List of works - Duane A Burnett

2-Azetidinone cholesterol absorption inhibitors: structure-activity relationships on the heterocyclic nucleus.

scientific article

2-Azetidinones as inhibitors of cholesterol absorption.

scientific article

A-ring modification of SCH 900229 and related chromene sulfone γ-secretase inhibitors

scientific article published on 28 November 2012

An enzymatic synthesis of glucuronides of azetidinone-based cholesterol absorption inhibitors

scientific article published on 01 October 1999

Cyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious γ-secretase modulators in vivo

scientific article published on 08 December 2011

Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists

scientific article published on 11 May 2006

Design and synthesis of tricyclic sulfones as gamma-secretase inhibitors with greatly reduced Notch toxicity

scientific article published on 23 February 2010

Design, Synthesis, and Evaluation of a Novel Series of Oxadiazine Gamma Secretase Modulators for Familial Alzheimer's Disease.

scientific article published on 23 February 2017

Discovery of 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)-(4 -hydroxyphenyl)-2-azetidinone (SCH 58235): a designed, potent, orally active inhibitor of cholesterol absorption

scientific article

Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes.

scientific article published on 12 March 2016

Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer's Disease.

scientific article

Discovery of a Novel, Potent Spirocyclic Series of γ-Secretase Inhibitors

scientific article

Discovery of new SCH 39166 analogs as potent and selective dopamine D1 receptor antagonists.

scientific article published on 4 January 2010

Discovery of orally efficacious tetracyclic metabotropic glutamate receptor 1 (mGluR1) antagonists for the treatment of chronic pain

scientific article published on 11 October 2007

Dopamine D1/D5 receptor antagonists with improved pharmacokinetics: design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists.

scientific article published on February 2005

Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain.

scientific article published on 3 January 2012

Hydrazides of clozapine: a new class of D1 dopamine receptor subtype selective antagonists

scientific article published on 30 June 2006

Hypocholesterolemic activity of a novel inhibitor of cholesterol absorption, SCH 48461

scientific article

Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes

scientific article published on 13 May 2011

Iminoheterocycles as gamma-secretase modulators.

scientific article published in August 2010

Novel aminobenzimidazoles as selective MCH-R1 antagonists for the treatment of metabolic diseases

scientific article published on 02 August 2006

SAR study of bicyclo[4.1.0]heptanes as melanin-concentrating hormone receptor R1 antagonists: taming hERG

scientific article published on 02 June 2007

Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors ⬇️

scientific article published on November 24, 2012

Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists

scientific article published on 01 July 1999

Synthesis and SAR Studies of Fused Oxadiazines as γ-Secretase Modulators for Treatment of Alzheimer's Disease

scientific article

Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain

scientific article

Synthesis and structure-activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists

scientific article published on 11 May 2006

Synthesis of fluorescent biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors.

scientific article published in February 2002

Synthesis of novel bicyclo[4.1.0]heptane and bicyclo[3.1.0]hexane derivatives as melanin-concentrating hormone receptor R1 antagonists

scientific article published on 17 June 2007

Tetracyclic sulfones as potent gamma-secretase inhibitors: synthesis and structure-activity relationship studies

scientific article published on 28 April 2010

Tetrahydroisoquinolines as MCH-R1 antagonists

scientific article published on 07 July 2006

The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption.

scientific article

The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)

scientific journal article

Tricyclic sulfones as orally active gamma-secretase inhibitors: synthesis and structure-activity relationship studies.

scientific article

Tricyclic thienopyridine-pyrimidones/thienopyrimidine-pyrimidones as orally efficacious mGluR1 antagonists for neuropathic pain.

scientific article published on 3 May 2009

List of works by Duane A Burnett

2-Azetidinone cholesterol absorption inhibitors: structure-activity relationships on the heterocyclic nucleus.

2-Azetidinones as inhibitors of cholesterol absorption.

A-ring modification of SCH 900229 and related chromene sulfone γ-secretase inhibitors

An enzymatic synthesis of glucuronides of azetidinone-based cholesterol absorption inhibitors

Cyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious γ-secretase modulators in vivo

Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists

Design and synthesis of tricyclic sulfones as gamma-secretase inhibitors with greatly reduced Notch toxicity

Design, Synthesis, and Evaluation of a Novel Series of Oxadiazine Gamma Secretase Modulators for Familial Alzheimer's Disease.

Discovery of 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)-(4 -hydroxyphenyl)-2-azetidinone (SCH 58235): a designed, potent, orally active inhibitor of cholesterol absorption

Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes.

Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer's Disease.

Discovery of a Novel, Potent Spirocyclic Series of γ-Secretase Inhibitors

Discovery of new SCH 39166 analogs as potent and selective dopamine D1 receptor antagonists.

Discovery of orally efficacious tetracyclic metabotropic glutamate receptor 1 (mGluR1) antagonists for the treatment of chronic pain

Dopamine D1/D5 receptor antagonists with improved pharmacokinetics: design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists.

Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain.

Hydrazides of clozapine: a new class of D1 dopamine receptor subtype selective antagonists

Hypocholesterolemic activity of a novel inhibitor of cholesterol absorption, SCH 48461

Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes

Iminoheterocycles as gamma-secretase modulators.

Novel aminobenzimidazoles as selective MCH-R1 antagonists for the treatment of metabolic diseases

SAR study of bicyclo[4.1.0]heptanes as melanin-concentrating hormone receptor R1 antagonists: taming hERG

Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors ⬇️

Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists

Synthesis and SAR Studies of Fused Oxadiazines as γ-Secretase Modulators for Treatment of Alzheimer's Disease

Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain

Synthesis and structure-activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists

Synthesis of fluorescent biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors.

Synthesis of novel bicyclo[4.1.0]heptane and bicyclo[3.1.0]hexane derivatives as melanin-concentrating hormone receptor R1 antagonists

Tetracyclic sulfones as potent gamma-secretase inhibitors: synthesis and structure-activity relationship studies

Tetrahydroisoquinolines as MCH-R1 antagonists

The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption.

The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)

Tricyclic sulfones as orally active gamma-secretase inhibitors: synthesis and structure-activity relationship studies.

Tricyclic thienopyridine-pyrimidones/thienopyrimidine-pyrimidones as orally efficacious mGluR1 antagonists for neuropathic pain.