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List of works by Shinya Dohgu

A Role for Hypothalamic AMP-Activated Protein Kinase in the Mediation of Hyperphagia and Weight Gain Induced by Chronic Treatment with Olanzapine in Female Rats ⬇️

scientific article published on June 17, 2011

Activation of the α7 nicotinic acetylcholine receptor upregulates blood-brain barrier function through increased claudin-5 and occludin expression in rat brain endothelial cells

scientific article published on 16 November 2018

Adrenomedullin-induced relaxation of rat brain pericytes is related to the reduced phosphorylation of myosin light chain through the cAMP/PKA signaling pathway

scientific article

Adverse effect of cyclosporin A on barrier functions of cerebral microvascular endothelial cells after hypoxia-reoxygenation damage in vitro

scientific article

Alpha Adrenergic Induction of Transport of Lysosomal Enzyme across the Blood-Brain Barrier

scientific article published on 6 November 2015

An inhibitory role of nitric oxide in the dynamic regulation of the blood-brain barrier function

scientific article published on 23 February 2007

Analysis of Catecholamine and Their Metabolites in Mice Brain by Liquid Chromatography-Mass Spectrometry Using Sulfonated Mixed-mode Copolymer Column

scientific article published on 21 December 2018

Autocrine and paracrine up-regulation of blood-brain barrier function by plasminogen activator inhibitor-1

scientific article published on October 29, 2010

Brain pericyte-derived soluble factors enhance insulin sensitivity in GT1-7 hypothalamic neurons

scientific article

Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitro ⬇️

scientific article published on August 26, 2011

Brain pericytes are the most thrombin-sensitive matrix metalloproteinase-9-releasing cell type constituting the blood-brain barrier in vitro

scientific article

Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production.

scientific article

Brain pericytes increase the lipopolysaccharide-enhanced transcytosis of HIV-1 free virus across the in vitro blood-brain barrier: evidence for cytokine-mediated pericyte-endothelial cell crosstalk

scientific article published on July 2013

Brain pericytes regulate the blood-brain barrier function

scientific article published on 01 July 2015

Brain-transportable dipeptides across the blood-brain barrier in mice

scientific article published on 08 April 2019

Brain-transportable soy dipeptide, Tyr-Pro, attenuates amyloid β peptide25-35-induced memory impairment in mice

scientific article published on 01 May 2020

Compounds blocking methylglyoxal-induced protein modification and brain endothelial injury

scientific article

Contrast media increase vascular endothelial permeability by inhibiting nitric-oxide production

scientific article published in January 2002

Contribution of thrombin-reactive brain pericytes to blood-brain barrier dysfunction in an in vivo mouse model of obesity-associated diabetes and an in vitro rat model

scientific article

Copper complexing decreases the ability of amyloid beta peptide to cross the BBB and enter brain parenchyma

scientific article published on 18 May 2007

Cyclophilin A secreted from fibroblast-like synoviocytes is involved in the induction of CD147 expression in macrophages of mice with collagen-induced arthritis ⬇️

scientific article published on November 20, 2012

Cyclosporin A aggravates electroshock-induced convulsions in mice with a transient middle cerebral artery occlusion

scientific article published in August 2005

Cyclosporin A induces hyperpermeability of the blood-brain barrier by inhibiting autocrine adrenomedullin-mediated up-regulation of endothelial barrier function

scientific article published on 8 June 2010

Cyclosporine A-increased nitric oxide production in the rat dorsal hippocampus mediates convulsions

scientific article published in December 2002

Detachment of brain pericytes from the basal lamina is involved in disruption of the blood-brain barrier caused by lipopolysaccharide-induced sepsis in mice

scientific article published on 6 November 2008

Disruption of the blood-brain barrier in collagen-induced arthritic mice

scientific article

Edaravone protects against methylglyoxal-induced barrier damage in human brain endothelial cells

scientific article

Elevated permeability of the blood-brain barrier in mice intratracheally administered porcine pancreatic elastase

scientific article published on 3 September 2015

Feeding-produced subchronic high plasma levels of uric acid improve behavioral dysfunction in 6-hydroxydopamine-induced mouse model of Parkinson's disease

scientific article published on 01 February 2019

Human Immunodeficiency Virus-1 Uses the Mannose-6-Phosphate Receptor to Cross the Blood-Brain Barrier ⬇️

scientific article published on June 25, 2012

In vitro blood-brain barrier models using brain capillary endothelial cells isolated from neonatal and adult rats retain age-related barrier properties

scientific article

Increased Plasma VEGF Levels in Patients with Cerebral Large Artery Disease Are Associated with Cerebral Microbleeds

scientific article published on 30 April 2019

Inhibition of transforming growth factor-beta production in brain pericytes contributes to cyclosporin A-induced dysfunction of the blood-brain barrier

scientific article published on 28 December 2006

Levetiracetam treatment influences blood-brain barrier failure associated with angiogenesis and inflammatory responses in the acute phase of epileptogenesis in post-status epilepticus mice

scientific article published on 27 September 2016

Lipopolysaccharide alters the blood-brain barrier transport of amyloid beta protein: a mechanism for inflammation in the progression of Alzheimer's disease

scientific article published on 06 February 2009

Lipopolysaccharide-activated microglia induce dysfunction of the blood-brain barrier in rat microvascular endothelial cells co-cultured with microglia

scientific article published on 29 August 2009

Lipopolysaccharide-activated microglia lower P-glycoprotein function in brain microvascular endothelial cells ⬇️

scientific article published on July 16, 2012

Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF ⬇️

scientific article published on November 30, 2011

Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by the p38 mitogen-activated protein kinase pathway

scientific article published on 19 January 2008

Metformin induces up-regulation of blood–brain barrier functions by activating AMP-activated protein kinase in rat brain microvascular endothelial cells ⬇️

scientific article published on March 21, 2013

Monomeric α-synuclein induces blood-brain barrier dysfunction through activated brain pericytes releasing inflammatory mediators in vitro

scientific article published on 15 March 2019

Nitric oxide isoenzymes regulate lipopolysaccharide-enhanced insulin transport across the blood-brain barrier.

scientific article published on 10 January 2008

Nitric oxide mediates cyclosporine-induced impairment of the blood-brain barrier in cocultures of mouse brain endothelial cells and rat astrocytes

scientific article

Oligodendrocytes upregulate blood-brain barrier function through mechanisms other than the PDGF-BB/PDGFRα pathway in the barrier-tightening effect of oligodendrocyte progenitor cells

scientific article published on 31 October 2019

Oncostatin M-induced blood-brain barrier impairment is due to prolonged activation of STAT3 signaling in vitro

scientific article published on 04 August 2018

Oncostatin-M-Reactive Pericytes Aggravate Blood-Brain Barrier Dysfunction by Activating JAK/STAT3 Signaling In Vitro

scientific article published on 06 November 2019

Paracellular Barrier and Tight Junction Protein Expression in the Immortalized Brain Endothelial Cell Lines bEND.3, bEND.5 and Mouse Brain Endothelial Cell 4 ⬇️

scientific article published on January 1, 2013

Partial hepatectomy aggravates cyclosporin A-induced neurotoxicity by lowering the function of the blood–brain barrier in mice ⬇️

scientific article published on January 22, 2011

Peroxisome proliferator-activated receptor-gamma-mediated positive energy balance in the rat is associated with reduced sympathetic drive to adipose tissues and thyroid status

scientific article published on 24 January 2008

Release of cytokines by brain endothelial cells: A polarized response to lipopolysaccharide

scientific article published on 23 November 2005

Role of thrombin-PAR1-PKCθ/δ axis in brain pericytes in thrombin-induced MMP-9 production and blood-brain barrier dysfunction in vitro

scientific article published on 23 March 2017

Serum amyloid A-induced blood-brain barrier dysfunction associated with decreased claudin-5 expression in rat brain endothelial cells and its inhibition by high-density lipoprotein in vitro

scientific article published on 12 September 2020

Subchronic treatment with cyclosporin A decreases the binding properties of the GABAA receptor in ovariectomized rats

scientific article published in December 2002

TNF-α-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IκB-NFκB and JAK-STAT3 pathways.

scientific article

Testing the neurovascular hypothesis of Alzheimer's disease: LRP-1 antisense reduces blood-brain barrier clearance, increases brain levels of amyloid-beta protein, and impairs cognition

scientific article

Transforming growth factor-beta1 upregulates the tight junction and P-glycoprotein of brain microvascular endothelial cells

scientific article published on June 2004

Tumor necrosis factor-alpha mediates the blood-brain barrier dysfunction induced by activated microglia in mouse brain microvascular endothelial cells

scientific article published on 30 January 2010

Tumor necrosis factor-α-stimulated brain pericytes possess a unique cytokine and chemokine release profile and enhance microglial activation

scientific article published on 30 June 2014

Uptake and efflux of quinacrine, a candidate for the treatment of prion diseases, at the blood-brain barrier

scientific article published on April 2004

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