Search filters

List of works by Gökhan Hotamışlıgil

12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat

scientific article published on 25 July 2019

A central role for JNK in obesity and insulin resistance

scientific article (publication date: 21 November 2002)

A critical role for PKR complexes with TRBP in Immunometabolic regulation and eIF2α phosphorylation in obesity

scientific article published on 2 April 2015

A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting

scientific article published on 14 November 2013

A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use.

scientific article

A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease

scholarly article

A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity

scientific article

A prospective study of inflammatory cytokines and diabetes mellitus in a multiethnic cohort of postmenopausal women.

scientific article published in August 2007

Aberrant islet unfolded protein response in type 2 diabetes

scientific article published on 11 February 2014

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

scientific article

Adipocyte Lipid Chaperone aP2 Is a Secreted Adipokine Regulating Hepatic Glucose Production ⬇️

scientific article published on May 7, 2013

Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia

scientific article

Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes

scientific article

Adipocyte/macrophage fatty acid binding proteins in metabolic syndrome

scientific article published on September 2007

Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice

scientific article published on July 2008

Adipocytes promote interleukin-18 binding to its receptors during abdominal aortic aneurysm formation in mice

scientific article published on 10 December 2019

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

scientific article

Adipokine FABP4 integrates energy stores and counterregulatory metabolic responses

article

Adiponectin: Stability in Plasma over 36 Hours and Within-Person Variation over 1 Year

scientific article published on 01 April 2003

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance ⬇️

scientific article published on January 1, 1993

Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists

scientific article

Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways

scientific article (publication date: 6 July 2011)

Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance.

scientific article

Altered insulin secretion associated with reduced lipolytic efficiency in aP2-/- mice.

scientific article

Altered tumor necrosis factor-alpha (TNF-alpha) processing in adipocytes and increased expression of transmembrane TNF-alpha in obesity

scientific article published on June 2002

Association between dietary factors and plasma adiponectin concentrations in men.

scientific article

Autoamplification of tumor necrosis factor-alpha: a potential mechanism for the maintenance of elevated tumor necrosis factor-alpha in male but not female obese mice

scientific article

Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.

scientific article

Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes

scientific article

Capillary endothelial fatty acid binding proteins 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle.

scientific article published on 22 August 2013

Cell Signaling and Stress Responses.

scientific article

Cell fate in the mammary gland

scientific article published in Nature

Characterisation of receptor-specific TNFalpha functions in adipocyte cell lines lacking type 1 and 2 TNF receptors

scientific article

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

scientific article (publication date: 25 August 2006)

Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity

scientific article

Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of women.

scientific article

Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes ⬇️

scientific article published on October 13, 2010

Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice.

scientific article

Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis

scientific article

Coordinated regulation of protein synthesis and degradation by mTORC1

scientific article (publication date: 18 September 2014)

Correction: A Predominant Role for Parenchymal c-Jun Amino Terminal Kinase (JNK) in the Regulation of Systemic Insulin Sensitivity.

scientific article published on 20 January 2009

Corrigendum: The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue.

scientific article published in November 2017

Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms

scientific article

Damned If You Do, Damned If You Don’t: The Conundrum of Adipose Tissue Vascularization ⬇️

scientific article published on January 8, 2013

De Novo Lipogenesis Products and Endogenous Lipokines

scientific article

Defective STIM-mediated store operated Ca2+ entry in hepatocytes leads to metabolic dysfunction in obesity.

scientific article

Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance.

scientific article

Deficiency of fatty acid-binding proteins in mice confers protection from development of experimental autoimmune encephalomyelitis

scientific article published in July 2007

Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes

scientific article

Dietary and lifestyle factors in relation to plasma leptin concentrations among normal weight and overweight men

scientific article published on 01 January 2001

Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance

scientific article published on 01 March 1997

Divergent androgen regulation of unfolded protein response pathways drives prostate cancer.

scientific article

Divergent roles for p55 and p75 TNF-alpha receptors in the induction of plasminogen activator inhibitor-1.

scientific article

Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis

scientific journal article

Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion

scientific article

Dual role of fatty acid-binding protein 5 on endothelial cell fate: a potential link between lipid metabolism and angiogenic responses

scientific article published in December 2015

ER Stress Promotes Inflammation through Re-wIREd Macrophages in Obesity

scientific article published in June 2017

Effects of obesity and weight loss on the expression of proteins involved in fatty acid metabolism in human adipose tissue

scientific article published on 01 October 2002

Endoplasmic Reticulum Stress and Inflammation in Obesity and Diabetes ⬇️

scientific article published on September 3, 2010

Endoplasmic reticulum stress and atherosclerosis

scientific article

Endoplasmic reticulum stress and inflammation in obesity and type 2 diabetes.

scientific article published in January 2007

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

scientific article

Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss

scientific article published on 09 December 2008

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

scientific journal article

Endothelial cell-fatty acid binding protein 4 promotes angiogenesis: role of stem cell factor/c-kit pathway

scientific article published on 5 May 2012

Exclusive action of transmembrane TNF alpha in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistance

scientific article published in April 2002

FABP4 attenuates PPARγ and adipogenesis and is inversely correlated with PPARγ in adipose tissues.

scientific article

Fatty acid binding protein 4 deficiency protects against oxygen-induced retinopathy in mice

scientific article

Fatty acid binding protein 4 regulates VEGF-induced airway angiogenesis and inflammation in a transgenic mouse model: implications for asthma

scientific article

Fatty acid binding protein expression in different adipose tissue depots from lean and obese individuals.

scientific article

Fatty acid binding proteins--the evolutionary crossroads of inflammatory and metabolic responses.

scientific article published in September 2004

Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets

scientific article

Foundations of Immunometabolism and Implications for Metabolic Health and Disease

scientific article

Function of GATA transcription factors in preadipocyte-adipocyte transition

scientific article published on October 2000

Functional RNA Interference (RNAi) Screen Identifies System A Neutral Amino Acid Transporter 2 (SNAT2) as a Mediator of Arsenic-induced Endoplasmic Reticulum Stress ⬇️

scientific article published on January 3, 2012

Functional analysis of tumor necrosis factor (TNF) receptors in TNF-alpha-mediated insulin resistance in genetic obesity

scientific article

Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance

scholarly article

GATA transcription factors and fat cell formation.

scientific article published on November 2003

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice

scientific article published on 26 July 2009

Glycemic status and soluble tumor necrosis factor receptor levels in relation to plasma leptin concentrations among normal weight and overweight US men

scientific article published on 01 September 2000

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women

scientific article

Hereditary variations in monoamine oxidase as a risk factor for Parkinson's disease

scientific article published on 01 May 1994

Host and microbes in a pickle

scientific article published in Nature

Human monoamine oxidase A gene determines levels of enzyme activity ⬇️

scientific article published on August 1, 1991

IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

scientific article (publication date: 2 February 1996)

Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism

scientific article

Impact of ER Protein Homeostasis on Metabolism ⬇️

scientific article published on March 1, 2013

Improved Glucose and Lipid Metabolism in Genetically Obese Mice Lacking aP2

Improved glucose and lipid metabolism in genetically obese mice lacking aP2.

scientific article published on September 2000

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance

scientific article (publication date: May 1995)

Inflammation and endoplasmic reticulum stress in obesity and diabetes

scientific article

Inflammation and metabolic disorders

scientific article (publication date: 14 December 2006)

Inflammation, metaflammation and immunometabolic disorders

scientific article

Inflammation, stress, and diabetes

scientific article

Inflammatory Mechanisms in Obesity ⬇️

scientific article published on January 1, 2011

Inflammatory pathways and insulin action

scientific article published on 01 December 2003

Interaction between GATA and the C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation

scientific article

Interaction of tumor necrosis factor-alpha- and thiazolidinedione-regulated pathways in obesity

scientific article published on 05 February 2004

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism

scientific article published on 09 December 2020

JNK1 deficiency does not enhance muscle glucose metabolism in lean mice

scientific article published on 6 October 2006

Jnk1 Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null Mice.

scientific article published on 21 April 2016

Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis

scientific article (publication date: June 2001)

Leisure-Time Physical Activity and Reduced Plasma Levels of Obesity-Related Inflammatory Markers

scholarly article by Tobias Pischon et al published September 2003 in Obesity

Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages

scientific article

Linking the inflammasome to obesity-related disease ⬇️

scientific article published on 01 February 2011

Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment

scientific article published on 21 June 2016

Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle.

scientific article

Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis

scientific article

METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction.

scientific article published on July 2015

Macrophage Mal1 deficiency suppresses atherosclerosis in low-density lipoprotein receptor-null mice by activating peroxisome proliferator-activated receptor-γ-regulated genes.

scientific article

Mechanisms of TNF-alpha-induced insulin resistance

scientific article

Metabolic functions of FABPs--mechanisms and therapeutic implications

scientific article

Molecular mechanisms of adipocyte differentiation

scientific article

Molecular mechanisms of insulin resistance and the role of the adipocyte

scientific article published on 01 November 2000

Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis

scientific article

NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.

scientific article published in November 2017

Neuronal PTP1B regulates body weight, adiposity and leptin action.

scientific article published on 16 July 2006

Nonalcoholic fatty liver disease: Cytokine-adipokine interplay and regulation of insulin resistance

scientific article published on September 2006

Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders

scientific article

Novel role of PKR in inflammasome activation and HMGB1 release

scientific article

Nutrient sensing and inflammation in metabolic diseases

scientific article

OR01-1 Leveraging Immunometabolic Control to Prevent and Treat Obesity Related Asthma.

scientific article

Obesity modulates the expression of haptoglobin in the white adipose tissue via TNFalpha.

scientific article

Obesity-induced inflammatory changes in adipose tissue.

scientific article published on December 2003

Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity

scientific article (publication date: 17 June 2015)

Plasma adiponectin levels and risk of myocardial infarction in men.

scientific article published in April 2004

Plasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men.

scientific article published in August 2001

Plasma leptin concentrations and four-year weight gain among US men

scientific article published on 01 March 2001

Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting.

scientific article

Potential role for snoRNAs in PKR activation during metabolic stress

scientific article published on 6 April 2015

Promoting Atherosclerosis in Type 1 Diabetes Through the Selective Activation of Arachidonic Acid and PGE 2 Production ⬇️

scientific article published on 01 August 2012

Protection from obesity-induced insulin resistance in mice lacking TNF-α function ⬇️

scientific article (publication date: 9 October 1997)

Proteus syndrome and neurofibromatosis

scientific article published in January 1989

Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha ⬇️

scientific article published on October 1, 1994

Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis

scientific article published on 29 November 2009

Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes

scientific article

Regulation of adiponectin in adipocytes upon exposure to HIV-1

scientific article published on 01 May 2006

Regulation of adiponectin in human immunodeficiency virus-infected patients: relationship to body composition and metabolic indices

scientific article published in April 2003

Regulation of dendritic cell function and T cell priming by the fatty acid-binding protein AP2.

scientific article

Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice

scientific article published on July 2006

Relationship between platelet monoamine oxidase B activity and alleles at the MAOB locus

scientific article published on 01 December 1992

Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes

scientific article

Restoring endoplasmic reticulum function by chemical chaperones: an emerging therapeutic approach for metabolic diseases.

scientific article published on October 2010

Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes

scientific article

Role of the fatty acid binding protein mal1 in obesity and insulin resistance

scientific journal article

SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice

scientific article published on 16 October 2001

Secretion of fatty acid binding protein aP2 from adipocytes through a nonclassical pathway in response to adipocyte lipase activity

scientific article

Serum fatty acid-binding protein 4 is a predictor of cardiovascular events in end-stage renal disease

scientific article

Signaling pathways utilized by tumor necrosis factor receptor 1 in adipocytes to suppress differentiation

scientific article

Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice.

scientific article published on 22 October 2013

Stability of human plasma leptin concentrations within 36 hours following specimen collection

scientific article published on 01 February 1999

Stamp2 controls macrophage inflammation through nicotinamide adenine dinucleotide phosphate homeostasis and protects against atherosclerosis.

scientific article

Stressing the brain, fattening the body

scientific article

Structure of the human gene for monoamine oxidase type A.

scientific article

Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism.

scientific article published on 20 February 2017

TMEM2 Modulates ER Stress in a Non-canonical Manner

scientific article published on 01 December 2019

Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women.

scientific article

The Proteus syndrome: association with nephrogenic diabetes insipidus.

scientific article published on August 1990

The Role of Adipocyte XBP1 in Metabolic Regulation during Lactation ⬇️

scientific article published on April 25, 2013

The Role of JNK Proteins in Metabolism ⬇️

scientific article published on December 1, 2010

The Unfolded Protein Response Regulates Hepatic Autophagy by sXBP1-mediated Activation of TFEB

scientific article published on 28 June 2020

The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation

scientific article

The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue

scientific article published on 27 March 2017

The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities

scientific journal article

The interaction of hepatic lipid and glucose metabolism in liver diseases

scientific article

The irresistible biology of resistin

scientific article

The role of TNF alpha in adipocyte metabolism.

scientific article

The role of TNFalpha and TNF receptors in obesity and insulin resistance

scientific article

The role of fatty acid binding proteins in metabolic syndrome and atherosclerosis

scientific article

The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans

scientific article published on 01 April 2019

The transcription factor GATA2 regulates differentiation of brown adipocytes

scientific journal article

Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease

scientific article published on 9 May 2007

Through thick and thin: wasting, obesity, and TNF alpha

scientific article

Time to Look Back and to Look Forward

scientific article published on 01 April 2014

Trans-palmitoleic acid, metabolic risk factors, and new-onset diabetes in U.S. adults: a cohort study

scientific article

Transmembrane tumor necrosis factor (TNF)-alpha inhibits adipocyte differentiation by selectively activating TNF receptor 1

scientific article published on 01 September 1999

Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2

scientific article

Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase

scientific article published on May 1996

Tumor necrosis factor alpha inhibits signaling from the insulin receptor

scientific article

Tumor necrosis factor alpha is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1

scientific article

Tumor necrosis factor alpha mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity

scientific article

Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling

scientific article published on 01 December 2006

Tumor necrosis factor alpha: a key component of the obesity-diabetes link

scientific article published on November 1994

Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes ⬇️

scientific article published on December 1, 1997

Turning off the inflammatory, but not the metabolic, flames.

scientific article published in March 2013

Type I Interferons Interfere with Liver Glucose Metabolism

scientific article published on 01 June 2017

Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins

scientific article published in October 2017

Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein

scientific article

Upregulation of uncoupling protein 2 mRNA in genetic obesity: lack of an essential role for leptin, hyperphagia, increased tissue lipid content, and TNF-alpha

scientific article published on February 2000

β-Adrenergic Regulation of IL-6 Release from Adipose Tissue:In Vivoandin VitroStudies ⬇️

scientific article published on December 1, 2001

Paulina is supported by:

About Paulina

Help