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List of works by Denzil Bernard

2D conformationally sampled pharmacophore: a ligand-based pharmacophore to differentiate delta opioid agonists from antagonists.

scientific article

A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice.

scientific article published on 20 June 2013

AM-8553: A Novel MDM2 Inhibitor with a Promising Outlook for Potential Clinical Development ⬇️

scientific article published on May 24, 2012

Computer-Aided Drug Design: Structure-Activity Relationships of Delta Opioid Ligands

Conformationally sampled pharmacophore for peptidic delta opioid ligands.

scientific article published in December 2005

Functionalization of the 6,14-bridge of the orvinols. 2. Preparation of 18- and 19-hydroxyl-substituted thevinols and their treatment with benzyl bromide.

scientific article

High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction

scientific article

Position of Coordination of the Lithium Ion Determines the Regioselectivity of Demethylations of 3,4-Dimethoxymorphinans with L-Selectride

scientific article published on 01 June 2005

Quantitative conformationally sampled pharmacophore for delta opioid ligands: reevaluation of hydrophobic moieties essential for biological activity

scientific article published on 17 March 2007

Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer

scientific article

Rearrangement of 5-trimethylsilylthebaine on treatment with L-selectride: an efficient synthesis of (+)-bractazonine.

scientific article published in March 2003

Split Renilla luciferase protein fragment-assisted complementation (SRL-PFAC) to characterize Hsp90-Cdc37 complex and identify critical residues in protein/protein interactions.

scientific article

Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors. ⬇️

scientific article published on May 2010

Structure-Based Design of High-Affinity Macrocyclic Peptidomimetics to Block the Menin-Mixed Lineage Leukemia 1 (MLL1) Protein–Protein Interaction ⬇️

scientific article published on January 17, 2013

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

scholarly article

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