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List of works by Zoltan Ungvari

A heart that beats for 500 years: age-related changes in cardiac proteasome activity, oxidative protein damage and expression of heat shock proteins, inflammatory factors, and mitochondrial complexes in Arctica islandica, the longest-living noncolon

scientific article

AMPA-Kainate Receptor Inhibition Promotes Neurologic Recovery in Premature Rabbits with Intraventricular Hemorrhage

scientific article

Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia

scientific article

Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment.

scientific article published on 4 January 2012

Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta.

scientific article

Age-dependent cardiovascular effects of sepsis in a murine model of cecal ligation and puncture: implications for the design of interventional studies

scientific article published on 03 August 2018

Age-related autoregulatory dysfunction and cerebromicrovascular injury in mice with angiotensin II-induced hypertension.

scientific article published on 14 August 2013

Age-related decline in peripheral vascular health predicts cognitive impairment.

scientific article published on 27 April 2019

Age-related decline of autocrine pituitary adenylate cyclase-activating polypeptide impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.

scientific article published on 18 August 2014

Age-related focal loss of contractile vascular smooth muscle cells in retinal arterioles is accelerated by caveolin-1 deficiency

scientific article published on 10 July 2018

Age-related impairment of metabovascular coupling during cortical spreading depolarizations

scientific article published on 25 August 2017

Aging Exacerbates Pressure-Induced Mitochondrial Oxidative Stress in Mouse Cerebral Arteries.

scientific article

Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection.

scientific article published on 9 February 2015

Aging exacerbates microvascular endothelial damage induced by circulating factors present in the serum of septic patients.

scientific article published on 26 November 2012

Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice

scientific article

Aging exacerbates obesity-induced oxidative stress and inflammation in perivascular adipose tissue in mice: a paracrine mechanism contributing to vascular redox dysregulation and inflammation

scientific article published on 3 December 2012

Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells

scientific article published on 13 December 2012

Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function

scientific article

Aging‐induced proinflammatory shift in cytokine expression profile in rat coronary arteries ⬇️

scientific article published on April 22, 2003

Altered mitochondrial energy metabolism may play a role in vascular aging

scientific article published on 05 June 2006

Angiogenic inhibition reduces germinal matrix hemorrhage

scientific article published in April 2007

Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1.

scientific article published on 21 June 2009

Are sirtuins viable targets for improving healthspan and lifespan?

scientific article

Assessment of age-related decline of neurovascular coupling responses by functional near-infrared spectroscopy (fNIRS) in humans

Assessment of endothelial function in leptomeningeal arterioles derived from patients with Alzheimer's disease and vascular cognitive impairment

scientific article published on 22 June 2018

Association between daily walking and antioxidant capacity in patients with symptomatic peripheral artery disease

scientific article published on March 2017

Association between gait characteristics and endothelial oxidative stress and inflammation in patients with symptomatic peripheral artery disease

scientific article published on 06 June 2016

Beneficial effects of acute inhibition of the oxidative pentose phosphate pathway in the failing heart

scientific article published on 10 January 2014

Biotin-conjugated fusogenic liposomes for high-quality cell purification.

scientific article published on 15 October 2015

Bone morphogenetic protein-2 induces proinflammatory endothelial phenotype

scientific article

Brain and cerebrovascular aging--new mechanisms and insights.

scientific article published in November 2014

CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion

scientific article

CD82-TRPM7-Numb signaling mediates age-related cognitive impairment

scientific article published on 22 February 2020

CORRIGENDUM: SRT1720 improves survival and healthspan of obese mice.

scientific article published on 16 January 2013

Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats

scientific article

Caveolin-1 limits the contribution of BK(Ca) channel to EDHF-mediated arteriolar dilation: implications in diet-induced obesity

scientific article

Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice

scientific article published on 01 April 2019

Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer's Disease and Related Tauopathies

scientific article

Cerebral microhemorrhages: mechanisms, consequences, and prevention

scientific article

Cerebral venous congestion promotes blood-brain barrier disruption and neuroinflammation, impairing cognitive function in mice

scientific article published on 01 October 2019

Cerebromicrovascular dysfunction predicts cognitive decline and gait abnormalities in a mouse model of whole brain irradiation-induced accelerated brain senescence.

scientific article

Chemically induced carcinogenesis in rodent models of aging: assessing organismal resilience to genotoxic stressors in geroscience research

scientific article published on 29 April 2019

Chronic high pressure-induced arterial oxidative stress: involvement of protein kinase C-dependent NAD(P)H oxidase and local renin-angiotensin system

scientific article

Cigarette smoke-induced proinflammatory alterations in the endothelial phenotype: role of NAD(P)H oxidase activation

scientific article published on 01 January 2007

Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging.

scientific article published on 9 September 2016

Circulating anti-geronic factors from heterochonic parabionts promote vascular rejuvenation in aged mice: transcriptional footprint of mitochondrial protection, attenuation of oxidative stress, and rescue of endothelial function by young blood

scientific article published on 15 March 2020

Circulating factors induced by caloric restriction in the nonhuman primate Macaca mulatta activate angiogenic processes in endothelial cells.

scientific article published on 17 August 2012

Companion animals likely do not spread COVID-19 but may get infected themselves

scientific article published on 07 August 2020

Comparative gerontology--from mussels to man ⬇️

scientific article published on 08 November 2010

Comparison of endothelial function, O2-* and H2O2 production, and vascular oxidative stress resistance between the longest-living rodent, the naked mole rat, and mice

scientific article published on 01 December 2006

Connective tissue growth factor (CTGF) in age-related vascular pathologies.

scientific article

Consequences of intraventricular hemorrhage in a rabbit pup model.

scientific article published on 6 August 2009

Correction to: Pharmacologically induced impairment of neurovascular coupling responses alters gait coordination in mice.

scientific article

Demonstration of impaired neurovascular coupling responses in TG2576 mouse model of Alzheimer's disease using functional laser speckle contrast imaging.

scientific article

Different roles of PKC and MAP kinases in arteriolar constrictions to pressure and agonists

scientific article published in December 2002

Differential proinflammatory and prooxidant effects of bone morphogenetic protein-4 in coronary and pulmonary arterial endothelial cells

scientific article published on 6 June 2008

Disruption of Interneuron Neurogenesis in Premature Newborns and Reversal with Estrogen Treatment

scientific article

Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: implications for microvascular aging

scientific article

Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies.

scientific article

Downregulation of bone morphogenetic protein 4 expression in coronary arterial endothelial cells: role of shear stress and the cAMP/protein kinase A pathway

scientific journal article

Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats

scientific article published on 07 March 2008

Effect of prenatal glucocorticoids on cerebral vasculature of the developing brain

scientific article

Endothelial Cell Inflammation and Antioxidant Capacity are Associated With 6-Minute Walk Performance in Patients With Symptomatic Peripheral Artery Disease.

scientific article

Endothelial Cell Inflammation and Antioxidant Capacity are Associated With Exercise Performance and Microcirculation in Patients With Symptomatic Peripheral Artery Disease.

scientific article published on 20 January 2015

Endothelial deficiency of insulin-like growth factor-1 receptor (IGF1R) impairs neurovascular coupling responses in mice, mimicking aspects of the brain aging phenotype

scientific article published on 12 August 2021

Endothelial dysfunction and angiogenesis impairment in the ageing vasculature

scientific article published on 01 September 2018

Endothelial dysfunction and vascular inflammation in type 2 diabetes: interaction of AGE/RAGE and TNF-alpha signaling

scientific article published on 3 July 2008

Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice

scientific article published on 29 August 2008

Endothelin-1-induced focal cerebral ischemia in the growth hormone/IGF-1 deficient Lewis Dwarf rat.

scientific article

Extreme longevity is associated with increased resistance to oxidative stress in Arctica islandica, the longest-living non-colonial animal

scientific article

Free radical production, antioxidant capacity, and oxidative stress response signatures in fibroblasts from Lewis dwarf rats: effects of life span-extending peripubertal GH treatment.

scientific article

Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging

scientific article published on 28 October 2016

Fusogenic liposomes effectively deliver resveratrol to the cerebral microcirculation and improve endothelium-dependent neurovascular coupling responses in aged mice

scientific article published on 25 October 2019

Gender and racial differences in endothelial oxidative stress and inflammation in patients with symptomatic peripheral artery disease.

scientific article

GeroScience: understanding the interaction of processes of aging and chronic diseases.

scientific article

Glycogen synthase kinase-3β inhibition enhances myelination in preterm newborns with intraventricular hemorrhage, but not recombinant Wnt3A

scientific article published on 22 June 2018

Greater endothelial apoptosis and oxidative stress in patients with peripheral artery disease

scientific article

Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging

scientific article

Hemodynamic forces, vascular oxidative stress, and regulation of BMP-2/4 expression

scientific article

High pressure induces superoxide production in isolated arteries via protein kinase C-dependent activation of NAD(P)H oxidase

scientific article published on 21 July 2003

Hypertension Exacerbates Cerebrovascular Oxidative Stress Induced by Mild Traumatic Brain Injury: Protective Effects of the Mitochondria-Targeted Antioxidative Peptide SS-31

scientific article published on 01 August 2019

Hypertension impairs neurovascular coupling and promotes microvascular injury: role in exacerbation of Alzheimer's disease.

scientific article

Hypertension-induced synapse loss and impairment in synaptic plasticity in the mouse hippocampus mimics the aging phenotype: implications for the pathogenesis of vascular cognitive impairment.

scientific article published on 29 June 2017

IGF-1 Deficiency Promotes Pathological Remodeling of Cerebral Arteries: A Potential Mechanism Contributing to the Pathogenesis of Intracerebral Hemorrhages in Aging.

scientific article

IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms

scientific article published on 10 August 2015

IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice

scientific article

IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging

scientific article

IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis.

scientific article published on 26 August 2016

IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan.

scientific article

INFLUENCE OF DIABETES ON AMBULATION AND INFLAMMATION IN MEN AND WOMEN WITH SYMPTOMATIC PERIPHERAL ARTERY DISEASE

scientific article published on December 2015

Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline

scientific article published on 11 November 2016

Impaired nitric oxide-mediated flow-induced coronary dilation in hyperhomocysteinemia: morphological and functional evidence for increased peroxynitrite formation

scientific article published on July 2002

Impaired vascular endothelial growth factor A and inflammation in patients with peripheral artery disease

scientific article

Increased NO-mediated and reduced TxA2-dependent responses in skeletal muscle arterioles in pregnancy

scientific article published in January 2002

Increased mitochondrial H2O2 production promotes endothelial NF-kappaB activation in aged rat arteries

scientific article published on 06 April 2007

Increased superoxide production in coronary arteries in hyperhomocysteinemia: role of tumor necrosis factor-alpha, NAD(P)H oxidase, and inducible nitric oxide synthase

scientific article

Increases in endothelial Ca(2+) activate K(Ca) channels and elicit EDHF-type arteriolar dilation via gap junctions

scientific article published in May 2002

Increases in hypertension-induced cerebral microhemorrhages exacerbate gait dysfunction in a mouse model of Alzheimer's disease

scientific article published on 25 August 2020

Inflammation and endothelial dysfunction during aging: role of NF-kappaB

scientific article published on 03 July 2008

Inhibition of NAD(P)H oxidase attenuates aggregation of platelets from high-risk cardiac patients with aspirin resistance

scientific article

Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype

scientific article

Insulin-like growth factor-1 in CNS and cerebrovascular aging ⬇️

scientific article published on 02 July 2013

Intramyocardial VEGF-B167 gene delivery delays the progression towards congestive failure in dogs with pacing-induced dilated cardiomyopathy

scientific article published on 29 April 2010

Intraventricular hemorrhage induces deposition of proteoglycans in premature rabbits, but their in vivo degradation with chondroitinase does not restore myelination, ventricle size and neurological recovery ⬇️

scientific article published on March 6, 2013

Ionizing radiation promotes the acquisition of a senescence-associated secretory phenotype and impairs angiogenic capacity in cerebromicrovascular endothelial cells: role of increased DNA damage and decreased DNA repair capacity in microvascular rad

scientific article published on 20 May 2013

Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging

scientific article published on 21 October 2011

Longevity is associated with increased vascular resistance to high glucose-induced oxidative stress and inflammatory gene expression in Peromyscus leucopus

scientific article published on 30 January 2009

Maturational changes in laminin, fibronectin, collagen IV, and perlecan in germinal matrix, cortex, and white matter and effect of betamethasone

scientific article published in May 2008

Mechanisms of Vascular Aging

scientific article published on 01 September 2018

Mechanisms of Vascular Aging, A Geroscience Perspective: JACC Focus Seminar

scientific article published on 01 March 2020

Mechanisms of vascular aging: new perspectives.

scientific article

Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging.

scientific article published on March 2008

Mechanosensitive production of reactive oxygen species in endothelial and smooth muscle cells: role in microvascular remodeling?

scientific article published on July 2006

Microvascular contributions to age-related macular degeneration (AMD): from mechanisms of choriocapillaris aging to novel interventions

scientific article published on 04 December 2019

Midlife Obesity Impairs Neurovascular Coupling Responses

scientific article published on 05 December 2020

Mitochondria and aging in the vascular system.

scientific article published on 17 August 2010

Mitochondria and cardiovascular aging

scientific article

Mitochondrial protection by resveratrol.

scientific article

Neuroprotection in a rabbit model of intraventricular haemorrhage by cyclooxygenase-2, prostanoid receptor-1 or tumour necrosis factor-alpha inhibition

scientific article

Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects

scientific article published on 28 August 2019

Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects

scientific article published on 13 February 2020

Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice

article

Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment

scientific article published on 29 May 2019

Novel organotypic in vitro slice culture model for intraventricular hemorrhage of premature infants ⬇️

scientific article published on July 17, 2012

Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype

scientific article published on 01 June 2018

Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass.

scientific article published on 6 April 2018

Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation

scientific article published on 23 November 2018

Nrf2 dysfunction and impaired cellular resilience to oxidative stressors in the aged vasculature: from increased cellular senescence to the pathogenesis of age-related vascular diseases

scientific article published on 26 October 2019

Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction

scholarly article

Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline.

scientific article published in February 2019

Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease

scientific article

Old blood from heterochronic parabionts accelerates vascular aging in young mice: transcriptomic signature of pathologic smooth muscle remodeling

scientific article published on 05 February 2022

Overexpression of catalase targeted to mitochondria improves neurovascular coupling responses in aged mice

scientific article published on 23 October 2019

Oxidative stress and accelerated vascular aging: implications for cigarette smoking

scientific article published on January 2009

Oxidative stress in vascular senescence: lessons from successfully aging species

scientific article published on May 2008

Oxidative-nitrosative stress in a rabbit pup model of germinal matrix hemorrhage: role of NAD(P)H oxidase

scientific article published on 16 April 2009

Paucity of pericytes in germinal matrix vasculature of premature infants.

scientific article published in October 2007

Pentose phosphate pathway coordinates multiple redox-controlled relaxing mechanisms in bovine coronary arteries

scientific article published on 21 August 2003

Pharmacological Strategies to Retard Cardiovascular Aging ⬇️

scientific article published on May 2016

Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation-induced impairment of neurovascular coupling responses protecting cognitive function in mice

scientific article published on 20 January 2020

Pharmacologically induced impairment of neurovascular coupling responses alters gait coordination in mice.

scientific article

Pharmacologically-induced neurovascular uncoupling is associated with cognitive impairment in mice.

scientific article published on 15 July 2015

Potential Adverse Cardiovascular Effects of Treatment With Fluoxetine and Other Selective Serotonin Reuptake Inhibitors (SSRIs) in Patients With Geriatric Depression: Implications for Atherogenesis and Cerebromicrovascular Dysregulation

scientific article published on 20 September 2019

Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging

scientific article published on 12 March 2004

Prostaglandin E2, a postulated mediator of neurovascular coupling, at low concentrations dilates whereas at higher concentrations constricts human cerebral parenchymal arterioles

scientific article published on 02 November 2019

Purinergic glio-endothelial coupling during neuronal activity: role of P2Y1 receptors and eNOS in functional hyperemia in the mouse somatosensory cortex.

scientific article

Recent Developments in Understanding Brain Aging: Implications for Alzheimer's Disease and Vascular Cognitive Impairment.

scientific article published on 20 November 2015

Reduced mitochondrial ROS, enhanced antioxidant defense, and distinct age-related changes in oxidative damage in muscles of long-lived Peromyscus leucopus ⬇️

scientific article published on January 16, 2013

Regulation of bone morphogenetic protein-2 expression in endothelial cells: role of nuclear factor-kappaB activation by tumor necrosis factor-alpha, H2O2, and high intravascular pressure

scientific article published on 25 April 2005

Regulation of proliferation and gene expression in cultured human aortic smooth muscle cells by resveratrol and standardized grape extracts

scientific article

Repeated Valsalva maneuvers promote symptomatic manifestations of cerebral microhemorrhages: implications for the pathogenesis of vascular cognitive impairment in older adults

scientific article published on 04 October 2018

Resistance to genotoxic stresses in Arctica islandica, the longest living noncolonial animal: is extreme longevity associated with a multistress resistance phenotype?

scientific article published on 10 October 2012

Resveratrol attenuates TNF-alpha-induced activation of coronary arterial endothelial cells: role of NF-kappaB inhibition

scientific article published in October 2006

Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells

scientific article published on 11 September 2009

Resveratrol confers endothelial protection in insulin-dependent diabetes mellitus: editorial to: "Resveratrol shows vasoprotective effect reducing oxidative stress without affecting metabolic disturbances in insulin-dependent diabetes of rabbits" by

scientific article published on 01 April 2011

Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2.

scientific article

Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

scientific article

Resveratrol encapsulated in novel fusogenic liposomes activates Nrf2 and attenuates oxidative stress in cerebromicrovascular endothelial cells from aged rats

scientific article

Resveratrol improves endothelial function: role of TNF{alpha} and vascular oxidative stress

scientific article published on 28 May 2009

Resveratrol improves left ventricular diastolic relaxation in type 2 diabetes by inhibiting oxidative/nitrative stress: in vivo demonstration with magnetic resonance imaging ⬇️

scientific article published on July 30, 2010

Resveratrol increases vascular oxidative stress resistance

scientific article

Resveratrol induces mitochondrial biogenesis in endothelial cells

scientific article published on 08 May 2009

Resveratrol inhibits aggregation of platelets from high-risk cardiac patients with aspirin resistance

scientific article (publication date: August 2006)

Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates.

scientific article

Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats.

scientific article published on 13 July 2009

Resveratrol supplementation confers neuroprotection in cortical brain tissue of nonhuman primates fed a high-fat/sucrose diet.

scientific article published on 09 April 2016

Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase.

scientific article

Retinal biomarkers for Alzheimer's disease and vascular cognitive impairment and dementia (VCID): implication for early diagnosis and prognosis

scientific article published on 04 October 2020

Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice

scientific article published on 04 October 2013

Role of NAD(P)H Oxidase in Superoxide Generation and Endothelial Dysfunction in Goto-Kakizaki (GK) Rats as a Model of Nonobese NIDDM ⬇️

scientific article published on July 26, 2010

Role of age-related alterations of the cerebral venous circulation in the pathogenesis of vascular cognitive impairment

scientific article published on 08 March 2019

Role of endothelial NAD+ deficiency in age-related vascular dysfunction

scientific article published on 15 March 2019

Role of mitochondrial oxidative stress in hypertension

scientific article published on 16 September 2013

Role of oxidative and nitrosative stress, longevity genes and poly(ADP-ribose) polymerase in cardiovascular dysfunction associated with aging

scientific article published in July 2005

SRT1720 improves survival and healthspan of obese mice

scientific article

Serotonin reuptake inhibitors fluoxetine and citalopram relax intestinal smooth muscle

scholarly article by Pal Pacher et al published 2001 in Canadian Journal of Physiology and Pharmacology

Short-term weight loss reverses obesity-induced microvascular endothelial dysfunction

scientific article published on 18 June 2018

Simultaneous assessment of cognitive function, circadian rhythm, and spontaneous activity in aging mice.

scientific article

Single Mild Traumatic Brain Injury Induces Persistent Disruption of the Blood-Brain Barrier, Neuroinflammation and Cognitive Decline in Hypertensive Rats

scientific article published on 30 June 2019

Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain

scientific article published on 31 March 2020

Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain

scientific article published on 31 January 2022

Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in β-amyloid generation and Alzheimer's disease

scientific article published on 16 August 2013

Synergistic effects of vascular IL-17 and TNFalpha may promote coronary artery disease

scientific article published on 01 January 2004

Systemic influences contribute to prolonged microvascular rarefaction after brain irradiation: a role for endothelial progenitor cells

scientific article

Testing hypotheses of aging in long-lived mice of the genus Peromyscus: association between longevity and mitochondrial stress resistance, ROS detoxification pathways, and DNA repair efficiency

scientific article published on 14 June 2008

Testing predictions of the oxidative stress hypothesis of aging using a novel invertebrate model of longevity: the giant clam (Tridacna derasa)

scientific article (publication date: April 2013)

Testing the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production?

scientific article (publication date: August 2012)

The Emerging Role of IGF-1 Deficiency in Cardiovascular Aging: Recent Advances ⬇️

scientific article published on March 26, 2012

The GH/IGF-1 axis in a critical period early in life determines cellular DNA repair capacity by altering transcriptional regulation of DNA repair-related genes: implications for the developmental origins of cancer.

scientific article published on 23 February 2017

The Krebs cycle and mitochondrial mass are early victims of endothelial dysfunction: proteomic approach

scientific article

Traumatic Brain Injury Impairs Myogenic Constriction of Cerebral Arteries: Role of Mitochondria-Derived H2O2 and TRPV4-Dependent Activation of BKca Channels

scientific article published on 27 November 2017

Traumatic brain injury-induced autoregulatory dysfunction and spreading depression-related neurovascular uncoupling: Pathomechanisms, perspectives, and therapeutic implications

scientific article published on 9 September 2016

Traumatic brain injury-induced cerebral microbleeds in the elderly

scientific article published on 03 October 2020

Treatment with the cytochrome P450 ω-hydroxylase inhibitor HET0016 attenuates cerebrovascular inflammation, oxidative stress and improves vasomotor function in spontaneously hypertensive rats

scientific article published on April 2013

Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice.

scientific article published on 6 February 2018

Treatment with the poly(ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and cognitive performance in aged mice, supporting the NAD+ depletion hypothesis of neurovascular agi

scientific article published on 01 October 2019

Use of selective serotonin reuptake inhibitors and myocardial infarction

scientific article

Vascular aging in the longest-living rodent, the naked mole rat.

scientific article

Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogen

scientific article

Vascular inflammation in aging

scientific article

Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response

scientific article

Vascular superoxide and hydrogen peroxide production and oxidative stress resistance in two closely related rodent species with disparate longevity

scientific article published on 8 October 2007

Vasculoprotective effects of anti-tumor necrosis factor-alpha treatment in aging

scientific article published on January 2007

Vasoprotective effects of life span-extending peripubertal GH replacement in Lewis dwarf rats

scientific article

Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations

scientific article published on 18 April 2008

Whole brain irradiation in mice causes long-term impairment in astrocytic calcium signaling but preserves astrocyte-astrocyte coupling

scientific article published on 22 October 2020

Whole brain radiation-induced vascular cognitive impairment: mechanisms and implications

scientific article published on October 2013

Why publish in the American Journal of Physiology-Heart and Circulatory Physiology?

scientific article published on 16 June 2017

Xanthine oxidase-derived reactive oxygen species convert flow-induced arteriolar dilation to constriction in hyperhomocysteinemia: possible role of peroxynitrite

scientific article published in January 2002

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