon and Aldicarb adducts of butyrylcholinesterase, detected by mass spectrometry in human plasma following deliberate overdose

scientific article

Differential sensitivity of plasma carboxylesterase-null mice to parathion, chlorpyrifos and chlorpyrifos oxon, but not to diazinon, dichlorvos, diisopropylfluorophosphate, cresyl saligenin phosphate, cyclosarin thiocholine, tabun thiocholine, and c

scientific article published on December 24, 2011

Dramatic depletion of cell surface m2 muscarinic receptor due to limited delivery from intracytoplasmic stores in neurons of acetylcholinesterase-deficient mice

scientific article

Drastic decrease in dopamine receptor levels in the striatum of acetylcholinesterase knock-out mouse.

scientific article published in January 2010

Effects of rivastigmine and donepezil on brain acetylcholine levels in acetylcholinesterase-deficient mice.

scientific article published in January 2009

Effects of viscosity and osmotic stress on the reaction of human butyrylcholinesterase with cresyl saligenin phosphate, a toxicant related to aerotoxic syndrome: kinetic and molecular dynamics studies

scientific article

Engineering of a monomeric and low-glycosylated form of human butyrylcholinesterase: expression, purification, characterization and crystallization

scientific article published in January 2002

Evaluation of mass spectrometry MS/MS spectra for the presence of isopeptide crosslinked peptides

scientific article published on 09 July 2021

Excessive hippocampal acetylcholine levels in acetylcholinesterase-deficient mice are moderated by butyrylcholinesterase activity

scientific journal article

Exposure to tri-o-cresyl phosphate detected in jet airplane passengers ⬇️

scientific article published on June 24, 2011

Expression of three naturally occurring genetic variants (G75R, E90D, I99M) of the BCHE gene of human butyrylcholinesterase

scientific article published on September 2007

Fast affinity purification coupled with mass spectrometry for identifying organophosphate labeled plasma butyrylcholinesterase

scientific article published on 2 May 2008

Five new naturally occurring mutations of the BCHE gene and frequencies of 12 butyrylcholinesterase alleles in a Brazilian population.

scientific article

Five tyrosines and two serines in human albumin are labeled by the organophosphorus agent FP-biotin.

scientific article published on 16 August 2008

Gene transfer of acetylcholinesterase protects the knockout mouse from the toxicity of DFP.

scientific article published in January 2006

Half-life of chlorpyrifos oxon and other organophosphorus esters in aqueous solution

scientific article published on 08 August 2019

High activity of human butyrylcholinesterase at low pH in the presence of excess butyrylthiocholine

scientific article published in January 2003

Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure

scientific article

Hydrolysis of oxo- and thio-esters by human butyrylcholinesterase

scientific article published on 9 November 2006

Hysteresis of butyrylcholinesterase in the approach to steady-state kinetics

scientific article published on 27 October 2005

Identification of Carboxylesterase, Butyrylcholinesterase, Acetylcholinesterase, Paraoxonase, and Albumin Pseudoesterase in Guinea Pig Plasma through Nondenaturing Gel Electrophoresis

scientific article published on 02 October 2018

Identification of organophosphate-reactive proteins by tandem mass spectrometry

scientific article published in December 2005

Immunopurification of Acetylcholinesterase from Red Blood Cells for Detection of Nerve Agent Exposure.

scientific article published on 11 September 2017

Impaired formation of the inner retina in an AChE knockout mouse results in degeneration of all photoreceptors

scientific journal article

Increased hepatotoxicity and cardiac fibrosis in cocaine-treated butyrylcholinesterase knockout mice

scientific article

Induction of plasma acetylcholinesterase activity in mice challenged with organophosphorus poisons

scientific article published on 2 July 2011

Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry

scientific article

Kinetic analysis of effector modulation of butyrylcholinesterase-catalysed hydrolysis of acetanilides and homologous esters

scientific article published on 15 April 2008

Lamellipodin proline rich peptides associated with native plasma butyrylcholinesterase tetramers

scientific article published in April 2008

Life without acetylcholinesterase: the implications of cholinesterase inhibitor toxicity in AChE-knockout mice

scientific article published on 26 January 2005

Markers of organophosphate exposure in human serum

scientific article published on 01 January 2006

Mass Spectral Detection of Diethoxyphospho-Tyrosine Adducts on Proteins from HEK293 Cells Using Monoclonal Antibody depY for Enrichment.

scientific article

Mass Spectrometry Identifies Isopeptide Cross-Links Promoted by Diethylphosphorylated Lysine in Proteins Treated with Chlorpyrifos Oxon

scientific article published on 07 March 2019

Mass spectral characterization of organophosphate-labeled lysine in peptides

scientific article published on 09 July 2009

Mass spectral characterization of organophosphate-labeled, tyrosine-containing peptides: characteristic mass fragments and a new binding motif for organophosphates

scientific article

Mass spectrometry identifies covalent binding of soman, sarin, chlorpyrifos oxon, diisopropyl fluorophosphate, and FP-biotin to tyrosines on tubulin: a potential mechanism of long term toxicity by organophosphorus agents

scientific article

Mass spectrometry identifies multiple organophosphorylated sites on tubulin

scientific article published on 24 July 2009

Mass spectrometry method to identify aging pathways of Sp- and Rp-tabun adducts on human butyrylcholinesterase based on the acid labile P-N bond

scientific article

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay for organophosphorus toxicants bound to human albumin at Tyr411.

scientific article

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of titanium oxide-enriched peptides for detection of aged organophosphorus adducts on human butyrylcholinesterase

scientific article

Mice treated with a nontoxic dose of chlorpyrifos oxon have diethoxyphosphotyrosine labeled proteins in blood up to 4 days post exposure, detected by mass spectrometry ⬇️

scientific article published on March 8, 2012

Mice treated with chlorpyrifos or chlorpyrifos oxon have organophosphorylated tubulin in the brain and disrupted microtubule structures, suggesting a role for tubulin in neurotoxicity associated with exposure to organophosphorus agents.

scientific article

Monoclonal Antibodies That Recognize Various Folding States of Pure Human Butyrylcholinesterase Can Immunopurify Butyrylcholinesterase from Human Plasma Stored at Elevated Temperatures.

scientific article published on 13 December 2016

Monoclonal Antibody That Recognizes Diethoxyphosphotyrosine-Modified Proteins and Peptides Independent of Surrounding Amino Acids

scientific article published on 14 November 2017

Monoclonal antibodies to human butyrylcholinesterase reactive with butyrylcholinesterase in animal plasma

scientific article

Mutant of Bungarus fasciatus acetylcholinesterase with low affinity and low hydrolase activity toward organophosphorus esters

scientific article published on 04 August 2006

Nanoimages show disruption of tubulin polymerization by chlorpyrifos oxon: implications for neurotoxicity

scientific article

Naturally Occurring Genetic Variants of Human Acetylcholinesterase and Butyrylcholinesterase and Their Potential Impact on the Risk of Toxicity from Cholinesterase Inhibitors.

scientific article published on 23 August 2016

Naturally occurring mutation Leu307Pro of human butyrylcholinesterase in the Vysya community of India

scientific article

Naturally occurring mutation, Asp70his, in human butyrylcholinesterase

scientific article

Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase

scientific article

Neuropathological and immunochemical studies of brain parenchyma in acetylcholinesterase knockout mice: implications in Alzheimer's disease.

scientific article published in July 2007

Optimization of Cholinesterase-Based Catalytic Bioscavengers Against Organophosphorus Agents.

scientific article published on 13 March 2018

Origin of polyproline-rich peptides in human butyrylcholinesterase tetramers.

scientific article published on 11 February 2016

PHOS-select iron affinity beads enrich peptides for the detection of organophosphorus adducts on albumin.

scientific article

Phenotype Comparison of Three Acetylcholinesterase Knockout Strains

scientific article published on 01 January 2006

Polyclonal antibody to soman-tyrosine

scientific article published on 21 March 2013

Polyproline tetramer organizing peptides in fetal bovine serum acetylcholinesterase

scientific article published on 23 January 2013

Polyproline-rich peptides associated with Torpedo californica acetylcholinesterase tetramers

scientific article published on 20 February 2020

Production of ES1 Plasma Carboxylesterase Knockout Mice for Toxicity Studies ⬇️

scientific article published on September 7, 2011

Production of the butyrylcholinesterase knockout mouse.

scientific article

Proline 285 is integral for the reactivation of organophosphate-inhibited human butyrylcholinesterase by 2-PAM

scientific article published on 09 April 2020

Prolonged toxic effects after cocaine challenge in butyrylcholinesterase/plasma carboxylesterase double knockout mice: a model for butyrylcholinesterase-deficient humans

scientific article published on 3 May 2011

Protection from the toxicity of diisopropylfluorophosphate by adeno-associated virus expressing acetylcholinesterase

scientific article

Protein tyrosine adduct in humans self-poisoned by chlorpyrifos

scientific article

Pseudo-esterase activity of human albumin: slow turnover on tyrosine 411 and stable acetylation of 82 residues including 59 lysines

scientific article published on 24 June 2008

Pure human butyrylcholinesterase hydrolyzes octanoyl ghrelin to desacyl ghrelin

scientific article published on 12 June 2015

Purification of human butyrylcholinesterase from frozen Cohn fraction IV-4 by ion exchange and Hupresin affinity chromatography

scientific article published in PLoS ONE

Purification of recombinant human butyrylcholinesterase on Hupresin®

scientific article published on 25 October 2018

Rate-determining step of butyrylcholinesterase-catalyzed hydrolysis of benzoylcholine and benzoylthiocholine. Volumetric study of wild-type and D70G mutant behavior

scientific article

Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase

scientific article published in April 2005

Reaction of Cresyl Saligenin Phosphate, the Organophosphorus Agent Implicated in Aerotoxic Syndrome, with Human Cholinesterases: Mechanistic Studies Employing Kinetics, Mass Spectrometry, and X-ray Structure Analysis

scientific article

Reaction of human albumin with aspirin in vitro: mass spectrometric identification of acetylated lysines 199, 402, 519, and 545.

scientific article

Reduced acetylcholine receptor density, morphological remodeling, and butyrylcholinesterase activity can sustain muscle function in acetylcholinesterase knockout mice

scientific article

Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice

scientific article published in March 2003

Rescue of the acetylcholinesterase knockout mouse by feeding a liquid diet; phenotype of the adult acetylcholinesterase deficient mouse

scientific article published in July 2002

Resistance to organophosphorus agent toxicity in transgenic mice expressing the G117H mutant of human butyrylcholinesterase.

scientific article published in May 2004

Review of tyrosine and lysine as new motifs for organophosphate binding to proteins that have no active site serine

scientific article

Role of Acetylcholinesterase on the Structure and Function of Cholinergic Synapses: Insights Gained from Studies on Knockout Mice

scientific article published on 03 May 2011

Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging

scientific article

Screening assays for cholinesterases resistant to inhibition by organophosphorus toxicants

scientific article

Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmis

scientific article published on 2 December 2006

Signature Ions in MS/MS Spectra for Dansyl-Aminohexyl-QQIV Adducts on Lysine

scientific article published on 08 June 2020

Structural approach to the aging of phosphylated cholinesterases

scientific article published on 23 March 2010

Substrate activation in acetylcholinesterase induced by low pH or mutation in the pi-cation subsite

scientific article published in February 2002

Tetramer organizing polyproline-rich peptides identified by mass spectrometry after release of the peptides from Hupresin-purified butyrylcholinesterase tetramers isolated from milk of domestic pig ()

Tetramer-organizing polyproline-rich peptides differ in CHO cell-expressed and plasma-derived human butyrylcholinesterase tetramers

scientific article

The C5 Variant of the Butyrylcholinesterase Tetramer Includes a Noncovalently Bound 60 kDa Lamellipodin Fragment

scientific article published on 29 June 2017

The butyrylcholinesterase knockout mouse a research tool in the study of drug sensitivity, bio-distribution, obesity and Alzheimer's disease

scientific article published on 01 May 2009

The butyrylcholinesterase knockout mouse as a model for human butyrylcholinesterase deficiency

scientific article

The butyrylcholinesterase knockout mouse is obese on a high-fat diet

scientific article published on 22 March 2008

The kinetic study of the inhibition of human cholinesterases by demeton-S-methyl shows that cholinesterase-based titration methods are not suitable for this organophosphate ⬇️

scientific article published on January 14, 2011

Tyrosines of human and mouse transferrin covalently labeled by organophosphorus agents: a new motif for binding to proteins that have no active site serine

scientific article

Use of Hupresin To Capture Red Blood Cell Acetylcholinesterase for Detection of Soman Exposure.

scientific article

Whole body and tissue imaging of the butyrylcholinesterase knockout mouse injected with near infrared dye labeled butyrylcholinesterase

scientific article published on 07 March 2008

Wild-type and A328W mutant human butyrylcholinesterase tetramers expressed in Chinese hamster ovary cells have a 16-hour half-life in the circulation and protect mice from cocaine toxicity

scientific article

X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger

scientific article

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