List of works - Almudena Porras

A role for p38alpha mitogen-activated protein kinase in embryonic cardiac differentiation

scientific article published on 29 February 2008

Activation of Ras by insulin in 3T3 L1 cells does not involve GTPase-activating protein phosphorylation

scientific article published on October 1992

Activation of p38MAPK by TGF-beta in fetal rat hepatocytes requires radical oxygen production, but is dispensable for cell death

scientific article published in June 2001

Adrenergic regulation of the uncoupling protein expression in foetal rat brown adipocytes in primary culture

scientific article

Apoptosis by cisplatin requires p53 mediated p38alpha MAPK activation through ROS generation.

scientific article published on September 2007

C3G Is Upregulated in Hepatocarcinoma, Contributing to Tumor Growth and Progression and to HGF/MET Pathway Activation

scientific article published on 14 August 2020

C3G down-regulates p38 MAPK activity in response to stress by Rap-1 independent mechanisms: involvement in cell death.

scientific article

C3G forms complexes with Bcr-Abl and p38α MAPK at the focal adhesions in chronic myeloid leukemia cells: implication in the regulation of leukemic cell adhesion.

scientific article published on 23 January 2013

C3G knock-down enhances migration and invasion by increasing Rap1-mediated p38α activation, while it impairs tumor growth through p38α-independent mechanisms.

scientific article published on 07 June 2016

C3G silencing enhances STI-571-induced apoptosis in CML cells through p38 MAPK activation, but it antagonizes STI-571 inhibitory effect on survival.

scientific article published on 24 March 2009

C3G transgenic mouse models with specific expression in platelets reveal a new role for C3G in platelet clotting through its GEF activity.

scientific article published on 29 May 2012

Correlation between DNA synthesis in the second, third and fourth generations of spermatogonia and the occurrence of apoptosis in both spermatogonia and spermatocytes

scientific article published in November 2003

Critical role of hydrogen peroxide signaling in the sequential activation of p38 MAPK and eNOS in laminar shear stress.

scientific article published on 14 January 2012

Development of the uncoupling protein in the rat brown-adipose tissue during the perinatal period. Its relationship with the mitochondrial GDP-binding and GDP-sensitive ion permeabilities and respiration

scientific article published on 01 February 1990

Differential role of PPAR gamma in the regulation of UCP-1 and adipogenesis by TNF-alpha in brown adipocytes.

scientific article

Differentiation of 3T3-L1 fibroblasts to adipocytes induced by transfection of ras oncogenes

scientific article published on August 1991

Dissociation between activation of Raf-1 kinase and the 42-kDa mitogen-activated protein kinase/90-kDa S6 kinase (MAPK/RSK) cascade in the insulin/Ras pathway of adipocytic differentiation of 3T3 L1 cells.

scientific article published on April 1994

Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development

scientific article published on 01 July 2000

Establishment of permanent brown adipocyte cell lines achieved by transfection with SV40 large T antigen and ras genes

scientific article published on December 1993

HGF/c-Met signaling promotes liver progenitor cell migration and invasion by an epithelial-mesenchymal transition-independent, phosphatidyl inositol-3 kinase-dependent pathway in an in vitro model.

scientific article

Long-term treatment with insulin induces apoptosis in brown adipocytes: role of oxidative stress.

scientific article published on 18 September 2003

Met acts on Mdm2 via mTOR to signal cell survival during development.

scientific article published on 28 February 2007

Met signaling in cardiomyocytes is required for normal cardiac function in adult mice

scientific article

Mitogen-activated protein kinase activation is not necessary for, but antagonizes, 3T3-L1 adipocytic differentiation

scientific article published on October 1997

Negative regulation of Akt activity by p38alpha MAP kinase in cardiomyocytes involves membrane localization of PP2A through interaction with caveolin-1

scientific article published on 14 July 2006

Notch-1 controls the expression of fatty acid-activated transcription factors and is required for adipogenesis

scientific article published on November 1997

P38 alpha mitogen-activated protein kinase sensitizes cells to apoptosis induced by different stimuli.

scientific article published on 14 November 2003

Ras proteins mediate induction of uncoupling protein, IGF-I, and IGF-I receptor in rat fetal brown adipocyte cell lines

scientific article published on 01 November 1996

TNF-alpha induces apoptosis in rat fetal brown adipocytes in primary culture

scientific article published on 01 October 1997

TNF-alpha inhibits UCP-1 expression in brown adipocytes via ERKs. Opposite effect of p38MAPK

scientific article published on 01 March 2001

TWEAK prevents TNF-α-induced insulin resistance through PP2A activation in human adipocytes

scientific article published on 7 May 2013

TWEAK promotes migration and invasion in MEFs through a mechanism dependent on ERKs activation and Fibulin 3 down-regulation

scientific article published on 6 April 2017

The insulin/Ras pathway of adipocytic differentiation of 3T3 L1 cells: dissociation between Raf-1 kinase and the MAPK/RSK cascade

scientific article published on 01 March 1996

The ras signaling pathway mimics insulin action on glucose transporter translocation

scientific article

Triiodothyronine Induces the Transcription of the Uncoupling Protein Gene and Stabilizes Its mRNA in Fetal Rat Brown Adipocyte Primary Cultures

scientific article published in Journal of Biological Chemistry

Triiodothyronine induces the expression of the uncoupling protein in long term fetal rat brown adipocyte primary cultures: role of nuclear thyroid hormone receptor expression

scientific article published on 01 March 1994

p21ras-induced meiotic maturation of Xenopus oocytes in the absence of protein synthesis: MPF activation is preceded by activation of MAP and S6 kinases

scientific article published in February 1993

p38 MAP kinases: beyond the stress response

scientific article

p38 MAPK down-regulates fibulin 3 expression through methylation of gene regulatory sequences: role in migration and invasion.

scientific article published on 29 December 2014

p38 MAPK enhances STAT1-dependent transcription independently of Ser-727 phosphorylation

scientific article

p38 mitogen-activated protein kinase mediates tumor necrosis factor-alpha-induced apoptosis in rat fetal brown adipocytes

scientific article published on 01 December 2000

p38alpha MAPK can positively or negatively regulate Rac-1 activity depending on the presence of serum.

scientific article published on 16 July 2007

p38α mediates cell survival in response to oxidative stress via induction of antioxidant genes: effect on the p70S6K pathway

scientific article published on 2 December 2011

p42/p44 mitogen-activated protein kinases activation is required for the insulin-like growth factor-I/insulin induced proliferation, but inhibits differentiation, in rat fetal brown adipocytes

scientific article published in June 1998

List of works by Almudena Porras

A role for p38alpha mitogen-activated protein kinase in embryonic cardiac differentiation

Activation of Ras by insulin in 3T3 L1 cells does not involve GTPase-activating protein phosphorylation

Activation of p38MAPK by TGF-beta in fetal rat hepatocytes requires radical oxygen production, but is dispensable for cell death

Adrenergic regulation of the uncoupling protein expression in foetal rat brown adipocytes in primary culture

Apoptosis by cisplatin requires p53 mediated p38alpha MAPK activation through ROS generation.

C3G Is Upregulated in Hepatocarcinoma, Contributing to Tumor Growth and Progression and to HGF/MET Pathway Activation

C3G down-regulates p38 MAPK activity in response to stress by Rap-1 independent mechanisms: involvement in cell death.

C3G forms complexes with Bcr-Abl and p38α MAPK at the focal adhesions in chronic myeloid leukemia cells: implication in the regulation of leukemic cell adhesion.

C3G knock-down enhances migration and invasion by increasing Rap1-mediated p38α activation, while it impairs tumor growth through p38α-independent mechanisms.

C3G silencing enhances STI-571-induced apoptosis in CML cells through p38 MAPK activation, but it antagonizes STI-571 inhibitory effect on survival.

C3G transgenic mouse models with specific expression in platelets reveal a new role for C3G in platelet clotting through its GEF activity.

Correlation between DNA synthesis in the second, third and fourth generations of spermatogonia and the occurrence of apoptosis in both spermatogonia and spermatocytes

Critical role of hydrogen peroxide signaling in the sequential activation of p38 MAPK and eNOS in laminar shear stress.

Development of the uncoupling protein in the rat brown-adipose tissue during the perinatal period. Its relationship with the mitochondrial GDP-binding and GDP-sensitive ion permeabilities and respiration

Differential role of PPAR gamma in the regulation of UCP-1 and adipogenesis by TNF-alpha in brown adipocytes.

Differentiation of 3T3-L1 fibroblasts to adipocytes induced by transfection of ras oncogenes

Dissociation between activation of Raf-1 kinase and the 42-kDa mitogen-activated protein kinase/90-kDa S6 kinase (MAPK/RSK) cascade in the insulin/Ras pathway of adipocytic differentiation of 3T3 L1 cells.

Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development

Establishment of permanent brown adipocyte cell lines achieved by transfection with SV40 large T antigen and ras genes

HGF/c-Met signaling promotes liver progenitor cell migration and invasion by an epithelial-mesenchymal transition-independent, phosphatidyl inositol-3 kinase-dependent pathway in an in vitro model.

Long-term treatment with insulin induces apoptosis in brown adipocytes: role of oxidative stress.

Met acts on Mdm2 via mTOR to signal cell survival during development.

Met signaling in cardiomyocytes is required for normal cardiac function in adult mice

Mitogen-activated protein kinase activation is not necessary for, but antagonizes, 3T3-L1 adipocytic differentiation

Negative regulation of Akt activity by p38alpha MAP kinase in cardiomyocytes involves membrane localization of PP2A through interaction with caveolin-1

Notch-1 controls the expression of fatty acid-activated transcription factors and is required for adipogenesis

P38 alpha mitogen-activated protein kinase sensitizes cells to apoptosis induced by different stimuli.

Ras proteins mediate induction of uncoupling protein, IGF-I, and IGF-I receptor in rat fetal brown adipocyte cell lines

TNF-alpha induces apoptosis in rat fetal brown adipocytes in primary culture

TNF-alpha inhibits UCP-1 expression in brown adipocytes via ERKs. Opposite effect of p38MAPK

TWEAK prevents TNF-α-induced insulin resistance through PP2A activation in human adipocytes

TWEAK promotes migration and invasion in MEFs through a mechanism dependent on ERKs activation and Fibulin 3 down-regulation

The insulin/Ras pathway of adipocytic differentiation of 3T3 L1 cells: dissociation between Raf-1 kinase and the MAPK/RSK cascade

The ras signaling pathway mimics insulin action on glucose transporter translocation

Triiodothyronine Induces the Transcription of the Uncoupling Protein Gene and Stabilizes Its mRNA in Fetal Rat Brown Adipocyte Primary Cultures

Triiodothyronine induces the expression of the uncoupling protein in long term fetal rat brown adipocyte primary cultures: role of nuclear thyroid hormone receptor expression

p21ras-induced meiotic maturation of Xenopus oocytes in the absence of protein synthesis: MPF activation is preceded by activation of MAP and S6 kinases

p38 MAP kinases: beyond the stress response

p38 MAPK down-regulates fibulin 3 expression through methylation of gene regulatory sequences: role in migration and invasion.

p38 MAPK enhances STAT1-dependent transcription independently of Ser-727 phosphorylation

p38 mitogen-activated protein kinase mediates tumor necrosis factor-alpha-induced apoptosis in rat fetal brown adipocytes

p38alpha MAPK can positively or negatively regulate Rac-1 activity depending on the presence of serum.

p38α mediates cell survival in response to oxidative stress via induction of antioxidant genes: effect on the p70S6K pathway

p42/p44 mitogen-activated protein kinases activation is required for the insulin-like growth factor-I/insulin induced proliferation, but inhibits differentiation, in rat fetal brown adipocytes