List of works by Paola Chiarugi

22 : 6n-3 DHA inhibits differentiation of prostate fibroblasts into myofibroblasts and tumorigenesis

scientific article

3-Adrenoreceptors Control Mitochondrial Dormancy in Melanoma and Embryonic Stem Cells

scientific article published on 13 November 2018

5-fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like traits

scientific article published on 21 October 2015

A novel redox-based switch: LMW-PTP oxidation enhances Grb2 binding and leads to ERK activation

scientific article published on 28 July 2006

Adiponectin in health and diseases: from metabolic syndrome to tissue regeneration

scientific article published on February 2010

Anchorage-dependent cell growth: tyrosine kinases and phosphatases meet redox regulation

scientific article

Angiopoietin-like 7, a novel pro-angiogenetic factor over-expressed in cancer.

scientific article

Anoikis molecular pathways and its role in cancer progression

scientific article

Anoikis: a necessary death program for anchorage-dependent cells

scientific article published on 25 July 2008

Beta-catenin interacts with low-molecular-weight protein tyrosine phosphatase leading to cadherin-mediated cell-cell adhesion increase.

scientific article published on November 2002

Bone marrow-derived mesenchymal stem cells promote invasiveness and transendothelial migration of osteosarcoma cells via a mesenchymal to amoeboid transition.

scientific article

Cancer associated fibroblasts exploit reactive oxygen species through a proinflammatory signature leading to epithelial mesenchymal transition and stemness

scientific article published on 28 March 2011

Cancer associated fibroblasts: the dark side of the coin.

scientific article published on 12 March 2011

Cancer-associated fibroblasts promote prostate cancer malignancy via metabolic rewiring and mitochondrial transfer

scientific article published on 01 April 2019

Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression

scientific article published on June 2012

Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells

scientific article published on 08 May 2013

Conjugation of a GM3 lactone mimetic on carbon nanotubes enhances the related inhibition of melanoma-associated metastatic events

scientific article published on 01 August 2018

Correction: miR-27a is a master regulator of metabolic reprogramming and chemoresistance in colorectal cancer

scientific article published on 17 April 2020

Down-Regulation of SOX2 Underlies the Inhibitory Effects of the Triphenylmethane Gentian Violet on Melanoma Cell Self-Renewal and Survival

scientific article published on 29 June 2016

EMT and oxidative stress: a bidirectional interplay affecting tumor malignancy

scientific article

ERMP1, a novel potential oncogene involved in UPR and oxidative stress defense, is highly expressed in human cancer

scientific article published on 23 August 2016

EphA2 induces metastatic growth regulating amoeboid motility and clonogenic potential in prostate carcinoma cells

scientific article published on 4 January 2011

EphA2 reexpression prompts invasion of melanoma cells shifting from mesenchymal to amoeboid-like motility style

scientific article

EphA2-mediated mesenchymal-amoeboid transition induced by endothelial progenitor cells enhances metastatic spread due to cancer-associated fibroblasts

scientific article published on 19 August 2012

EphrinA1 activates a Src/focal adhesion kinase-mediated motility response leading to rho-dependent actino/myosin contractility

scientific article published on 22 April 2007

EphrinA1 repulsive response is regulated by an EphA2 tyrosine phosphatase

scientific article

Escaping from, moving towards, following a path, squeezing through: lots of opportunities for moving cells ⬇️

scientific article published on September 7, 2010

Etoposide-Bevacizumab a new strategy against human melanoma cells expressing stem-like traits

scientific article published on 09 June 2016

From anchorage dependent proliferation to survival: lessons from redox signalling

scientific article published on May 2008

Globular adiponectin activates motility and regenerative traits of muscle satellite cells

scientific article (publication date: 2012)

Globular adiponectin induces differentiation and fusion of skeletal muscle cells.

scientific article published on May 2009

Glucose Metabolic Reprogramming of ER Breast Cancer in Acquired Resistance to the CDK4/6 Inhibitor Palbociclib

scientific article published on 10 March 2020

HIF-1α stabilization by mitochondrial ROS promotes Met-dependent invasive growth and vasculogenic mimicry in melanoma cells

scientific article

Insight into the role of low molecular weight phosphotyrosine phosphatase (LMW-PTP) on platelet-derived growth factor receptor (PDGF-r) signaling. LMW-PTP controls PDGF-r kinase activity through TYR-857 dephosphorylation

scientific article published on 30 July 2002

Integrated gene and miRNA expression analysis of prostate cancer associated fibroblasts supports a prominent role for interleukin-6 in fibroblast activation

scientific article published on 8 September 2015

Integrin-mediated cell adhesion and spreading engage different sources of reactive oxygen species.

scientific article published on April 2007

Intracellular reactive oxygen species activate Src tyrosine kinase during cell adhesion and anchorage-dependent cell growth

scientific article

Kinase-dependent and -independent roles of EphA2 in the regulation of prostate cancer invasion and metastasis

scientific article

LMW-PTP is a positive regulator of tumor onset and growth

scientific article published on May 2004

Lactate Rewires Lipid Metabolism and Sustains a Metabolic-Epigenetic Axis in Prostate Cancer

scientific article published on 01 April 2022

Lactate in Sarcoma Microenvironment: Much More than just a Waste Product

scientific article published on 24 February 2020

Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX).

scientific article

Lymphocyte function-associated antigen-1-mediated T cell adhesion is impaired by low molecular weight phosphotyrosine phosphatase-dependent inhibition of FAK activity

scientific article

Mesenchymal Stem Cells are Recruited and Activated into Carcinoma-Associated Fibroblasts by Prostate Cancer Microenvironment-Derived TGF-β1.

scientific article published on 14 June 2016

Mesenchymal to amoeboid transition is associated with stem-like features of melanoma cells

scientific article

Metabolic exchanges within tumor microenvironment.

scientific article

Metabolic implication of tumor:stroma crosstalk in breast cancer

scientific article published on 24 January 2014

Metabolic shift toward oxidative phosphorylation in docetaxel resistant prostate cancer cells

scientific article published on 16 August 2016

Metastasis: cancer cell's escape from oxidative stress.

scientific article

Microenvironment and tumor cell plasticity: an easy way out.

scientific article published on 31 January 2013

Mitochondrial Oxidative Stress due to Complex I Dysfunction Promotes Fibroblast Activation and Melanoma Cell Invasiveness.

scientific article published on 4 January 2012

New perspectives in PDGF receptor downregulation: the main role of phosphotyrosine phosphatases.

scientific article published on May 2002

Norepinephrine promotes tumor microenvironment reactivity through β3-adrenoreceptors during melanoma progression

scientific article published on March 2015

Nutrient Exploitation within the Tumor-Stroma Metabolic Crosstalk

scientific article published on 6 December 2016

Nutritional Exchanges Within Tumor Microenvironment: Impact for Cancer Aggressiveness

scientific article published on 24 March 2020

Oxidation and inactivation of low molecular weight protein tyrosine phosphatase by the anticancer drug Aplidin.

scientific article

PTPs versus PTKs: the redox side of the coin

scientific article

Protein tyrosine phosphorylation and reversible oxidation: two cross-talking posttranslation modifications

scientific article published on January 2007

Rac and Rho GTPases in cancer cell motility control

scientific article

Reactive oxygen species as essential mediators of cell adhesion: the oxidative inhibition of a FAK tyrosine phosphatase is required for cell adhesion.

scientific article

Reactive oxygen species as mediators of cell adhesion.

scientific article

Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness

scientific article published on 10 August 2010

Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay

scientific article

Redox circuitries driving Src regulation

scientific article published on 20 September 2013

Redox molecular machines involved in tumor progression

scientific article published on 08 January 2013

Redox regulation of ephrin/integrin cross-talk.

scientific article published on 29 January 2007

Redox regulation of protein tyrosine phosphatases during receptor tyrosine kinase signal transduction

scientific article

Redox signalling in anchorage-dependent cell growth

scientific article published on 28 November 2006

Redox-based escape mechanism from death: the cancer lesson.

scientific article

Redox-dependent and ligand-independent trans-activation of insulin receptor by globular adiponectin

scientific article published on July 2007

Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer

scientific article published on 01 July 2019

Senescent stroma promotes prostate cancer progression: the role of miR-210.

scientific article

Sphingosine 1-phosphate increases glucose uptake through trans-activation of insulin receptor.

scientific article

Src redox regulation: again in the front line

scientific article published on 29 April 2010

Src redox regulation: there is more than meets the eye.

scientific article published on 05 September 2008

Stromal fibroblasts synergize with hypoxic oxidative stress to enhance melanoma aggressiveness

scientific article

Stromal-induced downregulation of miR-1247 promotes prostate cancer malignancy

Targeted DNA oxidation by LSD1-SMAD2/3 primes TGF-β1/ EMT genes for activation or repression

scientific article published on 22 July 2020

Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread.

scientific article published on 27 June 2015

Targeting the Metabolic Reprogramming That Controls Epithelial-to-Mesenchymal Transition in Aggressive Tumors

scientific article published on 14 March 2017

Targeting the receptor tyrosine kinase RET in combination with aromatase inhibitors in ER positive breast cancer xenografts

scientific article published on 02 September 2016

The effects of CA IX catalysis products within tumor microenvironment.

scientific article published on 29 October 2013

The receptor for urokinase-plasminogen activator (uPAR) controls plasticity of cancer cell movement in mesenchymal and amoeboid migration style

scientific article published on March 2014

The “click-on-tube” approach for the production of efficient drug carriers based on oxidized multi-walled carbon nanotubes

scientific article published on 09 May 2016

Time-dependent stabilization of hypoxia inducible factor-1α by different intracellular sources of reactive oxygen species

scientific article

Treatment with Cannabinoids as a Promising Approach for Impairing Fibroblast Activation and Prostate Cancer Progression

scientific article published on 25 January 2020

Tumor microenvironment and metabolism in prostate cancer

scientific article published on 05 March 2014

Tumor microenvironment: bone marrow-mesenchymal stem cells as key players

scientific article published on 29 October 2013

Tumor-stroma metabolic relationship based on lactate shuttle can sustain prostate cancer progression

scientific article

Tumors and their stroma: mitochondria at the crossroad

scientific article published on 15 January 2012

Zoledronic Acid Inhibits the RhoA-mediated Amoeboid Motility of Prostate Cancer Cells

scientific article published on 01 January 2019

Zoledronic acid impairs stromal reactivity by inhibiting M2-macrophages polarization and prostate cancer-associated fibroblasts

scientific article published on 20 May 2016

miR-155 Drives Metabolic Reprogramming of ER+ Breast Cancer Cells Following Long-Term Estrogen Deprivation and Predicts Clinical Response to Aromatase Inhibitors

scientific article published on 21 January 2016

miR-205 hinders the malignant interplay between prostate cancer cells and associated fibroblasts

scientific article published on 17 September 2013

miR-27a is a master regulator of metabolic reprogramming and chemoresistance in colorectal cancer

scientific article published on 05 March 2020

β3-adrenoreceptor and tumor microenvironment: a new hub.

scientific article

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