List of works - Bluma Brenner

A Template-Dependent Dislocation Mechanism Potentiates K65R Reverse Transcriptase Mutation Development in Subtype C Variants of HIV-1 ⬇️

scientific article published on May 31, 2011

A V106M mutation in HIV-1 clade C viruses exposed to efavirenz confers cross-resistance to non-nucleoside reverse transcriptase inhibitors

scientific article published in January 2003

A significant reduction in the frequency of HIV-1 drug resistance in Québec from 2001 to 2011 is associated with a decrease in the monitored viral load

scientific article

Altered Constitutive and Stress-Regulated Heat Shock Protein 27 Expression in HIV Type 1-Infected Cell Lines ⬇️

scientific article published on June 1, 1995

Antiretroviral drug resistance in human immunodeficiency virus type 2.

scientific article published on 26 May 2009

Antiviral Activity of Bictegravir and Cabotegravir Against Integrase Inhibitor Resistant SIVmac239 and HIV-1.

scientific article published on 18 September 2017

Apricitabine does not select additional drug resistance mutations in tissue culture in human immunodeficiency virus type 1 variants containing K65R, M184V, or M184V plus thymidine analogue mutations

scientific article (publication date: April 2009)

Basis for Early and Preferential Selection of the E138K Mutation in HIV-1 Reverse Transcriptase ⬇️

scientific article published on July 15, 2013

Biochemical and virological analysis of the preference for the K65R multi-resistance nucleoside mutation in subtype C viruses

Changing patterns in the selection of viral mutations among patients receiving nucleoside and nucleotide drug combinations directed against human immunodeficiency virus type 1 reverse transcriptase

scientific article

Characterization of the Drug Resistance Profiles of Integrase Strand Transfer Inhibitors in Simian Immunodeficiency Virus SIVmac239.

scientific article

Characterization of the E138K Resistance Mutation in HIV-1 Reverse Transcriptase Conferring Susceptibility to Etravirine in B and Non-B HIV-1 Subtypes ⬇️

scientific article published on December 6, 2010

Clinical benefit of dolutegravir in HIV-1 management related to the high genetic barrier to drug resistance

scientific article

Co-receptor usage and HIV-1 intra-clade C polymorphisms in the protease and reverse transcriptase genes of HIV-1 isolates from Ethiopia and Botswana.

scientific article

Compensation by the E138K mutation in HIV-1 reverse transcriptase for deficits in viral replication capacity and enzyme processivity associated with the M184I/V mutations

scientific article

Correcting covariate-dependent measurement error with non-zero mean

scientific article published on 9 April 2017

D-Glucose uptake and insulin binding by the human adipose cell plasma membrane as a function of its polypeptide composition

scientific article published on 01 February 1977

Dates of HIV infection can be estimated for seroprevalent patients by coalescent analysis of serial next-generation sequencing data

scientific article

Detectable signals of episodic risk effects on acute HIV transmission: strategies for analyzing transmission systems using genetic data

scientific article

Detection of human immunodeficiency virus (HIV) type 1 M184V and K103N minority variants in patients with primary HIV infection.

scientific article published on 26 January 2009

Development of a G118R mutation in HIV-1 integrase following a switch to dolutegravir monotherapy leading to cross-resistance to integrase inhibitors

scientific article published on 29 March 2016

Development of antiretroviral drug resistance

scientific article published on 01 August 2011

Didanosine, interferon-alfa and ribavirin: a highly synergistic combination with potential activity against HIV-1 and hepatitis C virus

scientific article published on May 2, 2003

Differential maintenance of the M184V substitution in the reverse transcriptase of human immunodeficiency virus type 1 by various nucleoside antiretroviral agents in tissue culture

scientific article published on November 2004

Diminished representation of HIV-1 variants containing select drug resistance-conferring mutations in primary HIV-1 infection

scientific article published in December 2004

Discrepancies in assignment of subtype/recombinant forms by genotyping programs for HIV type 1 drug resistance testing may falsely predict superinfection.

scientific article

Distinct resistance patterns to etravirine and rilpivirine in viruses containing nonnucleoside reverse transcriptase inhibitor mutations at baseline ⬇️

scientific article published on March 27, 2013

Does antiretroviral treatment change HIV-1 codon usage patterns in its genes: a preliminary bioinformatics study

scientific article

Dolutegravir inhibits HIV-1 Env evolution in primary human cells

scientific article published on March 2015

Durable suppression of HIV-1 with resistance mutations to integrase inhibitors by dolutegravir following drug washout

article

Effects of the K65R and K65R/M184V reverse transcriptase mutations in subtype C HIV on enzyme function and drug resistance

scientific article

Evolution of a novel pathway leading to dolutegravir resistance in a patient harbouring N155H and multiclass drug resistance

scientific article published on 3 October 2014

Future of phylogeny in HIV prevention

scientific article published on July 2013

Genetic divergence of human immunodeficiency virus type 1 Ethiopian clade C reverse transcriptase (RT) and rapid development of resistance against nonnucleoside inhibitors of RT.

scientific article

Genotypic and Phylogenetic Insights on Prevention of the Spread of HIV-1 and Drug Resistance in "Real-World" Settings

scientific article published on 28 December 2017

HIV drug resistance against strand transfer integrase inhibitors

scientific article published on 5 June 2017

HIV drug resistance and optimization of antiviral treatment in resource-poor countries

scientific article published in October 2004

HIV-1 Group O Resistance Against Integrase Inhibitors

scientific article published on 21 May 2015

HIV-1 drug resistance: can we overcome?

scientific article

HIV-1 genetic diversity in antenatal cohort, Canada.

scientific article published in August 2005

HIV-1 group O integrase displays lower enzymatic efficiency and higher susceptibility to raltegravir than HIV-1 group M subtype B integrase

scientific article

HIV-1 group O integrase displays lower susceptibility to raltegravir and has a different mutational pathway for resistance than HIV-1 group M.

scientific article published on 2 November 2014

HIV-1 resistance to dolutegravir is affected by cellular histone acetyltransferase activity

scientific article published on 23 August 2017

HIV-1 subtype C viruses rapidly develop K65R resistance to tenofovir in cell culture.

scientific article published in June 2006

Heat shock proteins: novel therapeutic tools for HIV-infection? ⬇️

scientific article published on January 1, 2001

High prevalence of the K65R mutation in human immunodeficiency virus type 1 subtype C isolates from infected patients in Botswana treated with didanosine-based regimens

scientific article

High rates of forward transmission events after acute/early HIV-1 infection

scientific article published on 16 February 2007

Highly diversified multiply drug-resistant HIV-1 quasispecies in PBMCs: a case report.

scientific article published on 30 May 2008

Impact of clade diversity on HIV-1 virulence, antiretroviral drug sensitivity and drug resistance

scientific article

Impact of human immunodeficiency virus type 1 subtype C on drug resistance mutations in patients from Botswana failing a nelfinavir-containing regimen

scientific article

In vitro and structural evaluation of PL-100 as a potential second-generation HIV-1 protease inhibitor

scientific article

Isolation of drug-resistant mutant HIV variants using tissue culture drug selection.

scientific article

Large cluster outbreaks sustain the HIV epidemic among men having sex with men (MSM) in Quebec from 2002 to 2015.

scientific article

Limiting cardiovascular events associated with HIV and antiretroviral therapy

scientific article published in November 2017

Modulation of Stress Protein (hsp27 and hsp70) Expression in CD4+ Lymphocytic Cells Following Acute Infection with Human Immunodeficiency Virus Type-1 ⬇️

scientific article published on July 7, 1997

Multiple effects of the M184V resistance mutation in the reverse transcriptase of human immunodeficiency virus type 1

scientific article published on November 2003

Natural polymorphisms in the human immunodeficiency virus type 2 protease can accelerate time to development of resistance to protease inhibitors

scientific article published on 20 November 2006

Near full-length genomic analysis of a novel subtype A1/C recombinant HIV type 1 isolate from Canada.

scientific article

Nucleoside and nucleotide analogs select in culture for different patterns of drug resistance in human immunodeficiency virus types 1 and 2.

scientific article published on 08 December 2008

Nucleotide and amino acid polymorphisms at drug resistance sites in non-B-subtype variants of human immunodeficiency virus type 1.

scientific article published on August 2004

Peripheral blood natural killer cell activity in human breast cancer patients and its modulation by T-cell growth factor and autologous plasma.

scientific article

Persistence and fitness of multidrug-resistant human immunodeficiency virus type 1 acquired in primary infection

scientific article

Phylogenetic inferences on HIV-1 transmission: implications for the design of prevention and treatment interventions

scientific article published on April 2013

Polymorphisms of cytotoxic T-lymphocyte (CTL) and T-helper epitopes within reverse transcriptase (RT) of HIV-1 subtype C from Ethiopia and Botswana following selection of antiretroviral drug resistance

scientific article

Predicting tipranavir and darunavir resistance using genotypic, phenotypic, and virtual phenotypic resistance patterns: an independent cohort analysis of clinical isolates highly resistant to all other protease inhibitors

scientific article

Pressure of zidovudine accelerates the reversion of lamivudine resistance-conferring M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1.

scientific article published on July 2002

Prevalence of HIV-1 resistant to antiretroviral drugs in 81 individuals newly infected by sexual contact or injecting drug use. Investigators of the Quebec Primary Infection Study.

scientific article

Purification of Zika virus RNA-dependent RNA polymerase and its use to identify small-molecule Zika inhibitors

scientific article (publication date: 8 January 2017)

Relationships among various nucleoside resistance-conferring mutations in the reverse transcriptase of HIV-1.

scientific article published on 25 November 2003

Resistance and viral subtypes: how important are the differences and why do they occur?

scientific article

Role of HIV Subtype Diversity in the Development of Resistance to Antiviral Drugs.

scientific article

Selective acquisition of G190S in HIV-1 subtype A from Russia leading to efavirenz and nevirapine treatment failure

scientific article published in November 2014

Selective resistance profiles emerging in patient-derived clinical isolates with cabotegravir, bictegravir, dolutegravir, and elvitegravir

scholarly article by Maureen Oliveira published in August 2018

Substitutions in the Reverse Transcriptase and Protease Genes of HIV-1 Subtype B in Untreated Individuals and Patients Treated With Antiretroviral Drugs

scientific article published on 23 March 2005

Subtype diversity associated with the development of HIV‐1 resistance to integrase inhibitors ⬇️

scientific article published on February 25, 2011

Subunit-selective mutational analysis and tissue culture evaluations of the interactions of the E138K and M184I mutations in HIV-1 reverse transcriptase

scientific article

Sugar transport and glut transporter expression in a variety of human immunodeficiency virus-1 (HIV-1) chronically infected target cell lines.

scientific article published on September 1998

Template usage is responsible for the preferential acquisition of the K65R reverse transcriptase mutation in subtype C variants of human immunodeficiency virus type 1.

scientific article published on 10 December 2008

The Gap Procedure: for the identification of phylogenetic clusters in HIV-1 sequence data

scientific article

The Impact of HIV Genetic Polymorphisms and Subtype Differences on the Occurrence of Resistance to Antiretroviral Drugs ⬇️

scientific article published on June 26, 2012

The K65R mutation in HIV-1 reverse transcriptase: genetic barriers, resistance profile and clinical implications.

scientific article

The M184V substitution in human immunodeficiency virus type 1 reverse transcriptase delays the development of resistance to amprenavir and efavirenz in subtype B and C clinical isolates

scientific article

The Role of Phylogenetics in Unravelling Patterns of HIV Transmission towards Epidemic Control: The Quebec Experience (2002–2020) ⬇️

journal article from 'Viruses' published in 2021

The dolutegravir R263K resistance mutation in HIV-1 integrase is incompatible with the emergence of resistance against raltegravir

scientific article published on 13 September 2015

The influence of protease inhibitor resistance profiles on selection of HIV therapy in treatment-naive patients.

scientific article published in June 2004

The preferential selection of K65R in HIV-1 subtype C is attenuated by nucleotide polymorphisms at thymidine analogue mutation sites ⬇️

scientific article published on June 7, 2013

Tissue culture drug resistance analysis of a novel HIV-1 protease inhibitor termed PL-100 in non-B HIV-1 subtypes.

scientific article published on 10 June 2010

Transmission clustering drives the onward spread of the HIV epidemic among men who have sex with men in Quebec

scientific article

Transmission networks of drug resistance acquired in primary/early stage HIV infection

scientific article

Variability in the PR and RT genes of HIV-1 isolated from recently infected subjects

scientific article

Variations in reverse transcriptase and RNase H domain mutations in human immunodeficiency virus type 1 clinical isolates are associated with divergent phenotypic resistance to zidovudine

scientific article

We need to use the best antiretroviral drugs worldwide to prevent HIV drug resistance.

scientific article

List of works by Bluma Brenner

A Template-Dependent Dislocation Mechanism Potentiates K65R Reverse Transcriptase Mutation Development in Subtype C Variants of HIV-1 ⬇️

A V106M mutation in HIV-1 clade C viruses exposed to efavirenz confers cross-resistance to non-nucleoside reverse transcriptase inhibitors

A significant reduction in the frequency of HIV-1 drug resistance in Québec from 2001 to 2011 is associated with a decrease in the monitored viral load

Altered Constitutive and Stress-Regulated Heat Shock Protein 27 Expression in HIV Type 1-Infected Cell Lines ⬇️

Antiretroviral drug resistance in human immunodeficiency virus type 2.

Antiviral Activity of Bictegravir and Cabotegravir Against Integrase Inhibitor Resistant SIVmac239 and HIV-1.

Apricitabine does not select additional drug resistance mutations in tissue culture in human immunodeficiency virus type 1 variants containing K65R, M184V, or M184V plus thymidine analogue mutations

Basis for Early and Preferential Selection of the E138K Mutation in HIV-1 Reverse Transcriptase ⬇️

Biochemical and virological analysis of the preference for the K65R multi-resistance nucleoside mutation in subtype C viruses

Changing patterns in the selection of viral mutations among patients receiving nucleoside and nucleotide drug combinations directed against human immunodeficiency virus type 1 reverse transcriptase

Characterization of the Drug Resistance Profiles of Integrase Strand Transfer Inhibitors in Simian Immunodeficiency Virus SIVmac239.

Characterization of the E138K Resistance Mutation in HIV-1 Reverse Transcriptase Conferring Susceptibility to Etravirine in B and Non-B HIV-1 Subtypes ⬇️

Clinical benefit of dolutegravir in HIV-1 management related to the high genetic barrier to drug resistance

Co-receptor usage and HIV-1 intra-clade C polymorphisms in the protease and reverse transcriptase genes of HIV-1 isolates from Ethiopia and Botswana.

Compensation by the E138K mutation in HIV-1 reverse transcriptase for deficits in viral replication capacity and enzyme processivity associated with the M184I/V mutations

Correcting covariate-dependent measurement error with non-zero mean

D-Glucose uptake and insulin binding by the human adipose cell plasma membrane as a function of its polypeptide composition

Dates of HIV infection can be estimated for seroprevalent patients by coalescent analysis of serial next-generation sequencing data

Detectable signals of episodic risk effects on acute HIV transmission: strategies for analyzing transmission systems using genetic data

Detection of human immunodeficiency virus (HIV) type 1 M184V and K103N minority variants in patients with primary HIV infection.

Development of a G118R mutation in HIV-1 integrase following a switch to dolutegravir monotherapy leading to cross-resistance to integrase inhibitors

Development of antiretroviral drug resistance

Didanosine, interferon-alfa and ribavirin: a highly synergistic combination with potential activity against HIV-1 and hepatitis C virus

Differential maintenance of the M184V substitution in the reverse transcriptase of human immunodeficiency virus type 1 by various nucleoside antiretroviral agents in tissue culture

Diminished representation of HIV-1 variants containing select drug resistance-conferring mutations in primary HIV-1 infection

Discrepancies in assignment of subtype/recombinant forms by genotyping programs for HIV type 1 drug resistance testing may falsely predict superinfection.

Distinct resistance patterns to etravirine and rilpivirine in viruses containing nonnucleoside reverse transcriptase inhibitor mutations at baseline ⬇️

Does antiretroviral treatment change HIV-1 codon usage patterns in its genes: a preliminary bioinformatics study

Dolutegravir inhibits HIV-1 Env evolution in primary human cells

Durable suppression of HIV-1 with resistance mutations to integrase inhibitors by dolutegravir following drug washout

Effects of the K65R and K65R/M184V reverse transcriptase mutations in subtype C HIV on enzyme function and drug resistance

Evolution of a novel pathway leading to dolutegravir resistance in a patient harbouring N155H and multiclass drug resistance

Future of phylogeny in HIV prevention

Genetic divergence of human immunodeficiency virus type 1 Ethiopian clade C reverse transcriptase (RT) and rapid development of resistance against nonnucleoside inhibitors of RT.

Genotypic and Phylogenetic Insights on Prevention of the Spread of HIV-1 and Drug Resistance in "Real-World" Settings

HIV drug resistance against strand transfer integrase inhibitors

HIV drug resistance and optimization of antiviral treatment in resource-poor countries

HIV-1 Group O Resistance Against Integrase Inhibitors

HIV-1 drug resistance: can we overcome?

HIV-1 genetic diversity in antenatal cohort, Canada.

HIV-1 group O integrase displays lower enzymatic efficiency and higher susceptibility to raltegravir than HIV-1 group M subtype B integrase

HIV-1 group O integrase displays lower susceptibility to raltegravir and has a different mutational pathway for resistance than HIV-1 group M.

HIV-1 resistance to dolutegravir is affected by cellular histone acetyltransferase activity

HIV-1 subtype C viruses rapidly develop K65R resistance to tenofovir in cell culture.

Heat shock proteins: novel therapeutic tools for HIV-infection? ⬇️

High prevalence of the K65R mutation in human immunodeficiency virus type 1 subtype C isolates from infected patients in Botswana treated with didanosine-based regimens

High rates of forward transmission events after acute/early HIV-1 infection

Highly diversified multiply drug-resistant HIV-1 quasispecies in PBMCs: a case report.

Impact of clade diversity on HIV-1 virulence, antiretroviral drug sensitivity and drug resistance

Impact of human immunodeficiency virus type 1 subtype C on drug resistance mutations in patients from Botswana failing a nelfinavir-containing regimen

In vitro and structural evaluation of PL-100 as a potential second-generation HIV-1 protease inhibitor

Isolation of drug-resistant mutant HIV variants using tissue culture drug selection.

Large cluster outbreaks sustain the HIV epidemic among men having sex with men (MSM) in Quebec from 2002 to 2015.

Limiting cardiovascular events associated with HIV and antiretroviral therapy

Modulation of Stress Protein (hsp27 and hsp70) Expression in CD4+ Lymphocytic Cells Following Acute Infection with Human Immunodeficiency Virus Type-1 ⬇️

Multiple effects of the M184V resistance mutation in the reverse transcriptase of human immunodeficiency virus type 1

Natural polymorphisms in the human immunodeficiency virus type 2 protease can accelerate time to development of resistance to protease inhibitors

Near full-length genomic analysis of a novel subtype A1/C recombinant HIV type 1 isolate from Canada.

Nucleoside and nucleotide analogs select in culture for different patterns of drug resistance in human immunodeficiency virus types 1 and 2.

Nucleotide and amino acid polymorphisms at drug resistance sites in non-B-subtype variants of human immunodeficiency virus type 1.

Peripheral blood natural killer cell activity in human breast cancer patients and its modulation by T-cell growth factor and autologous plasma.

Persistence and fitness of multidrug-resistant human immunodeficiency virus type 1 acquired in primary infection

Phylogenetic inferences on HIV-1 transmission: implications for the design of prevention and treatment interventions

Polymorphisms of cytotoxic T-lymphocyte (CTL) and T-helper epitopes within reverse transcriptase (RT) of HIV-1 subtype C from Ethiopia and Botswana following selection of antiretroviral drug resistance

Predicting tipranavir and darunavir resistance using genotypic, phenotypic, and virtual phenotypic resistance patterns: an independent cohort analysis of clinical isolates highly resistant to all other protease inhibitors

Pressure of zidovudine accelerates the reversion of lamivudine resistance-conferring M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1.

Prevalence of HIV-1 resistant to antiretroviral drugs in 81 individuals newly infected by sexual contact or injecting drug use. Investigators of the Quebec Primary Infection Study.

Purification of Zika virus RNA-dependent RNA polymerase and its use to identify small-molecule Zika inhibitors

Relationships among various nucleoside resistance-conferring mutations in the reverse transcriptase of HIV-1.

Resistance and viral subtypes: how important are the differences and why do they occur?

Role of HIV Subtype Diversity in the Development of Resistance to Antiviral Drugs.

Selective acquisition of G190S in HIV-1 subtype A from Russia leading to efavirenz and nevirapine treatment failure

Selective resistance profiles emerging in patient-derived clinical isolates with cabotegravir, bictegravir, dolutegravir, and elvitegravir

Substitutions in the Reverse Transcriptase and Protease Genes of HIV-1 Subtype B in Untreated Individuals and Patients Treated With Antiretroviral Drugs

Subtype diversity associated with the development of HIV‐1 resistance to integrase inhibitors ⬇️

Subunit-selective mutational analysis and tissue culture evaluations of the interactions of the E138K and M184I mutations in HIV-1 reverse transcriptase

Sugar transport and glut transporter expression in a variety of human immunodeficiency virus-1 (HIV-1) chronically infected target cell lines.

Template usage is responsible for the preferential acquisition of the K65R reverse transcriptase mutation in subtype C variants of human immunodeficiency virus type 1.

The Gap Procedure: for the identification of phylogenetic clusters in HIV-1 sequence data