List of works - Takashi Iwai

Characterization of the hypotensive effects of glucagon-like peptide-2 in anesthetized rats.

scientific article published on 15 July 2013

Design and synthesis of novel δ opioid receptor agonists with an azatricyclodecane skeleton for improving blood-brain barrier penetration

scientific article published on 26 May 2017

Design and synthesis of quinolinopropellane derivatives with selective δ opioid receptor agonism

scientific article

Design, synthesis, and structure-activity relationship of novel opioid κ receptor selective agonists: α-iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton

scientific article published on 21 September 2014

Dexamethasone indirectly induces Ndrg2 expression in rat astrocytes ⬇️

scientific article published on September 16, 2011

Electrophysiological evidence of increased glycine receptor-mediated phasic and tonic inhibition by blockade of glycine transporters in spinal superficial dorsal horn neurons of adult mice.

scientific article published on 27 February 2017

Exendin (5-39), an antagonist of GLP-1 receptor, modulates synaptic transmission via glutamate uptake in the dentate gyrus.

scientific article published on 11 January 2013

Glucagon-like peptide-1 inhibits LPS-induced IL-1beta production in cultured rat astrocytes.

scientific article published on 23 May 2006

Glucagon-like peptide-1 protects synaptic and learning functions from neuroinflammation in rodents.

scientific article published on 27 January 2014

Glucagon-like peptide-2 but not imipramine exhibits antidepressant-like effects in ACTH-treated mice.

scientific article published on 16 January 2013

Glucagon-like peptide-2-induced memory improvement and anxiolytic effects in mice.

scientific article published on 24 November 2014

Hydroxyobtustyrene protects neuronal cells from chemical hypoxia-induced cell death

scientific article published on 09 July 2018

Immunohistochemical determination of the site of hypotensive effects of glucagon-like peptide-2 in the rat brain ⬇️

scientific article published on April 16, 2012

Intraplantar injection of sialidase reduces mechanical allodynia during inflammatory pain.

scientific article published on 3 January 2017

Naltrindole derivatives with fluorinated ethyl substituents on the 17-nitrogen as δ opioid receptor inverse agonists

scientific article published on 22 May 2015

Neuromedin U inhibits inflammation-mediated memory impairment and neuronal cell-death in rodents

scientific article

Novel delta opioid receptor agonists with oxazatricyclodecane structure

scientific article

Novel delta opioid receptor agonists with oxazatricyclodecane structure showing potent agonistic activities

scientific article

Plasticity-related gene 1 is important for survival of neurons derived from rat neural stem cells

scientific article published on 30 August 2013

Rhotekin modulates differentiation of cultured neural stem cells to neurons ⬇️

scientific article published on March 13, 2012

Riluzole produces distinct anxiolytic-like effects in rats without the adverse effects associated with benzodiazepines.

scientific article published on 21 February 2012

Synthesis and Pharmacology of a Novel κ Opioid Receptor (KOR) Agonist with a 1,3,5-Trioxazatriquinane Skeleton.

scientific article published on 26 June 2014

Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies.

scientific article published on 12 August 2014

Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain.

scientific article published on 28 August 2015

Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 3: synthesis of novel triplet drugs with the bis(epoxymethano) or bis(dimethylepoxymethano) structure (double-capped triplet)

scientific article published on 13 October 2012

The effect of 17-N substituents on the activity of the opioid κ receptor in nalfurafine derivatives.

scientific article published on 30 October 2012

The most effective influence of 17-(3-ethoxypropyl) substituent on the binding affinity and the agonistic activity in KNT-127 derivatives, δ opioid receptor agonists.

scientific article published on 31 October 2013

List of works by Takashi Iwai

Characterization of the hypotensive effects of glucagon-like peptide-2 in anesthetized rats.

Design and synthesis of novel δ opioid receptor agonists with an azatricyclodecane skeleton for improving blood-brain barrier penetration

Design and synthesis of quinolinopropellane derivatives with selective δ opioid receptor agonism

Design, synthesis, and structure-activity relationship of novel opioid κ receptor selective agonists: α-iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton

Dexamethasone indirectly induces Ndrg2 expression in rat astrocytes ⬇️

Electrophysiological evidence of increased glycine receptor-mediated phasic and tonic inhibition by blockade of glycine transporters in spinal superficial dorsal horn neurons of adult mice.

Exendin (5-39), an antagonist of GLP-1 receptor, modulates synaptic transmission via glutamate uptake in the dentate gyrus.

Glucagon-like peptide-1 inhibits LPS-induced IL-1beta production in cultured rat astrocytes.

Glucagon-like peptide-1 protects synaptic and learning functions from neuroinflammation in rodents.

Glucagon-like peptide-2 but not imipramine exhibits antidepressant-like effects in ACTH-treated mice.

Glucagon-like peptide-2-induced memory improvement and anxiolytic effects in mice.

Hydroxyobtustyrene protects neuronal cells from chemical hypoxia-induced cell death

Immunohistochemical determination of the site of hypotensive effects of glucagon-like peptide-2 in the rat brain ⬇️

Intraplantar injection of sialidase reduces mechanical allodynia during inflammatory pain.

Naltrindole derivatives with fluorinated ethyl substituents on the 17-nitrogen as δ opioid receptor inverse agonists

Neuromedin U inhibits inflammation-mediated memory impairment and neuronal cell-death in rodents

Novel delta opioid receptor agonists with oxazatricyclodecane structure

Novel delta opioid receptor agonists with oxazatricyclodecane structure showing potent agonistic activities

Plasticity-related gene 1 is important for survival of neurons derived from rat neural stem cells

Rhotekin modulates differentiation of cultured neural stem cells to neurons ⬇️

Riluzole produces distinct anxiolytic-like effects in rats without the adverse effects associated with benzodiazepines.

Synthesis and Pharmacology of a Novel κ Opioid Receptor (KOR) Agonist with a 1,3,5-Trioxazatriquinane Skeleton.

Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies.

Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain.

Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 3: synthesis of novel triplet drugs with the bis(epoxymethano) or bis(dimethylepoxymethano) structure (double-capped triplet)

The effect of 17-N substituents on the activity of the opioid κ receptor in nalfurafine derivatives.

The most effective influence of 17-(3-ethoxypropyl) substituent on the binding affinity and the agonistic activity in KNT-127 derivatives, δ opioid receptor agonists.