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List of works by Graeme J Sills

A Caenorhabditis elegans assay of seizure-like activity optimised for identifying antiepileptic drugs and their mechanisms of action

article by Shi Quan Wong et al published 1 November 2018 in Journal of Neuroscience Methods

A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease.

scientific article

A comprehensive neuropsychological description of cognition in drug-refractory juvenile myoclonic epilepsy

scientific article published on 2 June 2014

A genome-wide association study of sodium levels and drug metabolism in an epilepsy cohort treated with carbamazepine and oxcarbazepine

scientific article published on 17 January 2019

Advantages of repeated low dose against single high dose of kainate in C57BL/6J mouse model of status epilepticus: behavioral and electroencephalographic studies

scientific article (publication date: 2014)

An integrative in silico system for predicting dysregulated genes in the human epileptic focus: Application to SLC transporters.

scientific article published on 16 July 2016

Antiepileptic drug therapy: does mechanism of action matter?

scientific article published on 16 July 2011

Antiepileptic drug therapy: does mechanism of action matter?

Antiepileptic drug transport--of mice and men.

scientific article published in March 2008

Binasal visual field defects are not specific to vigabatrin

scientific article published on 7 October 2009

Breaching the barrier and inflaming epilepsy research

scientific article published on September 2009

Changing channels: mechanisms and responsiveness to antiepileptic drugs in chronic epilepsy

scientific article published on May 2004

Clinical Drug Development in Epilepsy Revisited: A Proposal for a New Paradigm Streamlined Using Extrapolation.

scientific article

Cognitive effects of anticonvulsant monotherapy in elderly patients: a placebo-controlled study ⬇️

scientific article published on April 1, 1998

Combining antiepileptic drugs--rational polytherapy?

scientific article published on 08 February 2011

Comparative effectiveness of antiepileptic drugs in juvenile myoclonic epilepsy

scientific article published on 04 July 2019

Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis

scientific article published on 31 August 2017

Comparison of different water-miscible solvents for the preparation of plasma and urine samples in metabolic profiling studies

scientific article published on 14 August 2007

Concentration-effect studies with topiramate on selected enzymes and intermediates of the GABA shunt

scientific article published on 01 January 2000

Current limitations of antiepileptic drug therapy: a conference review.

scientific article

Differential effects of remacemide and desglycinyl-remacemide on epileptiform burst firing in the rat hippocampal slice

scientific article published in March 2002

Differential expression of multidrug resistance genes in naïve rat brain

scientific article published in March 2003

Drug resistance in epilepsy: why is a simple explanation not enough?

scientific article published on 01 December 2007

Effects of valproate, vigabatrin and tiagabine on GABA uptake into human astrocytes cultured from foetal and adult brain tissue

scientific article published on 01 September 1999

Excitable but lacking in energy: contradictions in the human epileptic hippocampus

scientific article published in January 2006

Genetic regulation of gene expression in the epileptic human hippocampus

scientific article

Genetic variants in microsomal epoxide hydrolase influence carbamazepine dosing.

scientific article published in July 2009

Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients

scientific article

HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans

scientific article

High dose gabapentin in refractory partial epilepsy: clinical observations in 50 patients ⬇️

scientific article published on January 1, 1998

High resolution micro-SPECT scanning in rats using 125I beta-CIT: effects of chronic treatment with carbamazepine.

scientific article

Identifying new antiepileptic drugs through genomics-based drug repurposing

scientific article published on 4 January 2017

Identifying the biological pathways underlying human focal epilepsy: from complexity to coherence to centrality

scientific article published on 4 May 2015

Inflammation and epilepsy: the foundations for a new therapeutic approach in epilepsy?

scientific article published on January 2012

Influence of cytochrome P450 induction on the pharmacokinetics and pharmacodynamics of remacemide hydrochloride

scientific article

Issues related to development of new antiseizure treatments

scientific article published on August 2013

Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment

scientific article

Lamotrigine and topiramate may be a useful combination

scientific article published on 01 March 1998

Means, motive, and opportunity: establishing culpability in pharmacoresistant epilepsy

scientific article published on March 2007

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy

scientific article

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy

article

Multidrug-resistant genotype (ABCB1) and seizure recurrence in newly treated epilepsy: data from international pharmacogenetic cohorts

scientific article

NRSF and BDNF polymorphisms as biomarkers of cognitive dysfunction in adults with newly diagnosed epilepsy

scientific article published on 17 December 2015

Na(+) channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes

scientific article published in March 2002

Neurochemical actions of gabapentin in mouse brain ⬇️

scientific article published on June 1, 1997

Neurochemical actions of the desglycinyl metabolite of remacemide hydrochloride (ARL 12495AA) in mouse brain ⬇️

scientific article published on July 1, 1997

Not another gabapentin mechanism!

scientific article published on March 2005

Novel therapeutic strategies for epilepsy--releasing the gene Genie

scientific article published on January 2009

N (w) -propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses.

scientific article published on 4 September 2012

Pharmacodynamic interaction studies with topiramate in the pentylenetetrazol and maximal electroshock seizure models

scientific article

Pharmacogenetics of antiepileptic drug-induced hypersensitivity

scientific article published on April 2014

Pharmacogenetics of epilepsy: one step forward?

scientific article published on November 2005

Pre-clinical studies with the GABAergic compounds vigabatrin and tiagabine.

scientific article

Predictors of pharmacoresistant epilepsy

scientific article published on July 2007

Prevalence of neurologic autoantibodies in cohorts of patients with new and established epilepsy

scientific article published on 06 March 2013

Prospective clinical trials to investigate clinical and molecular biomarkers.

scientific article

Rare coding variants in genes encoding GABAA receptors in genetic generalised epilepsies: an exome-based case-control study

article

Regional expression of multidrug resistance genes in genetically epilepsy-prone rat brain after a single audiogenic seizure

scientific article published in November 2002

Response to drug treatment in newly diagnosed epilepsy: a pilot study of (1)H NMR- and MS-based metabonomic analysis.

scientific article

SV2A in epilepsy: the plot thickens

scientific article published on March 2010

Seizures beget seizures: a lack of experimental evidence and clinical relevance fails to dampen enthusiasm

scientific article

Shared Genetic Risk Factors Across Carbamazepine-Induced Hypersensitivity Reactions

scientific article published on 03 July 2019

Sodium valproate versus lamotrigine: a randomised comparison of efficacy, tolerability and effects on circulating androgenic hormones in newly diagnosed epilepsy

scientific article published on 05 June 2007

Sudden unexpected death in epilepsy: a search for risk factors

scientific article published on 29 December 2006

Sulthiame add-on therapy for epilepsy

scientific article (publication date: 28 October 2015)

Sulthiame add-on therapy for epilepsy

scientific article

Sulthiame add-on therapy for epilepsy

scientific article (published 2011-12-07)

Sulthiame add-on therapy for epilepsy

scientific article published on 27 August 2019

Sulthiame monotherapy for epilepsy

scientific article

Sulthiame monotherapy for epilepsy

scientific article (publication date: 12 September 2012)

The impact of postsynaptic density 95 blocking peptide (Tat-NR2B9c) and an iNOS inhibitor (1400W) on proteomic profile of the hippocampus in C57BL/6J mouse model of kainate-induced epileptogenesis

scientific article published on 15 May 2019

The mechanisms of action of gabapentin and pregabalin

scientific article

The multidrug transporter hypothesis of refractory epilepsy: corroboration and contradiction in equal measure

scientific article published in March 2006

Topiramate in patients with learning disability and refractory epilepsy

scientific article published in April 2002

Topiramate in refractory epilepsy: a prospective observational study

scientific article published on 01 August 2000

Validation of a multigenic model to predict seizure control in newly treated epilepsy.

scientific article published on 16 September 2014

Vigabatrin, but not gabapentin or topiramate, produces concentration-related effects on enzymes and intermediates of the GABA shunt in rat brain and retina

scientific article

Visual field constriction: accumulation of vigabatrin but not tiagabine in the retina.

scientific article published in July 2001

What are the arguments for and against rational therapy for epilepsy?

scientific article published on January 2014

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