List of works - Jeff Ohren

2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)

scientific article

4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase

scientific article

A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore

scientific article

Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?

scientific article

Casein kinase 1δ/ε inhibitor PF-5006739 attenuates opioid drug-seeking behavior

scientific article published on 28 October 2014

Characterization of substrate binding and catalysis in the potential antibacterial targetN-acetylglucosamine-1-phosphate uridyltransferase (GlmU)

scientific article

Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ

scientific article

Discovery of a Series of Imidazo[4,5-b]pyridines with Dual Activity at Angiotensin II Type 1 Receptor and Peroxisome Proliferator-Activated Receptor-γ ⬇️

scientific article published on May 26, 2011

Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes

scientific article

Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase

scientific article

Inhibitors of Bcr-abl... breaking new ground again

scientific article published on 01 February 2006

Ligand-protein interactions of selective casein kinase 1δ inhibitors

scientific article

Novel and selective spiroindoline-based inhibitors of sky kinase ⬇️

scientific article published on November 16, 2011

Optimization of highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase.

scientific article

Rational protein engineering in action: the first crystal structure of a phenylalanine tRNA synthetase from Staphylococcus haemolyticus

scientific article

Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors

scientific article

Structural asymmetry and intersubunit communication in muscle creatine kinase.

scientific article published on 21 February 2007

The structure of the carboxyltransferase component of acetyl-coA carboxylase reveals a zinc-binding motif unique to the bacterial enzyme.

scientific article published in February 2006

The use of biochemical and biophysical tools for triage of high-throughput screening hits - A case study with Escherichia coli phosphopantetheine adenylyltransferase.

scientific article published in May 2010

List of works by Jeff Ohren

2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)

4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase

A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore

Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?

Casein kinase 1δ/ε inhibitor PF-5006739 attenuates opioid drug-seeking behavior

Characterization of substrate binding and catalysis in the potential antibacterial targetN-acetylglucosamine-1-phosphate uridyltransferase (GlmU)

Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ

Discovery of a Series of Imidazo[4,5-b]pyridines with Dual Activity at Angiotensin II Type 1 Receptor and Peroxisome Proliferator-Activated Receptor-γ ⬇️

Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes

Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase

Inhibitors of Bcr-abl... breaking new ground again

Ligand-protein interactions of selective casein kinase 1δ inhibitors

Novel and selective spiroindoline-based inhibitors of sky kinase ⬇️

Optimization of highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase.

Rational protein engineering in action: the first crystal structure of a phenylalanine tRNA synthetase from Staphylococcus haemolyticus

Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors

Structural asymmetry and intersubunit communication in muscle creatine kinase.

The structure of the carboxyltransferase component of acetyl-coA carboxylase reveals a zinc-binding motif unique to the bacterial enzyme.

The use of biochemical and biophysical tools for triage of high-throughput screening hits - A case study with Escherichia coli phosphopantetheine adenylyltransferase.