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List of works by Paola Picotti

A Complete Mass-spectrometric Map of a Eukaryotic Proteome

scientific article published on 01 September 2013

A Map of Protein-Metabolite Interactions Reveals Principles of Chemical Communication

scientific article published on 3 January 2018

A complete mass-spectrometric map of the yeast proteome applied to quantitative trait analysis

scientific article

A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body-like pathology

scientific article published on 01 June 2019

A database of mass spectrometric assays for the yeast proteome

scientific article

A machine learning-based chemoproteomic approach to identify drug targets and binding sites in complex proteomes

scientific article published on 21 August 2020

A quantitative targeted proteomics approach to validate predicted microRNA targets in C. elegans

scientific article

A sentinel protein assay for simultaneously quantifying cellular processes

scientific article published on 7 September 2014

ATAQS: A computational software tool for high throughput transition optimization and validation for selected reaction monitoring mass spectrometry ⬇️

scientific article published on March 18, 2011

Abstract 2755: Limited proteolysis coupled to mass spectrometry (LiP-MS), a novel drug target deconvolution strategy

scholarly article

Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo ⬇️

scientific article published on 24 March 2014

Amyloid fibril formation and disaggregation of fragment 1-29 of apomyoglobin: insights into the effect of pH on protein fibrillogenesis

scientific article published on 3 February 2007

Biology/Disease-Driven Initiative on Protein-Aggregation Diseases of the Human Proteome Project: Goals and Progress to Date

scientific article published on 28 September 2018

Biomarker Validation in Blood Specimens by Selected Reaction Monitoring Mass Spectrometry of N-Glycosites ⬇️

scientific article published on January 1, 2011

C7 is expressed on endothelial cells as a trap for the assembling terminal complement complex and may exert anti-inflammatory function

scientific article published on 29 January 2009

Calcineurin determines toxic versus beneficial responses to α-synuclein

scientific article

Cancer genetics-guided discovery of serum biomarker signatures for diagnosis and prognosis of prostate cancer

scientific article

Cell-wide analysis of protein thermal unfolding reveals determinants of thermostability.

scientific article

Chemical stresses fail to mimic the unfolded protein response resulting from luminal load with unfolded polypeptides

scientific article published on 16 February 2018

Combining CRISPRi and metabolomics for functional annotation of compound libraries

scientific article published on 22 February 2022

Combining data integration and molecular dynamics for target identification in α-Synuclein-aggregating neurodegenerative diseases: Structural insights on Synaptojanin-1 (Synj1)

scientific article published on 22 April 2020

Comparative analysis of the intracellular responses to disease-related aggregation-prone proteins

scientific article published on 11 June 2020

Comprehensive quantitative analysis of central carbon and amino‐acid metabolism in Saccharomyces cerevisiae under multiple conditions by targeted proteomics ⬇️

scientific article published on February 1, 2011

Conformational stability of neuroglobin helix F--possible effects on the folding pathway within the globin family

scientific article

Corrigendum: Cortical dynamics during cell motility are regulated by CRL3(KLHL21) E3 ubiquitin ligase

scientific article published on 31 October 2016

Cortical dynamics during cell motility are regulated by CRL3(KLHL21) E3 ubiquitin ligase

scientific article

Detecting Protein-Small Molecule Interactions Using Limited Proteolysis-Mass Spectrometry (LiP-MS)

scientific article published on 29 May 2020

Differential glucose repression in common yeast strains in response to HXK2 deletion

scientific article published on 22 January 2010

Dynamic 3D proteomes reveal protein functional alterations at high resolution in situ

scientific article published on 22 December 2020

Erratum: A quantitative targeted proteomics approach to validate predicted microRNA targets in C. elegans

scholarly article published in Nature Methods

Erratum: Phosphoproteomics takes it easy

scientific article published on 01 April 2016

FKBP12 contributes to α-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome

scientific article published on 11 December 2017

Facing challenges in Proteomics today and in the coming decade: Report of Roundtable Discussions at the 4th EuPA Scientific Meeting, Portugal, Estoril 2010.

scientific article published on 3 May 2011

Full dynamic range proteome analysis of S. cerevisiae by targeted proteomics

scientific article

Functional and stoichiometric analysis of subunit e in bovine heart mitochondrial F(0)F(1)ATP synthase

scientific article published in August 2008

Global analysis of protein structural changes in complex proteomes

scientific article published on 14 September 2014

High-performance metabolic marker assessment in breast cancer tissue by mass spectrometry

High-throughput generation of selected reaction-monitoring assays for proteins and proteomes

scientific article

High-throughput metabolomic analysis predicts mode of action of uncharacterized antimicrobial compounds.

scientific article published in February 2018

Host cell entry of respiratory syncytial virus involves macropinocytosis followed by proteolytic activation of the F protein

scientific article

Human SRMAtlas: A Resource of Targeted Assays to Quantify the Complete Human Proteome

scientific article

IPM: An integrated protein model for false discovery rate estimation and identification in high-throughput proteomics

scientific article published on 21 June 2011

Increased Selectivity, Analytical Precision, and Throughput in Targeted Proteomics ⬇️

scientific article published on July 27, 2010

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

scientific article published on 13 October 2016

Mass spectrometry analysis of the structural proteome

scientific article published on 13 December 2019

Measuring protein structural changes on a proteome-wide scale using limited proteolysis-coupled mass spectrometry

scientific article

Mitotic Disassembly of Nuclear Pore Complexes Involves CDK1- and PLK1-Mediated Phosphorylation of Key Interconnecting Nucleoporins

scientific article published on October 2017

Mitotic redistribution of the mitochondrial network by Miro and Cenp-F.

scientific article

Modulation of the structural integrity of helix F in apomyoglobin by single amino acid replacements

scientific article

Modules, networks and systems medicine for understanding disease and aiding diagnosis.

scientific article

Network Rewiring of Homologous Recombination Enzymes during Mitotic Proliferation and Meiosis

scientific article published on 24 July 2019

Nicked apomyoglobin: a noncovalent complex of two polypeptide fragments comprising the entire protein chain

scientific article

Perspectives of targeted mass spectrometry for protein biomarker verification

scientific article published on 07 October 2009

PhosphoPep--a database of protein phosphorylation sites in model organisms

scientific article published on December 2008

Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast

scientific article

Phosphoproteomics takes it easy

scientific article published on 01 September 2015

Phosphorylation of nuclear Tau is modulated by distinct cellular pathways

scientific article published in Scientific Reports

Preparation and Characterization of Stable α-Synuclein Lipoprotein Particles

scientific article published on 4 February 2016

Probing protein structure by limited proteolysis.

scientific article

Probing protein structure by limited proteolysis.

scientific article published in 2004

Protein significance analysis in selected reaction monitoring (SRM) measurements

scientific article published on 21 December 2011

Proteomic analysis of F1F0-ATP synthase super-assembly in mitochondria of cardiomyoblasts undergoing differentiation to the cardiac lineage

scientific article published on 12 April 2013

Proteomics beyond large-scale protein expression analysis

scientific article

Proteomics meets the scientific method.

scientific article

Proteomics-Based Monitoring of Pathway Activity Reveals that Blocking Diacylglycerol Biosynthesis Rescues from Alpha-Synuclein Toxicity

scientific article published on 11 September 2019

Publisher Correction: Systems NMR: single-sample quantification of RNA, proteins and metabolites for biomolecular network analysis

scientific article published on 01 September 2019

Pyruvate kinase variant of fission yeast tunes carbon metabolism, cell regulation, growth and stress resistance

scientific article published on 01 April 2020

Quantitative proteomics of model organisms

scientific article published in 2017

RIP-chip-SRM--a new combinatorial large-scale approach identifies a set of translationally regulated bantam/miR-58 targets in C. elegans

scientific article

Regulation of yeast central metabolism by enzyme phosphorylation

scientific article

Reproducibility of combinatorial peptide ligand libraries for proteome capture evaluated by selected reaction monitoring

scientific article

Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly

scientific article published in 2021

Reversible protein aggregation is a protective mechanism to ensure cell cycle restart after stress.

scientific article published on 28 August 2017

Selected Reaction Monitoring to Measure Proteins of Interest in Complex Samples: A Practical Guide.

scientific article

Selected reaction monitoring for quantitative proteomics: a tutorial

scientific article published on 14 October 2008

Selected reaction monitoring-based proteomics: workflows, potential, pitfalls and future directions

scientific article

Shotgun proteomics analysis reveals new unsuspected molecular effectors of nitrogen-containing bisphosphonates in osteocytes.

scientific article

Stepwise priming by acidic pH and a high K+ concentration is required for efficient uncoating of influenza A virus cores after penetration

scientific article

Structural basis of calmodulin modulation of the rod cyclic nucleotide-gated channel

scientific article published on 3 April 2023

Systematic measurement of transcription factor-DNA interactions by targeted mass spectrometry identifies candidate gene regulatory proteins

scientific article published on 6 February 2013

Systems NMR: single-sample quantification of RNA, proteins and metabolites for biomolecular network analysis

scientific article published on 29 July 2019

TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates

scientific article published on 17 December 2018

Targeted proteomics reveals compositional dynamics of 60S pre‐ribosomes after nuclear export ⬇️

scientific article published on January 1, 2012

Temporal system-level organization of the switch from glycolytic to gluconeogenic operation in yeast

scientific article published on January 2013

The Replisome-Coupled E3 Ubiquitin Ligase Rtt101Mms22 Counteracts Mrc1 Function to Tolerate Genotoxic Stress

scientific article published on 5 February 2016

The implications of proteolytic background for shotgun proteomics

scientific article published on 28 May 2007

The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.

scientific article published on 18 June 2018

Tradeoff between enzyme and metabolite efficiency maintains metabolic homeostasis upon perturbations in enzyme capacity.

scientific article published on April 2010

USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit

scientific article published on 04 March 2020

Unraveling condition‐dependent networks of transcription factors that control metabolic pathway activity in yeast ⬇️

scientific article published on November 30, 2010

Unusual stability of human neuroglobin at low pH--molecular mechanisms and biological significance

scientific article published on 27 October 2009

Voices in methods development

scientific article published on 01 October 2019

Voices of biotech

scientific article published on March 2016

mProphet: automated data processing and statistical validation for large-scale SRM experiments

scientific article

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