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List of works by David J MacEwan

Activity of Bruton's tyrosine-kinase inhibitor ibrutinib in patients with CD117-positive acute myeloid leukaemia: a mechanistic study using patient-derived blast cells

scientific article

Agonist regulation of adenylate cyclase activity in neuroblastoma x glioma hybrid NG108-15 cells transfected to co-express adenylate cyclase type II and the beta 2-adrenoceptor. Evidence that adenylate cyclase is the limiting component for receptor-

scientific article

Attenuation of dexamethasone-induced cell death in multiple myeloma is mediated by miR-125b expression

scientific article published on 11 June 2013

Bortezomib induces heme oxygenase-1 expression in multiple myeloma ⬇️

scientific article published on June 15, 2012

Calcium influx through 'L'-type channels into rat anterior pituitary cells can be modulated in two ways by protein kinase C (PKC-isoform selectivity of 1,2-dioctanoyl sn-glycerol?).

scientific article published on October 1991

Characterisation of protein kinase C isoforms and enzymic activity from the alpha T3-1 gonadotroph-derived cell line.

scientific article published on October 1993

Differential activation of nuclear factor-kappaB by tumour necrosis factor receptor subtypes. TNFR1 predominates whereas TNFR2 activates transcription poorly

scientific article published on March 2002

Distinct regulation of cytosolic phospholipase A2 phosphorylation, translocation, proteolysis and activation by tumour necrosis factor-receptor subtypes

scientific article published on September 2003

Elevated NF-kappaB responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis

scientific article

Elevated cPLA2 levels as a mechanism by which the p70 TNF and p75 NGF receptors enhance apoptosis

scientific article published on 01 January 1996

Emerging therapeutic aspects in oncology.

scientific article

Epigenetics and pharmacology

scientific article published on June 2015

Evidence for a distinct H7-resistant form of protein kinase C in rat anterior pituitary gland.

scientific article published in August 1993

Evidence that protein kinase C alpha has reduced affinity towards 1,2-dioctanoyl-sn-glycerol: the effects of lipid activators on phorbol ester binding and kinase activity.

scientific article published in June 1993

Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers

scientific article published in April 2018

Experimental design and analysis and their reporting: new guidance for publication in BJP.

scientific article published on July 2015

Functional expression of 5-HT1c receptor cDNA in COS 7 cells and its influence on protein kinase C.

scientific article published in February 1993

G-protein palmitoylation: regulation and functional significance.

scientific article published on August 1995

Goals and practicalities of immunoblotting and immunohistochemistry: A guide for submission to the British Journal of Pharmacology

scientific article published in February 2018

HO-1 underlies resistance of AML cells to TNF-induced apoptosis

scientific article

High Basal Nuclear Levels of Nrf2 in Acute Myeloid Leukemia Reduces Sensitivity to Proteasome Inhibitors ⬇️

scientific article published on January 6, 2011

Ibrutinib inhibits BTK-driven NF-κB p65 activity to overcome bortezomib-resistance in multiple myeloma.

scientific article

Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML

scientific article

Identification of Bruton's tyrosine kinase as a therapeutic target in acute myeloid leukemia.

scientific article published on 4 December 2013

Influx of extracellular Ca2+ is necessary for electrotaxis in Dictyostelium

scientific article published on 31 October 2006

Inhibition of depolarisation-induced calcium influx into GH3 cells by arachidonic acid: the involvement of protein kinase C.

scientific article published in September 1991

Interactions between TNF and GnRH.

scientific article published on 6 November 2007

Interferon alpha induces protein kinase C-epsilon (PKC-epsilon) gene expression and a 4.7-kb PKC-epsilon-related transcript

scientific article

Involvement of multiple protein kinase C isozymes in the ACTH secretory pathway of AtT-20 cells

scientific article published in May 1995

Modulation by caspases of tumor necrosis factor-stimulated c-Jun N-terminal kinase activation but not nuclear factor-kappaB signaling

scientific article published on 01 January 2003

NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival.

scientific article

New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome

scientific article published on 18 December 2017

Oestradiol-17 beta modulates the actions of pharmacologically distinct forms of protein kinase C in rat anterior pituitary cells.

scientific article published in January 1993

Oxidative stress responses and NRF2 in human leukaemia

scientific article

Phorbol ester and diacylglycerol activation of native protein kinase C species from various tissues.

scientific article published on May 1995

Protection of acute myeloid leukaemia cells from apoptosis induced by front-line chemotherapeutics is mediated by haem oxygenase-1 ⬇️

scientific article published on September 1, 2011

Regulation of the Stoichiometry of Protein Components of the Stimulatory Adenylyl Cyclase Cascade

scientific article published on January 1, 1998

Silencing FLIP(L) modifies TNF-induced apoptotic protein expression.

scientific article published on April 2011

Stimulation of stress-activated but not mitogen-activated protein kinases by tumour necrosis factor receptor subtypes in airway smooth muscle

scientific article published on 01 March 2001

TNF ligands and receptors--a matter of life and death

scientific article

TNF mediates the sustained activation of Nrf2 in human monocytes

scientific article published on 13 June 2011

TNF receptor subtype signalling: differences and cellular consequences

scientific article

TNF signaling gets FLIPped off: TNF-induced regulation of FLIP.

scientific article published on 12 October 2007

TNF-alpha receptors simultaneously activate Ca2+ mobilisation and stress kinases in cultured sensory neurones.

scientific article published in January 2002

TNFR1-induced NF-kappaB, but not ERK, p38MAPK or JNK activation, mediates TNF-induced ICAM-1 and VCAM-1 expression on endothelial cells

scientific article published on 18 January 2007

TWEAKing for a fight with GVHD.

scientific article

Targeting BTK for the treatment of FLT3-ITD mutated acute myeloid leukemia.

scientific article

The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemo-resistance.

scientific article published on 17 October 2012

The influence of alkyl pyridinium sponge toxins on membrane properties, cytotoxicity, transfection and protein expression in mammalian cells.

scientific article published in August 2003

The involvement of dihydropyridine-sensitive calcium channels in phorbol ester-induced luteinizing hormone and growth hormone release.

scientific article published in September 1993

The role of nrf2 and cytoprotection in regulating chemotherapy resistance of human leukemia cells

scientific article published on 29 March 2011

Tumor necrosis factor-alpha-induced activation of RhoA in airway smooth muscle cells: role in the Ca2+ sensitization of myosin light chain20 phosphorylation

scientific article

Tumour necrosis factor-alpha activates a calcium sensitization pathway in guinea-pig bronchial smooth muscle

scientific article published on 01 July 1999

Tumour necrosis factor-induced activation of c-Jun N-terminal kinase is sensitive to caspase-dependent modulation while activation of mitogen-activated protein kinase (MAPK) or p38 MAPK is not.

scientific article published on August 2002

Type II tumour necrosis factor-alpha receptor (TNFR2) activates c-Jun N-terminal kinase (JNK) but not mitogen-activated protein kinase (MAPK) or p38 MAPK pathways.

scientific article published in November 2001

Understanding life and death decisions in human leukaemias.

scientific article

Understanding the role of NRF2-regulated miRNAs in human malignancies.

scientific article published on August 2013

Updating the guidelines for data transparency in the British Journal of Pharmacology - data sharing and the use of scatter plots instead of bar charts

scientific article published on September 2017

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