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List of works by Federica Piccioni

A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering

scientific article published on 01 November 2019

A Functional Landscape of Resistance to MEK1/2 and CDK4/6 Inhibition in NRAS-Mutant Melanoma

scientific article published on 28 February 2019

A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.

scientific article published in November 2017

A combination CDK4/6 and IGF1R inhibitor strategy for Ewing sarcoma

scientific article published on 05 November 2018

A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies

scientific article published on 01 August 2019

A functional landscape of resistance to ALK inhibition in lung cancer

scientific article

A genome-scale CRISPR screen identifies the ERBB and mTOR signalling networks as key determinants of response to PI3K inhibition in pancreatic cancer

scientific article published on 05 May 2020

A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor

scientific article published on 01 June 2020

A melanocyte lineage program confers resistance to MAP kinase pathway inhibition

scientific article published on 3 November 2013

ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition.

scientific article published on February 2017

Acquired FGFR and FGF alterations confer resistance to estrogen receptor (ER) targeted therapy in ER+ metastatic breast cancer

scientific article published on 28 July 2020

An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia

scientific article

BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma

scientific article published in 2022

CREB5 Promotes Resistance to Androgen-Receptor Antagonists and Androgen Deprivation in Prostate Cancer

scientific article published on 01 November 2019

Considerations and practical implications of performing a phenotypic CRISPR/Cas survival screen

scientific article published on 17 February 2022

Defining the landscape of ATP-competitive inhibitor resistance residues in protein kinases

scientific article published on 10 January 2020

ER stress signaling promotes the survival of cancer 'persister cells' tolerant to EGFR tyrosine kinase inhibitors

scientific article published on 19 December 2017

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers

scientific article published on September 2016

Genetic modifiers of EGFR dependence in non-small cell lung cancer

scientific article

Genotype-Fitness Maps of EGFR-Mutant Lung Adenocarcinoma Chart the Evolutionary Landscape of Resistance for Combination Therapy Optimization

scientific article published on 23 October 2019

High-throughput Phenotyping of Lung Cancer Somatic Mutations

scientific article published on 28 July 2016

High-throughput Phenotyping of Lung Cancer Somatic Mutations

scientific article published in December 2017

KRAS and YAP1 converge to regulate EMT and tumor survival

scientific article

MEDU-36. BCL2 FAMILY MEMBERS ATTENUATE RESPONSE OF MYC-DRIVEN MEDULLOBLASTOMAS TO BET-BROMODOMAIN INHIBITION

scientific article published on 23 April 2019

MEDU-37. NEURONAL DIFFERENTIATION AND CELL-CYCLE PROGRAMS MEDIATE RESPONSE AND RESISTANCE TO BET-BROMODOMAIN INHIBITION IN MYC-DRIVEN MEDULLOBLASTOMA

Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies

scientific article published on 19 September 2019

Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects

scientific article published on 21 July 2015

Mutational processes shape the landscape of TP53 mutations in human cancer.

scientific article

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

scientific article published on 03 June 2019

Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities

scientific article published in Nature Communications

PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation

scientific article published on 01 February 2022

Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants

scientific article published on October 2016

Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer

scientific article published on 28 August 2019

Pooled Lentiviral-Delivery Genetic Screens

scientific article published on 16 January 2018

RAS-MAPK reactivation facilitates acquired resistance in FGFR1-amplified lung cancer and underlies a rationale for upfront FGFR-MEK blockade

scientific article published on 13 April 2018

Regulation of Cellular Heterogeneity and Rates of Symmetric and Asymmetric Divisions in Triple-Negative Breast Cancer

scientific article published on 01 September 2018

Resistance Mechanisms to SYK Inhibition in Acute Myeloid Leukemia

scientific article published on 26 November 2019

Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling

scientific article published on 01 December 2018

Synergistic interactions with PI3K inhibition that induce apoptosis.

scientific article

Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q

scientific article published on 01 December 2020

Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers

scientific article published on 01 October 2019

Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles

scientific article

TRTH-15. RESISTANCE MECHANISMS TO BET-BROMODOMAIN INHIBITION IN MYC-AMPLIFIED MEDULLOBLASTOMA.

scientific article published on 31 May 2017

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