List of works - Alex J Parker

Chromatin remodeller CHD7 is required for GABAergic neuron development by promoting PAQR3 expression

scientific article published on 26 April 2021

Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells

scientific article published on 21 June 2008

Deciphering genetic interactions between ALS genes using C. elegans

scientific article published on 8 May 2014

Evaluation of longevity enhancing compounds against transactive response DNA-binding protein-43 neuronal toxicity.

scientific article published on 13 April 2013

Expression of human Bcl-xL (Ser49) and (Ser62) mutants in Caenorhabditis elegans causes germline defects and aneuploidy

scientific article

Fishing for causes and cures of motor neuron disorders

scientific article published on July 2014

Fragile lifespan expansion by dietary mitohormesis in C. elegans.

scientific article published on 13 January 2016

Genome-wide association study of determinants of anti-cyclic citrullinated peptide antibody titer in adults with rheumatoid arthritis

scientific article published on 06 March 2009

Glucose delays age-dependent proteotoxicity.

scientific article published on August 2012

Heritable transmission of stress resistance by high dietary glucose in Caenorhabditis elegans

scientific article

Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity.

scientific article

Insulin signaling in the aging of healthy and proteotoxically stressed mechanosensory neurons

scientific article

Integration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity

scientific journal article

Large-scale functional RNAi screen in C. elegans identifies genes that regulate the dysfunction of mutant polyglutamine neurons.

scientific article

Maple Syrup Decreases TDP-43 Proteotoxicity in a Caenorhabditis elegans Model of Amyotrophic Lateral Sclerosis (ALS).

scientific article

Modulating the ER stress response attenuates neurodegeneration in a C. elegans model of spinal muscular atrophy

scientific article published on 08 October 2020

Morphological remodeling of C. elegans neurons during aging is modified by compromised protein homeostasis.

scientific article published on 07 April 2016

Neurodegeneration in C. elegans models of ALS requires TIR-1/Sarm1 immune pathway activation in neurons. ⬇️

scientific article

Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate

scientific article published on 01 August 2007

Pharmacological reduction of ER stress protects against TDP-43 neuronal toxicity in vivo.

scientific article published on 5 April 2013

RNA-Based Therapy Utilizing Oculopharyngeal Muscular Dystrophy Transcript Knockdown and Replacement

scientific article published on 15 February 2019

Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models.

scientific article published on 19 November 2012

Rescue of ATXN3 neuronal toxicity in Caenorhabditiselegans by chemical modification of endoplasmic reticulum stress.

scientific article

Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons

scientific article published in May 2005

Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.

scientific article

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

scientific article

Simple animal models for amyotrophic lateral sclerosis drug discovery

scientific article published on June 2016

TDP-43 toxicity proceeds via calcium dysregulation and necrosis in aging Caenorhabditis elegans motor neurons

scientific article

The stress response factor daf-16/FOXO is required for multiple compound families to prolong the function of neurons with Huntington's disease

scientific article

Valproic acid is protective in cellular and worm models of oculopharyngeal muscular dystrophy

Worming forward: amyotrophic lateral sclerosis toxicity mechanisms and genetic interactions in Caenorhabditis elegans

scientific article published on 17 April 2014

[Stress-induced propagation of neurodegeneration by wild-type proteins in simple models of ALS]

scientific article published on 26 April 2013

List of works by Alex J Parker

Chromatin remodeller CHD7 is required for GABAergic neuron development by promoting PAQR3 expression

Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells

Deciphering genetic interactions between ALS genes using C. elegans

Evaluation of longevity enhancing compounds against transactive response DNA-binding protein-43 neuronal toxicity.

Expression of human Bcl-xL (Ser49) and (Ser62) mutants in Caenorhabditis elegans causes germline defects and aneuploidy

Fishing for causes and cures of motor neuron disorders

Fragile lifespan expansion by dietary mitohormesis in C. elegans.

Genome-wide association study of determinants of anti-cyclic citrullinated peptide antibody titer in adults with rheumatoid arthritis

Glucose delays age-dependent proteotoxicity.

Heritable transmission of stress resistance by high dietary glucose in Caenorhabditis elegans

Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity.

Insulin signaling in the aging of healthy and proteotoxically stressed mechanosensory neurons

Integration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity

Large-scale functional RNAi screen in C. elegans identifies genes that regulate the dysfunction of mutant polyglutamine neurons.

Maple Syrup Decreases TDP-43 Proteotoxicity in a Caenorhabditis elegans Model of Amyotrophic Lateral Sclerosis (ALS).

Modulating the ER stress response attenuates neurodegeneration in a C. elegans model of spinal muscular atrophy

Morphological remodeling of C. elegans neurons during aging is modified by compromised protein homeostasis.

Neurodegeneration in C. elegans models of ALS requires TIR-1/Sarm1 immune pathway activation in neurons. ⬇️

Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate

Pharmacological reduction of ER stress protects against TDP-43 neuronal toxicity in vivo.

RNA-Based Therapy Utilizing Oculopharyngeal Muscular Dystrophy Transcript Knockdown and Replacement

Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models.

Rescue of ATXN3 neuronal toxicity in Caenorhabditiselegans by chemical modification of endoplasmic reticulum stress.

Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons

Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

Simple animal models for amyotrophic lateral sclerosis drug discovery

TDP-43 toxicity proceeds via calcium dysregulation and necrosis in aging Caenorhabditis elegans motor neurons

The stress response factor daf-16/FOXO is required for multiple compound families to prolong the function of neurons with Huntington's disease

Valproic acid is protective in cellular and worm models of oculopharyngeal muscular dystrophy

Worming forward: amyotrophic lateral sclerosis toxicity mechanisms and genetic interactions in Caenorhabditis elegans

[Stress-induced propagation of neurodegeneration by wild-type proteins in simple models of ALS]